Class information for:
Level 1: BRYOSTATIN//BRYOSTATIN 1//APLYSIATOXIN

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
17826 580 44.5 83%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
328 3       PHOSPHOLIPASE D//STIM1//REGUCALCIN 38118
1486 2             PROTEIN KINASE C//BRYOSTATIN//BRYOSTATIN 1 7631
17826 1                   BRYOSTATIN//BRYOSTATIN 1//APLYSIATOXIN 580

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BRYOSTATIN authKW 2948119 14% 67% 84
2 BRYOSTATIN 1 authKW 2832394 14% 68% 79
3 APLYSIATOXIN authKW 303331 2% 52% 11
4 BRYOSTATIN I authKW 210584 1% 100% 4
5 MARINE BRYOZOAN authKW 198428 1% 54% 7
6 BUGULA NERITINA authKW 181556 2% 27% 13
7 BRYOSTATIN 11 authKW 157938 1% 100% 3
8 APLOG 1 authKW 105292 0% 100% 2
9 D ISOBUTYL LACTATE authKW 105292 0% 100% 2
10 DABIS MALEATE authKW 105292 0% 100% 2

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Oncology 1872 30% 0% 176
2 Chemistry, Organic 818 18% 0% 105
3 Hematology 542 10% 0% 58
4 Chemistry, Medicinal 365 8% 0% 47
5 Pharmacology & Pharmacy 270 15% 0% 86
6 Chemistry, Multidisciplinary 104 12% 0% 67
7 Immunology 43 6% 0% 35
8 Medicine, Research & Experimental 20 3% 0% 20
9 Biochemistry & Molecular Biology 17 9% 0% 55
10 Plant Sciences 11 4% 0% 21

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 REGA MED MICROBIOL IMMUNOL 105292 0% 100% 2
2 INTERNAL MEDKARMANOS CANC 78966 1% 50% 3
3 BARTH LONDON 52646 0% 100% 1
4 CANC UK MED ONCOLCLIN TRIALS UNIT 52646 0% 100% 1
5 CHEM BIOL MASS SPE OMETRY IL 52646 0% 100% 1
6 CHRISTIE CANC 52646 0% 100% 1
7 COLUMBIA P BYTERIAN COMPREHENS CANC 52646 0% 100% 1
8 DRUG SCREENINGSHANGHAI BIOL SCI 52646 0% 100% 1
9 HEMATOL ONCOL HEMATOL ONCOL 52646 0% 100% 1
10 J AN SOC PROMOT SCI DC2 ORGAN CHEM LIFE SCI 52646 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 INVESTIGATIONAL NEW DRUGS 3467 2% 1% 13
2 MOLECULAR AND CELLULAR DIFFERENTIATION 2391 0% 5% 1
3 ENZYME & PROTEIN 2336 0% 2% 2
4 ORGANIC LETTERS 1477 5% 0% 27
5 JOURNAL OF NATURAL PRODUCTS 1245 3% 0% 17
6 LEUKEMIA RESEARCH 1236 2% 0% 12
7 LEUKEMIA 1159 2% 0% 13
8 CLINICAL CANCER RESEARCH 885 3% 0% 16
9 CANCER RESEARCH 876 4% 0% 26
10 ANTI-CANCER DRUGS 779 1% 0% 7

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 BRYOSTATIN 2948119 14% 67% 84 Search BRYOSTATIN Search BRYOSTATIN
2 BRYOSTATIN 1 2832394 14% 68% 79 Search BRYOSTATIN+1 Search BRYOSTATIN+1
3 APLYSIATOXIN 303331 2% 52% 11 Search APLYSIATOXIN Search APLYSIATOXIN
4 BRYOSTATIN I 210584 1% 100% 4 Search BRYOSTATIN+I Search BRYOSTATIN+I
5 MARINE BRYOZOAN 198428 1% 54% 7 Search MARINE+BRYOZOAN Search MARINE+BRYOZOAN
6 BUGULA NERITINA 181556 2% 27% 13 Search BUGULA+NERITINA Search BUGULA+NERITINA
7 BRYOSTATIN 11 157938 1% 100% 3 Search BRYOSTATIN+11 Search BRYOSTATIN+11
8 APLOG 1 105292 0% 100% 2 Search APLOG+1 Search APLOG+1
9 D ISOBUTYL LACTATE 105292 0% 100% 2 Search D+ISOBUTYL+LACTATE Search D+ISOBUTYL+LACTATE
10 DABIS MALEATE 105292 0% 100% 2 Search DABIS+MALEATE Search DABIS+MALEATE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 HALE, KJ , MANAVIAZAR, S , (2010) NEW APPROACHES TO THE TOTAL SYNTHESIS OF THE BRYOSTATIN ANTITUMOR MACROLIDES.CHEMISTRY-AN ASIAN JOURNAL. VOL. 5. ISSUE 4. P. 704-754 101 63% 62
2 RUAN, BF , ZHU, HL , (2012) THE CHEMISTRY AND BIOLOGY OF THE BRYOSTATINS: POTENTIAL PKC INHIBITORS IN CLINICAL DEVELOPMENT.CURRENT MEDICINAL CHEMISTRY. VOL. 19. ISSUE 16. P. 2652-2664 77 75% 24
3 KORTMANSKY, J , SCHWARTZ, GK , (2003) BRYOSTATIN-1: A NOVEL PKC INHIBITOR IN CLINICAL DEVELOPMENT.CANCER INVESTIGATION. VOL. 21. ISSUE 6. P. 924-936 85 79% 90
4 KRAFT, MB , POUDEL, YB , KEDEI, N , LEWIN, NE , PEACH, ML , BLUMBERG, PM , KECK, GE , (2014) SYNTHESIS OF A DES-B-RING BRYOSTATIN ANALOGUE LEADS TO AN UNEXPECTED RING EXPANSION OF THE BRYOLACTONE CORE.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. VOL. 136. ISSUE 38. P. 13202 -13208 50 85% 9
5 KETCHAM, JM , VOLCHKOV, I , CHEN, TY , BLUMBERG, PM , KEDEI, N , LEWIN, NE , KRISCHE, MJ , (2016) EVALUATION OF CHROMANE-BASED BRYOSTATIN ANALOGUES PREPARED VIA HYDROGEN-MEDIATED C-C BOND FORMATION: POTENCY DOES NOT CONFER BRYOSTATIN-LIKE BIOLOGY.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. VOL. 138. ISSUE 40. P. 13415 -13423 60 64% 0
6 ANDREWS, IP , KETCHAM, JM , BLUMBERG, PM , KEDEI, N , LEWIN, NE , PEACH, ML , KRISCHE, MJ , (2014) SYNTHESIS OF SECO-B-RING BRYOSTATIN ANALOGUE WN-1 VIA C-C BOND-FORMING HYDROGENATION: CRITICAL CONTRIBUTION OF THE B-RING IN DETERMINING BRYOSTATIN-LIKE AND PHORBOL 12-MYRISTATE 13-ACETATE-LIKE PROPERTIES.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. VOL. 136. ISSUE 38. P. 13209 -13216 52 71% 5
7 CLAMP, A , JAYSON, GC , (2002) THE CLINICAL DEVELOPMENT OF THE BRYOSTATINS.ANTI-CANCER DRUGS. VOL. 13. ISSUE 7. P. 673 -683 56 84% 64
8 TROST, BM , FRONTIER, AJ , THIEL, OR , YANG, HB , DONG, GB , (2011) TOTAL SYNTHESIS OF BRYOSTATINS: THE DEVELOPMENT OF METHODOLOGY FOR THE ATOM-ECONOMIC AND STEREOSELECTIVE SYNTHESIS OF THE RING C SUBUNIT.CHEMISTRY-A EUROPEAN JOURNAL. VOL. 17. ISSUE 35. P. 9762 -9776 57 68% 5
9 LU, Y , KRISCHE, MJ , (2009) CONCISE SYNTHESIS OF THE BRYOSTATIN A-RING VIA CONSECUTIVE C-C BOND FORMING TRANSFER HYDROGENATIONS.ORGANIC LETTERS. VOL. 11. ISSUE 14. P. 3108 -3111 50 79% 14
10 BALL, M , BARON, A , BRADSHAW, B , DUMEUNIER, R , O'BRIEN, M , THOMAS, EJ , (2016) THE EVOLUTION OF A STEREOSELECTIVE SYNTHESIS OF THE C1-C16 FRAGMENT OF BRYOSTATINS.ORGANIC & BIOMOLECULAR CHEMISTRY. VOL. 14. ISSUE 40. P. 9650 -9681 45 71% 0

Classes with closest relation at Level 1


Rank Class id link
1 1767 PROTEIN KINASE C//PKC DELTA//CELLULAR CARCINOGENESIS TUMOR PROMOT
2 21004 TELEOCIDIN//TUMOR PROMOTER//PENDOLMYCIN
3 14510 DOLASTATIN 10//DIDEMNIN B//CRYPTOPHYCIN
4 25613 UCN 01//7 HYDROXYSTAUROSPORINE//CGP41251
5 9655 PRINS CYCLIZATION//TETRAHYDROPYRAN//CENTROLOBINE
6 3210 PROTEIN KINASE C//PHORBOL ESTER//COW MAMMARY GLAND
7 34291 SAFDIE AIDS IMMUNOL//AS101//CAIR
8 32191 ENZASTAURIN//LY317615//INTRATUMORAL VESSELS
9 24831 CROCACIN//HYDROAMIDATION//AMATHASPIRAMIDE
10 19186 REDUCTION DIASTEREOSELECTIVE//ALDOL PRODUCTS//POLYENE MACROLIDE

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