Class information for:
Level 1: UCN 01//7 HYDROXYSTAUROSPORINE//CGP41251

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
25613 276 39.4 89%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
328 3       PHOSPHOLIPASE D//STIM1//REGUCALCIN 38118
1486 2             PROTEIN KINASE C//BRYOSTATIN//BRYOSTATIN 1 7631
25613 1                   UCN 01//7 HYDROXYSTAUROSPORINE//CGP41251 276

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 UCN 01 authKW 1847025 13% 45% 37
2 7 HYDROXYSTAUROSPORINE authKW 417003 3% 54% 7
3 CGP41251 authKW 331905 1% 100% 3
4 7 HYDROXYSTAUROSPORINE UCN 01 authKW 295024 1% 67% 4
5 STAUROSPORINE ANALOGS authKW 248927 1% 75% 3
6 STAUROSPORINE authKW 239736 16% 5% 43
7 CAS 120685 11 2 authKW 221270 1% 100% 2
8 CYCLIN DEPENDENT KINASE MODULATOR authKW 221270 1% 100% 2
9 CGP 41 251 authKW 221266 1% 50% 4
10 IN VITRO ANTIPROLIFERATION authKW 147512 1% 67% 2

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Oncology 2910 53% 0% 146
2 Pharmacology & Pharmacy 374 23% 0% 64
3 Cell Biology 184 15% 0% 41
4 Biophysics 47 6% 0% 16
5 Hematology 45 5% 0% 13
6 Biochemistry & Molecular Biology 31 13% 0% 37
7 Biochemical Research Methods 17 4% 0% 10
8 Biology 11 3% 0% 7
9 Chemistry, Analytical 6 4% 0% 10
10 Toxicology 6 2% 0% 6

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOL CELLULAIRE VIRALE 110635 0% 100% 1
2 BIOL CHEM MOLEC THER EUT SECT 110635 0% 100% 1
3 BIOMED INFORMAT ENVIRONM HLTH 110635 0% 100% 1
4 BIOSTAT ANAT 110635 0% 100% 1
5 CANC BIOL PATIENT TAILORING DISCOVERY ONCOL 110635 0% 100% 1
6 DEV CHEMOTHER Y SERV SOLID TUMORS 110635 0% 100% 1
7 INFECT DIS SMIT 110635 0% 100% 1
8 INTERNAL MEDCANC MOL 110635 0% 100% 1
9 LIVER DISHMR 101 110635 0% 100% 1
10 MED GASTROINTESTINAL TUMOR SERV 110635 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CELL GROWTH & DIFFERENTIATION 2821 2% 0% 6
2 CANCER CHEMOTHERAPY AND PHARMACOLOGY 2535 5% 0% 13
3 CLINICAL CANCER RESEARCH 1662 5% 0% 15
4 CANCER RESEARCH 1003 7% 0% 19
5 CANCER BIOLOGY & THERAPY 978 2% 0% 5
6 ANTI-CANCER DRUGS 840 2% 0% 5
7 YAKHTEH 766 0% 1% 1
8 INVESTIGATIONAL NEW DRUGS 687 1% 0% 4
9 MOLECULAR PHARMACOLOGY 545 3% 0% 7
10 JAPANESE JOURNAL OF CANCER RESEARCH 493 1% 0% 4

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 UCN 01 1847025 13% 45% 37 Search UCN+01 Search UCN+01
2 7 HYDROXYSTAUROSPORINE 417003 3% 54% 7 Search 7+HYDROXYSTAUROSPORINE Search 7+HYDROXYSTAUROSPORINE
3 CGP41251 331905 1% 100% 3 Search CGP41251 Search CGP41251
4 7 HYDROXYSTAUROSPORINE UCN 01 295024 1% 67% 4 Search 7+HYDROXYSTAUROSPORINE+UCN+01 Search 7+HYDROXYSTAUROSPORINE+UCN+01
5 STAUROSPORINE ANALOGS 248927 1% 75% 3 Search STAUROSPORINE+ANALOGS Search STAUROSPORINE+ANALOGS
6 STAUROSPORINE 239736 16% 5% 43 Search STAUROSPORINE Search STAUROSPORINE
7 CAS 120685 11 2 221270 1% 100% 2 Search CAS+120685+11+2 Search CAS+120685+11+2
8 CYCLIN DEPENDENT KINASE MODULATOR 221270 1% 100% 2 Search CYCLIN+DEPENDENT+KINASE+MODULATOR Search CYCLIN+DEPENDENT+KINASE+MODULATOR
9 CGP 41 251 221266 1% 50% 4 Search CGP+41+251 Search CGP+41+251
10 IN VITRO ANTIPROLIFERATION 147512 1% 67% 2 Search IN+VITRO+ANTIPROLIFERATION Search IN+VITRO+ANTIPROLIFERATION

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 FUSE, E , KUWABARA, T , SPARREBOOM, A , SAUSVILLE, EA , FIGG, WD , (2005) REVIEW OF UCN-01 DEVELOPMENT: A LESSON IN THE IMPORTANCE OF CLINICAL PHARMACOLOGY.JOURNAL OF CLINICAL PHARMACOLOGY. VOL. 45. ISSUE 4. P. 394 -403 21 84% 71
2 KUMMAR, S , GUTIERREZ, ME , GARDNER, ER , FIGG, WD , MELILLO, G , DANCEY, J , SAUSVILLE, EA , CONLEY, BA , MURGO, AJ , DOROSHOW, JH , (2010) A PHASE I TRIAL OF UCN-01 AND PREDNISONE IN PATIENTS WITH REFRACTORY SOLID TUMORS AND LYMPHOMAS.CANCER CHEMOTHERAPY AND PHARMACOLOGY. VOL. 65. ISSUE 2. P. 383 -389 20 74% 11
3 FRACASSO, PM , WILLIAMS, KJ , CHEN, RC , PICUS, J , MA, CX , ELLIS, MJ , TAN, BR , PLUARD, TJ , ADKINS, DR , NAUGHTON, MJ , ET AL (2011) A PHASE 1 STUDY OF UCN-01 IN COMBINATION WITH IRINOTECAN IN PATIENTS WITH RESISTANT SOLID TUMOR MALIGNANCIES.CANCER CHEMOTHERAPY AND PHARMACOLOGY. VOL. 67. ISSUE 6. P. 1225 -1237 29 45% 24
4 HOTTE, SJ , OZA, A , WINQUIST, EW , MOORE, M , CHEN, EX , BROWN, S , POND, GR , DANCEY, JE , HIRTE, HW , (2006) PHASE I TRIAL OF UCN-01 IN COMBINATION WITH TOPOTECAN IN PATIENTS WITH ADVANCED SOLID CANCERS: A PRINCESS MARGARET HOSPITAL PHASE II CONSORTIUM STUDY.ANNALS OF ONCOLOGY. VOL. 17. ISSUE 2. P. 334-340 19 66% 61
5 DEES, EC , BAKER, SD , O'REILLY, S , RUDEK, MA , DAVIDSON, SB , AYLESWORTH, C , ELZA-BROWN, K , CARDUCCI, MA , DONEHOWER, RC , (2005) A PHASE I AND PHARMACOKINETIC STUDY OF SHORT INFUSIONS OF UCN-01 IN PATIENTS WITH REFRACTORY SOLID TUMORS.CLINICAL CANCER RESEARCH. VOL. 11. ISSUE 2. P. 664-671 20 67% 40
6 SMITH, JA , CORTES, J , NEWMAN, RA , MADDEN, TL , (2001) DEVELOPMENT OF A SIMPLIFIED, SENSITIVE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD USING FLUORESCENCE DETECTION TO DETERMINE THE CONCENTRATION OF UCN-01 IN HUMAN PLASMA.JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES. VOL. 760. ISSUE 2. P. 247 -253 17 94% 1
7 YASOSHIMA, K , KUWABARA, T , FUSE, E , KURAMITU, T , KURATA, N , NISHIIE, H , OISHI, T , KOBAYASHI, H , KOBAYASHI, S , (2001) PHARMACOKINETICS, DISTRIBUTION, METABOLISM AND EXCRETION OF [H-3]UCN-01 IN RATS AND DOGS AFTER INTRAVENOUS ADMINISTRATION.CANCER CHEMOTHERAPY AND PHARMACOLOGY. VOL. 47. ISSUE 2. P. 106-112 16 100% 3
8 HAGENAUER, B , MAIER-SALAMON, A , THALHAMMER, T , ZOLLNER, P , SENDEROWICZ, A , JAGER, W , (2004) METABOLISM OF UCN-01 IN ISOLATED PERFUSED RAT LIVER: ROLE OF MRP2 IN THE BILIARY EXCRETION OF GLUCURONIDES.ONCOLOGY REPORTS. VOL. 11. ISSUE 5. P. 1069-1075 17 81% 6
9 MACK, PC , JONES, AA , GUSTAFSSON, MH , GANDARA, DR , GUMERLOCK, PH , GOLDBERG, Z , (2004) ENHANCEMENT OF RADIATION CYTOTOXICITY BY UCN-01 IN NON-SMALL CELL LUNG CARCINOMA CELLS.RADIATION RESEARCH. VOL. 162. ISSUE 6. P. 623 -634 25 49% 7
10 LARA, PN , MACK, PC , SYNOLD, T , FRANKEL, P , LONGMATE, J , GUMERLOCK, PH , DOROSHOW, JH , GANDARA, DR , (2005) THE CYCLIN-DEPENDENT KINASE INHIBITOR UCN-01 PLUS CISPLATIN IN ADVANCED SOLID TUMORS: A CALIFORNIA CANCER CONSORTIUM PHASE I PHARMACOKINETIC AND MOLECULAR CORRELATIVE TRIAL.CLINICAL CANCER RESEARCH. VOL. 11. ISSUE 12. P. 4444-4450 15 71% 52

Classes with closest relation at Level 1


Rank Class id link
1 12530 INDOLOCARBAZOLE//REBECCAMYCIN//GRANULATIMIDE
2 7118 FLAVOPIRIDOL//CYCLIN DEPENDENT KINASE//ROSCOVITINE
3 32191 ENZASTAURIN//LY317615//INTRATUMORAL VESSELS
4 32633 THIOSENS//PHARMACOL CELLULAIRE MOL ANTICANC//ALPHANIZOMENON FLOS AQUAE
5 2448 CHK1//CHECKPOINT//RAD9
6 17826 BRYOSTATIN//BRYOSTATIN 1//APLYSIATOXIN
7 1767 PROTEIN KINASE C//PKC DELTA//CELLULAR CARCINOGENESIS TUMOR PROMOT
8 16864 G2 REPAIR//G2 DELAY//G2 M BLOCK ABROGATION
9 33386 COMPETITIVE TEMPLATE//GIANT CANCER CELLS//RAJU CELLS
10 30791 PUMA//PUMA GENE//P53 UPREGULATED MODULATOR OF APOPTOSIS PUMA

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