Class information for:
Level 1: PAR 4//ATYPICAL PROTEIN KINASE C//PROTEIN KINASE C IOTA

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
19822 488 44.1 93%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
328 3       PHOSPHOLIPASE D//STIM1//REGUCALCIN 38118
1486 2             PROTEIN KINASE C//BRYOSTATIN//BRYOSTATIN 1 7631
19822 1                   PAR 4//ATYPICAL PROTEIN KINASE C//PROTEIN KINASE C IOTA 488

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PAR 4 authKW 2566595 13% 63% 65
2 ATYPICAL PROTEIN KINASE C authKW 1143947 6% 63% 29
3 PROTEIN KINASE C IOTA authKW 362014 2% 64% 9
4 PROSTATE APOPTOSIS RESPONSE 4 authKW 333709 2% 67% 8
5 PKC IOTA authKW 298126 2% 53% 9
6 LP MARKEY CANC address 250278 2% 50% 8
7 ATYPICAL PKCS authKW 223466 1% 71% 5
8 P62 authKW 208399 7% 9% 36
9 PROGRAM CELLULAR MOL BIOSCI address 200219 2% 40% 8
10 PB1 DOMAIN authKW 150164 1% 40% 6

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Cell Biology 1700 31% 0% 151
2 Biochemistry & Molecular Biology 1179 42% 0% 205
3 Oncology 1068 25% 0% 124
4 Endocrinology & Metabolism 173 8% 0% 41
5 Genetics & Heredity 52 6% 0% 28
6 Medicine, Research & Experimental 49 5% 0% 24
7 Biophysics 38 4% 0% 21
8 Neurosciences 26 7% 0% 34
9 Pathology 23 3% 0% 13
10 Chemistry, Medicinal 4 2% 0% 8

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 LP MARKEY CANC 250278 2% 50% 8
2 PROGRAM CELLULAR MOL BIOSCI 200219 2% 40% 8
3 GLAXO WELLCOME CSIC BIOL MOL CELULAR 125143 0% 100% 2
4 GRP CELLULAR SIGNALING 125143 0% 100% 2
5 ALLERGY PULM CRIT CARE MED MEDTHORAC 62571 0% 100% 1
6 BILIARY PANCREAT SURGCANC 62571 0% 100% 1
7 BIO5OV 62571 0% 100% 1
8 DKFZ JR GRP BRAIN TUMOR TRANSLAT TARGETS 62571 0% 100% 1
9 DPT G DELSOL 62571 0% 100% 1
10 GENE EXP S MODERN DIAGNOST THER METHODS 62571 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ADVANCES IN ENZYME REGULATION 939 1% 1% 3
2 ONCOGENE 758 3% 0% 15
3 EXPERT OPINION ON THERAPEUTIC TARGETS 722 1% 0% 4
4 EMBO REPORTS 715 1% 0% 5
5 MOLECULAR AND CELLULAR BIOLOGY 696 3% 0% 16
6 JOURNAL OF BIOLOGICAL CHEMISTRY 643 8% 0% 41
7 CANCER BIOLOGY & THERAPY 549 1% 0% 5
8 EMBO JOURNAL 508 2% 0% 12
9 CANCER RESEARCH 493 4% 0% 18
10 PEZCOLLER FOUNDATION SYMPOSIA 489 1% 0% 4

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 PAR 4 2566595 13% 63% 65 Search PAR+4 Search PAR+4
2 ATYPICAL PROTEIN KINASE C 1143947 6% 63% 29 Search ATYPICAL+PROTEIN+KINASE+C Search ATYPICAL+PROTEIN+KINASE+C
3 PROTEIN KINASE C IOTA 362014 2% 64% 9 Search PROTEIN+KINASE+C+IOTA Search PROTEIN+KINASE+C+IOTA
4 PROSTATE APOPTOSIS RESPONSE 4 333709 2% 67% 8 Search PROSTATE+APOPTOSIS+RESPONSE+4 Search PROSTATE+APOPTOSIS+RESPONSE+4
5 PKC IOTA 298126 2% 53% 9 Search PKC+IOTA Search PKC+IOTA
6 ATYPICAL PKCS 223466 1% 71% 5 Search ATYPICAL+PKCS Search ATYPICAL+PKCS
7 P62 208399 7% 9% 36 Search P62 Search P62
8 PB1 DOMAIN 150164 1% 40% 6 Search PB1+DOMAIN Search PB1+DOMAIN
9 PKC ZETA 144281 3% 14% 16 Search PKC+ZETA Search PKC+ZETA
10 AUROTHIOMALATE 129168 2% 26% 8 Search AUROTHIOMALATE Search AUROTHIOMALATE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 RASOOL, RU , NAYAK, D , CHAKRABORTY, S , KATOCH, A , FAHEEM, MM , AMIN, H , GOSWAMI, A , (2016) A JOURNEY BEYOND APOPTOSIS: NEW ENIGMA OF CONTROLLING METASTASIS BY PRO-APOPTOTIC PAR-4.CLINICAL & EXPERIMENTAL METASTASIS. VOL. 33. ISSUE 8. P. 757 -764 46 81% 0
2 IRBY, RB , KLINE, CLB , (2013) PAR-4 AS A POTENTIAL TARGET FOR CANCER THERAPY.EXPERT OPINION ON THERAPEUTIC TARGETS. VOL. 17. ISSUE 1. P. 77-87 50 58% 7
3 SATHERLEY, LK , SUN, PH , JI, K , MASON, M , HARGEST, R , JIANG, WG , YE, L , (2016) PROSTATE APOPTOSIS RESPONSE-4 (PAR4) SUPPRESSES GROWTH AND INVASION OF BREAST CANCER CELLS AND IS POSITIVELY ASSOCIATED WITH PATIENT SURVIVAL.ANTICANCER RESEARCH. VOL. 36. ISSUE 3. P. 1227 -1235 24 89% 0
4 FIELDS, AP , LINCH, M , RIOU, P , JUSTILIEN, V , PARKER, PJ , (2014) ATYPICAL PROTEIN KINASE C IOTA AS A HUMAN ONCOGENE AND THERAPEUTIC TARGET.BIOCHEMICAL PHARMACOLOGY. VOL. 88. ISSUE 1. P. 1 -11 41 45% 19
5 LIU, YX , GILBERT, MR , KYPRIANOU, N , RANGNEKAR, VM , HORBINSKI, C , (2014) THE TUMOR SUPPRESSOR PROSTATE APOPTOSIS RESPONSE-4 (PAR-4) IS REGULATED BY MUTANT IDH1 AND KILLS GLIOMA STEM CELLS.ACTA NEUROPATHOLOGICA. VOL. 128. ISSUE 5. P. 723 -732 34 62% 1
6 HEBBAR, N , SHRESTHA-BHATTARAI, T , RANGNEKAR, VM , (2014) CANCER-SELECTIVE APOPTOSIS BY TUMOR SUPPRESSOR PAR-4.ANTICANCER GENES. VOL. 818. ISSUE . P. 155 -166 26 76% 1
7 PEREIRA, MC , DE BESSA-GARCIA, SA , BURIKHANOV, R , PAVANELLI, AC , ANTUNES, L , RANGNEKAR, VM , NAGAI, MA , (2013) PROSTATE APOPTOSIS RESPONSE-4 IS INVOLVED IN THE APOPTOSIS RESPONSE TO DOCETAXEL IN MCF-7 BREAST CANCER CELLS.INTERNATIONAL JOURNAL OF ONCOLOGY. VOL. 43. ISSUE 2. P. 531-538 27 63% 6
8 MURRAY, NR , KALARI, KR , FIELDS, AP , (2011) PROTEIN KINASE C IOTA EXPRESSION AND ONCOGENIC SIGNALING MECHANISMS IN CANCER.JOURNAL OF CELLULAR PHYSIOLOGY. VOL. 226. ISSUE 4. P. 879 -887 37 41% 40
9 SHRESTHA-BHATTARAI, T , RANGNEKAR, VM , (2010) CANCER-SELECTIVE APOPTOTIC EFFECTS OF EXTRACELLULAR AND INTRACELLULAR PAR-4.ONCOGENE. VOL. 29. ISSUE 27. P. 3873 -3880 27 59% 37
10 ROFFEY, JRA , OTT, GR , (2014) MODULATORS OF ATYPICAL PROTEIN KINASE C AS ANTICANCER AGENTS.ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 49. VOL. 49. ISSUE . P. 189 -206 38 42% 0

Classes with closest relation at Level 1


Rank Class id link
1 11431 CRUMBS//SCRIBBLE//ERBIN
2 1767 PROTEIN KINASE C//PKC DELTA//CELLULAR CARCINOGENESIS TUMOR PROMOT
3 29086 KIBRA//PKM ZETA//PROTEIN KINASE M ZETA
4 22246 DAP KINASE//DEATH ASSOCIATED PROTEIN KINASE//DAPK
5 32191 ENZASTAURIN//LY317615//INTRATUMORAL VESSELS
6 22274 ERK5//MEK5//EXTRACELLULAR SIGNAL REGULATED KINASE 5
7 24159 FAT10//MALLORY BODIES//MALLORY DENK BODIES MDBS
8 29205 BUXACEAE//SARCOCOCCA SALIGNA//CYCLOVIROBUXINE D
9 15482 BCL10//PKC THETA//CARMA3
10 9406 INSULIN RECEPTOR SUBSTRATE//INSULIN RECEPTOR SUBSTRATE 1//IRS 1

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