Class information for:
Level 1: RUBOXISTAURIN//LY333531//PKC BETA II INHIBITORS

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
18494 549 47.8 87%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
298 3       UROLOGY & NEPHROLOGY//PROTEINURIA//NEPHROTIC SYNDROME 41270
572 2             PODOCYTE//NEPHRIN//KIDNEY INTERNATIONAL 14360
18494 1                   RUBOXISTAURIN//LY333531//PKC BETA II INHIBITORS 549

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 RUBOXISTAURIN authKW 389318 3% 50% 14
2 LY333531 authKW 115867 1% 42% 5
3 PKC BETA II INHIBITORS authKW 111238 0% 100% 2
4 UNIDAD HIPERTENSAO address 111238 0% 100% 2
5 DIABETIC NEPHROPATHY authKW 79630 15% 2% 82
6 BEETHAM EYE OPHTHALMOL address 62567 1% 38% 3
7 HIGH GLUCOSE authKW 60008 5% 4% 28
8 PROTEIN KINASE C authKW 58457 18% 1% 99
9 25 MM D GLUCOSE authKW 55619 0% 100% 1
10 7302 address 55619 0% 100% 1

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Urology & Nephrology 3296 23% 0% 126
2 Endocrinology & Metabolism 2734 28% 0% 152
3 Physiology 456 11% 0% 59
4 Peripheral Vascular Diseases 310 8% 0% 42
5 Medicine, Research & Experimental 306 10% 0% 54
6 Pharmacology & Pharmacy 131 11% 0% 63
7 Ophthalmology 68 4% 0% 20
8 Integrative & Complementary Medicine 34 1% 0% 6
9 Cardiac & Cardiovascular System 25 4% 0% 22
10 Cell Biology 20 5% 0% 29

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 UNIDAD HIPERTENSAO 111238 0% 100% 2
2 BEETHAM EYE OPHTHALMOL 62567 1% 38% 3
3 7302 55619 0% 100% 1
4 BANCO SANGUE REG RIBEIRAO PRETO 55619 0% 100% 1
5 BEETHAM EYE EYE 55619 0% 100% 1
6 BEETHMAN EYE 55619 0% 100% 1
7 BIOMED ENGN CELLULAR INTEGRAT PHYSIOL 55619 0% 100% 1
8 BIOREGULAT SCI 55619 0% 100% 1
9 BK21 BIOTHER Y HUMAN OURCES 55619 0% 100% 1
10 CANADA GRP DIABET NEPHROPATHY MED 55619 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DIABETES 9366 8% 0% 45
2 KIDNEY INTERNATIONAL 6742 8% 0% 42
3 AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 3716 4% 0% 21
4 KIDNEY & BLOOD PRESSURE RESEARCH 3066 1% 1% 8
5 JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 2744 3% 0% 19
6 DIABETOLOGIA 1915 3% 0% 17
7 NEPHRON EXPERIMENTAL NEPHROLOGY 1765 1% 1% 4
8 JOURNAL OF DIABETES AND ITS COMPLICATIONS 1101 1% 0% 6
9 EXPERIMENTAL NEPHROLOGY 903 1% 1% 3
10 DIABETES RESEARCH AND CLINICAL PRACTICE 837 2% 0% 9

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 RUBOXISTAURIN 389318 3% 50% 14 Search RUBOXISTAURIN Search RUBOXISTAURIN
2 LY333531 115867 1% 42% 5 Search LY333531 Search LY333531
3 PKC BETA II INHIBITORS 111238 0% 100% 2 Search PKC+BETA+II+INHIBITORS Search PKC+BETA+II+INHIBITORS
4 DIABETIC NEPHROPATHY 79630 15% 2% 82 Search DIABETIC+NEPHROPATHY Search DIABETIC+NEPHROPATHY
5 HIGH GLUCOSE 60008 5% 4% 28 Search HIGH+GLUCOSE Search HIGH+GLUCOSE
6 PROTEIN KINASE C 58457 18% 1% 99 Search PROTEIN+KINASE+C Search PROTEIN+KINASE+C
7 25 MM D GLUCOSE 55619 0% 100% 1 Search 25+MM+D+GLUCOSE Search 25+MM+D+GLUCOSE
8 ACORTATARIN A 55619 0% 100% 1 Search ACORTATARIN+A Search ACORTATARIN+A
9 ALLBUMINURIA 55619 0% 100% 1 Search ALLBUMINURIA Search ALLBUMINURIA
10 APICAL TRANSPORTER 55619 0% 100% 1 Search APICAL+TRANSPORTER Search APICAL+TRANSPORTER

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 GERALDES, P , KING, GL , (2010) ACTIVATION OF PROTEIN KINASE C ISOFORMS AND ITS IMPACT ON DIABETIC COMPLICATIONS.CIRCULATION RESEARCH. VOL. 106. ISSUE 8. P. 1319-1331 41 30% 236
2 DAS EVCIMEN, N , KING, GL , (2007) THE ROLE OF PROTEIN KINASE C ACTIVATION AND THE VASCULAR COMPLICATIONS OF DIABETES.PHARMACOLOGICAL RESEARCH. VOL. 55. ISSUE 6. P. 498-510 44 29% 165
3 KOYA, D , KING, GL , (1998) PROTEIN KINASE C ACTIVATION AND THE DEVELOPMENT OF DIABETIC COMPLICATIONS.DIABETES. VOL. 47. ISSUE 6. P. 859 -866 32 33% 753
4 MEIER, M , MENNE, J , HALLER, H , (2009) TARGETING THE PROTEIN KINASE C FAMILY IN THE DIABETIC KIDNEY: LESSONS FROM ANALYSIS OF MUTANT MICE.DIABETOLOGIA. VOL. 52. ISSUE 5. P. 765-775 32 42% 24
5 BURKEY, JL , CAMPANALE, KM , BARBUCH, R , O'BANNON, D , RASH, J , BENSON, C , SMALL, D , (2006) DISPOSITION OF [C-14] RUBOXISTAURIN IN HUMANS.DRUG METABOLISM AND DISPOSITION. VOL. 34. ISSUE 11. P. 1909-1917 15 94% 6
6 AIELLO, LP , VIGNATI, L , SHEETZ, MJ , ZHI, X , GIRACH, A , DAVIS, MD , WOLKA, AM , SHAHRI, N , MILTON, RC , (2011) ORAL PROTEIN KINASE C BETA INHIBITION USING RUBOXISTAURIN EFFICACY, SAFETY, AND CAUSES OF VISION LOSS AMONG 813 PATIENTS (1,392 EYES) WITH DIABETIC RETINOPATHY IN THE PROTEIN KINASE C BETA INHIBITOR-DIABETIC RETINOPATHY STUDY AND THE PROTEIN KINASE C BETA INHIBITOR-DIABETIC RETINOPATHY STUDY 2.RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES. VOL. 31. ISSUE 10. P. 2084-2094 12 86% 37
7 WAY, KJ , KATAI, N , KING, GL , (2001) PROTEIN KINASE C AND THE DEVELOPMENT OF DIABETIC VASCULAR COMPLICATIONS.DIABETIC MEDICINE. VOL. 18. ISSUE 12. P. 945 -959 43 28% 185
8 MENNE, J , SHUSHAKOVA, N , BARTELS, J , KIYAN, Y , LAUDELEY, R , HALLER, H , PARK, JK , MEIER, M , (2013) DUAL INHIBITION OF CLASSICAL PROTEIN KINASE C-ALPHA AND PROTEIN KINASE C-BETA ISOFORMS PROTECTS AGAINST EXPERIMENTAL MURINE DIABETIC NEPHROPATHY.DIABETES. VOL. 62. ISSUE 4. P. 1167-1174 16 57% 21
9 WHITESIDE, CI , DLUGOSZ, JA , (2002) MESANGIAL CELL PROTEIN KINASE C ISOZYME ACTIVATION IN THE DIABETIC MILIEU.AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY. VOL. 282. ISSUE 6. P. F975 -F980 30 42% 66
10 HANEDA, M , KOYA, D , ISONO, M , KIKKAWA, R , (2003) OVERVIEW OF GLUCOSE SIGNALING IN MESANGIAL CELLS IN DIABETIC NEPHROPATHY.JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. VOL. 14. ISSUE 5. P. 1374-1382 35 34% 65

Classes with closest relation at Level 1


Rank Class id link
1 20077 DIABETIC NEPHROPATHY//URINE CYTOKINES CHEMOKINES//TNF SYSTEM
2 8946 MESANGIAL CELLS//THY 1 NEPHRITIS//NEPHROL OSTEOL
3 18674 MESANGIAL CELLS//IMMUNOGLOBULIN G COMPLEXES//MESANGIUM
4 30687 KANGEN KARYU//DAN GUA FANG//ALDOSE REDUCTASE INHIBITOR ONO 2235
5 9930 PHYSIOL MORPHOL//RAT AORTAE//DIABETES
6 32191 ENZASTAURIN//LY317615//INTRATUMORAL VESSELS
7 18940 HEMODYNAMIC MALADJUSTMENT//GLOMERULAR ENDOTHELIAL DYSFUNCTION//MOL PATHOL IMMUNOL CORE
8 4577 DIABETIC RETINOPATHY//K GE EYE//OPHTHALMOL
9 27625 METABOLIC MEMORY//IL RISK ASSESSMENT INTERVENT STUDIES//HYPERGLYCEMIC MEMORY
10 12579 NPPG//ORAL CRANIO MAXILLO IAL PLAST IAL SUR//PLATELET GLUTATHIONE

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