Class information for:
Level 1: CYP2C9//VKORC1//WARFARIN

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
2607 2197 34.5 79%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
8 4 CARDIAC & CARDIOVASCULAR SYSTEM//PERIPHERAL VASCULAR DISEASES//CARDIOL 1276458
131 3       HEMATOLOGY//HAEMOPHILIA//TRANSFUSION 66936
767 2             WARFARIN//CYP2C9//VKORC1 12292
2607 1                   CYP2C9//VKORC1//WARFARIN 2197

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CYP2C9 authKW 3911530 20% 63% 448
2 VKORC1 authKW 2914891 12% 82% 255
3 WARFARIN authKW 1996131 34% 20% 736
4 ACENOCOUMAROL authKW 609350 4% 48% 92
5 CYP4F2 authKW 568053 3% 74% 55
6 CYTOCHROME P450 2C9 authKW 322427 2% 63% 37
7 DOSING ALGORITHM authKW 290847 1% 70% 30
8 PHARMACOGENETICS authKW 220891 12% 6% 259
9 PHENPROCOUMON authKW 201346 2% 32% 46
10 CYP2C9 POLYMORPHISM authKW 183926 1% 88% 15

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Pharmacology & Pharmacy 17870 52% 0% 1152
2 Hematology 3803 13% 0% 292
3 Peripheral Vascular Diseases 1909 9% 0% 204
4 Medical Laboratory Technology 975 4% 0% 82
5 Medicine, General & Internal 669 10% 0% 211
6 Genetics & Heredity 388 7% 0% 152
7 Toxicology 206 4% 0% 81
8 Cardiac & Cardiovascular System 130 4% 0% 96
9 Medicine, Research & Experimental 51 3% 0% 67
10 Chemistry, Analytical 34 3% 0% 73

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 METHODIST INPATIENT PHYS 41691 0% 100% 3
2 ANTICOAGULAT 27794 0% 100% 2
3 ATHEROTHROMBOSISMED CLIN 1 27794 0% 100% 2
4 BROWNSTONE OUTPATIENT CLIN 27794 0% 100% 2
5 CLIN PHARM CLIN CHEM HAEMATOL 27794 0% 100% 2
6 MULTIDISCIPLINARY MOL BIOL DIAGNOST 27794 0% 100% 2
7 PERIPHERAL VASC ENDOVASC SCI 27794 0% 100% 2
8 PHYSIOPATHOL GENET CARDIOVASC 27794 0% 100% 2
9 QUAL PATIENTSAFETY 27794 0% 100% 2
10 PHARMACOTHER Y TRANSLAT 24779 1% 8% 22

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PHARMACOGENOMICS 60668 4% 5% 88
2 CLINICAL PHARMACOLOGY & THERAPEUTICS 24244 5% 2% 101
3 PHARMACOGENETICS 22293 2% 4% 39
4 EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY 19952 5% 1% 101
5 PHARMACOGENETICS AND GENOMICS 17638 2% 3% 38
6 PHARMACOGENOMICS JOURNAL 14757 1% 4% 29
7 JOURNAL OF THROMBOSIS AND THROMBOLYSIS 12554 2% 2% 41
8 BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 11141 4% 1% 81
9 PHARMACOTHERAPY 9186 3% 1% 55
10 PERSONALIZED MEDICINE 8257 1% 3% 18

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 CYP2C9 3911530 20% 63% 448 Search CYP2C9 Search CYP2C9
2 VKORC1 2914891 12% 82% 255 Search VKORC1 Search VKORC1
3 WARFARIN 1996131 34% 20% 736 Search WARFARIN Search WARFARIN
4 ACENOCOUMAROL 609350 4% 48% 92 Search ACENOCOUMAROL Search ACENOCOUMAROL
5 CYP4F2 568053 3% 74% 55 Search CYP4F2 Search CYP4F2
6 CYTOCHROME P450 2C9 322427 2% 63% 37 Search CYTOCHROME+P450+2C9 Search CYTOCHROME+P450+2C9
7 DOSING ALGORITHM 290847 1% 70% 30 Search DOSING+ALGORITHM Search DOSING+ALGORITHM
8 PHARMACOGENETICS 220891 12% 6% 259 Search PHARMACOGENETICS Search PHARMACOGENETICS
9 PHENPROCOUMON 201346 2% 32% 46 Search PHENPROCOUMON Search PHENPROCOUMON
10 CYP2C9 POLYMORPHISM 183926 1% 88% 15 Search CYP2C9+POLYMORPHISM Search CYP2C9+POLYMORPHISM

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 FUNG, E , PATSOPOULOS, NA , BELKNAP, SM , O'ROURKE, DJ , ROBB, JF , ANDERSON, JL , SHWORAK, NW , MOORE, JH , (2012) EFFECT OF GENETIC VARIANTS, ESPECIALLY CYP2C9 AND VKORC1, ON THE PHARMACOLOGY OF WARFARIN.SEMINARS IN THROMBOSIS AND HEMOSTASIS. VOL. 38. ISSUE 8. P. 893-904 139 87% 10
2 JORGENSEN, AL , FITZGERALD, RJ , OYEE, J , PIRMOHAMED, M , WILLIAMSON, PR , (2012) INFLUENCE OF CYP2C9 AND VKORC1 ON PATIENT RESPONSE TO WARFARIN: A SYSTEMATIC REVIEW AND META-ANALYSIS.PLOS ONE. VOL. 7. ISSUE 8. P. - 111 88% 46
3 WANG, B , WANG, J , HUANG, SQ , SU, HH , ZHOU, SF , (2009) GENETIC POLYMORPHISM OF THE HUMAN CYTOCHROME P450 2C9 GENE AND ITS CLINICAL SIGNIFICANCE.CURRENT DRUG METABOLISM. VOL. 10. ISSUE 7. P. 781 -834 209 49% 41
4 VERHOEF, TI , REDEKOP, WK , DALY, AK , VAN SCHIE, RMF , DE BOER, A , MAITLAND-VAN DER ZEE, AH , (2014) PHARMACOGENETIC-GUIDED DOSING OF COUMARIN ANTICOAGULANTS: ALGORITHMS FOR WARFARIN, ACENOCOUMAROL AND PHENPROCOUMON.BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. VOL. 77. ISSUE 4. P. 626-641 96 79% 32
5 SCHALEKAMP, T , DE BOER, A , (2010) PHARMACOGENETICS OF ORAL ANTICOAGULANT THERAPY.CURRENT PHARMACEUTICAL DESIGN. VOL. 16. ISSUE 2. P. 187-203 118 76% 23
6 DALY, AK , (2013) OPTIMAL DOSING OF WARFARIN AND OTHER COUMARIN ANTICOAGULANTS: THE ROLE OF GENETIC POLYMORPHISMS.ARCHIVES OF TOXICOLOGY. VOL. 87. ISSUE 3. P. 407-420 94 83% 17
7 GAIKWAD, T , GHOSH, K , SHETTY, S , (2014) VKORC1 AND CYP2C9 GENOTYPE DISTRIBUTION IN ASIAN COUNTRIES.THROMBOSIS RESEARCH. VOL. 134. ISSUE 3. P. 537 -544 83 93% 4
8 STEHLE, S , KIRCHHEINER, J , LAZAR, A , FUHR, U , (2008) PHARMACOGENETICS OF ORAL ANTICOAGULANTS - A BASIS FOR DOSE INDIVIDUALIZATION.CLINICAL PHARMACOKINETICS. VOL. 47. ISSUE 9. P. 565-594 105 77% 62
9 HE, SM , ZHOU, ZW , LI, XT , ZHOU, SF , (2011) CLINICAL DRUGS UNDERGOING POLYMORPHIC METABOLISM BY HUMAN CYTOCHROME P450 2C9 AND THE IMPLICATION IN DRUG DEVELOPMENT.CURRENT MEDICINAL CHEMISTRY. VOL. 18. ISSUE 5. P. 667 -713 143 54% 25
10 BARANOVA, EV , VERHOEF, TI , ASSELBERGS, FW , DE BOER, A , MAITLAND-VAN DER ZEE, AH , (2015) GENOTYPE-GUIDED COUMARIN DOSING: WHERE ARE WE NOW AND WHERE DO WE NEED TO GO NEXT?.EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY. VOL. 11. ISSUE 4. P. 509 -522 76 88% 0

Classes with closest relation at Level 1


Rank Class id link
1 5951 INTERNATIONAL NORMALIZED RATIO//PROTHROMBIN TIME//INR
2 13846 ANTICOAGULANT RESISTANCE//VKOR//GAMMA GLUTAMYL CARBOXYLASE
3 8662 PHARMACOGENOMICS//HLA B5701//PERSONALIZED MEDICINE
4 19162 PROTHROMBIN COMPLEX CONCENTRATE//ANTICOAGULATION REVERSAL//WARFARIN REVERSAL
5 17257 POTENTIAL DRUG DRUG INTERACTIONS//DRUG DRUG INTERACTIONS//DRUG INTERACTIONS
6 6086 CYP2C19//OMEPRAZOLE//PANTOPRAZOLE
7 16225 REPAGLINIDE//NATEGLINIDE//MITIGLINIDE
8 16017 ANTICOAGULANT RODENTICIDES//RODENTICIDE//BRODIFACOUM
9 1626 CYP2D6//DEBRISOQUINE//CYP2D6 POLYMORPHISM
10 4852 6 BETA HYDROXYCORTISOL//COCKTAIL//CYP3A

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