Class information for:
Level 1: TYRPHOSTIN//AG957//INOSTAMYCIN

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
24850 299 35.7 80%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
317 3       HER2//TRASTUZUMAB//CHRONIC MYELOID LEUKEMIA 39408
1452 2             CHRONIC MYELOID LEUKEMIA//IMATINIB//NILOTINIB 7818
24850 1                   TYRPHOSTIN//AG957//INOSTAMYCIN 299

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 TYRPHOSTIN authKW 852356 13% 22% 38
2 AG957 authKW 510623 2% 100% 5
3 INOSTAMYCIN authKW 454913 2% 64% 7
4 ADAPHOSTIN authKW 408494 2% 67% 6
5 MOL LEVEL INTER E MIRC address 204249 1% 100% 2
6 STYRYL DIPHENYLAMINE DERIVATIVE authKW 204249 1% 100% 2
7 ERBSTATIN authKW 204241 2% 33% 6
8 1 BENZYLIDENE 3 4 DIHYDRO 1H 6H 1 4OXAZINO 3 4 B QUINAZOLIN 6 ONES 1 PHENYLHYDRAZONO 3 4 DIHYDRO 1H 6H 1 4OXA authKW 102125 0% 100% 1
9 17 DEMETHOXYGELDANAMYCIN authKW 102125 0% 100% 1
10 3 5 DISUBSTITUTED 1 3 4 OXADIAZOL 23H ONE DERIVATIVES authKW 102125 0% 100% 1

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Medicinal 1229 19% 0% 58
2 Oncology 693 26% 0% 78
3 Pharmacology & Pharmacy 530 26% 0% 78
4 Biochemistry & Molecular Biology 310 29% 0% 88
5 Biophysics 136 9% 0% 26
6 Cell Biology 104 11% 0% 34
7 Chemistry, Organic 48 7% 0% 22
8 Biotechnology & Applied Microbiology 13 4% 0% 13
9 Biochemical Research Methods 8 3% 0% 8
10 Immunology 5 4% 0% 12

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MOL LEVEL INTER E MIRC 204249 1% 100% 2
2 ALBERT SILBERMAN LIFE SCI BIOL CHEM 102125 0% 100% 1
3 BIOCHEM MIHAMA KU 102125 0% 100% 1
4 BIOL SCI TECHNOLLIFE SYST 102125 0% 100% 1
5 CLIN IMMUNOENDOCRINOL 102125 0% 100% 1
6 CLIN TIALS UNIT 102125 0% 100% 1
7 ONCOL VIROL PHARMACEUT K125420 102125 0% 100% 1
8 PHARMACOL EXPT THER EUT SECTDEV THER EUT PRO 102125 0% 100% 1
9 SREENING TECHNOL BRANCH 102125 0% 100% 1
10 UNIT CELL DIFFENTIAT CANC 102125 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ANTI-CANCER DRUG DESIGN 16268 3% 2% 10
2 JOURNAL OF MEDICINAL CHEMISTRY 1200 5% 0% 16
3 JAPANESE JOURNAL OF CANCER RESEARCH 1029 2% 0% 6
4 JOURNAL OF ANTIBIOTICS 971 3% 0% 8
5 TOPICS IN CURRENT CHEMISTRY-SERIES 926 0% 1% 1
6 DRUGS UNDER EXPERIMENTAL AND CLINICAL RESEARCH 880 1% 0% 4
7 ADVANCES IN ENZYME REGULATION 681 1% 0% 2
8 CURRENT SIGNAL TRANSDUCTION THERAPY 469 0% 0% 1
9 PHYSIOLOGY AND MOLECULAR BIOLOGY OF PLANTS 413 0% 0% 1
10 NIPPON NOGEIKAGAKU KAISHI-JOURNAL OF THE JAPAN SOCIETY FOR BIOSCIENCE BIOTECHNOLOGY AND AGROCHEMISTRY 393 1% 0% 2

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 TYRPHOSTIN 852356 13% 22% 38 Search TYRPHOSTIN Search TYRPHOSTIN
2 AG957 510623 2% 100% 5 Search AG957 Search AG957
3 INOSTAMYCIN 454913 2% 64% 7 Search INOSTAMYCIN Search INOSTAMYCIN
4 ADAPHOSTIN 408494 2% 67% 6 Search ADAPHOSTIN Search ADAPHOSTIN
5 STYRYL DIPHENYLAMINE DERIVATIVE 204249 1% 100% 2 Search STYRYL+DIPHENYLAMINE+DERIVATIVE Search STYRYL+DIPHENYLAMINE+DERIVATIVE
6 ERBSTATIN 204241 2% 33% 6 Search ERBSTATIN Search ERBSTATIN
7 1 BENZYLIDENE 3 4 DIHYDRO 1H 6H 1 4OXAZINO 3 4 B QUINAZOLIN 6 ONES 1 PHENYLHYDRAZONO 3 4 DIHYDRO 1H 6H 1 4OXA 102125 0% 100% 1 Search 1+BENZYLIDENE+3+4+DIHYDRO+1H+6H+1+4OXAZINO+3+4+B+QUINAZOLIN+6+ONES+1+PHENYLHYDRAZONO+3+4+DIHYDRO+1H+6H+1+4OXA Search 1+BENZYLIDENE+3+4+DIHYDRO+1H+6H+1+4OXAZINO+3+4+B+QUINAZOLIN+6+ONES+1+PHENYLHYDRAZONO+3+4+DIHYDRO+1H+6H+1+4OXA
8 17 DEMETHOXYGELDANAMYCIN 102125 0% 100% 1 Search 17+DEMETHOXYGELDANAMYCIN Search 17+DEMETHOXYGELDANAMYCIN
9 3 5 DISUBSTITUTED 1 3 4 OXADIAZOL 23H ONE DERIVATIVES 102125 0% 100% 1 Search 3+5+DISUBSTITUTED+1+3+4+OXADIAZOL+23H+ONE+DERIVATIVES Search 3+5+DISUBSTITUTED+1+3+4+OXADIAZOL+23H+ONE+DERIVATIVES
10 AMIDO GROUP 102125 0% 100% 1 Search AMIDO+GROUP Search AMIDO+GROUP

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 LEVITZKI, A , GAZIT, A , (1995) TYROSINE KINASE INHIBITION - AN APPROACH TO DRUG DEVELOPMENT.SCIENCE. VOL. 267. ISSUE 5205. P. 1782-1788 28 32% 1403
2 LEVITZKI, A , (1999) PROTEIN TYROSINE KINASE INHIBITORS AS NOVEL THERAPEUTIC AGENTS.PHARMACOLOGY & THERAPEUTICS. VOL. 82. ISSUE 2-3. P. 231 -239 21 43% 166
3 LEVITZKI, A , (2002) TYROSINE KINASES AS TARGETS FOR CANCER THERAPY.EUROPEAN JOURNAL OF CANCER. VOL. 38. ISSUE . P. S11-S18 18 40% 64
4 SMYTH, MS , STEFANOVA, I , HARTMANN, F , HORAK, ID , OSHEROV, N , LEVITZKI, A , BURKE, TR , (1993) NON-AMINE BASED ANALOGS OF LAVENDUSTIN-A AS PROTEIN-TYROSINE KINASE INHIBITORS.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 36. ISSUE 20. P. 3010-3014 15 68% 35
5 CHEN, HX , BOIZIAU, J , PARKER, F , MAILLIET, P , COMMERCON, A , TOCQUE, B , LEPECQ, JB , ROQUES, BP , GARBAY, C , (1994) STRUCTURE-ACTIVITY-RELATIONSHIPS IN A SERIES OF 5-[(2,5-DIHYDROXYBENZYL)AMINO]SALICYLATE INHIBITORS OF EGF-RECEPTOR-ASSOCIATED TYROSINE KINASE - IMPORTANCE OF ADDITIONAL HYDROPHOBIC AROMATIC INTERACTIONS.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 37. ISSUE 6. P. 845-859 20 50% 22
6 HOFFMAN, R , DENNIS, IF , DONALDSON, J , (1995) PROTEIN-BINDING MODULATES INHIBITION OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR KINASE AND DNA-SYNTHESIS BY TYRPHOSTINS.CANCER CHEMOTHERAPY AND PHARMACOLOGY. VOL. 36. ISSUE 4. P. 316-324 14 67% 2
7 KAUR, G , NARAYANAN, VL , RISBOOD, PA , HOLLINGSHEAD, MG , STINSON, SF , VARMA, RK , SAUSVILLE, EA , (2005) SYNTHESIS, STRUCTURE-ACTIVITY RELATIONSHIP, AND P210(BCR-ABL) PROTEIN TYROSINE KINASE ACTIVITY OF NOVEL AG 957 ANALOGS.BIOORGANIC & MEDICINAL CHEMISTRY. VOL. 13. ISSUE 5. P. 1749-1761 12 50% 14
8 LEVITZKI, A , (1992) TYRPHOSTINS - TYROSINE KINASE BLOCKERS AS NOVEL ANTIPROLIFERATIVE AGENTS AND DISSECTORS OF SIGNAL TRANSDUCTION.FASEB JOURNAL. VOL. 6. ISSUE 14. P. 3275-3282 18 32% 293
9 LEVITZKI, A , (2001) PROTEIN TYROSINE KINASE INHIBITORS AS THERAPEUTIC AGENTS.BIOORGANIC CHEMISTRY OF BIOLOGICAL SIGNAL TRANSDUCTION. VOL. 211. ISSUE . P. 1 -15 17 33% 12
10 HORI, H , NAGASAWA, H , ISHIBASHI, M , UTO, Y , HIRATA, A , SAIJO, K , OHKURA, K , KIRK, KL , UEHARA, Y , (2002) TX-1123: AN ANTITUMOR 2-HYDROXYARYLIDENE-4-CYCLOPENTENE-1,3-DIONE AS A PROTEIN TYROSINE KINASE INHIBITOR HAVING LOW MITOCHONDRIAL TOXICITY.BIOORGANIC & MEDICINAL CHEMISTRY. VOL. 10. ISSUE 10. P. 3257-3265 12 44% 28

Classes with closest relation at Level 1


Rank Class id link
1 11421 ANILINOQUINAZOLINE//4 ANILINOQUINAZOLINE//VEGFR 2 INHIBITOR
2 16892 GENISTEIN INHIBITION//TYROSINE KINASE//ANGIOTENSIN II
3 3485 CSK//CSK HOMOLOGOUS KINASE//HEMATOL MED ENZYMOL
4 27761 IMINOCOUMARIN//BIS IMINOCOUMARINS//CHIM PL HETEROCYCLES CORPS GRAS POLYME
5 5087 EGF RECEPTOR//COMPUTER PROGRAM FOR MACINTOSHTMII//DIMERIZATION ARM
6 24831 CROCACIN//HYDROAMIDATION//AMATHASPIRAMIDE
7 5515 TRANSFORMING GROWTH FACTOR ALPHA//TGF ALPHA//TGF ALPHA ASE
8 33770 O AZAXYLYLENE//SECT ORGAN CHEM A MARCHESINI//1 2 3 4 TETRAHYDROQUINOLINE 8 OL
9 36141 ADENYLYL CYCLASE MECHANISM//QUOTIENT VELOCITY PLOT//ADENYLYL CYCLASE SYSTEM
10 25613 UCN 01//7 HYDROXYSTAUROSPORINE//CGP41251

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