Class information for:
Level 3: HER2//TRASTUZUMAB//CHRONIC MYELOID LEUKEMIA

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
317 39408 41.5 85%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
317 3       HER2//TRASTUZUMAB//CHRONIC MYELOID LEUKEMIA 39408
652 2             HER2//TRASTUZUMAB//HER 2 NEU 13568
1452 2             CHRONIC MYELOID LEUKEMIA//IMATINIB//NILOTINIB 7818
1648 2             EPIDERMAL GROWTH FACTOR//HB EGF//TRANSFORMING GROWTH FACTOR ALPHA 6893
1927 2             FGF21//FIBROBLAST GROWTH FACTOR//FIBROBLAST GROWTH FACTOR 21 5824
2452 2             HEPATOCYTE GROWTH FACTOR//C MET//HGF 4045
3948 2             SPROUTY//LRIG1//MIG 6 759
4187 2             MACC1//HEPATOMA DERIVED GROWTH FACTOR//METASTASIS ASSOCIATED IN COLON CANCER 1 501

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 HER2 authKW 418925 3% 46% 1194
2 TRASTUZUMAB authKW 356148 2% 50% 931
3 CHRONIC MYELOID LEUKEMIA authKW 326030 2% 45% 940
4 HEPATOCYTE GROWTH FACTOR authKW 287792 2% 46% 808
5 C MET authKW 274631 2% 59% 607
6 IMATINIB authKW 258910 2% 38% 880
7 ONCOLOGY WoSSC 185083 36% 2% 14229
8 NILOTINIB authKW 169462 1% 71% 309
9 DASATINIB authKW 149692 1% 55% 353
10 BCR ABL authKW 135636 1% 37% 480

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Oncology 185083 36% 2% 14229
2 Cell Biology 28361 15% 1% 6047
3 Biochemistry & Molecular Biology 13426 19% 0% 7574
4 Pathology 13394 6% 1% 2308
5 Hematology 9604 6% 1% 2184
6 Medicine, Research & Experimental 2586 4% 0% 1667
7 Endocrinology & Metabolism 2213 4% 0% 1648
8 Chemistry, Medicinal 1766 3% 0% 1094
9 Biophysics 1598 3% 0% 1364
10 Genetics & Heredity 1370 4% 0% 1561

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 MED ONCOL 38092 4% 3% 1560
2 PATHOL 35870 12% 1% 4844
3 LEUKEMIA 33540 1% 13% 328
4 ONCOL 25213 4% 2% 1589
5 MOL REGENERAT MED 24620 0% 36% 88
6 BREAST MED ONCOL 24326 1% 15% 210
7 COURSE ADV MED 21535 0% 57% 49
8 CANC 17933 3% 2% 1357
9 KRINGLE PHARMA JOINT REGENERAT DRUG DISCO 15836 0% 71% 29
10 HEMATOL ONCOL 14972 2% 2% 941

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BREAST CANCER RESEARCH AND TREATMENT 30757 1% 8% 544
2 CLINICAL CANCER RESEARCH 19282 2% 4% 624
3 ONCOGENE 17251 2% 4% 654
4 BREAST CANCER RESEARCH 16094 1% 10% 215
5 GROWTH FACTORS 15487 0% 16% 127
6 CANCER RESEARCH 11773 2% 2% 813
7 CLINICAL BREAST CANCER 11569 0% 14% 108
8 JOURNAL OF CLINICAL ONCOLOGY 9065 1% 3% 454
9 JOURNAL OF CELLULAR PHYSIOLOGY 8976 1% 4% 353
10 ANNALS OF ONCOLOGY 8384 1% 4% 308

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class		 LCSH search Wikipedia search
1 HER2 418925 3% 46% 1194 Search HER2 Search HER2
2 TRASTUZUMAB 356148 2% 50% 931 Search TRASTUZUMAB Search TRASTUZUMAB
3 CHRONIC MYELOID LEUKEMIA 326030 2% 45% 940 Search CHRONIC+MYELOID+LEUKEMIA Search CHRONIC+MYELOID+LEUKEMIA
4 HEPATOCYTE GROWTH FACTOR 287792 2% 46% 808 Search HEPATOCYTE+GROWTH+FACTOR Search HEPATOCYTE+GROWTH+FACTOR
5 C MET 274631 2% 59% 607 Search C+MET Search C+MET
6 IMATINIB 258910 2% 38% 880 Search IMATINIB Search IMATINIB
7 NILOTINIB 169462 1% 71% 309 Search NILOTINIB Search NILOTINIB
8 DASATINIB 149692 1% 55% 353 Search DASATINIB Search DASATINIB
9 BCR ABL 135636 1% 37% 480 Search BCR+ABL Search BCR+ABL
10 EGFR 133886 2% 18% 974 Search EGFR Search EGFR

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 WOLFF, AC , HAMMOND, MEH , HICKS, DG , DOWSETT, M , MCSHANE, LM , ALLISON, KH , ALLRED, DC , BARTLETT, JMS , BILOUS, M , FITZGIBBONS, P , ET AL (2013) RECOMMENDATIONS FOR HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 2 TESTING IN BREAST CANCER: AMERICAN SOCIETY OF CLINICAL ONCOLOGY/COLLEGE OF AMERICAN PATHOLOGISTS CLINICAL PRACTICE GUIDELINE UPDATE.JOURNAL OF CLINICAL ONCOLOGY. VOL. 31. ISSUE 31. P. 3997-+ 121 90% 644
2 SALOMON, DS , BRANDT, R , CIARDIELLO, F , NORMANNO, N , (1995) EPIDERMAL GROWTH FACTOR-RELATED PEPTIDES AND THEIR RECEPTORS IN HUMAN MALIGNANCIES.CRITICAL REVIEWS IN ONCOLOGY/HEMATOLOGY. VOL. 19. ISSUE 3. P. 183-232 316 61% 1762
3 HELDIN, CH , WESTERMARK, B , (1999) MECHANISM OF ACTION AND IN VIVO ROLE OF PLATELET-DERIVED GROWTH FACTOR.PHYSIOLOGICAL REVIEWS. VOL. 79. ISSUE 4. P. 1283 -1316 300 60% 1328
4 BACCARANI, M , DEININGER, MW , ROSTI, G , HOCHHAUS, A , SOVERINI, S , APPERLEY, JF , CERVANTES, F , CLARK, RE , CORTES, JE , GUILHOT, F , ET AL (2013) EUROPEAN LEUKEMIANET RECOMMENDATIONS FOR THE MANAGEMENT OF CHRONIC MYELOID LEUKEMIA: 2013.BLOOD. VOL. 122. ISSUE 6. P. 872 -884 130 95% 333
5 ROSS, JS , SLODKOWSKA, EA , SYMMANS, WF , PUSZTAI, L , RAVDIN, PM , HORTOBAGYI, GN , (2009) THE HER-2 RECEPTOR AND BREAST CANCER: TEN YEARS OF TARGETED ANTI-HER-2 THERAPY AND PERSONALIZED MEDICINE.ONCOLOGIST. VOL. 14. ISSUE 4. P. 320 -368 248 69% 414
6 WOLFF, AC , HAMMOND, MEH , HICKS, DG , DOWSETT, M , MCSHANE, LM , ALLISON, KH , ALLRED, DC , BARTLETT, JMS , BILOUS, M , FITZGIBBONS, P , ET AL (2014) RECOMMENDATIONS FOR HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 2 TESTING IN BREAST CANCER AMERICAN SOCIETY OF CLINICAL ONCOLOGY/COLLEGE OF AMERICAN PATHOLOGISTS CLINICAL PRACTICE GUIDELINE UPDATE.ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE. VOL. 138. ISSUE 2. P. 241 -256 122 90% 160
7 BASILICO, C , MOSCATELLI, D , (1992) THE FGF FAMILY OF GROWTH-FACTORS AND ONCOGENES.ADVANCES IN CANCER RESEARCH. VOL. 59. ISSUE . P. 115-165 209 84% 971
8 GHERARDI, E , BIRCHMEIER, W , BIRCHMEIER, C , WOUDE, GV , (2012) TARGETING MET IN CANCER: RATIONALE AND PROGRESS.NATURE REVIEWS CANCER. VOL. 12. ISSUE 2. P. 89 -103 117 67% 504
9 CHRISTENSEN, JG , BURROWS, J , SALGIA, R , (2005) C-MET AS A TARGET FOR HUMAN CANCER AND CHARACTERIZATION OF INHIBITORS FOR THERAPEUTIC INTERVENTION.CANCER LETTERS. VOL. 225. ISSUE 1. P. 1-26 181 88% 306
10 BACCARANI, M , CORTES, J , PANE, F , NIEDERWIESER, D , SAGLIO, G , APPERLEY, J , CERVANTES, F , DEININGER, M , GRATWOHL, A , GUILHOT, F , ET AL (2009) CHRONIC MYELOID LEUKEMIA: AN UPDATE OF CONCEPTS AND MANAGEMENT RECOMMENDATIONS OF EUROPEAN LEUKEMIANET.JOURNAL OF CLINICAL ONCOLOGY. VOL. 27. ISSUE 35. P. 6041-6051 106 96% 511

Classes with closest relation at Level 3


Rank Class id link
1 518 ANGIOGENESIS//RETINOPATHY OF PREMATURITY//ENDOSTATIN
2 296 BREAST//BREAST CANCER//LYMPHEDEMA
3 27 DEVELOPMENTAL BIOLOGY//DEVELOPMENT//AGR2
4 216 NON SMALL CELL LUNG CANCER//LUNG CANCER//THORAC SURG
5 373 ENDOGENOUS RETROVIRUS//VIROLOGY//JOURNAL OF VIROLOGY
6 269 CELL BIOLOGY//CAVEOLIN 1//CAVEOLAE
7 636 TIGHT JUNCTION//NOONAN SYNDROME//CLAUDIN
8 583 ANALYTICAL AND QUANTITATIVE CYTOLOGY AND HISTOLOGY//AGNOR//ANTIGEN RETRIEVAL
9 304 P53//RETINOBLASTOMA//MDM2
10 608 CIRCULATING TUMOR CELLS//CEA//CYFRA 21 1

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