Class information for:
Level 1: ANILINOQUINAZOLINE//4 ANILINOQUINAZOLINE//VEGFR 2 INHIBITOR

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
11421 983 38.4 82%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
317 3       HER2//TRASTUZUMAB//CHRONIC MYELOID LEUKEMIA 39408
1452 2             CHRONIC MYELOID LEUKEMIA//IMATINIB//NILOTINIB 7818
11421 1                   ANILINOQUINAZOLINE//4 ANILINOQUINAZOLINE//VEGFR 2 INHIBITOR 983

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ANILINOQUINAZOLINE authKW 448840 2% 85% 17
2 4 ANILINOQUINAZOLINE authKW 386654 2% 66% 19
3 VEGFR 2 INHIBITOR authKW 308786 1% 76% 13
4 COMBI MOLECULE authKW 289111 1% 85% 11
5 CANC DRUG address 279551 1% 75% 12
6 QUINAZOLINE authKW 226348 7% 11% 69
7 MED ONCOL MEDCANC DRUG address 217433 1% 100% 7
8 EGFR TK INHIBITORS authKW 180719 1% 73% 8
9 KDR KINASE authKW 180719 1% 73% 8
10 CANC DRUG MED MED ONCOL address 155310 1% 100% 5

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Medicinal 32412 53% 0% 525
2 Chemistry, Organic 4194 30% 0% 296
3 Pharmacology & Pharmacy 631 17% 0% 166
4 Biochemistry & Molecular Biology 501 22% 0% 219
5 Oncology 208 10% 0% 94
6 Chemistry, Multidisciplinary 178 12% 0% 114
7 Computer Science, Interdisciplinary Applications 141 4% 0% 38
8 Crystallography 84 3% 0% 31
9 Mathematical & Computational Biology 67 2% 0% 18
10 Biochemical Research Methods 34 3% 0% 29

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CANC DRUG 279551 1% 75% 12
2 MED ONCOL MEDCANC DRUG 217433 1% 100% 7
3 CANC DRUG MED MED ONCOL 155310 1% 100% 5
4 MED ONCOLCANC DRUG 155310 1% 100% 5
5 MED MED ONCOLCANC DRUG 99397 0% 80% 4
6 BIOMMUNOTHER Y 62124 0% 100% 2
7 CANC DRUG HLTH 62124 0% 100% 2
8 CHEM SCI ONCOL IMMUNOINFLAMMATORY 62124 0% 100% 2
9 MED ONCOLHLTH ROYAL VICTORIA HOSP 62124 0% 100% 2
10 RD FINE CHEM GUIZHOU PROV 62124 0% 100% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 23491 14% 1% 138
2 JOURNAL OF MEDICINAL CHEMISTRY 11672 9% 0% 90
3 BIOORGANIC & MEDICINAL CHEMISTRY 9438 6% 0% 63
4 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 8291 5% 1% 50
5 CHEMICAL BIOLOGY & DRUG DESIGN 6763 2% 1% 19
6 JOURNAL OF MOLECULAR GRAPHICS & MODELLING 3238 1% 1% 14
7 CURRENT MEDICINAL CHEMISTRY 2792 2% 0% 20
8 EXPERT OPINION ON THERAPEUTIC PATENTS 2713 1% 1% 14
9 MEDICINAL CHEMISTRY 2251 1% 1% 8
10 ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY 1853 1% 1% 8

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 ANILINOQUINAZOLINE 448840 2% 85% 17 Search ANILINOQUINAZOLINE Search ANILINOQUINAZOLINE
2 4 ANILINOQUINAZOLINE 386654 2% 66% 19 Search 4+ANILINOQUINAZOLINE Search 4+ANILINOQUINAZOLINE
3 VEGFR 2 INHIBITOR 308786 1% 76% 13 Search VEGFR+2+INHIBITOR Search VEGFR+2+INHIBITOR
4 COMBI MOLECULE 289111 1% 85% 11 Search COMBI+MOLECULE Search COMBI+MOLECULE
5 QUINAZOLINE 226348 7% 11% 69 Search QUINAZOLINE Search QUINAZOLINE
6 EGFR TK INHIBITORS 180719 1% 73% 8 Search EGFR+TK+INHIBITORS Search EGFR+TK+INHIBITORS
7 KDR KINASE 180719 1% 73% 8 Search KDR+KINASE Search KDR+KINASE
8 VEGFR2 145069 6% 8% 56 Search VEGFR2 Search VEGFR2
9 EGFR INHIBITORS 95902 3% 11% 27 Search EGFR+INHIBITORS Search EGFR+INHIBITORS
10 1 4 DIHYDROINDENO1 2 CPYRAZOLES 93186 0% 100% 3 Search 1+4+DIHYDROINDENO1+2+CPYRAZOLES Search 1+4+DIHYDROINDENO1+2+CPYRAZOLES

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 ZHANG, J , SHAN, Y , PAN, X , HE, L , (2011) RECENT ADVANCES IN ANTIANGIOGENIC AGENTS WITH VEGFR AS TARGET.MINI-REVIEWS IN MEDICINAL CHEMISTRY. VOL. 11. ISSUE 11. P. 920-946 70 63% 10
2 LIPUNOVA, GN , NOSOVA, EV , CHARUSHIN, VN , CHUPAKHIN, ON , (2016) SYNTHESIS AND ANTITUMOUR ACTIVITY OF 4-AMINOQUINAZOLINE DERIVATIVES.RUSSIAN CHEMICAL REVIEWS. VOL. 85. ISSUE 7. P. 759 -793 85 46% 0
3 KONG, Y , QU, D , CHEN, XY , GONG, YN , YAN, AX , (2016) SELF-ORGANIZING MAP (SOM) AND SUPPORT VECTOR MACHINE (SVM) MODELS FOR THE PREDICTION OF HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR/ERBB-1) INHIBITORS.COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING. VOL. 19. ISSUE 5. P. 400 -411 63 57% 1
4 WANG, C , GAO, H , DONG, J , WANG, F , LI, P , ZHANG, J , (2014) INSIGHT INTO THE MEDICINAL CHEMISTRY OF EGFR AND HER-2 INHIBITORS.CURRENT MEDICINAL CHEMISTRY. VOL. 21. ISSUE 11. P. 1336-1350 60 55% 4
5 LIU, F , TANG, BD , LIU, H , LI, L , LIU, GN , CHENG, Y , XU, Y , CHEN, WW , HUANG, YJ , (2016) 4-ANILINOQUINAZOLINE DERIVATIVES WITH EPIDERMAL GROWTH FACTOR RECEPTOR INHIBITOR ACTIVITY.ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY. VOL. 16. ISSUE 12. P. 1652 -1664 35 66% 0
6 LA MOTTA, C , SARTINI, S , TUCCINARDI, T , NERINI, E , DA SETTIMO, F , MARTINELLI, A , (2009) COMPUTATIONAL STUDIES OF EPIDERMAL GROWTH FACTOR RECEPTOR: DOCKING RELIABILITY, THREE-DIMENSIONAL QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP ANALYSIS, AND VIRTUAL SCREENING STUDIES.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 52. ISSUE 4. P. 964-975 40 56% 23
7 SRIVASTAVA, SK , KUMAR, V , AGARWAL, SK , MUKHERJEE, R , BURMAN, AC , (2009) SYNTHESIS OF QUINAZOLINES AS TYROSINE KINASE INHIBITORS.ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY. VOL. 9. ISSUE 3. P. 246-275 29 76% 11
8 SCHENONE, S , BONDAVALLI, F , BOTTA, M , (2007) ANTIANGIOGENIC AGENTS: AN UPDATE ON SMALL MOLECULE VEGFR INHIBITORS.CURRENT MEDICINAL CHEMISTRY. VOL. 14. ISSUE 23. P. 2495 -2516 53 37% 56
9 LI, DD , HOU, YP , WANG, W , ZHU, HL , (2012) EXPLORATION OF CHEMICAL SPACE BASED ON 4-ANILINOQUINAZOLINE.CURRENT MEDICINAL CHEMISTRY. VOL. 19. ISSUE 6. P. 871-892 42 42% 7
10 MOWAFY, S , FARAG, NA , ABOUZID, KAM , (2013) DESIGN, SYNTHESIS AND IN VITRO ANTI-PROLIFERATIVE ACTIVITY OF 4,6-QUINAZOLINEDIAMINES AS POTENT EGFR-TK INHIBITORS.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. VOL. 61. ISSUE . P. 132 -145 24 67% 20

Classes with closest relation at Level 1


Rank Class id link
1 35107 DIARYLAMIDE//DIARYLUREA//A375P
2 24850 TYRPHOSTIN//AG957//INOSTAMYCIN
3 4440 NIMOTUZUMAB//CETUXIMAB//EGFR
4 18265 VANDETANIB//NINTEDANIB//CEDIRANIB
5 3264 QUINAZOLINONE//43H QUINAZOLINONES//2 3 DIHYDROQUINAZOLIN 41H ONES
6 1475 VEGF//FLT 1//VEGF RECEPTORS
7 10711 SRC//SRC INHIBITORS//SARACATINIB
8 23991 REGORAFENIB//N DESETHYL SUNITINIB//N DESMETHYL IMATINIB
9 11391 GEWALD REACTION//THIENO2 3 DPYRIMIDINE//THIENOPYRIMIDINE
10 147 GEFITINIB//EGFR MUTATION//ERLOTINIB

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