Class information for:
Level 1: CYCLOOXYGENASE//PROSTAGLANDIN H SYNTHASE//AB HANCOCK JR MEM CANC

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
2243 2310 38.3 78%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
275 3       NSAIDS//CYCLOOXYGENASE//CYCLOOXYGENASE 2 43399
466 2             NSAIDS//NON STEROIDAL ANTI INFLAMMATORY DRUGS//COX 2 INHIBITORS 15930
2243 1                   CYCLOOXYGENASE//PROSTAGLANDIN H SYNTHASE//AB HANCOCK JR MEM CANC 2310

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CYCLOOXYGENASE authKW 308946 12% 8% 285
2 PROSTAGLANDIN H SYNTHASE authKW 202701 2% 34% 45
3 AB HANCOCK JR MEM CANC address 175488 1% 40% 33
4 COX 2 INHIBITORS authKW 169778 4% 14% 90
5 COX 1 authKW 111621 2% 16% 54
6 1 5 DIARYLPYRAZOLES authKW 94066 0% 65% 11
7 COX 2 authKW 89420 6% 5% 147
8 PROSTAGLANDIN ENDOPEROXIDE SYNTHASE authKW 82223 1% 27% 23
9 IMRECOXIB authKW 79302 0% 100% 6
10 SELECTIVE COX 2 INHIBITORS authKW 78192 1% 31% 19

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Medicinal 16467 25% 0% 584
2 Biochemistry & Molecular Biology 4834 39% 0% 912
3 Pharmacology & Pharmacy 2066 19% 0% 448
4 Chemistry, Organic 1749 14% 0% 318
5 Biophysics 886 8% 0% 187
6 Cell Biology 758 11% 0% 257
7 Rheumatology 220 2% 0% 48
8 Medicine, Research & Experimental 111 4% 0% 88
9 Endocrinology & Metabolism 66 3% 0% 78
10 Chemistry, Multidisciplinary 61 7% 0% 153

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 AB HANCOCK JR MEM CANC 175488 1% 40% 33
2 MEDIATOR SIGNAL TRANSDUCT PHARMACOL 30207 0% 57% 4
3 MOL BIOL 341 29737 0% 75% 3
4 AB HANCOCK MEM CANC 26434 0% 100% 2
5 DIPARTIMENTO STUDI CHIM TECNOL FARM 26434 0% 100% 2
6 MED BIOCHEM MOL TOXICOL 26434 0% 100% 2
7 S NEPHROL 26434 0% 100% 2
8 TAKSHASHILA PARISAR 26434 0% 100% 2
9 DIPARTIMENTO STUDI CHIM TECNOL FARMACO 26430 0% 50% 4
10 HLTH SCI INTERNAL MED HEMATOL 23788 0% 60% 3

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ADVANCES IN PROSTAGLANDIN THROMBOXANE AND LEUKOTRIENE RESEARCH 14962 1% 4% 30
2 PROSTAGLANDINS & OTHER LIPID MEDIATORS 9963 2% 2% 37
3 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 9552 6% 1% 136
4 BIOORGANIC & MEDICINAL CHEMISTRY 7945 4% 1% 89
5 MEDICINAL CHEMISTRY RESEARCH 6932 2% 1% 41
6 INFLAMMATION RESEARCH 4788 1% 1% 32
7 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 4367 2% 1% 56
8 JOURNAL OF MEDICINAL CHEMISTRY 3085 3% 0% 72
9 JOURNAL OF BIOLOGICAL CHEMISTRY 2592 8% 0% 180
10 EXPERT OPINION ON THERAPEUTIC PATENTS 2583 1% 1% 21

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 CYCLOOXYGENASE 308946 12% 8% 285 Search CYCLOOXYGENASE Search CYCLOOXYGENASE
2 PROSTAGLANDIN H SYNTHASE 202701 2% 34% 45 Search PROSTAGLANDIN+H+SYNTHASE Search PROSTAGLANDIN+H+SYNTHASE
3 COX 2 INHIBITORS 169778 4% 14% 90 Search COX+2+INHIBITORS Search COX+2+INHIBITORS
4 COX 1 111621 2% 16% 54 Search COX+1 Search COX+1
5 1 5 DIARYLPYRAZOLES 94066 0% 65% 11 Search 1+5+DIARYLPYRAZOLES Search 1+5+DIARYLPYRAZOLES
6 COX 2 89420 6% 5% 147 Search COX+2 Search COX+2
7 PROSTAGLANDIN ENDOPEROXIDE SYNTHASE 82223 1% 27% 23 Search PROSTAGLANDIN+ENDOPEROXIDE+SYNTHASE Search PROSTAGLANDIN+ENDOPEROXIDE+SYNTHASE
8 IMRECOXIB 79302 0% 100% 6 Search IMRECOXIB Search IMRECOXIB
9 SELECTIVE COX 2 INHIBITORS 78192 1% 31% 19 Search SELECTIVE+COX+2+INHIBITORS Search SELECTIVE+COX+2+INHIBITORS
10 CYCLOOXYGENASE 1 74487 2% 15% 38 Search CYCLOOXYGENASE+1 Search CYCLOOXYGENASE+1

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 SMITH, WL , DEWITT, DL , GARAVITO, RM , (2000) CYCLOOXYGENASES: STRUCTURAL, CELLULAR, AND MOLECULAR BIOLOGY.ANNUAL REVIEW OF BIOCHEMISTRY. VOL. 69. ISSUE . P. 145 -182 123 50% 1686
2 KULMACZ, RJ , VAN DER DONK, WA , TSAI, AL , (2003) COMPARISON OF THE PROPERTIES OF PROSTAGLANDIN H SYNTHASE-1 AND -2.PROGRESS IN LIPID RESEARCH. VOL. 42. ISSUE 5. P. 377-404 127 82% 50
3 SMITH, WL , DEWITT, DL , (1996) PROSTAGLANDIN ENDOPEROXIDE H SYNTHASES-1 AND -2.ADVANCES IN IMMUNOLOGY, VOL 62. VOL. 62. ISSUE . P. 167-215 123 65% 581
4 ROUZER, CA , MARNETT, LJ , (2003) MECHANISM OF FREE RADICAL OXYGENATION OF POLYUNSATURATED FATTY ACIDS BY CYCLOOXYGENASES.CHEMICAL REVIEWS. VOL. 103. ISSUE 6. P. 2239-2304 127 70% 129
5 TSAI, AL , KULMACZ, RJ , (2010) PROSTAGLANDIN H SYNTHASE: RESOLVED AND UNRESOLVED MECHANISTIC ISSUES.ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. VOL. 493. ISSUE 1. P. 103-124 98 78% 47
6 CHAKRABORTI, AK , GARG, SK , KUMAR, R , MOTIWALA, HF , JADHAVAR, PS , (2010) PROGRESS IN COX-2 INHIBITORS: A JOURNEY SO FAR.CURRENT MEDICINAL CHEMISTRY. VOL. 17. ISSUE 15. P. 1563-1593 105 70% 61
7 HERSCHMAN, HR , (1996) PROSTAGLANDIN SYNTHASE 2.BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM. VOL. 1299. ISSUE 1. P. 125-140 79 69% 999
8 SINGH, P , MITTAL, A , (2008) CURRENT STATUS OF COX-2 INHIBITORS.MINI-REVIEWS IN MEDICINAL CHEMISTRY. VOL. 8. ISSUE 1. P. 73-90 86 85% 38
9 SMITH, WL , GARAVITO, RM , DEWITT, DL , (1996) PROSTAGLANDIN ENDOPEROXIDE H SYNTHASES (CYCLOOXYGENASES)-1 AND -2.JOURNAL OF BIOLOGICAL CHEMISTRY. VOL. 271. ISSUE 52. P. 33157 -33160 53 80% 1471
10 SMITH, WL , DEWITT, DL , (1995) BIOCHEMISTRY OF PROSTAGLANDIN ENDOPEROXIDE-H SYNTHASE-1 AND SYNTHASE-2 AND THEIR DIFFERENTIAL SUSCEPTIBILITY TO NONSTEROIDAL ANTIINFLAMMATORY DRUGS.SEMINARS IN NEPHROLOGY. VOL. 15. ISSUE 3. P. 179-194 88 84% 251

Classes with closest relation at Level 1


Rank Class id link
1 20784 NIMESULIDE//CAS 51803 78 2//AULINR
2 21642 GEORGE M OBRIEN KIDNEY UROL DIS//GEORGE OBRIEN KIDNEY UROL DIS//MACULA DENSA
3 11362 COXIBS//SOLUMATRIX//ROFECOXIB
4 30350 LICOFELONE//TEPOXALIN//2 2 DIMETHYL 6 4 CHLOROPHENYL 7 PHENYL 2 3 DIHYDRO 1H PYRROLIZINE 5 YL ACETIC ACID
5 27806 EXPT THER EUT PHARMACOINFORMAT//PROSTACYCLIN SYNTHASE//PROSTACYCLIN SYNTHASE GENE
6 19756 MPGES 1//PROSTAGLANDIN E SYNTHASE//MPGES 1 INHIBITORS
7 180 CYCLOOXYGENASE 2//COX 2//CELECOXIB
8 10681 CYCLOOXYGENASE//NEUROINFLAMMAT S//BUTAPROST
9 21370 NO NSAIDS//NCX 4016//NO ASPIRIN
10 17750 PHARMACOL PROGRAM//ALGESIOMETRIC TESTS//BRAIN SEROTONIN RECEPTORS

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