Class information for:
Level 1: LICOFELONE//TEPOXALIN//2 2 DIMETHYL 6 4 CHLOROPHENYL 7 PHENYL 2 3 DIHYDRO 1H PYRROLIZINE 5 YL ACETIC ACID

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
30350 170 28.5 58%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
275 3       NSAIDS//CYCLOOXYGENASE//CYCLOOXYGENASE 2 43399
466 2             NSAIDS//NON STEROIDAL ANTI INFLAMMATORY DRUGS//COX 2 INHIBITORS 15930
30350 1                   LICOFELONE//TEPOXALIN//2 2 DIMETHYL 6 4 CHLOROPHENYL 7 PHENYL 2 3 DIHYDRO 1H PYRROLIZINE 5 YL ACETIC ACID 170

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 LICOFELONE authKW 1483135 10% 49% 17
2 TEPOXALIN authKW 1207440 6% 61% 11
3 2 2 DIMETHYL 6 4 CHLOROPHENYL 7 PHENYL 2 3 DIHYDRO 1H PYRROLIZINE 5 YL ACETIC ACID authKW 898103 3% 100% 5
4 ML3000 authKW 718482 2% 100% 4
5 COX 5 LOX INHIBITOR authKW 404145 2% 75% 3
6 CAS 156897 06 2 authKW 359241 1% 100% 2
7 LOX COX INHIBITOR authKW 359241 1% 100% 2
8 RWJ 20142 authKW 359241 1% 100% 2
9 CYCLOOXYGENASE LIPOXYGENASE INHIBITOR authKW 239493 1% 67% 2
10 ZLJ 6 authKW 239493 1% 67% 2

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Pharmacology & Pharmacy 1040 46% 0% 78
2 Chemistry, Medicinal 791 21% 0% 35
3 Chemistry, Organic 194 16% 0% 28
4 Rheumatology 101 5% 0% 8
5 Chemistry, Multidisciplinary 94 18% 0% 30
6 Veterinary Sciences 18 5% 0% 8
7 Geriatrics & Gerontology 13 2% 0% 3
8 Integrative & Complementary Medicine 12 1% 0% 2
9 Toxicology 9 3% 0% 5
10 Crystallography 7 2% 0% 4

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ATHEROSCLEROSIS DYSMETABOL DIS STUDY GC DES 179621 1% 100% 1
2 BLOOD VASC INTERACTIONS 179621 1% 100% 1
3 CHEM ORGAN METALL CPDS 179621 1% 100% 1
4 KLIN SPORTORTHOPADIE SPORTTRAUMATOL 179621 1% 100% 1
5 LUDWIG BOLTZMANN ANGEW BADER KUMAHEILKUNDE 179621 1% 100% 1
6 MED HAEMOTHER Y HAEMOSTASIS 179621 1% 100% 1
7 MED PL BIOTECHNOL D CAMPANACCI 179621 1% 100% 1
8 MED RHEUMATOL PATHOL 179621 1% 100% 1
9 ORIENTAL MED BONE JOINT 179621 1% 100% 1
10 GC DESCOVICH ATHEROSCLEROSIS METAB DIS 89809 1% 50% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ACTA POLONIAE PHARMACEUTICA 15177 6% 1% 11
2 ARCHIV DER PHARMAZIE 8180 8% 0% 14
3 CHEMIKER-ZEITUNG 3307 2% 0% 4
4 KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII 1809 5% 0% 8
5 JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS 1219 2% 0% 4
6 VASCULAR PHARMACOLOGY 633 1% 0% 2
7 INFLAMMATION RESEARCH 573 2% 0% 3
8 ARZNEIMITTELFORSCHUNG-DRUG RESEARCH 569 1% 0% 2
9 VETERINARY AND COMPARATIVE ONCOLOGY 494 1% 0% 1
10 IDRUGS 480 1% 0% 1

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 LICOFELONE 1483135 10% 49% 17 Search LICOFELONE Search LICOFELONE
2 TEPOXALIN 1207440 6% 61% 11 Search TEPOXALIN Search TEPOXALIN
3 2 2 DIMETHYL 6 4 CHLOROPHENYL 7 PHENYL 2 3 DIHYDRO 1H PYRROLIZINE 5 YL ACETIC ACID 898103 3% 100% 5 Search 2+2+DIMETHYL+6+4+CHLOROPHENYL+7+PHENYL+2+3+DIHYDRO+1H+PYRROLIZINE+5+YL+ACETIC+ACID Search 2+2+DIMETHYL+6+4+CHLOROPHENYL+7+PHENYL+2+3+DIHYDRO+1H+PYRROLIZINE+5+YL+ACETIC+ACID
4 ML3000 718482 2% 100% 4 Search ML3000 Search ML3000
5 COX 5 LOX INHIBITOR 404145 2% 75% 3 Search COX+5+LOX+INHIBITOR Search COX+5+LOX+INHIBITOR
6 CAS 156897 06 2 359241 1% 100% 2 Search CAS+156897+06+2 Search CAS+156897+06+2
7 LOX COX INHIBITOR 359241 1% 100% 2 Search LOX+COX+INHIBITOR Search LOX+COX+INHIBITOR
8 RWJ 20142 359241 1% 100% 2 Search RWJ+20142 Search RWJ+20142
9 CYCLOOXYGENASE LIPOXYGENASE INHIBITOR 239493 1% 67% 2 Search CYCLOOXYGENASE+LIPOXYGENASE+INHIBITOR Search CYCLOOXYGENASE+LIPOXYGENASE+INHIBITOR
10 ZLJ 6 239493 1% 67% 2 Search ZLJ+6 Search ZLJ+6

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 DE BOEVER, S , NEIRINCKX, E , BAERT, K , DE BACKER, P , CROUBELS, S , (2009) PHARMACOKINETICS OF TEPOXALIN AND ITS ACTIVE METABOLITE IN BROILER CHICKENS.JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS. VOL. 32. ISSUE 1. P. 97 -100 14 82% 5
2 DING, CH , CICUTTINI, F , (2003) LICOFELONE MERCKLE.IDRUGS. VOL. 6. ISSUE 8. P. 802-808 13 76% 15
3 KULKARNI, SK , SINGH, VP , (2007) LICOFELONE-A NOVEL ANALGESIC AND ANTI-INFLAMMATORY AGENT.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 7. ISSUE 3. P. 251-263 17 40% 32
4 GIORGI, M , MENGOZZI, G , RAFFAELLI, A , SABA, A , (2011) CHARACTERIZATION OF IN VIVO PLASMA METABOLITES OF TEPOXALIN IN HORSES USING LC-MS-MS.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. VOL. 56. ISSUE 1. P. 45-53 8 80% 2
5 CICERO, AFG , LAGHI, L , (2007) ACTIVITY AND POTENTIAL ROLE OF LICOFELONE IN THE MANAGEMENT OF OSTEOARTHRITIS.CLINICAL INTERVENTIONS IN AGING. VOL. 2. ISSUE 1. P. 73-79 15 43% 14
6 POLLOCK, CG , CARPENTER, JW , KOCH, DE , HUNTER, RP , (2008) SINGLE AND MULTIPLE-DOSE PHARMACOKINETICS OF TEPOXALIN AND ITS ACTIVE METABOLITE AFTER ORAL ADMINISTRATION TO RABBITS (ORYCTOLAGUS CUNICULUS).JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS. VOL. 31. ISSUE 2. P. 171 -174 6 100% 3
7 GIORGI, M , YE, GS , SGORBINI, M , CORAZZA, M , (2011) VALIDATION OF AN HPLC-FL METHOD FOR THE DETERMINATION OF TEPOXALIN AND ITS MAJOR METABOLITE IN HORSE PLASMA.JOURNAL OF CHROMATOGRAPHIC SCIENCE. VOL. 49. ISSUE 1. P. 79-83 6 86% 1
8 GOUDA, AM , ABDELAZEEM, AH , (2016) AN INTEGRATED OVERVIEW ON PYRROLIZINES AS POTENTIAL ANTI-INFLAMMATORY, ANALGESIC AND ANTIPYRETIC AGENTS.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. VOL. 114. ISSUE . P. 257 -292 16 27% 0
9 CICERO, AFG , DEROSA, G , GADDI, A , (2005) COMBINED LIPOXYGENASE/CYCLO-OXYGENASE INHIBITION IN THE ELDERLY - THE EXAMPLE OF LICOFELONE.DRUGS & AGING. VOL. 22. ISSUE 5. P. 393-403 16 31% 15
10 BANNWARTH, B , (2004) IS LICOFELONE, A DUAL INHIBITOR OF CYCLO-OXYGENASE AND 5-LIPOXYGENASE, A PROMISING ALTERNATIVE IN ANTI-INFLAMMATORY THERAPY?.FUNDAMENTAL & CLINICAL PHARMACOLOGY. VOL. 18. ISSUE 1. P. 125-130 10 53% 4

Classes with closest relation at Level 1


Rank Class id link
1 29518 ACEMETACIN//1 1 DIOXO 1 2 THIAZINE 6 CARBALDEHYDES//ACEMETACIN ACE
2 31466 SOLARE ENERGIETECH//PHOTOACYLATION//REACTIONS AND METHODS
3 2243 CYCLOOXYGENASE//PROSTAGLANDIN H SYNTHASE//AB HANCOCK JR MEM CANC
4 3852 5 LIPOXYGENASE//LEUKOTRIENES//5 LIPOXYGENASE ACTIVATING PROTEIN
5 19756 MPGES 1//PROSTAGLANDIN E SYNTHASE//MPGES 1 INHIBITORS
6 17640 12S HETE//LY293111//ZYFLAMEND
7 36078 KOLBE SCHMITT REACTION//3 6 DICHROLO SALICYLIC ACID//ADV ORGAN MAT CHEM
8 24229 1 2 4 DITIAZOLIUM SALTS//2 N CYANOIMINOTHIAZOLIDINE//PYRROLO2 3 BQUINOXALINE
9 21642 GEORGE M OBRIEN KIDNEY UROL DIS//GEORGE OBRIEN KIDNEY UROL DIS//MACULA DENSA
10 30780 1 AZABICYCLO330OCTANE//PILSICAINIDE HYDROCHLORIDE//SUN 1165

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