Class information for:
Level 1: MPGES 1//PROSTAGLANDIN E SYNTHASE//MPGES 1 INHIBITORS

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
19756 490 43.0 90%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
275 3       NSAIDS//CYCLOOXYGENASE//CYCLOOXYGENASE 2 43399
1311 2             PROSTAGLANDIN D 2//CRTH2//MOL BEHAV BIOL 8520
19756 1                   MPGES 1//PROSTAGLANDIN E SYNTHASE//MPGES 1 INHIBITORS 490

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MPGES 1 authKW 2834091 16% 60% 76
2 PROSTAGLANDIN E SYNTHASE authKW 763340 6% 44% 28
3 MPGES 1 INHIBITORS authKW 623160 2% 100% 10
4 MICROSOMAL PROSTAGLANDIN E SYNTHASE 1 authKW 458851 4% 41% 18
5 PGE SYNTHASE authKW 443536 2% 65% 11
6 MPGES 2 authKW 381684 1% 88% 7
7 MICROSOMAL PROSTAGLANDIN E 2 SYNTHASE 1 authKW 336499 2% 60% 9
8 MICROSOMAL PROSTAGLANDIN E SYNTHASE 1 MPGES 1 authKW 277584 1% 64% 7
9 CPGES authKW 199410 1% 80% 4
10 CYTOSOLIC PROSTAGLANDIN E SYNTHASE authKW 199410 1% 80% 4

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Medicinal 1259 16% 0% 76
2 Biochemistry & Molecular Biology 645 32% 0% 159
3 Cell Biology 318 15% 0% 72
4 Rheumatology 238 4% 0% 21
5 Pharmacology & Pharmacy 186 14% 0% 67
6 Biophysics 121 7% 0% 33
7 Peripheral Vascular Diseases 119 5% 0% 26
8 Chemistry, Organic 104 8% 0% 40
9 Oncology 82 9% 0% 43
10 Medicine, Research & Experimental 54 5% 0% 25

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PHARMACEUT ANALYT 169615 3% 19% 14
2 ANGIOL VASC BIOL INFLAMMAT 138785 1% 32% 7
3 CHAIR PHARMACEUT MED CHEM 98897 2% 16% 10
4 HLTH CHEM 92685 5% 6% 25
5 LIFF ZAFES 80117 1% 43% 3
6 ANESTHESIAHUNAN CANC HOSP 62316 0% 100% 1
7 BIO CHEM 1 62316 0% 100% 1
8 DORIS NEUROSCI 62316 0% 100% 1
9 GR LAENNEC HOSP 62316 0% 100% 1
10 HEMATOLGUANGDONG HIGHER EDUC 62316 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PROSTAGLANDINS & OTHER LIPID MEDIATORS 9955 3% 1% 17
2 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 1641 5% 0% 26
3 JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY 877 0% 1% 2
4 PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS 709 1% 0% 6
5 AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 595 2% 0% 8
6 JOURNAL OF BIOMOLECULAR SCREENING 574 1% 0% 4
7 BIOORGANIC & MEDICINAL CHEMISTRY 563 2% 0% 11
8 JOURNAL OF MEDICINAL CHEMISTRY 470 3% 0% 13
9 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 377 4% 0% 21
10 JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 265 1% 0% 3

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 MPGES 1 2834091 16% 60% 76 Search MPGES+1 Search MPGES+1
2 PROSTAGLANDIN E SYNTHASE 763340 6% 44% 28 Search PROSTAGLANDIN+E+SYNTHASE Search PROSTAGLANDIN+E+SYNTHASE
3 MPGES 1 INHIBITORS 623160 2% 100% 10 Search MPGES+1+INHIBITORS Search MPGES+1+INHIBITORS
4 MICROSOMAL PROSTAGLANDIN E SYNTHASE 1 458851 4% 41% 18 Search MICROSOMAL+PROSTAGLANDIN+E+SYNTHASE+1 Search MICROSOMAL+PROSTAGLANDIN+E+SYNTHASE+1
5 PGE SYNTHASE 443536 2% 65% 11 Search PGE+SYNTHASE Search PGE+SYNTHASE
6 MPGES 2 381684 1% 88% 7 Search MPGES+2 Search MPGES+2
7 MICROSOMAL PROSTAGLANDIN E 2 SYNTHASE 1 336499 2% 60% 9 Search MICROSOMAL+PROSTAGLANDIN+E+2+SYNTHASE+1 Search MICROSOMAL+PROSTAGLANDIN+E+2+SYNTHASE+1
8 MICROSOMAL PROSTAGLANDIN E SYNTHASE 1 MPGES 1 277584 1% 64% 7 Search MICROSOMAL+PROSTAGLANDIN+E+SYNTHASE+1+MPGES+1 Search MICROSOMAL+PROSTAGLANDIN+E+SYNTHASE+1+MPGES+1
9 CPGES 199410 1% 80% 4 Search CPGES Search CPGES
10 CYTOSOLIC PROSTAGLANDIN E SYNTHASE 199410 1% 80% 4 Search CYTOSOLIC+PROSTAGLANDIN+E+SYNTHASE Search CYTOSOLIC+PROSTAGLANDIN+E+SYNTHASE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 CHEN, YQ , LIU, HQ , XU, S , WANG, TL , LI, W , (2015) TARGETING MICROSOMAL PROSTAGLANDIN E-2 SYNTHASE-1 (MPGES-1): THE DEVELOPMENT OF INHIBITORS AS AN ALTERNATIVE TO NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDS).MEDCHEMCOMM. VOL. 6. ISSUE 12. P. 2081 -2123 115 64% 1
2 CHANG, HH , MEUILLET, EJ , (2011) IDENTIFICATION AND DEVELOPMENT OF MPGES-1 INHIBITORS: WHERE WE ARE AT?.FUTURE MEDICINAL CHEMISTRY. VOL. 3. ISSUE 15. P. 1909 -1934 83 75% 42
3 KOEBERLE, A , WERZ, O , (2015) PERSPECTIVE OF MICROSOMAL PROSTAGLANDIN E-2 SYNTHASE-1 AS DRUG TARGET IN INFLAMMATION-RELATED DISORDERS.BIOCHEMICAL PHARMACOLOGY. VOL. 98. ISSUE 1. P. 1 -15 75 71% 7
4 KOEBERLE, A , LAUFER, SA , WERZ, O , (2016) DESIGN AND DEVELOPMENT OF MICROSOMAL PROSTAGLANDIN E-2 SYNTHASE-1 INHIBITORS: CHALLENGES AND FUTURE DIRECTIONS.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 59. ISSUE 13. P. 5970 -5986 82 65% 1
5 KHURANA, P , JACHAK, SM , (2016) CHEMISTRY AND BIOLOGY OF MICROSOMAL PROSTAGLANDIN E-2 SYNTHASE-1 (MPGES-1) INHIBITORS AS NOVEL ANTI-INFLAMMATORY AGENTS: RECENT DEVELOPMENTS AND CURRENT STATUS.RSC ADVANCES. VOL. 6. ISSUE 34. P. 28343 -28369 75 68% 0
6 BAHIA, MS , KATARE, YK , SILAKARI, O , VYAS, B , SILAKARI, P , (2014) INHIBITORS OF MICROSOMAL PROSTAGLANDIN E-2 SYNTHASE-1 ENZYME AS EMERGING ANTI-INFLAMMATORY CANDIDATES.MEDICINAL RESEARCH REVIEWS. VOL. 34. ISSUE 4. P. 825 -855 87 52% 10
7 SAMUELSSON, B , MORGENSTERN, R , JAKOBSSON, PJ , (2007) MEMBRANE PROSTAGLANDIN E SYNTHASE-1: A NOVEL THERAPEUTIC TARGET.PHARMACOLOGICAL REVIEWS. VOL. 59. ISSUE 3. P. 207 -224 84 46% 260
8 KOROTKOVA, M , JAKOBSSON, PJ , (2014) CHARACTERIZATION OF MICROSOMAL PROSTAGLANDIN E SYNTHASE 1 INHIBITORS.BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY. VOL. 114. ISSUE 1. P. 64-69 45 75% 21
9 KOEBERLE, A , WERZ, O , (2009) INHIBITORS OF THE MICROSOMAL PROSTAGLANDIN E-2 SYNTHASE-1 AS ALTERNATIVE TO NON STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDS) - A CRITICAL REVIEW.CURRENT MEDICINAL CHEMISTRY. VOL. 16. ISSUE 32. P. 4274 -4296 87 42% 56
10 HARA, S , KAMEI, D , SASAKI, Y , TANEMOTO, A , NAKATANI, Y , MURAKAMI, M , (2010) PROSTAGLANDIN E SYNTHASES: UNDERSTANDING THEIR PATHOPHYSIOLOGICAL ROLES THROUGH MOUSE GENETIC MODELS.BIOCHIMIE. VOL. 92. ISSUE 6. P. 651-659 55 60% 57

Classes with closest relation at Level 1


Rank Class id link
1 5984 PROSTANOID RECEPTORS//EP3 RECEPTOR//IP RECEPTOR
2 27806 EXPT THER EUT PHARMACOINFORMAT//PROSTACYCLIN SYNTHASE//PROSTACYCLIN SYNTHASE GENE
3 21642 GEORGE M OBRIEN KIDNEY UROL DIS//GEORGE OBRIEN KIDNEY UROL DIS//MACULA DENSA
4 22578 MICROSOMAL GLUTATHIONE TRANSFERASE//MGST1//MOL GENET PHARMACOL
5 25991 15 HYDROXYPROSTAGLANDIN DEHYDROGENASE//15 PGDH//15 HYDROXYPROSTAGLANDIN DEHYDROGENASE 15 PGDH
6 11362 COXIBS//SOLUMATRIX//ROFECOXIB
7 30350 LICOFELONE//TEPOXALIN//2 2 DIMETHYL 6 4 CHLOROPHENYL 7 PHENYL 2 3 DIHYDRO 1H PYRROLIZINE 5 YL ACETIC ACID
8 10681 CYCLOOXYGENASE//NEUROINFLAMMAT S//BUTAPROST
9 180 CYCLOOXYGENASE 2//COX 2//CELECOXIB
10 2243 CYCLOOXYGENASE//PROSTAGLANDIN H SYNTHASE//AB HANCOCK JR MEM CANC

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