Class information for:
Level 1: MRNA DELIVERY//LIPIDOID//MRNA VACCINE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
21247 427 48.1 92%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
227 3       MICRORNA//MIRNA//GENE DELIVERY 49432
476 2             GENE DELIVERY//CELL PENETRATING PEPTIDE//CATIONIC LIPID 15822
21247 1                   MRNA DELIVERY//LIPIDOID//MRNA VACCINE 427

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MRNA DELIVERY authKW 715105 2% 100% 10
2 LIPIDOID authKW 389332 2% 78% 7
3 MRNA VACCINE authKW 367766 1% 86% 6
4 PH SENSITIVE CATIONIC LIPID authKW 214531 1% 100% 3
5 RIBOL address 214531 1% 100% 3
6 RNACTIVE authKW 214531 1% 100% 3
7 SELF AMPLIFYING MRNA authKW 214531 1% 100% 3
8 TRANSLAT GENOM GENE THER Y address 214531 1% 100% 3
9 LIPID NANOPARTICLES authKW 197975 7% 9% 30
10 MOL IMMUNOL EXPT ONCOL address 175192 2% 35% 7

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Medicine, Research & Experimental 1436 22% 0% 95
2 Biotechnology & Applied Microbiology 595 17% 0% 72
3 Materials Science, Biomaterials 584 6% 0% 27
4 Pharmacology & Pharmacy 552 23% 0% 97
5 Chemistry, Multidisciplinary 506 24% 0% 103
6 Nanoscience & Nanotechnology 428 11% 0% 49
7 Genetics & Heredity 272 12% 0% 50
8 Multidisciplinary Sciences 210 4% 0% 17
9 Immunology 179 11% 0% 49
10 Engineering, Biomedical 117 5% 0% 20

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 RIBOL 214531 1% 100% 3
2 TRANSLAT GENOM GENE THER Y 214531 1% 100% 3
3 MOL IMMUNOL EXPT ONCOL 175192 2% 35% 7
4 TRON TRANSLAT ONCOL 128704 2% 20% 9
5 TRANSLAT EXPT ONCOL 127691 1% 36% 5
6 DAVID H KOCH INTEGRAT CANC 103082 8% 4% 33
7 TRANSLAT ONCOL IMMUNOL TRON 95346 0% 67% 2
8 AUDIE L MURPHY GERIATR EDUC CLIN 71510 0% 100% 1
9 BIOMED 898 71510 0% 100% 1
10 BIONTECH AG 71510 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MOLECULAR THERAPY-NUCLEIC ACIDS 15139 2% 3% 8
2 MOLECULAR THERAPY 8877 5% 1% 21
3 JOURNAL OF CONTROLLED RELEASE 6482 6% 0% 26
4 ADVANCES IN GENETICS 5142 1% 1% 5
5 PROGRESS IN TUMOR RESEARCH 3971 0% 6% 1
6 MOLECULAR PHARMACEUTICS 3822 3% 0% 13
7 ADVANCED HEALTHCARE MATERIALS 3286 2% 1% 7
8 NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 2721 2% 1% 7
9 NATURE BIOTECHNOLOGY 1734 2% 0% 8
10 GENE THERAPY 1466 2% 0% 9

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 MRNA DELIVERY 715105 2% 100% 10 Search MRNA+DELIVERY Search MRNA+DELIVERY
2 LIPIDOID 389332 2% 78% 7 Search LIPIDOID Search LIPIDOID
3 MRNA VACCINE 367766 1% 86% 6 Search MRNA+VACCINE Search MRNA+VACCINE
4 PH SENSITIVE CATIONIC LIPID 214531 1% 100% 3 Search PH+SENSITIVE+CATIONIC+LIPID Search PH+SENSITIVE+CATIONIC+LIPID
5 RNACTIVE 214531 1% 100% 3 Search RNACTIVE Search RNACTIVE
6 SELF AMPLIFYING MRNA 214531 1% 100% 3 Search SELF+AMPLIFYING+MRNA Search SELF+AMPLIFYING+MRNA
7 LIPID NANOPARTICLES 197975 7% 9% 30 Search LIPID+NANOPARTICLES Search LIPID+NANOPARTICLES
8 SIRNA DELIVERY 149270 7% 7% 30 Search SIRNA+DELIVERY Search SIRNA+DELIVERY
9 CHEMICALLY MODIFIED MRNA 143021 0% 100% 2 Search CHEMICALLY+MODIFIED+MRNA Search CHEMICALLY+MODIFIED+MRNA
10 CHEMICALLY MODIFIED MRNA CMRNA 143021 0% 100% 2 Search CHEMICALLY+MODIFIED+MRNA+CMRNA Search CHEMICALLY+MODIFIED+MRNA+CMRNA

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 KAUFFMAN, KJ , WEBBER, MJ , ANDERSON, DG , (2016) MATERIALS FOR NON-VIRAL INTRACELLULAR DELIVERY OF MESSENGER RNA THERAPEUTICS.JOURNAL OF CONTROLLED RELEASE. VOL. 240. ISSUE . P. 227 -234 45 46% 6
2 SERGEEVA, OV , KOTELIANSKY, VE , ZATSEPIN, TS , (2016) MRNA-BASED THERAPEUTICS-ADVANCES AND PERSPECTIVES.BIOCHEMISTRY-MOSCOW. VOL. 81. ISSUE 7. P. 709 -722 51 46% 3
3 ISLAM, MA , REESOR, EKG , XU, YJ , ZOPE, HR , ZETTER, BR , SHI, JJ , (2015) BIOMATERIALS FOR MRNA DELIVERY.BIOMATERIALS SCIENCE. VOL. 3. ISSUE 12. P. 1519 -1533 42 40% 8
4 THESS, A , GRUND, S , MUI, BL , HOPE, MJ , BAUMHOF, P , FOTIN-MLECZEK, M , SCHLAKE, T , (2015) SEQUENCE-ENGINEERED MRNA WITHOUT CHEMICAL NUCLEOSIDE MODIFICATIONS ENABLES AN EFFECTIVE PROTEIN THERAPY IN LARGE ANIMALS.MOLECULAR THERAPY. VOL. 23. ISSUE 9. P. 1456 -1464 25 60% 12
5 DEERING, RP , KOMMAREDDY, S , ULMER, JB , BRITO, LA , GEALL, AJ , (2014) NUCLEIC ACID VACCINES: PROSPECTS FOR NON-VIRAL DELIVERY OF MRNA VACCINES.EXPERT OPINION ON DRUG DELIVERY. VOL. 11. ISSUE 6. P. 885 -899 39 38% 15
6 SUZUKI, Y , ISHIHARA, H , (2016) STRUCTURE, ACTIVITY AND UPTAKE MECHANISM OF SIRNA-LIPID NANOPARTICLES WITH AN ASYMMETRIC IONIZABLE LIPID.INTERNATIONAL JOURNAL OF PHARMACEUTICS. VOL. 510. ISSUE 1. P. 350 -358 25 64% 0
7 PARDI, N , TUYISHIME, S , MURAMATSU, H , KARIKO, K , MUI, BL , TAM, YK , MADDEN, TD , HOPE, MJ , WEISSMAN, D , (2015) EXPRESSION KINETICS OF NUCLEOSIDE-MODIFIED MRNA DELIVERED IN LIPID NANOPARTICLES TO MICE BY VARIOUS ROUTES.JOURNAL OF CONTROLLED RELEASE. VOL. 217. ISSUE . P. 345 -351 18 78% 7
8 LOOMIS, KH , KIRSCHMAN, JL , BHOSLE, S , BELLAMKONDA, RV , SANTANGELO, PJ , (2016) STRATEGIES FOR MODULATING INNATE IMMUNE ACTIVATION AND PROTEIN PRODUCTION OF IN VITRO TRANSCRIBED MRNAS.JOURNAL OF MATERIALS CHEMISTRY B. VOL. 4. ISSUE 9. P. 1619 -1632 37 33% 3
9 KAUFFMAN, KJ , DORKIN, JR , YANG, JH , HEARTLEIN, MW , DEROSA, F , MIR, FF , FENTON, OS , ANDERSON, DG , (2015) OPTIMIZATION OF LIPID NANOPARTICLE FORMULATIONS FOR MRNA DELIVERY IN VIVO WITH FRACTIONAL FACTORIAL AND DEFINITIVE SCREENING DESIGNS.NANO LETTERS. VOL. 15. ISSUE 11. P. 7300 -7306 21 60% 12
10 SAHIN, U , KARIKO, K , TURECI, O , (2014) MRNA-BASED THERAPEUTICS - DEVELOPING A NEW CLASS OF DRUGS.NATURE REVIEWS DRUG DISCOVERY. VOL. 13. ISSUE 10. P. 759 -780 46 21% 74

Classes with closest relation at Level 1


Rank Class id link
1 385 SIRNA//RNA INTERFERENCE//RNAI
2 2198 CATIONIC LIPID//CATIONIC LIPOSOMES//LIPOPLEX
3 168 GENE DELIVERY//POLYETHYLENIMINE//POLYPLEX
4 21269 PHYS CHEM MICRO REACT TECHNOL//PHYS CHEM MICROREACT TECHNOL//MICRO CONTINUOUS FLOW
5 26051 CALCIUM PHOSPHATE NANOPARTICLES//CHARGE CONVERSIONAL POLYMER//NANOTECHNOL DRUG DELIVERY
6 643 DENDRITIC CELLS//IMMUNOTHERAPY//TUMOR LYSATE
7 3573 DNA VACCINE//DNA IMMUNIZATION//DNA VACCINATION
8 17872 EXON SKIPPING//MC LOCKWOOD MUSCULAR DYSTROPHY//NEUROMUSCULAR ALS
9 16206 GENE MED GRP//GENEMED GRP//EXPT TREATMENT CYST FIBROSIS
10 2061 CELL PENETRATING PEPTIDE//PROTEIN TRANSDUCTION DOMAIN//PROTEIN TRANSDUCTION

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