Class information for:
Level 1: SIRNA//RNA INTERFERENCE//RNAI

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
385 3552 50.4 93%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
227 3       MICRORNA//MIRNA//GENE DELIVERY 49432
476 2             GENE DELIVERY//CELL PENETRATING PEPTIDE//CATIONIC LIPID 15822
385 1                   SIRNA//RNA INTERFERENCE//RNAI 3552

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 SIRNA authKW 965794 20% 16% 723
2 RNA INTERFERENCE authKW 938845 20% 15% 709
3 RNAI authKW 617057 14% 15% 485
4 SMALL INTERFERING RNA authKW 293203 5% 19% 182
5 SHRNA authKW 273874 5% 20% 163
6 GENE SILENCING authKW 211167 6% 12% 202
7 SIRNA DESIGN authKW 146112 0% 100% 17
8 U6 PROMOTER authKW 126279 1% 64% 23
9 SHORT HAIRPIN RNA authKW 114123 2% 22% 61
10 SHORT INTERFERING RNA authKW 111508 1% 28% 46

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Biotechnology & Applied Microbiology 6446 19% 0% 675
2 Biochemistry & Molecular Biology 6327 37% 0% 1309
3 Medicine, Research & Experimental 4843 15% 0% 520
4 Virology 2707 7% 0% 252
5 Genetics & Heredity 2553 12% 0% 438
6 Cell Biology 1849 13% 0% 476
7 Pharmacology & Pharmacy 1406 14% 0% 494
8 Biophysics 813 7% 0% 232
9 Biochemical Research Methods 762 6% 0% 206
10 Chemistry, Medicinal 372 4% 0% 135

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ANTIVIRAL GENE THER Y UNIT 101327 1% 47% 25
2 SKIP ACKERMAN MOL THER EUT 63286 0% 82% 9
3 GLOBAL RNAI MED 43176 0% 36% 14
4 GLOBAL PHARMACEUT ANALYT SCI 22917 0% 67% 4
5 GENE FUNCT 22569 1% 12% 22
6 CINIMA MED 19337 0% 75% 3
7 MED MICROBIOL EXPT VIROL 17917 0% 17% 12
8 ANTISENSE CORE 17190 0% 100% 2
9 BRAIN KOREA CHEM MAT SCI 21 17190 0% 100% 2
10 FORMULAT S TECHNOL DEV 17190 0% 100% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 OLIGONUCLEOTIDES 64626 1% 17% 45
2 NUCLEIC ACID THERAPEUTICS 22828 1% 10% 26
3 MOLECULAR THERAPY 20394 3% 3% 92
4 MOLECULAR THERAPY-NUCLEIC ACIDS 13734 1% 7% 22
5 CURRENT OPINION IN MOLECULAR THERAPEUTICS 8224 1% 3% 29
6 RNA 7409 1% 2% 47
7 NUCLEIC ACIDS RESEARCH 6498 5% 0% 176
8 GENE THERAPY 6314 2% 1% 54
9 ANTIVIRAL RESEARCH 4949 1% 1% 45
10 JOURNAL OF GENE MEDICINE 4410 1% 2% 27

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 SIRNA 965794 20% 16% 723 Search SIRNA Search SIRNA
2 RNA INTERFERENCE 938845 20% 15% 709 Search RNA+INTERFERENCE Search RNA+INTERFERENCE
3 RNAI 617057 14% 15% 485 Search RNAI Search RNAI
4 SMALL INTERFERING RNA 293203 5% 19% 182 Search SMALL+INTERFERING+RNA Search SMALL+INTERFERING+RNA
5 SHRNA 273874 5% 20% 163 Search SHRNA Search SHRNA
6 GENE SILENCING 211167 6% 12% 202 Search GENE+SILENCING Search GENE+SILENCING
7 SIRNA DESIGN 146112 0% 100% 17 Search SIRNA+DESIGN Search SIRNA+DESIGN
8 U6 PROMOTER 126279 1% 64% 23 Search U6+PROMOTER Search U6+PROMOTER
9 SHORT HAIRPIN RNA 114123 2% 22% 61 Search SHORT+HAIRPIN+RNA Search SHORT+HAIRPIN+RNA
10 SHORT INTERFERING RNA 111508 1% 28% 46 Search SHORT+INTERFERING+RNA Search SHORT+INTERFERING+RNA

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 SHUKLA, S , SUMARIA, CS , PRADEEPKUMAR, PI , (2010) EXPLORING CHEMICAL MODIFICATIONS FOR SIRNA THERAPEUTICS: A STRUCTURAL AND FUNCTIONAL OUTLOOK.CHEMMEDCHEM. VOL. 5. ISSUE 3. P. 328 -349 151 70% 76
2 KURRECK, J , (2009) RNA INTERFERENCE: FROM BASIC RESEARCH TO THERAPEUTIC APPLICATIONS.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. VOL. 48. ISSUE 8. P. 1378 -1398 116 72% 183
3 RETTIG, GR , BEHLKE, MA , (2012) PROGRESS TOWARD IN VIVO USE OF SIRNAS-II.MOLECULAR THERAPY. VOL. 20. ISSUE 3. P. 483-512 152 54% 83
4 WATTS, JK , DELEAVEY, GF , DAMHA, MJ , (2008) CHEMICALLY MODIFIED SIRNA: TOOLS AND APPLICATIONS.DRUG DISCOVERY TODAY. VOL. 13. ISSUE 19-20. P. 842 -855 104 81% 183
5 GRINEV, VV , (2012) DESIGN AND QUALITY CONTROL OF SHORT INTERFERING RNA.MOLECULAR BIOLOGY. VOL. 46. ISSUE 6. P. 739-754 124 78% 1
6 BEHLKE, MA , (2006) PROGRESS TOWARDS IN VIVO USE OF SIRNAS.MOLECULAR THERAPY. VOL. 13. ISSUE 4. P. 644 -670 129 57% 296
7 PEI, Y , TUSCHL, T , (2006) ON THE ART OF IDENTIFYING EFFECTIVE AND SPECIFIC SIRNAS.NATURE METHODS. VOL. 3. ISSUE 9. P. 670-676 86 93% 157
8 WHITEHEAD, KA , LANGER, R , ANDERSON, DG , (2009) KNOCKING DOWN BARRIERS: ADVANCES IN SIRNA DELIVERY.NATURE REVIEWS DRUG DISCOVERY. VOL. 8. ISSUE 2. P. 129-138 57 58% 1148
9 DE FOUGEROLLES, A , VORNLOCHER, HP , MARAGANORE, J , LIEBERMAN, J , (2007) INTERFERING WITH DISEASE: A PROGRESS REPORT ON SIRNA-BASED THERAPEUTICS.NATURE REVIEWS DRUG DISCOVERY. VOL. 6. ISSUE 6. P. 443 -453 69 69% 650
10 BOS, TJ , DE BRUYNE, E , HEIRMAN, C , VANDERKERKEN, K , (2009) IN SEARCH OF THE MOST SUITABLE LENTIVIRAL SHRNA SYSTEM.CURRENT GENE THERAPY. VOL. 9. ISSUE 3. P. 192 -211 146 59% 14

Classes with closest relation at Level 1


Rank Class id link
1 21247 MRNA DELIVERY//LIPIDOID//MRNA VACCINE
2 26208 RNA ACTIVATION//SMALL ACTIVATING RNA//SARNA
3 22884 SID 1//SYSTEMIC RNAI//DNA INSECTICIDES
4 8802 PIRNA//PIWI//PIWI INTERACTING RNA
5 5265 RNA SILENCING//POST TRANSCRIPTIONAL GENE SILENCING//VIRUS INDUCED GENE SILENCING
6 1139 MICRORNA//MIRNA//DROSHA
7 35065 IN OVO ELECTROPORATION//CAXIN2//CELL TRACKING CELL LINEAGE
8 14692 CYTOPLASMIC RNA VIRUSES//EBV ASSOCIATED GASTRIC CARCINOMA EBVAGC//EBV MIR BART7
9 28947 DICER//DROSHA//AGO2
10 11243 HIGH CONTENT SCREENING//LOCATION PROTEOMICS//BIOIMAGE INFORMAT

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