Class information for:
Level 1: CHIRAL INVERSION//DEXIBUPROFEN//IBUPROFEN

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
7453 1365 27.8 61%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
275 3       NSAIDS//CYCLOOXYGENASE//CYCLOOXYGENASE 2 43399
466 2             NSAIDS//NON STEROIDAL ANTI INFLAMMATORY DRUGS//COX 2 INHIBITORS 15930
7453 1                   CHIRAL INVERSION//DEXIBUPROFEN//IBUPROFEN 1365

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CHIRAL INVERSION authKW 393864 3% 46% 38
2 DEXIBUPROFEN authKW 223666 1% 50% 20
3 IBUPROFEN authKW 176264 10% 6% 142
4 2 ARYLPROPIONIC ACIDS authKW 173509 1% 48% 16
5 KETOPROFEN authKW 151083 6% 9% 77
6 FLOBUFEN authKW 137006 1% 88% 7
7 R IBUPROFEN authKW 130140 1% 73% 8
8 CHIRAL EXCIPIENT authKW 115037 0% 86% 6
9 STEREOSELECTIVE DISSOLUTION authKW 111843 0% 100% 5
10 KETOPROFEN ENANTIOMERS authKW 109602 1% 70% 7

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Pharmacology & Pharmacy 15297 61% 0% 833
2 Chemistry, Analytical 5290 27% 0% 373
3 Chemistry, Medicinal 3010 14% 0% 197
4 Biochemical Research Methods 706 8% 0% 115
5 Rheumatology 355 3% 0% 44
6 Chemistry, Multidisciplinary 255 12% 0% 160
7 Veterinary Sciences 194 5% 0% 72
8 Chemistry, Organic 178 7% 0% 93
9 Toxicology 64 3% 0% 39
10 Medicine, General & Internal 21 4% 0% 50

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MICROBIAL BIOTRANSFORMAT GRP 67106 0% 100% 3
2 STN PERPETUA 44737 0% 100% 2
3 UNIDAD ESTUDIOS FARMACOL CLIN 29823 0% 67% 2
4 5297 KUMEGAWA CHO 22369 0% 100% 1
5 ANALYT CHEM ETILER 22369 0% 100% 1
6 ANAT PHARAMCOL FORENS MED 22369 0% 100% 1
7 BAHAGIAN TEKNOL PERUBATAN 22369 0% 100% 1
8 BIO PHARMACEUT PHARMACOKINET 22369 0% 100% 1
9 BIOANALYSIS METAB PHARMACOKINET S 22369 0% 100% 1
10 BIOGENESIS NAT CPDS BIOTECHNOL 22369 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CHIRALITY 44585 6% 3% 78
2 JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS 9938 3% 1% 40
3 JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS 7975 2% 1% 29
4 JOURNAL OF CLINICAL PHARMACOLOGY 6538 3% 1% 40
5 EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS 5790 1% 1% 20
6 BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 5525 3% 1% 45
7 JOURNAL OF PHARMACEUTICAL SCIENCES 5331 4% 0% 52
8 EUROPEAN JOURNAL OF RHEUMATOLOGY AND INFLAMMATION 5021 0% 4% 6
9 CLINICAL PHARMACOKINETICS 4156 2% 1% 21
10 EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY 4049 3% 1% 36

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 CHIRAL INVERSION 393864 3% 46% 38 Search CHIRAL+INVERSION Search CHIRAL+INVERSION
2 DEXIBUPROFEN 223666 1% 50% 20 Search DEXIBUPROFEN Search DEXIBUPROFEN
3 IBUPROFEN 176264 10% 6% 142 Search IBUPROFEN Search IBUPROFEN
4 2 ARYLPROPIONIC ACIDS 173509 1% 48% 16 Search 2+ARYLPROPIONIC+ACIDS Search 2+ARYLPROPIONIC+ACIDS
5 KETOPROFEN 151083 6% 9% 77 Search KETOPROFEN Search KETOPROFEN
6 FLOBUFEN 137006 1% 88% 7 Search FLOBUFEN Search FLOBUFEN
7 R IBUPROFEN 130140 1% 73% 8 Search R+IBUPROFEN Search R+IBUPROFEN
8 CHIRAL EXCIPIENT 115037 0% 86% 6 Search CHIRAL+EXCIPIENT Search CHIRAL+EXCIPIENT
9 STEREOSELECTIVE DISSOLUTION 111843 0% 100% 5 Search STEREOSELECTIVE+DISSOLUTION Search STEREOSELECTIVE+DISSOLUTION
10 KETOPROFEN ENANTIOMERS 109602 1% 70% 7 Search KETOPROFEN+ENANTIOMERS Search KETOPROFEN+ENANTIOMERS

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 DAVIES, NM , (1998) CLINICAL PHARMACOKINETICS OF IBUPROFEN - THE FIRST 30 YEARS.CLINICAL PHARMACOKINETICS. VOL. 34. ISSUE 2. P. 101 -154 155 60% 168
2 WSOL, V , SKALOVA, L , SZOTAKOVA, B , (2004) CHIRAL INVERSION OF DRUGS: COINCIDENCE OR PRINCIPLE?.CURRENT DRUG METABOLISM. VOL. 5. ISSUE 6. P. 517-533 107 64% 43
3 BARBANOJ, MJ , ANTONIJOAN, RM , GICH, I , (2001) CLINICAL PHARMACOKINETICS OF DEXKETOPROFEN.CLINICAL PHARMACOKINETICS. VOL. 40. ISSUE 4. P. 245 -262 68 81% 52
4 TAN, SC , PATEL, BK , JACKSON, SHD , SWIFT, CG , HUTT, AJ , (2002) STEREOSELECTIVITY OF IBUPROFEN METABOLISM AND PHARMACOKINETICS FOLLOWING THE ADMINISTRATION OF THE RACEMATE TO HEALTHY VOLUNTEERS.XENOBIOTICA. VOL. 32. ISSUE 8. P. 683 -697 42 95% 45
5 EVANS, AM , (1992) ENANTIOSELECTIVE PHARMACODYNAMICS AND PHARMACOKINETICS OF CHIRAL NONSTEROIDAL ANTIINFLAMMATORY DRUGS.EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. VOL. 42. ISSUE 3. P. 237-256 69 66% 168
6 LANDONI, MF , SORACI, A , (2001) PHARMACOLOGY OF CHIRAL COMPOUNDS: 2-ARYLPROPIONIC ACID DERIVATIVES.CURRENT DRUG METABOLISM. VOL. 2. ISSUE 1. P. 37 -51 52 70% 55
7 MUSTONEN, K , NIEMI, A , RAEKALLIO, M , HEINONEN, M , PELTONIEMI, OAT , PALVIAINEN, M , SIVEN, M , PELTONIEMI, M , VAINIO, O , (2012) ENANTIOSPECIFIC KETOPROFEN CONCENTRATIONS IN PLASMA AFTER ORAL AND INTRAMUSCULAR ADMINISTRATION IN GROWING PIGS.ACTA VETERINARIA SCANDINAVICA. VOL. 54. ISSUE . P. - 32 86% 4
8 SHARMA, P , GUTTIKAR, S , SOLANKI, G , PATEL, DP , SHRIVASTAV, PS , (2012) DETERMINATION OF (S)-(+)- AND (R)-(-)-IBUPROFEN ENANTIOMERS IN HUMAN PLASMA AFTER CHIRAL PRECOLUMN DERIVATIZATION BY REVERSED-PHASE LC-ESI-MS/MS.BIOANALYSIS. VOL. 4. ISSUE 24. P. 2909-2927 29 88% 5
9 HAO, HP , WANG, GJ , SUN, JG , (2005) ENANTIOSELECTIVE PHARMACOKINETICS OF IBUPROFEN AND INVOLVED MECHANISMS.DRUG METABOLISM REVIEWS. VOL. 37. ISSUE 1. P. 215 -234 51 57% 42
10 MULLANGI, R , YAO, M , SRINIVAS, NR , (2003) RESOLUTION OF ENANTIOMERS OF KETOPROFEN BY HPLC: A REVIEW.BIOMEDICAL CHROMATOGRAPHY. VOL. 17. ISSUE 7. P. 423 -434 38 83% 22

Classes with closest relation at Level 1


Rank Class id link
1 20630 NABUMETONE//6 METHOXY 2 NAPHTHYLACETIC ACID//NAPROXEN
2 34043 LOXOPROFEN//CS 670//PELUBIPROFEN
3 14478 ACYL GLUCURONIDE//ZOMEPIRAC//DRUG PROTEIN ADDUCTS
4 25566 OXAPROZIN//4 5 DIARYLOXAZOLE//4 ACETAMIDOPHENYL 2 5 P TOLUYL 1 METHYLPYRROLEACETATE PHARMACOKINETICS
5 13403 ACECLOFENAC//ETHAMSYLATE//MEFENAMIC ACID
6 30067 ZALTOPROFEN//CAS 18683 91 5//CHILLS DRUG THERAPY
7 37157 OSCILLATORY CHIRAL CONVERSION//OSCILLATORY TRANSENANTIOMERIZATION//2 ARYLPROPIONIC ACIDS 2 APA
8 17116 ETODOLAC//EUROPEAN JOURNAL OF RHEUMATOLOGY AND INFLAMMATION//CAS 41340 25 4
9 31777 INDOBUFEN//CAS 106498991//INDOBUFEN ENANTIOMERS
10 34161 MAZAPERTINE//RAT HEPATIC S9//1 3 4 2 1 METHYLETHOXYPHENYL 1 PIPERAZINYLMETHYLBENZOYPIPERIDINE SUCCINATE

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