Class information for:
Level 1: ENDOTHELIN CONVERTING ENZYME//NEPRILYSIN//PHOSPHORAMIDON

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
14477 767 38.9 90%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
8 4 CARDIAC & CARDIOVASCULAR SYSTEM//PERIPHERAL VASCULAR DISEASES//CARDIOL 1276458
668 3       ENDOTHELIN//ENDOTHELIN 1//ENDOTHELIN RECEPTORS 9913
1078 2             ENDOTHELIN//ENDOTHELIN 1//ENDOTHELIN RECEPTORS 9913
14477 1                   ENDOTHELIN CONVERTING ENZYME//NEPRILYSIN//PHOSPHORAMIDON 767

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ENDOTHELIN CONVERTING ENZYME authKW 2470734 17% 47% 133
2 NEPRILYSIN authKW 1925649 17% 38% 129
3 PHOSPHORAMIDON authKW 812212 9% 30% 67
4 ENDOTHELIN CONVERTING ENZYME 1 authKW 429761 3% 47% 23
5 BIG ENDOTHELIN 1 authKW 300065 4% 27% 28
6 ENDOTHELIN CONVERTING ENZYME ECE authKW 201530 1% 56% 9
7 NEPRILYSIN 2 authKW 199050 1% 100% 5
8 BIG ENDOTHELIN authKW 192488 2% 27% 18
9 STRUCT BIOINFORMAT UNIT address 184909 2% 39% 12
10 ECE 1 authKW 178395 1% 41% 11

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 1281 36% 0% 275
2 Pharmacology & Pharmacy 1153 24% 0% 186
3 Biophysics 890 13% 0% 101
4 Neurosciences 846 21% 0% 162
5 Cardiac & Cardiovascular System 358 10% 0% 74
6 Medicine, Research & Experimental 240 8% 0% 59
7 Cell Biology 128 9% 0% 66
8 Chemistry, Medicinal 118 4% 0% 34
9 Geriatrics & Gerontology 87 2% 0% 16
10 Peripheral Vascular Diseases 39 3% 0% 22

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 STRUCT BIOINFORMAT UNIT 184909 2% 39% 12
2 PROTEOLYT NEUROSCI 161103 3% 16% 26
3 NEURODEGENERAT DIS GENE DISCOVERY 79620 0% 100% 2
4 PRECLIN CARDIOVASC 79616 1% 50% 4
5 ALZHEIMERS BIOMED SCI 39810 0% 100% 1
6 AU CARDIOVASC MED 39810 0% 100% 1
7 BIOCH MOL BIOL 39810 0% 100% 1
8 BIOTECHNOL A2 39810 0% 100% 1
9 CLIN PHARM CJ1020 39810 0% 100% 1
10 CNS P IMED 39810 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF CARDIOVASCULAR PHARMACOLOGY 14339 8% 1% 63
2 JOURNAL OF ALZHEIMERS DISEASE 2229 2% 0% 16
3 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 1853 7% 0% 57
4 FRONTIERS IN AGING NEUROSCIENCE 1792 1% 1% 7
5 CURRENT ALZHEIMER RESEARCH 1043 1% 1% 5
6 BRITISH JOURNAL OF PHARMACOLOGY 867 3% 0% 20
7 INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS 658 0% 1% 3
8 FEBS LETTERS 528 3% 0% 24
9 JOURNAL OF MOLECULAR NEUROSCIENCE 517 1% 0% 6
10 LIFE SCIENCES 419 2% 0% 15

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 ENDOTHELIN CONVERTING ENZYME 2470734 17% 47% 133 Search ENDOTHELIN+CONVERTING+ENZYME Search ENDOTHELIN+CONVERTING+ENZYME
2 NEPRILYSIN 1925649 17% 38% 129 Search NEPRILYSIN Search NEPRILYSIN
3 PHOSPHORAMIDON 812212 9% 30% 67 Search PHOSPHORAMIDON Search PHOSPHORAMIDON
4 ENDOTHELIN CONVERTING ENZYME 1 429761 3% 47% 23 Search ENDOTHELIN+CONVERTING+ENZYME+1 Search ENDOTHELIN+CONVERTING+ENZYME+1
5 BIG ENDOTHELIN 1 300065 4% 27% 28 Search BIG+ENDOTHELIN+1 Search BIG+ENDOTHELIN+1
6 ENDOTHELIN CONVERTING ENZYME ECE 201530 1% 56% 9 Search ENDOTHELIN+CONVERTING+ENZYME+ECE Search ENDOTHELIN+CONVERTING+ENZYME+ECE
7 NEPRILYSIN 2 199050 1% 100% 5 Search NEPRILYSIN+2 Search NEPRILYSIN+2
8 BIG ENDOTHELIN 192488 2% 27% 18 Search BIG+ENDOTHELIN Search BIG+ENDOTHELIN
9 ECE 1 178395 1% 41% 11 Search ECE+1 Search ECE+1
10 CGS 26303 162552 1% 58% 7 Search CGS+26303 Search CGS+26303

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 MARR, RA , SPENCER, BJ , (2010) DIABETES NEP-LIKE ENDOPEPTIDASES AND ALZHEIMER'S DISEASE.CURRENT ALZHEIMER RESEARCH. VOL. 7. ISSUE 3. P. 223-229 64 59% 13
2 WANG, SQ , WANG, R , CHEN, L , BENNETT, DA , DICKSON, DW , WANG, DS , (2010) EXPRESSION AND FUNCTIONAL PROFILING OF NEPRILYSIN, INSULIN-DEGRADING ENZYME, AND ENDOTHELIN-CONVERTING ENZYME IN PROSPECTIVELY STUDIED ELDERLY AND ALZHEIMER'S BRAIN.JOURNAL OF NEUROCHEMISTRY. VOL. 115. ISSUE 1. P. 47-57 45 65% 65
3 MINERS, JS , BARUA, N , KEHOE, PG , GILL, S , LOVE, S , (2011) A BETA-DEGRADING ENZYMES: POTENTIAL FOR TREATMENT OF ALZHEIMER DISEASE.JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. VOL. 70. ISSUE 11. P. 944-959 81 30% 82
4 NALIVAEVA, NN , BELYAEV, ND , KERRIDGE, C , TURNER, AJ , (2014) AMYLOID-CLEARING PROTEINS AND THEIR EPIGENETIC REGULATION AS A THERAPEUTIC TARGET IN ALZHEIMER'S DISEASE.FRONTIERS IN AGING NEUROSCIENCE. VOL. 6. ISSUE . P. - 60 37% 19
5 NALIVAEVA, NN , BECKETT, C , BELYAEV, ND , TURNER, AJ , (2012) ARE AMYLOID-DEGRADING ENZYMES VIABLE THERAPEUTIC TARGETS IN ALZHEIMER'S DISEASE?.JOURNAL OF NEUROCHEMISTRY. VOL. 120. ISSUE . P. 167 -185 64 32% 60
6 HAFEZ, D , HUANG, JY , HUYNH, AM , VALTIERRA, S , ROCKENSTEIN, E , BRUNO, AM , LU, B , DESGROSEILLERS, L , MASLIAH, E , MARR, RA , (2011) NEPRILYSIN-2 IS AN IMPORTANT BETA-AMYLOID DEGRADING ENZYME.AMERICAN JOURNAL OF PATHOLOGY. VOL. 178. ISSUE 1. P. 306-312 28 78% 22
7 D'ORLEANS-JUSTE, P , PLANTE, M , HONORE, JC , CARRIER, E , LABONTE, J , (2003) SYNTHESIS AND DEGRADATION OF ENDOTHELIN-1.CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. VOL. 81. ISSUE 6. P. 503-510 45 57% 47
8 ECKMAN, EA , REED, DK , ECKMAN, CB , (2001) DEGRADATION OF THE ALZHEIMER'S AMYLOID BETA PEPTIDE BY ENDOTHELIN-CONVERTING ENZYME.JOURNAL OF BIOLOGICAL CHEMISTRY. VOL. 276. ISSUE 27. P. 24540-24548 36 62% 211
9 TURNER, AJ , MURPHY, LJ , (1996) MOLECULAR PHARMACOLOGY OF ENDOTHELIN CONVERTING ENZYMES.BIOCHEMICAL PHARMACOLOGY. VOL. 51. ISSUE 2. P. 91-102 55 48% 186
10 HUTTENRAUCH, M , BACHES, S , GERTH, J , BAYER, TA , WEGGEN, S , WIRTHS, O , (2015) NEPRILYSIN DEFICIENCY ALTERS THE NEUROPATHOLOGICAL AND BEHAVIORAL PHENOTYPE IN THE 5XFAD MOUSE MODEL OF ALZHEIMER'S DISEASE.JOURNAL OF ALZHEIMERS DISEASE. VOL. 44. ISSUE 4. P. 1291 -1302 24 71% 5

Classes with closest relation at Level 1


Rank Class id link
1 5205 NEUTRAL ENDOPEPTIDASE//VASOPEPTIDASE INHIBITOR//OMAPATRILAT
2 463 ENDOTHELIN//ENDOTHELIN RECEPTORS//SARAFOTOXIN
3 496 ENDOTHELIN//ENDOTHELIN 1//ENDOTHELIN RECEPTORS
4 10613 ENDOTHELIN 1//ENDOTHELIN//BQ 123
5 9990 INSULIN DEGRADING ENZYME//INSULIN DEGRADATION//IDE
6 16384 MOL PATHOL ULTRASTRUCT//ENDOTHELIN AXIS//ZIBOTENTAN
7 32051 CD10//CD10 EXPRESSION//BIOPATHOLUMR 599
8 31261 WEIBEL PALADE BODIES//TOAD AORTA//SANQUIN AMC LANDSTEINER
9 20963 GLUTAMINYL CYCLASE//INTRANEURONAL A BETA//PYROGLUTAMATE
10 3379 ALZHEIMERS DISEASE//BAPINEUZUMAB//AMYLOID BETA

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