Class information for:
Level 1: INSULIN DEGRADING ENZYME//INSULIN DEGRADATION//IDE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
9990 1100 35.8 61%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
176 3       DIABETES CARE//ENDOCRINOLOGY & METABOLISM//TYPE 2 DIABETES 58057
1552 2             INSULIN RECEPTOR//INSULIN DEGRADING ENZYME//INOSITOL PHOSPHOGLYCAN 7396
9990 1                   INSULIN DEGRADING ENZYME//INSULIN DEGRADATION//IDE 1100

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 INSULIN DEGRADING ENZYME authKW 1153265 8% 48% 86
2 INSULIN DEGRADATION authKW 240199 1% 58% 15
3 IDE authKW 213148 2% 32% 24
4 INSULYSIN authKW 186586 1% 61% 11
5 NARDILYSIN authKW 149885 1% 60% 9
6 PITRILYSIN authKW 111031 0% 100% 4
7 INSULIN DEGRADING ENZYME GENE authKW 83274 0% 100% 3
8 INVERZINCIN authKW 83274 0% 100% 3
9 M16 FAMILY authKW 83274 0% 100% 3
10 INSULINASE authKW 62454 0% 75% 3

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Endocrinology & Metabolism 4280 25% 0% 271
2 Biochemistry & Molecular Biology 2858 43% 0% 477
3 Biophysics 747 10% 0% 114
4 Physiology 352 7% 0% 78
5 Cell Biology 315 11% 0% 116
6 CYTOLOGY & HISTOLOGY 83 0% 0% 5
7 Medicine, Research & Experimental 61 4% 0% 44
8 Geriatrics & Gerontology 45 1% 0% 15
9 Biochemical Research Methods 36 3% 0% 32
10 Neurosciences 26 6% 0% 62

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOMED CORDELIERS BIOL ODONTOL 55516 0% 100% 2
2 HTAL NINOS R GUTIERREZ 55516 0% 100% 2
3 MOL PATHOL UNITSAKYO KU 55516 0% 100% 2
4 NUCL RECEPTORS CARDIOVASC DIS DIABET U1011 55516 0% 100% 2
5 PROTE INFORMAT SERV IL 35685 0% 43% 3
6 U510 34448 1% 21% 6
7 149 BIOL SCI BLDG 27758 0% 100% 1
8 ANAESTHESIA PROGRAM 27758 0% 100% 1
9 BIOCHIM SCI TECH 27758 0% 100% 1
10 CARDES HLTH CARE 27758 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DIABETES 6688 5% 0% 54
2 ENDOCRINOLOGY 3202 5% 0% 54
3 ACTA PHYSIOLOGICA LATINOAMERICANA 2286 0% 3% 3
4 BIOCHEMICAL JOURNAL 1950 4% 0% 46
5 HORMONE AND METABOLIC RESEARCH 1905 2% 0% 21
6 AMERICAN JOURNAL OF PHYSIOLOGY 1654 4% 0% 39
7 ACTA PHYSIOLOGICA ET PHARMACOLOGICA LATINOAMERICANA 1649 0% 1% 4
8 JOURNAL OF BIOLOGICAL CHEMISTRY 1501 9% 0% 94
9 DIABETOLOGIA 1442 2% 0% 21
10 BIOCHIMICA ET BIOPHYSICA ACTA 1341 3% 0% 38

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 INSULIN DEGRADING ENZYME 1153265 8% 48% 86 Search INSULIN+DEGRADING+ENZYME Search INSULIN+DEGRADING+ENZYME
2 INSULIN DEGRADATION 240199 1% 58% 15 Search INSULIN+DEGRADATION Search INSULIN+DEGRADATION
3 IDE 213148 2% 32% 24 Search IDE Search IDE
4 INSULYSIN 186586 1% 61% 11 Search INSULYSIN Search INSULYSIN
5 NARDILYSIN 149885 1% 60% 9 Search NARDILYSIN Search NARDILYSIN
6 PITRILYSIN 111031 0% 100% 4 Search PITRILYSIN Search PITRILYSIN
7 INSULIN DEGRADING ENZYME GENE 83274 0% 100% 3 Search INSULIN+DEGRADING+ENZYME+GENE Search INSULIN+DEGRADING+ENZYME+GENE
8 INVERZINCIN 83274 0% 100% 3 Search INVERZINCIN Search INVERZINCIN
9 M16 FAMILY 83274 0% 100% 3 Search M16+FAMILY Search M16+FAMILY
10 INSULINASE 62454 0% 75% 3 Search INSULINASE Search INSULINASE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 DUCKWORTH, WC , BENNETT, RG , HAMEL, FG , (1998) INSULIN DEGRADATION: PROGRESS AND POTENTIAL.ENDOCRINE REVIEWS. VOL. 19. ISSUE 5. P. 608 -624 147 71% 394
2 FERNANDEZ-GAMBA, A , LEAL, MC , MORELLI, L , CASTANO, EM , (2009) INSULIN-DEGRADING ENZYME: STRUCTURE-FUNCTION RELATIONSHIP AND ITS POSSIBLE ROLES IN HEALTH AND DISEASE.CURRENT PHARMACEUTICAL DESIGN. VOL. 15. ISSUE 31. P. 3644-3655 73 69% 50
3 DURHAM, TB , TOTH, JL , KLIMKOWSKI, VJ , CAO, JXC , SIESKY, AM , ALEXANDER-CHACKO, J , WU, GY , DIXON, JT , MCGEE, JE , WANG, Y , ET AL (2015) DUAL EXOSITE-BINDING INHIBITORS OF INSULIN-DEGRADING ENZYME CHALLENGE ITS ROLE AS THE PRIMARY MEDIATOR OF INSULIN CLEARANCE IN VIVO.JOURNAL OF BIOLOGICAL CHEMISTRY. VOL. 290. ISSUE 33. P. 20044 -20059 40 98% 4
4 TANG, WJ , (2016) TARGETING INSULIN-DEGRADING ENZYME TO TREAT TYPE 2 DIABETES MELLITUS.TRENDS IN ENDOCRINOLOGY AND METABOLISM. VOL. 27. ISSUE 1. P. 24 -34 43 59% 5
5 DUCKWORTH, WC , (1988) INSULIN DEGRADATION - MECHANISMS, PRODUCTS, AND SIGNIFICANCE.ENDOCRINE REVIEWS. VOL. 9. ISSUE 3. P. 319-345 132 46% 250
6 PIVOVAROVA, O , HOHN, A , GRUNE, T , PFEIFFER, AFH , RUDOVICH, N , (2016) INSULIN-DEGRADING ENZYME: NEW THERAPEUTIC TARGET FOR DIABETES AND ALZHEIMER'S DISEASE?.ANNALS OF MEDICINE. VOL. 48. ISSUE 8. P. 614 -624 54 60% 0
7 HAQUE, R , NAZIR, A , (2014) INSULIN-DEGRADING ENZYME: A LINK BETWEEN ALZHEIMER'S AND TYPE 2 DIABETES MELLITUS.CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS. VOL. 13. ISSUE 2. P. 259 -264 37 76% 8
8 HULSE, RE , RALAT, LA , TANG, WJ , (2009) STRUCTURE, FUNCTION, AND REGULATION OF INSULIN-DEGRADING ENZYME.VITAMINS AND HORMONES INSULIN AND IGFS. VOL. 80. ISSUE . P. 635-648 37 88% 7
9 AUTHIER, F , POSNER, BI , BERGERON, JJM , (1996) INSULIN-DEGRADING ENZYME.CLINICAL AND INVESTIGATIVE MEDICINE-MEDECINE CLINIQUE ET EXPERIMENTALE. VOL. 19. ISSUE 3. P. 149-160 43 83% 116
10 TUNDO, GR , DI MUZIO, E , CIACCIO, C , SBARDELLA, D , DI PIERRO, D , POLTICELLI, F , COLETTA, M , MARINI, S , (2016) MULTIPLE ALLOSTERIC SITES ARE INVOLVED IN THE MODULATION OF INSULIN-DEGRADING-ENZYME ACTIVITY BY SOMATOSTATIN.FEBS JOURNAL. VOL. 283. ISSUE 20. P. 3755 -3770 31 76% 0

Classes with closest relation at Level 1


Rank Class id link
1 1594 INSULIN RECEPTOR//LEPRECHAUNISM//DONOHUE SYNDROME
2 16270 PLACENTAL INSULIN RECEPTORS//AARHUS KOMMUNE HOSP OBSTET GYNECOL//BLOOD GROUPING TISSUE TYPING
3 14477 ENDOTHELIN CONVERTING ENZYME//NEPRILYSIN//PHOSPHORAMIDON
4 17101 GLUCAGON RECEPTOR//GLUCAGON RECEPTOR ANTAGONIST//GLUCAGON ANTAGONIST
5 30687 KANGEN KARYU//DAN GUA FANG//ALDOSE REDUCTASE INHIBITOR ONO 2235
6 24093 CLIN MEDDISCIPLINA MED INTERNA//BRAIN INSULIN//BALANCO HIDRO SALINO NUCL MED CIRURGIA EXPT
7 7576 ASIALOGLYCOPROTEIN RECEPTOR//ASGPR//ASIALOGLYCOPROTEIN RECEPTOR ASGPR
8 29870 CHAIR INTERNAL MED DIABETOL//AURON MISHIEL THERAPY//CENTER PUBL HLTH GENOM
9 34723 CSE1L//PHOSPHO CSE1L//CELLULAR APOPTOSIS SUSCEPTIBILITY
10 10931 MONOMERIC INSULIN//INSULIN MUTANT//FAST ACTING INSULIN

Go to start page