Class information for:
Level 1: DIRECTED EVOLUTION//DNA SHUFFLING//RANDOM MUTAGENESIS

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
10945 1022 43.7 84%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
5 4 CHEMISTRY, ORGANIC//CHEMISTRY, INORGANIC & NUCLEAR//CHEMISTRY, MULTIDISCIPLINARY 1745167
239 3       LIPASE//JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC//BIOCATALYSIS 47598
2423 2             CATALYTIC ANTIBODIES//ABZYME//DIRECTED EVOLUTION 4132
10945 1                   DIRECTED EVOLUTION//DNA SHUFFLING//RANDOM MUTAGENESIS 1022

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DIRECTED EVOLUTION authKW 1547134 25% 21% 252
2 DNA SHUFFLING authKW 498609 5% 32% 52
3 RANDOM MUTAGENESIS authKW 216634 5% 15% 49
4 SATURATION MUTAGENESIS authKW 190389 3% 23% 28
5 EPPCR authKW 124484 0% 83% 5
6 MUTATIONAL ADDITIVITY authKW 106699 0% 71% 5
7 PROTEIN ENGINEERING authKW 105613 10% 4% 98
8 BIOTECHNOL ENZYME CATALYSIS address 101439 2% 14% 25
9 CHEM CHEM ENGN 21041 address 95603 0% 80% 4
10 CODON REDUNDANCY authKW 89629 0% 100% 3

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biotechnology & Applied Microbiology 5208 31% 0% 314
2 Biochemistry & Molecular Biology 3261 47% 0% 485
3 Biochemical Research Methods 2391 17% 0% 171
4 Mathematical & Computational Biology 316 4% 0% 36
5 Chemistry, Medicinal 230 5% 0% 53
6 Biophysics 227 6% 0% 66
7 Chemistry, Multidisciplinary 133 10% 0% 106
8 Biology 47 3% 0% 27
9 Microbiology 36 4% 0% 41
10 Genetics & Heredity 34 4% 0% 40

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOTECHNOL ENZYME CATALYSIS 101439 2% 14% 25
2 CHEM CHEM ENGN 21041 95603 0% 80% 4
3 FENSKE 112 79668 0% 67% 4
4 UNITE CHIM ORGANURA 2128 59753 0% 100% 2
5 WARTIK 414 49015 1% 21% 8
6 CHEM CHEM ENGN 210 41 43444 1% 18% 8
7 ABT MOL GEN PR ARAT MOL BIOL 29876 0% 100% 1
8 BIOACTIV CHEM 29876 0% 100% 1
9 BIOCATALYSIS PROT ENGN GRP 29876 0% 100% 1
10 BIOCHEM FUNDAMENTAL MOL EVOLUT 29876 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PROTEIN ENGINEERING DESIGN & SELECTION 27600 3% 3% 31
2 PROTEIN ENGINEERING 14350 3% 1% 33
3 CHEMBIOCHEM 9657 4% 1% 38
4 CURRENT OPINION IN CHEMICAL BIOLOGY 9121 2% 1% 24
5 CURRENT OPINION IN BIOTECHNOLOGY 6790 2% 1% 23
6 NATURE BIOTECHNOLOGY 4530 2% 1% 20
7 BIOMOLECULAR ENGINEERING 4356 1% 2% 7
8 ACS SYNTHETIC BIOLOGY 3417 1% 1% 8
9 BIOTECHNIQUES 3294 3% 0% 26
10 CHEMISTRY & BIOLOGY 3214 2% 1% 17

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 DIRECTED EVOLUTION 1547134 25% 21% 252 Search DIRECTED+EVOLUTION Search DIRECTED+EVOLUTION
2 DNA SHUFFLING 498609 5% 32% 52 Search DNA+SHUFFLING Search DNA+SHUFFLING
3 RANDOM MUTAGENESIS 216634 5% 15% 49 Search RANDOM+MUTAGENESIS Search RANDOM+MUTAGENESIS
4 SATURATION MUTAGENESIS 190389 3% 23% 28 Search SATURATION+MUTAGENESIS Search SATURATION+MUTAGENESIS
5 EPPCR 124484 0% 83% 5 Search EPPCR Search EPPCR
6 MUTATIONAL ADDITIVITY 106699 0% 71% 5 Search MUTATIONAL+ADDITIVITY Search MUTATIONAL+ADDITIVITY
7 PROTEIN ENGINEERING 105613 10% 4% 98 Search PROTEIN+ENGINEERING Search PROTEIN+ENGINEERING
8 CODON REDUNDANCY 89629 0% 100% 3 Search CODON+REDUNDANCY Search CODON+REDUNDANCY
9 ERROR PRONE PCR 87654 2% 15% 19 Search ERROR+PRONE+PCR Search ERROR+PRONE+PCR
10 INCREMENTAL TRUNCATION 82986 0% 56% 5 Search INCREMENTAL+TRUNCATION Search INCREMENTAL+TRUNCATION

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 CURRIN, A , SWAINSTON, N , DAY, PJ , KELL, DB , (2015) SYNTHETIC BIOLOGY FOR THE DIRECTED EVOLUTION OF PROTEIN BIOCATALYSTS: NAVIGATING SEQUENCE SPACE INTELLIGENTLY.CHEMICAL SOCIETY REVIEWS. VOL. 44. ISSUE 5. P. 1172 -1239 181 16% 42
2 REETZ, MT , (2011) LABORATORY EVOLUTION OF STEREOSELECTIVE ENZYMES: A PROLIFIC SOURCE OF CATALYSTS FOR ASYMMETRIC REACTIONS.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. VOL. 50. ISSUE 1. P. 138 -174 89 32% 128
3 KUMAR, A , SINGH, S , (2013) DIRECTED EVOLUTION: TAILORING BIOCATALYSTS FOR INDUSTRIAL APPLICATIONS.CRITICAL REVIEWS IN BIOTECHNOLOGY. VOL. 33. ISSUE 4. P. 365 -378 68 50% 17
4 REETZ, MT , KAHAKEAW, D , LOHMER, R , (2008) ADDRESSING THE NUMBERS PROBLEM IN DIRECTED EVOLUTION.CHEMBIOCHEM. VOL. 9. ISSUE 11. P. 1797-1804 54 56% 147
5 WONG, TS , ROCCATANO, D , SCHWANEBERG, U , (2007) STEERING DIRECTED PROTEIN EVOLUTION: STRATEGIES TO MANAGE COMBINATORIAL COMPLEXITY OF MUTANT LIBRARIES.ENVIRONMENTAL MICROBIOLOGY. VOL. 9. ISSUE 11. P. 2645-2659 59 65% 26
6 NEYLON, C , (2004) CHEMICAL AND BIOCHEMICAL STRATEGIES FOR THE RANDOMIZATION OF PROTEIN ENCODING DNA SEQUENCES: LIBRARY CONSTRUCTION METHODS FOR DIRECTED EVOLUTION.NUCLEIC ACIDS RESEARCH. VOL. 32. ISSUE 4. P. 1448 -1459 47 72% 135
7 RUFF, AJ , DENNIG, A , SCHWANEBERG, U , (2013) TO GET WHAT WE AIM FOR-PROGRESS IN DIVERSITY GENERATION METHODS.FEBS JOURNAL. VOL. 280. ISSUE 13. P. 2961 -2978 51 59% 11
8 REETZ, MT , (2013) BIOCATALYSIS IN ORGANIC CHEMISTRY AND BIOTECHNOLOGY: PAST, PRESENT, AND FUTURE.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. VOL. 135. ISSUE 34. P. 12480 -12496 57 32% 152
9 KILLE, S , ACEVEDO-ROCHA, CG , PARRA, LP , ZHANG, ZG , OPPERMAN, DJ , REETZ, MT , ACEVEDO, JP , (2013) REDUCING CODON REDUNDANCY AND SCREENING EFFORT OF COMBINATORIAL PROTEIN LIBRARIES CREATED BY SATURATION MUTAGENESIS.ACS SYNTHETIC BIOLOGY. VOL. 2. ISSUE 2. P. 83-92 40 68% 24
10 FENG, XJ , SANCHIS, J , REETZ, MT , RABITZ, H , (2012) ENHANCING THE EFFICIENCY OF DIRECTED EVOLUTION IN FOCUSED ENZYME LIBRARIES BY THE ADAPTIVE SUBSTITUENT REORDERING ALGORITHM.CHEMISTRY-A EUROPEAN JOURNAL. VOL. 18. ISSUE 18. P. 5646-5654 42 71% 11

Classes with closest relation at Level 1


Rank Class id link
1 24597 ACTIVITY FINGERPRINT//2D FLUORESEENCE SPECTROSCOPY//ADRENALIN TEST AND COPPER CALCEIN ASSAY FOR AMINO ACIDS
2 13291 COMPUTATIONAL PROTEIN DESIGN//PROTEIN DESIGN//DEAD END ELIMINATION
3 14625 RIBOSOME DISPLAY//MRNA DISPLAY//FOUR BASE CODON
4 15387 MEGAPRIMER//MULTIPLE SITE DIRECTED MUTAGENESIS//OVERLAP EXTENSION
5 18729 OMEGA TRANSAMINASE//CHIRAL AMINES//TRANSAMINASES
6 12643 PSYCHROPHILE//COLD ADAPTATION//THERMOPHILIC PROTEIN
7 25675 PROTEIN SWITCH//CIRCULAR PERMUTATION//BIOMED ST PAU IIB SANTPAU
8 19390 ARTIFICIAL METALLOENZYMES//BIOHYBRID CATALYSIS//CHEMOGENETIC OPTIMIZATION
9 11602 GLUTAMYL ENDOPEPTIDASE//SUBTILISIN//INTRAMOLECULAR CHAPERONE
10 19393 TRANSALDOLASE//ALDOLASE//2 DEOXY D RIBOSE 5 PHOSPHATE ALDOLASE

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