Class information for:
Level 1: S 2250 KAWAGISHI//TAUROMUSTINE//SARCNU

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
16078 674 24.5 38%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
142 3       DNA REPAIR//INTERNATIONAL JOURNAL OF RADIATION BIOLOGY//RADIATION RESEARCH 64602
2147 2             MGMT//O 6 METHYLGUANINE DNA METHYLTRANSFERASE//O 6 ALKYLGUANINE DNA ALKYLTRANSFERASE 5031
16078 1                   S 2250 KAWAGISHI//TAUROMUSTINE//SARCNU 674

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 S 2250 KAWAGISHI address 226517 1% 100% 5
2 TAUROMUSTINE authKW 221982 1% 70% 7
3 SARCNU authKW 188762 1% 83% 5
4 NITROSOUREA authKW 156598 3% 15% 23
5 ANTITUMOR DRUG SCREEN authKW 144969 1% 80% 4
6 L ORNITHINE DERIVATIVES authKW 135910 0% 100% 3
7 L LYSINE DERIVATIVES authKW 101931 0% 75% 3
8 CHLOROETHYLNITROSOCARBAMOYL AMINO ACIDS authKW 90607 0% 100% 2
9 N 3 SUBSTITUTED DERIVATIVES authKW 90607 0% 100% 2
10 NITROSOUREA DERIVATE authKW 90607 0% 100% 2

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Oncology 5047 45% 0% 303
2 Chemistry, Medicinal 2040 17% 0% 113
3 Pharmacology & Pharmacy 1893 32% 0% 216
4 Chemistry, Multidisciplinary 155 13% 0% 85
5 Chemistry, Organic 73 6% 0% 43
6 Toxicology 64 4% 0% 25
7 Chemistry, Analytical 37 5% 0% 32
8 Biochemical Research Methods 5 2% 0% 13
9 CYTOLOGY & HISTOLOGY 4 0% 0% 1
10 Biochemistry & Molecular Biology 4 7% 0% 49

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 S 2250 KAWAGISHI 226517 1% 100% 5
2 EORTC CLIN ONCOL UNIT SCREENING PHARMACOL GRP 45303 0% 100% 1
3 MED ONCOLMOLEC PHARMACOL 45303 0% 100% 1
4 NCIIST NAZL TUMORI 45303 0% 100% 1
5 UNITE MIXTE 176 45303 0% 100% 1
6 PHYSIOL PATHOPHYSIOL PHARMACOL 27177 0% 20% 3
7 BPMERU 22651 0% 50% 1
8 BREEDING AGR 22651 0% 50% 1
9 UNITE ONCOTHER IE PL 22651 0% 50% 1
10 THER EUT CANCEROL 11324 0% 25% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CANCER CHEMOTHERAPY AND PHARMACOLOGY 15411 7% 1% 50
2 ANTI-CANCER DRUG DESIGN 10381 2% 2% 12
3 CANCER TREATMENT REPORTS 8197 3% 1% 20
4 EUROPEAN JOURNAL OF CANCER & CLINICAL ONCOLOGY 6931 3% 1% 17
5 GANN 3871 1% 1% 8
6 JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 3378 3% 0% 19
7 ADVANCES IN PHARMACOLOGY AND CHEMOTHERAPY 2515 0% 6% 1
8 CANCER RESEARCH 2098 6% 0% 43
9 JOURNAL OF MEDICINAL CHEMISTRY 1861 4% 0% 30
10 BIOMEDICINE EXPRESS 1586 0% 2% 2

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 TAUROMUSTINE 221982 1% 70% 7 Search TAUROMUSTINE Search TAUROMUSTINE
2 SARCNU 188762 1% 83% 5 Search SARCNU Search SARCNU
3 NITROSOUREA 156598 3% 15% 23 Search NITROSOUREA Search NITROSOUREA
4 ANTITUMOR DRUG SCREEN 144969 1% 80% 4 Search ANTITUMOR+DRUG+SCREEN Search ANTITUMOR+DRUG+SCREEN
5 L ORNITHINE DERIVATIVES 135910 0% 100% 3 Search L+ORNITHINE+DERIVATIVES Search L+ORNITHINE+DERIVATIVES
6 L LYSINE DERIVATIVES 101931 0% 75% 3 Search L+LYSINE+DERIVATIVES Search L+LYSINE+DERIVATIVES
7 CHLOROETHYLNITROSOCARBAMOYL AMINO ACIDS 90607 0% 100% 2 Search CHLOROETHYLNITROSOCARBAMOYL+AMINO+ACIDS Search CHLOROETHYLNITROSOCARBAMOYL+AMINO+ACIDS
8 N 3 SUBSTITUTED DERIVATIVES 90607 0% 100% 2 Search N+3+SUBSTITUTED+DERIVATIVES Search N+3+SUBSTITUTED+DERIVATIVES
9 NITROSOUREA DERIVATE 90607 0% 100% 2 Search NITROSOUREA+DERIVATE Search NITROSOUREA+DERIVATE
10 FOTEMUSTINE 87096 2% 13% 15 Search FOTEMUSTINE Search FOTEMUSTINE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 GNEWUCH, CT , SOSNOVSKY, G , (1997) A CRITICAL APPRAISAL OF THE EVOLUTION OF N-NITROSOUREAS AS ANTICANCER DRUGS.CHEMICAL REVIEWS. VOL. 97. ISSUE 3. P. 829-1013 199 47% 122
2 MCCORMICK, JE , MCELHINNEY, RS , (1990) NITROSOUREAS FROM CHEMIST TO PHYSICIAN - CLASSIFICATION AND RECENT APPROACHES TO DRUG DESIGN.EUROPEAN JOURNAL OF CANCER. VOL. 26. ISSUE 3. P. 207-221 51 70% 23
3 JOHNSTON, TP , MONTGOMERY, JA , (1986) RELATIONSHIP OF STRUCTURE TO ANTICANCER ACTIVITY AND TOXICITY OF THE NITROSOUREAS IN ANIMAL SYSTEMS.CANCER TREATMENT REPORTS. VOL. 70. ISSUE 1. P. 13-30 35 85% 54
4 SUPKO, JG , PHILLIPS, LR , MALSPEIS, L , (1996) SPECIFIC HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC ASSAY WITH ULTRAVIOLET DETECTION FOR THE DETERMINATION OF 1-(2-CHLOROETHYL)-3-SARCOSINAMIDE-1-NITROSOUREA IN PLASMA.JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES. VOL. 677. ISSUE 2. P. 351-362 18 72% 6
5 CELLARIER, E , TERRET, C , LABARRE, P , OUABDESSELAM, R , CURE, H , MARCHENAY, C , MAURIZIS, JC , MADELMONT, JC , CHOLLET, P , ARMAND, JP , (2002) PHARMACOKINETIC STUDY OF CYSTEMUSTINE, ADMINISTERED ON A WEEKLY SCHEDULE IN CANCER PATIENTS.ANNALS OF ONCOLOGY. VOL. 13. ISSUE 5. P. 760-769 18 56% 2
6 BARTOSEK, I , CORADA, M , DALLARDA, S , LUCAS, C , DELOFFRE, P , GUAITANI, A , (1991) PHARMACOKINETIC PROFILE OF FOTEMUSTINE IN RAT PLASMA BY ELECTROCHEMICAL DETECTION.XENOBIOTICA. VOL. 21. ISSUE 2. P. 235-242 15 100% 2
7 SOSNOVSKY, G , PRAKASH, I , RAO, NUM , (1993) IN THE SEARCH FOR NEW ANTICANCER DRUGS .24. SYNTHESIS AND ANTICANCER ACTIVITY OF AMINO-ACIDS AND DIPEPTIDES CONTAINING THE 2-CHLOROETHYL-AMINOCARBONYL AND [N'-(2-CHLOROETHYL)-N'-NITROSO]-AMINOCARBONYL GROUPS.JOURNAL OF PHARMACEUTICAL SCIENCES. VOL. 82. ISSUE 1. P. 1-10 17 74% 8
8 SHARF, VG , (1989) BIOTRANSFORMATION OF ALKYLNITROSOUREA (A REVIEW).KHIMIKO-FARMATSEVTICHESKII ZHURNAL. VOL. 23. ISSUE 10. P. 1157-1172 30 50% 2
9 MCELHINNEY, RS , MCCORMICK, JE , BIBBY, MC , DOUBLE, JA , RADACIC, M , DUMONT, P , (1996) NUCLEOSIDE ANALOGS .14. THE SYNTHESIS AND ANTITUMOR ACTIVITY IN MICE OF MOLECULAR COMBINATIONS OF 5-FLUOROURACIL AND N-(2-CHLOROETHYL)-N-NITROSOUREA MOIETIES SEPARATED BY A THREE-CARBON CHAIN.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 39. ISSUE 7. P. 1403-1412 18 58% 7
10 GODENECHE, D , LABARRE, P , CUSSAC, C , MADELMONT, JC , DUPUY, JM , FONTANON, C , TISSERANT, A , CHOLLET, P , BAUDRY, JP , VEYRE, A , (1994) PHARMACOKINETICS OF 2 NEW 2-CHLOROETHYLNITROSOUREAS IN CANCER-PATIENTS SUBMITTED TO PHASE-II CLINICAL-TRIALS.DRUG INVESTIGATION. VOL. 7. ISSUE 5. P. 234-243 11 100% 0

Classes with closest relation at Level 1


Rank Class id link
1 18844 N NITROSATION//QUIM FIS EQI//N NITROSOAMINES
2 1097 MGMT//O 6 METHYLGUANINE DNA METHYLTRANSFERASE//O 6 ALKYLGUANINE DNA ALKYLTRANSFERASE
3 20094 MELPHALAN//CHLORAMBUCIL//PREDNIMUSTINE
4 12145 RMP 7//INTRACAROTID CHEMOTHERAPY//BLOOD TUMOR BARRIER
5 37139 CISPLATIN PHOSPHONIC ACIDS//COLONY STIMULATING FACTOR CSF//COLONY FORMING UNIT CFU
6 27087 HOMO AZA STEROIDAL ESTERS//STEROIDAL ESTERS//HOMO AZA STEROIDS
7 35981 ACID INDUCED INDOLE CYCLIZATION//22810 TAMAGAWA SETAGAYA KU//1 1 7 7 TETRAMETHOXY 4 HEPTANONE DERIVATIVE
8 31931 BAYERS JUNCTIONS//DNA MEMBRANE COMPLEXES//DNA MEMBRANE CONTACTS
9 26128 CLORETAZINE//VNP40101M//NEW ANTICANCER AGENT
10 31090 HIGH DENSITY SEEDING//IRF7 SIGNATURE//MACROMASS CULTURE

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