Class information for:
Level 1: CLORETAZINE//VNP40101M//NEW ANTICANCER AGENT

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
26128 262 27.1 48%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
142 3       DNA REPAIR//INTERNATIONAL JOURNAL OF RADIATION BIOLOGY//RADIATION RESEARCH 64602
2147 2             MGMT//O 6 METHYLGUANINE DNA METHYLTRANSFERASE//O 6 ALKYLGUANINE DNA ALKYLTRANSFERASE 5031
26128 1                   CLORETAZINE//VNP40101M//NEW ANTICANCER AGENT 262

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CLORETAZINE authKW 971221 4% 83% 10
2 VNP40101M authKW 932376 3% 100% 8
3 NEW ANTICANCER AGENT authKW 407907 3% 50% 7
4 SULFONYL HYDRAZONE authKW 381421 2% 55% 6
5 DIPHOSPHINE DISULFIDE authKW 372949 2% 80% 4
6 1 2 BISSULFONYLHYDRAZINES authKW 349641 1% 100% 3
7 ONRIGIN TM authKW 349641 1% 100% 3
8 SELECTIVE LIQUID SOLID EXTRACTION authKW 349641 1% 100% 3
9 SULFONYLHYDRAZINE PRODRUGS authKW 349641 1% 100% 3
10 BISSULFONYLHYDRAZINES authKW 233094 1% 100% 2

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Inorganic & Nuclear 902 21% 0% 56
2 Chemistry, Medicinal 520 14% 0% 36
3 Spectroscopy 361 11% 0% 28
4 Oncology 201 16% 0% 42
5 Chemistry, Organic 109 11% 0% 28
6 Pharmacology & Pharmacy 62 11% 0% 30
7 Biochemical Research Methods 46 5% 0% 14
8 Crystallography 36 4% 0% 10
9 Chemistry, Analytical 25 6% 0% 15
10 Chemistry, Multidisciplinary 23 9% 0% 24

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ANTICANC DRUG DEV CHEMOTHER Y 174817 1% 50% 3
2 USC INRA OENOL 1366 155395 1% 67% 2
3 BIOCHEM MOL BIOL INFECT DIS 116547 0% 100% 1
4 ECOL INGN TRAVAUX AGR BORDEUX 116547 0% 100% 1
5 BLOOD MARROW TRANSPLANT GRP 58272 0% 50% 1
6 COMMUNITY BERGAMA 58272 0% 50% 1
7 DESIGN SYNTH BIOACT SUBST L ESSB 38848 0% 33% 1
8 PHARMACOL DEV THER EUT PROGRAM 38848 0% 33% 1
9 EA OENOL 4577 33831 1% 10% 3
10 DEV THER EUT PROGRAM 27142 6% 1% 16

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 SYNTHESIS AND REACTIVITY IN INORGANIC METAL-ORGANIC AND NANO-METAL CHEMISTRY 3129 3% 0% 8
2 SYNTHESIS AND REACTIVITY IN INORGANIC AND METAL-ORGANIC CHEMISTRY 2761 3% 0% 8
3 ORGANIC MASS SPECTROMETRY 2734 3% 0% 7
4 NEOPLASMA 1834 3% 0% 7
5 TRANSITION METAL CHEMISTRY 1477 3% 0% 8
6 JOURNAL OF MOLECULAR STRUCTURE 1288 6% 0% 15
7 JOURNAL OF COORDINATION CHEMISTRY 1226 3% 0% 8
8 JOURNAL OF MEDICINAL CHEMISTRY 1205 6% 0% 15
9 MEDICINAL CHEMISTRY RESEARCH 910 2% 0% 5
10 AAPS PHARMSCI 664 0% 1% 1

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 CLORETAZINE 971221 4% 83% 10 Search CLORETAZINE Search CLORETAZINE
2 VNP40101M 932376 3% 100% 8 Search VNP40101M Search VNP40101M
3 NEW ANTICANCER AGENT 407907 3% 50% 7 Search NEW+ANTICANCER+AGENT Search NEW+ANTICANCER+AGENT
4 SULFONYL HYDRAZONE 381421 2% 55% 6 Search SULFONYL+HYDRAZONE Search SULFONYL+HYDRAZONE
5 DIPHOSPHINE DISULFIDE 372949 2% 80% 4 Search DIPHOSPHINE+DISULFIDE Search DIPHOSPHINE+DISULFIDE
6 1 2 BISSULFONYLHYDRAZINES 349641 1% 100% 3 Search 1+2+BISSULFONYLHYDRAZINES Search 1+2+BISSULFONYLHYDRAZINES
7 ONRIGIN TM 349641 1% 100% 3 Search ONRIGIN+TM Search ONRIGIN+TM
8 SELECTIVE LIQUID SOLID EXTRACTION 349641 1% 100% 3 Search SELECTIVE+LIQUID+SOLID+EXTRACTION Search SELECTIVE+LIQUID+SOLID+EXTRACTION
9 SULFONYLHYDRAZINE PRODRUGS 349641 1% 100% 3 Search SULFONYLHYDRAZINE+PRODRUGS Search SULFONYLHYDRAZINE+PRODRUGS
10 BISSULFONYLHYDRAZINES 233094 1% 100% 2 Search BISSULFONYLHYDRAZINES Search BISSULFONYLHYDRAZINES

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 SHYAM, K , PENKETH, PG , BAUMANN, RP , FINCH, RA , ZHU, R , ZHU, YL , SARTORELLI, AC , (2015) ANTITUMOR SULFONYLHYDRAZINES: DESIGN, STRUCTURE-ACTIVITY RELATIONSHIPS, RESISTANCE MECHANISMS, AND STRATEGIES FOR IMPROVING THERAPEUTIC UTILITY.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 58. ISSUE 9. P. 3639 -3671 46 35% 5
2 GUNDUZALP, AB , OZMEN, UO , CEVRIMLI, BS , MAMAS, S , CETE, S , (2014) SYNTHESIS, CHARACTERIZATION, ELECTROCHEMICAL BEHAVIOR, AND ANTIMICROBIAL ACTIVITIES OF AROMATIC/HETEROAROMATIC SULFONYLHYDRAZONE DERIVATIVES.MEDICINAL CHEMISTRY RESEARCH. VOL. 23. ISSUE 7. P. 3255 -3268 19 61% 3
3 SORBERA, LA , SERRADELL, N , (2006) VNP-40101M. DNA ALKYLATING AGENT, ONCOLYTIC..DRUGS OF THE FUTURE. VOL. 31. ISSUE 12. P. 1062-1068 15 94% 2
4 ZHU, R , BAUMANN, RP , PATRIDGE, E , PENKETH, PG , SHYAM, K , ISHIGURO, K , SARTORELLI, AC , (2013) CHLOROETHYLATING AND METHYLATING DUAL FUNCTION ANTINEOPLASTIC AGENTS DISPLAY SUPERIOR CYTOTOXICITY AGAINST REPAIR PROFICIENT TUMOR CELLS.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. VOL. 23. ISSUE 6. P. 1853 -1859 19 59% 2
5 PENKETH, PG , PATRIDGE, E , SHYAM, K , BAUMANN, RP , ZHU, R , ISHIGURO, K , SARTORELLI, AC , (2014) INFLUENCE OF GLUTATHIONE AND GLUTATHIONE S-TRANSFERASES ON DNA INTERSTRAND CROSS-LINK FORMATION BY 1,2-BIS(METHYLSULFONYL)-1-(2-CHLOROETHYL)HYDRAZINE, THE ACTIVE ANTICANCER MOIETY GENERATED BY LAROMUSTINE.CHEMICAL RESEARCH IN TOXICOLOGY. VOL. 27. ISSUE 8. P. 1440 -1449 20 51% 0
6 ASLAN, HG , OZCAN, S , KARACAN, N , (2012) THE ANTIBACTERIAL ACTIVITY OF SOME SULFONAMIDES AND SULFONYL HYDRAZONES, AND 2D-QSAR STUDY OF A SERIES OF SULFONYL HYDRAZONES.SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY. VOL. 98. ISSUE . P. 329 -336 16 64% 10
7 GILES, F , VEY, N , DEANGELO, D , SEITER, K , STOCK, W , STUART, R , BOSKOVIC, D , PIGNEUX, A , TALLMAN, M , BRANDWEIN, J , ET AL (2009) PHASE 3 RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLIND STUDY OF HIGH-DOSE CONTINUOUS INFUSION CYTARABINE ALONE OR WITH LAROMUSTINE (VNP40101M) IN PATIENTS WITH ACUTE MYELOID LEUKEMIA IN FIRST RELAPSE.BLOOD. VOL. 114. ISSUE 19. P. 4027-4033 15 68% 16
8 SCHILLER, GJ , O'BRIEN, SM , PIGNEUX, A , DEANGELO, DJ , VEY, N , KELL, J , SOLOMON, S , STUART, RK , KARSTEN, V , CAHILL, AL , ET AL (2010) SINGLE-AGENT LAROMUSTINE, A NOVEL ALKYLATING AGENT, HAS SIGNIFICANT ACTIVITY IN OLDER PATIENTS WITH PREVIOUSLY UNTREATED POOR-RISK ACUTE MYELOID LEUKEMIA.JOURNAL OF CLINICAL ONCOLOGY. VOL. 28. ISSUE 5. P. 815-821 21 45% 24
9 ROCKWELL, S , LIU, YF , SEOW, HA , ISHIGURO, K , BAUMANN, RP , PENKETH, PG , SHYAM, K , AKINTUJOYE, OM , GLAZER, PM , SARTORELLI, AC , (2012) PRECLINICAL EVALUATION OF LAROMUSTINE FOR USE IN COMBINATION WITH RADIATION THERAPY IN THE TREATMENT OF SOLID TUMORS.INTERNATIONAL JOURNAL OF RADIATION BIOLOGY. VOL. 88. ISSUE 3. P. 277 -285 15 63% 0
10 PENKETH, PG , SHYAM, K , ZHU, R , BAUMANN, RP , ISHIGURO, K , SARTORELLI, AC , (2014) INFLUENCE OF PHOSPHATE AND PHOSPHOESTERS ON THE DECOMPOSITION PATHWAY OF 1,2-BIS(METHYLSULFONYL)-1-(2-CHLOROETHYHYDRAZINE (90CE), THE ACTIVE ANTICANCER MOIETY GENERATED BY LAROMUSTINE, KS119, AND KS119W.CHEMICAL RESEARCH IN TOXICOLOGY. VOL. 27. ISSUE 5. P. 818 -833 17 52% 1

Classes with closest relation at Level 1


Rank Class id link
1 19617 SULFATHIAZOLE COMPLEXES//N SUBSTITUTED SULFONAMIDES//SULFONAMIDE LIGANDS
2 24238 SULFONYL CHLORIDES//4 CHLOROBENZENESULFONYL CHLORIDE//ENZYME INHIBITION ACTIVITY
3 33272 2 CHLOROGLYCIDIC ESTER//ALPHA CHLOROGLYCIDIC ESTER//1 ALKOXYCARBONLY 2 ALKOXY AZIRIDINES
4 1097 MGMT//O 6 METHYLGUANINE DNA METHYLTRANSFERASE//O 6 ALKYLGUANINE DNA ALKYLTRANSFERASE
5 14591 N ACYLHYDRAZONE//HYDRAZIDE HYDRAZONE//LASSBIO
6 24723 METHYL ISOCYANATE//BHOPAL GAS TRAGEDY//METHYL ISOCYANATE TOXICITY
7 32124 MERCURYII EDTA DEHYDROGENATION//C AMINOMETHYLATION//HGII INDUCED DEHYDROGENATION
8 16078 S 2250 KAWAGISHI//TAUROMUSTINE//SARCNU
9 31193 CHLOROSULFONATION//CHLOROSULFONATION OF N BENZYL 4 CHLOROBENZAMIDE//CRISSCROSS CYCLOADDUCTS
10 35995 1H PYRIDO3 2 1 K LPHENOTHIAZINES//1H PYRIDO3 2 1 K LPHENOXAZINES//BENZALDEHYDE INHIBITION

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