Class information for:
Level 1: PEGYLATION//MONOMETHOXYPOLYETHYLENE GLYCOL//PEGYLATED PROTEINS

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
7258 1389 35.4 71%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
12 4 POLYMER SCIENCE//MATERIALS SCIENCE, PAPER & WOOD//CHEMISTRY, PHYSICAL 1084170
582 3       AQUEOUS TWO PHASE SYSTEMS//SIMULATED MOVING BED//JOURNAL OF CHROMATOGRAPHY A 15824
2337 2             AQUEOUS TWO PHASE SYSTEMS//PEGYLATION//AQUEOUS BIPHASIC SYSTEMS 4423
7258 1                   PEGYLATION//MONOMETHOXYPOLYETHYLENE GLYCOL//PEGYLATED PROTEINS 1389

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PEGYLATION authKW 1288577 18% 23% 252
2 MONOMETHOXYPOLYETHYLENE GLYCOL authKW 264690 1% 71% 17
3 PEGYLATED PROTEINS authKW 219048 1% 59% 17
4 PROTEIN PEGYLATION authKW 140682 1% 80% 8
5 BRANCHED PEG authKW 119677 1% 78% 7
6 NONCOVALENT PEGYLATION authKW 109910 0% 100% 5
7 POLYETHYLENE GLYCOL authKW 94677 11% 3% 154
8 PEG PROTEIN authKW 87928 0% 100% 4
9 PEG PROTEIN CONJUGATES authKW 87928 0% 100% 4
10 BOLDERPATH INC address 79131 0% 60% 6

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemical Research Methods 3604 18% 0% 244
2 Pharmacology & Pharmacy 2118 24% 0% 339
3 Polymer Science 1392 13% 0% 179
4 Biochemistry & Molecular Biology 1316 28% 0% 394
5 Chemistry, Multidisciplinary 1276 22% 0% 301
6 Chemistry, Organic 1087 14% 0% 194
7 Biotechnology & Applied Microbiology 1084 13% 0% 181
8 Materials Science, Biomaterials 575 4% 0% 50
9 Chemistry, Analytical 509 10% 0% 133
10 Chemistry, Medicinal 488 6% 0% 87

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BOLDERPATH INC 79131 0% 60% 6
2 ENZYMOL PL 65946 0% 100% 3
3 PHARMA TECH OPERAT BIOTECHNOL 43964 0% 100% 2
4 NORMAL BETHUNE MED 28259 0% 43% 3
5 DRUG TARGETING 27141 1% 7% 19
6 BIOTECHNOL PHARMACEUT ENGN ZHEJIANG PRO 25117 0% 29% 4
7 ANALYT SCI SECT 21982 0% 100% 1
8 ANTIFIBROSIS BIOTHER Y HEILONGJIANG PROV 21982 0% 100% 1
9 ASBMRACPAC RHEUMATOL 21982 0% 100% 1
10 BIOCONJUGATES DEV SCALE UP 21982 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOCONJUGATE CHEMISTRY 58316 8% 2% 115
2 JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS 7137 1% 2% 17
3 ADVANCED DRUG DELIVERY REVIEWS 5955 2% 1% 27
4 JOURNAL OF CONTROLLED RELEASE 5927 3% 1% 45
5 BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY 1248 1% 1% 11
6 INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY 1178 1% 0% 12
7 JOURNAL OF PHARMACEUTICAL SCIENCES 1090 2% 0% 24
8 BIOTECHNOLOGY JOURNAL 1081 1% 1% 7
9 CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS 1071 0% 1% 4
10 BIOPHARM INTERNATIONAL 1041 0% 1% 5

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 PEGYLATION 1288577 18% 23% 252 Search PEGYLATION Search PEGYLATION
2 MONOMETHOXYPOLYETHYLENE GLYCOL 264690 1% 71% 17 Search MONOMETHOXYPOLYETHYLENE+GLYCOL Search MONOMETHOXYPOLYETHYLENE+GLYCOL
3 PEGYLATED PROTEINS 219048 1% 59% 17 Search PEGYLATED+PROTEINS Search PEGYLATED+PROTEINS
4 PROTEIN PEGYLATION 140682 1% 80% 8 Search PROTEIN+PEGYLATION Search PROTEIN+PEGYLATION
5 BRANCHED PEG 119677 1% 78% 7 Search BRANCHED+PEG Search BRANCHED+PEG
6 NONCOVALENT PEGYLATION 109910 0% 100% 5 Search NONCOVALENT+PEGYLATION Search NONCOVALENT+PEGYLATION
7 POLYETHYLENE GLYCOL 94677 11% 3% 154 Search POLYETHYLENE+GLYCOL Search POLYETHYLENE+GLYCOL
8 PEG PROTEIN 87928 0% 100% 4 Search PEG+PROTEIN Search PEG+PROTEIN
9 PEG PROTEIN CONJUGATES 87928 0% 100% 4 Search PEG+PROTEIN+CONJUGATES Search PEG+PROTEIN+CONJUGATES
10 GLYCOPEGYLATION 70341 0% 80% 4 Search GLYCOPEGYLATION Search GLYCOPEGYLATION

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 TURECEK, PL , BOSSARD, MJ , SCHOETENS, F , IVENS, IA , (2016) PEGYLATION OF BIOPHARMACEUTICALS: A REVIEW OF CHEMISTRY AND NONCLINICAL SAFETY INFORMATION OF APPROVED DRUGS.JOURNAL OF PHARMACEUTICAL SCIENCES. VOL. 105. ISSUE 2. P. 460 -475 70 71% 19
2 PAYNE, RW , MURPHY, BM , MANNING, MC , (2011) PRODUCT DEVELOPMENT ISSUES FOR PEGYLATED PROTEINS.PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY. VOL. 16. ISSUE 5. P. 423 -440 145 67% 23
3 GONZALEZ, M , VAILLARD, SE , (2013) EVOLUTION OF REACTIVE MPEG POLYMERS FOR THE CONJUGATION OF PEPTIDES AND PROTEINS.CURRENT ORGANIC CHEMISTRY. VOL. 17. ISSUE 9. P. 975-998 113 64% 2
4 PFISTER, D , MORBIDELLI, M , (2014) PROCESS FOR PROTEIN PEGYLATION.JOURNAL OF CONTROLLED RELEASE. VOL. 180. ISSUE . P. 134 -149 76 65% 33
5 JEVSEVAR, S , KUNSTELJ, M , POREKAR, VG , (2010) PEGYLATION OF THERAPEUTIC PROTEINS.BIOTECHNOLOGY JOURNAL. VOL. 5. ISSUE 1. P. 113-128 52 71% 262
6 ROBERTS, MJ , BENTLEY, MD , HARRIS, JM , (2002) CHEMISTRY FOR PEPTIDE AND PROTEIN PEGYLATION.ADVANCED DRUG DELIVERY REVIEWS. VOL. 54. ISSUE 4. P. 459 -476 37 86% 925
7 BAILON, P , WON, CY , (2009) PEG-MODIFIED BIOPHARMACEUTICALS.EXPERT OPINION ON DRUG DELIVERY. VOL. 6. ISSUE 1. P. 1-16 48 74% 171
8 VERONESE, FM , (2001) PEPTIDE AND PROTEIN PEGYLATION: A REVIEW OF PROBLEMS AND SOLUTIONS.BIOMATERIALS. VOL. 22. ISSUE 5. P. 405-417 43 80% 578
9 ROBERTS, MJ , BENTLEY, MD , HARRIS, JM , (2012) CHEMISTRY FOR PEPTIDE AND PROTEIN PEGYLATION.ADVANCED DRUG DELIVERY REVIEWS. VOL. 64. ISSUE . P. 116-127 37 86% 66
10 KODERA, Y , MATSUSHIMA, A , HIROTO, M , NISHIMURA, H , ISHII, A , UENO, T , INADA, Y , (1998) PEGYLATION OF PROTEINS AND BIOACTIVE SUBSTANCES FOR MEDICAL AND TECHNICAL APPLICATIONS.PROGRESS IN POLYMER SCIENCE. VOL. 23. ISSUE 7. P. 1233 -1271 102 53% 71

Classes with closest relation at Level 1


Rank Class id link
1 24561 PROTEIN POLYMER CONJUGATE//PROTEIN POLYMER HYBRIDS//CBSA 147
2 27341 ENZYME TECHNOL GRP//MODIFIED ENZYME//BIOTECHNOL STUDIES
3 8461 HPMA COPOLYMER//POLYMER THER EUT//HPMA
4 34751 3 ACYLLACTAMS//CYCLIC IMINES//2 ACYL LACTAMS
5 34366 RADIX OPHIOPOGONIS POLYSACCHARIDE//ENGN MODERN PREPARAT TECHNOL TCM//ENGN MODERN PREPARAT TECHNOL
6 26935 ROYAL FREE HOSP MED MOLEC CELL PATHOL//COUNTERCURRENT DISTRIBUTION//A TISELIUS
7 23511 URICASE//UNIT ANALYT PROBES PROT BIOTECHNOLEDUC MINIST//URATE OXIDASE
8 21790 N SUCCINYL CHITOSAN//DEXTRAN PRODRUGS//BIOPHARMACEUT DRUG METAB
9 8348 L ASPARAGINASE//ASPARAGINASE//PEG ASPARAGINASE
10 26291 IN VIVO ANTITUMOUR ACTIVITY//MOUSE LYMPHOID NEOPLASMA P 388//MOUSE MAMMARY CARCINOMA FM 3A

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