Class information for:
Level 1: BONE TARGETING//OSTEOTROPIC DRUG DELIVERY SYSTEM//ACIDIC OLIGOPEPTIDE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
26214 260 35.8 69%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
14 4 ORTHOPEDICS//DENTISTRY, ORAL SURGERY & MEDICINE//SPORT SCIENCES 808941
32 3       OSTEOPOROSIS//VITAMIN D//OSTEOPOROSIS INTERNATIONAL 107093
1401 2             BISPHOSPHONATES//ZOLEDRONIC ACID//BONE METASTASES 8069
26214 1                   BONE TARGETING//OSTEOTROPIC DRUG DELIVERY SYSTEM//ACIDIC OLIGOPEPTIDE 260

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BONE TARGETING authKW 2842093 17% 55% 44
2 OSTEOTROPIC DRUG DELIVERY SYSTEM authKW 822104 3% 100% 7
3 ACIDIC OLIGOPEPTIDE authKW 375818 2% 80% 4
4 MINERAL AFFINITY authKW 352330 1% 100% 3
5 ASP OLIGOPEPTIDES authKW 234887 1% 100% 2
6 DELIVERY TARGETING CONCEPT authKW 234887 1% 100% 2
7 FEED QUAL INSPECT address 234887 1% 100% 2
8 THERAPEUTIC AVAILABILITY authKW 234887 1% 100% 2
9 HYDROXYAPATITE AFFINITY authKW 176162 1% 50% 3
10 1 PHOSPHONYL 1 THIAZOLYLETHYLENES authKW 117443 0% 100% 1

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Materials Science, Biomaterials 591 8% 0% 21
2 Pharmacology & Pharmacy 528 28% 0% 72
3 Chemistry, Organic 348 18% 0% 46
4 Chemistry, Medicinal 306 11% 0% 28
5 Chemistry, Multidisciplinary 179 19% 0% 50
6 Engineering, Biomedical 114 6% 0% 15
7 Oncology 75 11% 0% 28
8 Radiology, Nuclear Medicine & Medical Imaging 73 8% 0% 20
9 Endocrinology & Metabolism 30 5% 0% 14
10 Medicine, Research & Experimental 22 5% 0% 12

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 FEED QUAL INSPECT 234887 1% 100% 2
2 BIOENGN RADIOBIOL 117443 0% 100% 1
3 BIOMED ENGN HLTH TECSHENZHEN ADV TEC 117443 0% 100% 1
4 BIOMOLECULES MAX MOUSSERON 117443 0% 100% 1
5 CHILDRENS HOSP BOSTON ANESTHESIOL CRIT C 117443 0% 100% 1
6 CNRS UM1 UM2ENSCMUMR 5247 117443 0% 100% 1
7 DRUG DELIVERY SYST EDUC MINIST 117443 0% 100% 1
8 FUNCT MAT MED DENT MED 117443 0% 100% 1
9 PREVENT ORAL HLTH 117443 0% 100% 1
10 TI RELEVANCE EXCELLENCE NEW DRUG DELIVER 93952 1% 40% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF CONTROLLED RELEASE 1899 4% 0% 11
2 JOURNAL OF DRUG TARGETING 1881 2% 0% 5
3 BIOCONJUGATE CHEMISTRY 1498 3% 0% 8
4 DRUG DELIVERY 1442 2% 0% 4
5 LETTERS IN ORGANIC CHEMISTRY 1074 2% 0% 4
6 MOLECULAR PHARMACEUTICS 925 2% 0% 5
7 MACROMOLECULAR BIOSCIENCE 925 2% 0% 4
8 NUKLEARMEDIZINER 792 0% 1% 1
9 BIOMATERIALS SCIENCE 775 1% 0% 2
10 INVESTIGATIONAL NEW DRUGS 730 2% 0% 4

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 BONE TARGETING 2842093 17% 55% 44 Search BONE+TARGETING Search BONE+TARGETING
2 OSTEOTROPIC DRUG DELIVERY SYSTEM 822104 3% 100% 7 Search OSTEOTROPIC+DRUG+DELIVERY+SYSTEM Search OSTEOTROPIC+DRUG+DELIVERY+SYSTEM
3 ACIDIC OLIGOPEPTIDE 375818 2% 80% 4 Search ACIDIC+OLIGOPEPTIDE Search ACIDIC+OLIGOPEPTIDE
4 MINERAL AFFINITY 352330 1% 100% 3 Search MINERAL+AFFINITY Search MINERAL+AFFINITY
5 ASP OLIGOPEPTIDES 234887 1% 100% 2 Search ASP+OLIGOPEPTIDES Search ASP+OLIGOPEPTIDES
6 DELIVERY TARGETING CONCEPT 234887 1% 100% 2 Search DELIVERY+TARGETING+CONCEPT Search DELIVERY+TARGETING+CONCEPT
7 THERAPEUTIC AVAILABILITY 234887 1% 100% 2 Search THERAPEUTIC+AVAILABILITY Search THERAPEUTIC+AVAILABILITY
8 HYDROXYAPATITE AFFINITY 176162 1% 50% 3 Search HYDROXYAPATITE+AFFINITY Search HYDROXYAPATITE+AFFINITY
9 1 PHOSPHONYL 1 THIAZOLYLETHYLENES 117443 0% 100% 1 Search 1+PHOSPHONYL+1+THIAZOLYLETHYLENES Search 1+PHOSPHONYL+1+THIAZOLYLETHYLENES
10 2 PHOSPHONO PYRIDINES 117443 0% 100% 1 Search 2+PHOSPHONO+PYRIDINES Search 2+PHOSPHONO+PYRIDINES

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 COLE, LE , VARGO-GOGOLA, T , ROEDER, RK , (2016) TARGETED DELIVERY TO BONE AND MINERAL DEPOSITS USING BISPHOSPHONATE LIGANDS.ADVANCED DRUG DELIVERY REVIEWS. VOL. 99. ISSUE . P. 12 -27 48 28% 3
2 ZHAO, Y , HE, DS , MA, LF , GUO, L , (2015) SYNTHESIS AND PRELIMINARY EVALUATION OF NOVEL BONE-TARGETING NSAIDS PRODRUGS BASED ON GLUTAMIC ACID OLIGOPEPTIDES.LETTERS IN DRUG DESIGN & DISCOVERY. VOL. 12. ISSUE 7. P. 585 -590 16 73% 0
3 OSSIPOV, DA , (2015) BISPHOSPHONATE-MODIFIED BIOMATERIALS FOR DRUG DELIVERY AND BONE TISSUE ENGINEERING.EXPERT OPINION ON DRUG DELIVERY. VOL. 12. ISSUE 9. P. 1443 -1458 27 39% 4
4 ULUDAG, H , (2002) BISPHOSPHONATES AS A FOUNDATION OF DRUG DELIVERY TO BONE.CURRENT PHARMACEUTICAL DESIGN. VOL. 8. ISSUE 21. P. 1929-1944 29 37% 75
5 OUYANG, L , HE, DS , ZHANG, J , HE, G , JIANG, B , WANG, Q , CHEN, ZJ , PAN, JZ , LI, YH , GUO, L , (2011) SELECTIVE BONE TARGETING 5-FLUOROURACIL PRODRUGS: SYNTHESIS AND PRELIMINARY BIOLOGICAL EVALUATION.BIOORGANIC & MEDICINAL CHEMISTRY. VOL. 19. ISSUE 12. P. 3750 -3756 15 56% 10
6 NEALE, JR , RICHTER, NB , MERTEN, KE , TAYLOR, KG , SINGH, S , WAITE, LC , EMERY, NK , SMITH, NB , CAI, J , PIERCE, WM , (2009) BONE SELECTIVE EFFECT OF AN ESTRADIOL CONJUGATE WITH A NOVEL TETRACYCLINE-DERIVED BONE-TARGETING AGENT.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. VOL. 19. ISSUE 3. P. 680-683 11 79% 14
7 HIRABAYASHI, H , FUJISAKI, J , (2003) BONE-SPECIFIC DRUG DELIVERY SYSTEMS - APPROACHES VIA CHEMICAL MODIFICATION OF BONE-SEEKING AGENTS.CLINICAL PHARMACOKINETICS. VOL. 42. ISSUE 15. P. 1319-1330 22 42% 65
8 IONESCU, C , RIZEA, SC , BARRAGAN-MONTERO, V , NEAMTU, J , (2013) SYNTHESIS AND CHARACTERIZATION OF A CARBOXYLIC ACID DERIVATIVE FOR LIPOSOMAL PREPARATIONS.FARMACIA. VOL. 61. ISSUE 4. P. 725-735 9 69% 0
9 YEWLE, JN , PULEO, DA , BACHAS, LG , (2013) BIFUNCTIONAL BISPHOSPHONATES FOR DELIVERING PTH (1-34) TO BONE MINERAL WITH ENHANCED BIOACTIVITY.BIOMATERIALS. VOL. 34. ISSUE 12. P. 3141-3149 17 35% 6
10 WANG, GL , MOSTAFA, NZ , INCANI, V , KUCHARSKI, C , ULUDAG, H , (2012) BISPHOSPHONATE-DECORATED LIPID NANOPARTICLES DESIGNED AS DRUG CARRIERS FOR BONE DISEASES.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A. VOL. 100A. ISSUE 3. P. 684 -693 13 41% 20

Classes with closest relation at Level 1


Rank Class id link
1 2746 BISPHOSPHONATES//ZOLEDRONIC ACID//ALENDRONATE
2 9580 BONE PAIN PALLIATION//STRONTIUM 89//PAIN PALLIATION
3 30691 LCAGC//ADSORPTION OF COLLAGEN//ADSORPTION OF GLYCINE
4 8461 HPMA COPOLYMER//POLYMER THER EUT//HPMA
5 30034 ALENDRONATE SODIUM//BISPHOSPHONATE DRUG//3 AMINO 1 HYDROXYPROPYLIDENE 1
6 1643 BONE METASTASES//SKELETAL RELATED EVENTS//BONE METASTASIS
7 19663 SIMVASTATIN//STATINS//FLUVASTATIN GELATIN COMPLEX
8 28561 DENTAL POLYMERS//PHOSPHONATED METHACRYLATE//EQUIPE GENIE PROC MEMBRANAI
9 31256 DIACEREIN//DIACERHEIN//DIACETYLRHEIN
10 15519 RGD PEPTIDE//RGD//NANOENGN CRNE

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