Class information for:
Level 1: CCR5//CCR5 ANTAGONIST//MARAVIROC

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
772 3088 46.8 90%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
7 4 INFECTIOUS DISEASES//MICROBIOLOGY//VIROLOGY 1353914
29 3       HIV//VIROLOGY//HIV 1 108954
10 2             AIDS RESEARCH AND HUMAN RETROVIRUSES//VIROLOGY//HIV 1 39664
772 1                   CCR5//CCR5 ANTAGONIST//MARAVIROC 3088

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CCR5 authKW 1800164 13% 44% 412
2 CCR5 ANTAGONIST authKW 674789 3% 74% 92
3 MARAVIROC authKW 559472 4% 48% 118
4 CORECEPTOR authKW 470919 4% 42% 113
5 VICRIVIROC authKW 227962 1% 82% 28
6 TROPISM authKW 222538 3% 24% 93
7 CHEMOKINE RECEPTOR authKW 196836 6% 11% 182
8 HIV TROPISM authKW 179752 1% 91% 20
9 CXCR4 authKW 176785 6% 10% 182
10 CCR5 DELTA 32 authKW 172718 1% 56% 31

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Virology 79365 39% 1% 1189
2 Infectious Diseases 24781 27% 0% 832
3 Immunology 13354 32% 0% 994
4 Microbiology 1569 11% 0% 330
5 Chemistry, Medicinal 1226 7% 0% 204
6 Medicine, Research & Experimental 534 6% 0% 187
7 Pharmacology & Pharmacy 513 10% 0% 311
8 Biochemistry & Molecular Biology 273 13% 0% 386
9 Genetics & Heredity 155 4% 0% 137
10 Cell Biology 154 6% 0% 178

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CLIN VIROIMMUNOL 55837 1% 18% 31
2 VIROL PREVENT MED 40423 0% 27% 15
3 PROGRAM MOL MED AIDS 39546 0% 100% 4
4 VET ADM AIDS HIV INFECT 1 33356 0% 38% 9
5 MED TOULOUSE PURPAN 32021 0% 36% 9
6 AIDS IMMUNOPATHOGENESIS UNIT 30622 1% 16% 20
7 UNIT HUMAN VIROL 30448 0% 21% 15
8 AARON DIAMOND AIDS 30405 1% 8% 40
9 HIV S 29660 0% 100% 3
10 ID DMPK 29660 0% 100% 3

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 AIDS RESEARCH AND HUMAN RETROVIRUSES 61800 6% 3% 183
2 JOURNAL OF VIROLOGY 31034 11% 1% 354
3 AIDS 20466 4% 2% 134
4 RETROVIROLOGY 11676 1% 3% 38
5 VIROLOGY 8417 4% 1% 127
6 JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES 8068 2% 1% 59
7 JOURNAL OF HUMAN VIROLOGY 6576 0% 8% 8
8 CURRENT OPINION IN HIV AND AIDS 5722 1% 3% 22
9 JOURNAL OF INFECTIOUS DISEASES 5356 3% 1% 99
10 CURRENT HIV RESEARCH 5276 1% 3% 21

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 CCR5 1800164 13% 44% 412 Search CCR5 Search CCR5
2 CCR5 ANTAGONIST 674789 3% 74% 92 Search CCR5+ANTAGONIST Search CCR5+ANTAGONIST
3 MARAVIROC 559472 4% 48% 118 Search MARAVIROC Search MARAVIROC
4 CORECEPTOR 470919 4% 42% 113 Search CORECEPTOR Search CORECEPTOR
5 VICRIVIROC 227962 1% 82% 28 Search VICRIVIROC Search VICRIVIROC
6 TROPISM 222538 3% 24% 93 Search TROPISM Search TROPISM
7 CHEMOKINE RECEPTOR 196836 6% 11% 182 Search CHEMOKINE+RECEPTOR Search CHEMOKINE+RECEPTOR
8 HIV TROPISM 179752 1% 91% 20 Search HIV+TROPISM Search HIV+TROPISM
9 CXCR4 176785 6% 10% 182 Search CXCR4 Search CXCR4
10 CCR5 DELTA 32 172718 1% 56% 31 Search CCR5+DELTA+32 Search CCR5+DELTA+32

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 BERGER, EA , MURPHY, PM , FARBER, JM , (1999) CHEMOKINE RECEPTORS AS HIV-1 CORECEPTORS: ROLES IN VIRAL ENTRY, TROPISM, AND DISEASE.ANNUAL REVIEW OF IMMUNOLOGY. VOL. 17. ISSUE . P. 657 -700 162 76% 1524
2 ROCHE, M , BORM, K , FLYNN, JK , LEWIN, SR , CHURCHILL, MJ , GORRY, PR , (2016) MOLECULAR GYMNASTICS: MECHANISMS OF HIV-1 RESISTANCE TO CCR5 ANTAGONISTS AND IMPACT ON VIRUS PHENOTYPES.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 16. ISSUE 10. P. 1091 -1106 139 87% 0
3 TIAN, Y , ZHANG, DJ , ZHAN, P , LIU, XY , (2014) MEDICINAL CHEMISTRY OF SMALL MOLECULE CCR5 ANTAGONISTS FOR BLOCKING HIV-1 ENTRY: A REVIEW OF STRUCTURAL EVOLUTION.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 14. ISSUE 13. P. 1515 -1538 113 93% 0
4 ARENZANA-SEISDEDOS, F , PARMENTIER, M , (2006) GENETICS OF RESISTANCE TO HIV INFECTION: ROLE OF CO-RECEPTORS AND CO-RECEPTOR LIGANDS.SEMINARS IN IMMUNOLOGY. VOL. 18. ISSUE 6. P. 387 -403 145 76% 70
5 SCHUITEMAKER, H , VAN 'T WOUT, AB , LUSSO, P , (2011) CLINICAL SIGNIFICANCE OF HIV-1 CORECEPTOR USAGE.JOURNAL OF TRANSLATIONAL MEDICINE. VOL. 9. ISSUE . P. - 114 71% 30
6 PANOS, G , WATSON, DC , (2015) EFFECT OF HIV-1 SUBTYPE AND TROPISM ON TREATMENT WITH CHEMOKINE CORECEPTOR ENTRY INHIBITORS; OVERVIEW OF VIRAL ENTRY INHIBITION.CRITICAL REVIEWS IN MICROBIOLOGY. VOL. 41. ISSUE 4. P. 473 -487 119 67% 1
7 CAVARELLI, M , SCARLATTI, G , (2009) PHENOTYPE VARIATION IN HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 TRANSMISSION AND DISEASE PROGRESSION.DISEASE MARKERS. VOL. 27. ISSUE 3-4. P. 121 -136 121 71% 6
8 BLANPAIN, C , LIBERT, F , VASSART, G , PARMENTIER, M , (2002) CCR5 AND HIV INFECTION.RECEPTORS & CHANNELS. VOL. 8. ISSUE 1. P. 19-31 143 65% 52
9 KIM, MB , GIESLER, KE , TAHIROVIC, YA , TRUAX, VM , LIOTTA, DC , WILSON, LJ , (2016) CCR5 RECEPTOR ANTAGONISTS IN PRECLINICAL TO PHASE II CLINICAL DEVELOPMENT FOR TREATMENT OF HIV.EXPERT OPINION ON INVESTIGATIONAL DRUGS. VOL. 25. ISSUE 12. P. 1377 -1392 90 73% 0
10 REICHE, EMV , BONAMETTI, AM , VOLTARELLI, JC , MORIMOTO, HK , WATANABE, MAE , (2007) GENETIC POLYMORPHISMS IN THE CHEMOKINE AND CHEMOKINE RECEPTORS: IMPACT ON CLINICAL COURSE AND THERAPY OF THE HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 INFECTION (HIV-1).CURRENT MEDICINAL CHEMISTRY. VOL. 14. ISSUE 12. P. 1325-1334 99 76% 36

Classes with closest relation at Level 1


Rank Class id link
1 20980 EXPOSED UNINFECTED//HESN//HIV EXPOSED SERONEGATIVE
2 10596 ENFUVIRTIDE//GP41//FUSION INHIBITOR
3 19733 CCR2 ANTAGONIST//CCR2//CCR1
4 18490 CHEMOKINE STRUCTURE//LYMPHOTACTIN//CYTOKINE RECEPTOR INTERACTIONS
5 758 IAVI NEUTRALIZING ANTIBODY//DUKE HUMAN VACCINE//HIV AIDS VACCINE IMMUNOL IMMUNOGEN DISCOVER
6 21102 ANTI CD3 CD28 COATED BEADS//CD8 CELL ANTIVIRAL ACTIVITY//CD8 CELL ANTIVIRAL RESPONSES
7 1121 AIDS RESEARCH AND HUMAN RETROVIRUSES//V3 LOOP//GP120
8 28117 UF SIDA//P PHENOTYPE//UP A 6033
9 1531 CXCR4//CXCL12//CXCR7
10 9126 NAIVE AND MEMORY CD4 T CELLS//SECC INMUNOPEDIAT//BIOSISTEMA 1

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