Class information for:
Level 1: CCR2 ANTAGONIST//CCR2//CCR1

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
19733 491 45.6 88%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
578 3       CHEMOKINES//CXCR4//MACROPHAGE MIGRATION INHIBITORY FACTOR 16225
546 2             CHEMOKINES//CXCR4//CHEMOKINE RECEPTOR 14674
19733 1                   CCR2 ANTAGONIST//CCR2//CCR1 491

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CCR2 ANTAGONIST authKW 1106295 5% 68% 26
2 CCR2 authKW 610336 12% 17% 57
3 CCR1 authKW 426405 5% 29% 24
4 CCR1 ANTAGONIST authKW 222101 1% 71% 5
5 AZD 4818 authKW 186567 1% 100% 3
6 EXPT STN E336 address 139924 1% 75% 3
7 CC CHEMOKINE RECEPTOR 1 ANTAGONIST authKW 124378 0% 100% 2
8 CP 481715 authKW 124378 0% 100% 2
9 CYCLOPENTABFURAN authKW 124378 0% 100% 2
10 DOCKING EVALUATION authKW 124378 0% 100% 2

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Rheumatology 5496 19% 0% 95
2 Chemistry, Medicinal 4291 28% 0% 137
3 Immunology 731 20% 0% 97
4 Chemistry, Organic 458 15% 0% 74
5 Pharmacology & Pharmacy 325 17% 0% 84
6 Medicine, Research & Experimental 43 5% 0% 23
7 Pathology 28 3% 0% 14
8 Cell Biology 10 4% 0% 22
9 Crystallography 9 2% 0% 9
10 Biochemical Research Methods 7 2% 0% 11

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 EXPT STN E336 139924 1% 75% 3
2 I SMALL 124378 0% 100% 2
3 MED CHEM P INFLAMMAT AUTOIMMUN INNOVAT 124378 0% 100% 2
4 PREPARAT SEPARAT TECH 124378 0% 100% 2
5 HIGH OUTPUT SYNTH 82917 0% 67% 2
6 CLIN IMMUNOL RHEUMATOL F4 218 79954 1% 43% 3
7 AIDS HIV1 INFECT 62189 0% 100% 1
8 BIOL PARIS SEINE IBPS 3631 62189 0% 100% 1
9 CAS FOOD SAFETY 62189 0% 100% 1
10 CECILE VOGT CLIN NEUROL 62189 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ARTHRITIS RESEARCH 12290 1% 3% 6
2 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 10106 13% 0% 64
3 EXPERT OPINION ON THERAPEUTIC PATENTS 8058 3% 1% 17
4 ARTHRITIS AND RHEUMATISM 3763 5% 0% 25
5 EXPERT OPINION ON INVESTIGATIONAL DRUGS 1408 1% 0% 7
6 ARTHRITIS RESEARCH & THERAPY 1207 2% 0% 8
7 ACS MEDICINAL CHEMISTRY LETTERS 1123 1% 0% 5
8 ANNUAL REPORTS IN MEDICINAL CHEMISTRY 1111 1% 0% 4
9 CURRENT TOPICS IN MEDICINAL CHEMISTRY 978 1% 0% 6
10 PHARMACOLOGICAL REVIEWS 794 1% 0% 3

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 CCR2 ANTAGONIST 1106295 5% 68% 26 Search CCR2+ANTAGONIST Search CCR2+ANTAGONIST
2 CCR2 610336 12% 17% 57 Search CCR2 Search CCR2
3 CCR1 426405 5% 29% 24 Search CCR1 Search CCR1
4 CCR1 ANTAGONIST 222101 1% 71% 5 Search CCR1+ANTAGONIST Search CCR1+ANTAGONIST
5 AZD 4818 186567 1% 100% 3 Search AZD+4818 Search AZD+4818
6 CC CHEMOKINE RECEPTOR 1 ANTAGONIST 124378 0% 100% 2 Search CC+CHEMOKINE+RECEPTOR+1+ANTAGONIST Search CC+CHEMOKINE+RECEPTOR+1+ANTAGONIST
7 CP 481715 124378 0% 100% 2 Search CP+481715 Search CP+481715
8 CYCLOPENTABFURAN 124378 0% 100% 2 Search CYCLOPENTABFURAN Search CYCLOPENTABFURAN
9 DOCKING EVALUATION 124378 0% 100% 2 Search DOCKING+EVALUATION Search DOCKING+EVALUATION
10 INCB3344 124378 0% 100% 2 Search INCB3344 Search INCB3344

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 CARTER, PH , (2013) PROGRESS IN THE DISCOVERY OF CC CHEMOKINE RECEPTOR 2 ANTAGONISTS, 2009-2012.EXPERT OPINION ON THERAPEUTIC PATENTS. VOL. 23. ISSUE 5. P. 549 -568 60 67% 8
2 SZEKANECZ, Z , KOCH, AE , (2016) SUCCESSES AND FAILURES OF CHEMOKINE-PATHWAY TARGETING IN RHEUMATOID ARTHRITIS.NATURE REVIEWS RHEUMATOLOGY. VOL. 12. ISSUE 1. P. 5 -13 49 46% 6
3 KOCH, AE , TAK, PP , SZEKANECZ, Z , (2011) CHEMOKINE AND CHEMOKINE RECEPTOR BLOCKADE IN ARTHRITIS, A PROTOTYPE OF IMMUNE-MEDIATED INFLAMMATORY DISEASES.NETHERLANDS JOURNAL OF MEDICINE. VOL. 69. ISSUE 9. P. 356 -366 67 37% 17
4 PEASE, JE , HORUK, R , (2009) CHEMOKINE RECEPTOR ANTAGONISTS: PART 1.EXPERT OPINION ON THERAPEUTIC PATENTS. VOL. 19. ISSUE 1. P. 39-58 50 42% 74
5 LIU, JQ , MERRITT, JR , (2010) CC CHEMOKINE RECEPTOR SMALL MOLECULE ANTAGONISTS IN THE TREATMENT OF RHEUMATOID ARTHRITIS AND OTHER DISEASES: A CURRENT VIEW.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 10. ISSUE 13. P. 1250-1267 45 51% 6
6 CAVALLARO, CL , BRICENO, S , CHEN, J , CVIJIC, ME , DAVIES, P , HYNES, J , LIU, RQ , MANDLEKAR, S , ROSE, AV , TEBBEN, AJ , ET AL (2012) DISCOVERY AND LEAD OPTIMIZATION OF A NOVEL SERIES OF CC CHEMOKINE RECEPTOR 1 (CCR1)-SELECTIVE PIPERIDINE ANTAGONISTS VIA PARALLEL SYNTHESIS.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 55. ISSUE 22. P. 9643 -9653 24 86% 3
7 ZHANG, PL , DAIRAGHI, DJ , JAEN, JC , POWERS, JP , (2013) RECENT ADVANCES IN THE DISCOVERY AND DEVELOPMENT OF CCR1 ANTAGONISTS.ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 48. VOL. 48. ISSUE . P. 133-147 29 63% 1
8 SOBHIA, ME , SINGH, R , KARE, P , CHAVAN, S , (2010) RATIONAL DESIGN OF CCR2 ANTAGONISTS: A SURVEY OF COMPUTATIONAL STUDIES.EXPERT OPINION ON DRUG DISCOVERY. VOL. 5. ISSUE 6. P. 543-557 36 51% 7
9 ZHANG, XQ , HUFNAGEL, H , HOU, CF , OPAS, E , MCKENNEY, S , CRYSLER, C , O'NEILL, J , JOHNSON, D , SUI, ZH , (2011) DESIGN, SYNTHESIS AND SAR OF INDAZOLE AND BENZOISOXAZOLE CONTAINING 4-AZETIDINYL-1-ARYL-CYCLOHEXANES AS CCR2 ANTAGONISTS.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. VOL. 21. ISSUE 20. P. 6042 -6048 25 71% 8
10 CARTER, PH , (2010) SPIROINDENES AND SPIROINDANES AS ANTAGONISTS OF CC CHEMOKINE RECEPTOR 2: WO 2009023754.EXPERT OPINION ON THERAPEUTIC PATENTS. VOL. 20. ISSUE 2. P. 283-289 24 77% 2

Classes with closest relation at Level 1


Rank Class id link
1 14960 CHEMOKINES//CHEMOKINE RECEPTOR//EXPT CLIN NEUROL
2 7432 BB 10010//CCL2//LEUKOTACTIN 1
3 18490 CHEMOKINE STRUCTURE//LYMPHOTACTIN//CYTOKINE RECEPTOR INTERACTIONS
4 15178 MONOCYTE CHEMOATTRACTANT PROTEIN 1//MCP 1//MCP 1 POLYMORPHISM
5 10205 CXCR3//CXCL10//CXCL9
6 15536 TARC//THYMUS AND ACTIVATION REGULATED CHEMOKINE//CCR4
7 21780 DARC//DUFFY BLOOD GROUP//DUFFY ANTIGEN
8 23275 SYNOVIAL BIOPSY//SYNOVIAL TISSUE//SYNOVIAL BIOMARKERS
9 16547 CCL20//CCR6//CCL21
10 7041 INTERLEUKIN 8//CXCR2 ANTAGONIST//CXCR2

Go to start page