Class information for:
Level 1: CHEMOKINE STRUCTURE//LYMPHOTACTIN//CYTOKINE RECEPTOR INTERACTIONS

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
18490 549 48.7 92%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
578 3       CHEMOKINES//CXCR4//MACROPHAGE MIGRATION INHIBITORY FACTOR 16225
546 2             CHEMOKINES//CXCR4//CHEMOKINE RECEPTOR 14674
18490 1                   CHEMOKINE STRUCTURE//LYMPHOTACTIN//CYTOKINE RECEPTOR INTERACTIONS 549

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CHEMOKINE STRUCTURE authKW 222475 1% 100% 4
2 LYMPHOTACTIN authKW 181873 2% 30% 11
3 CYTOKINE RECEPTOR INTERACTIONS authKW 111238 0% 100% 2
4 IL 8 FAMILY authKW 111238 0% 100% 2
5 MED CHEM MED PHARMACOL address 111238 0% 100% 2
6 XCR1 RECEPTOR authKW 111238 0% 100% 2
7 CHEMOKINES authKW 107744 25% 1% 138
8 HERITAGE MED 713 address 99313 1% 36% 5
9 4 HELICAL CYTOKINE authKW 55619 0% 100% 1
10 7TMR ACTIVATION authKW 55619 0% 100% 1

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 3679 66% 0% 364
2 Immunology 728 19% 0% 103
3 Biophysics 405 11% 0% 59
4 Cell Biology 371 15% 0% 82
5 Biochemical Research Methods 227 8% 0% 42
6 Hematology 53 4% 0% 21
7 Chemistry, Medicinal 19 3% 0% 14
8 Transplantation 9 1% 0% 7
9 Biotechnology & Applied Microbiology 5 3% 0% 16
10 Rheumatology 3 1% 0% 4

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MED CHEM MED PHARMACOL 111238 0% 100% 2
2 HERITAGE MED 713 99313 1% 36% 5
3 BIOINFORMAT OURCE KECK IL 55619 0% 100% 1
4 BIOL EVALUAT US FDAHFM 535 55619 0% 100% 1
5 CANADIAN BLOOD SERVUNIV HLTH NETWORK 55619 0% 100% 1
6 DIPARTIMENTO BIOCHM BIOFIS 55619 0% 100% 1
7 GLYCOONCOL GRP 55619 0% 100% 1
8 IBSLBM 55619 0% 100% 1
9 IMD3 55619 0% 100% 1
10 IMPULSZENTRUM GRAZ WEST 55619 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOCHEMISTRY 3111 10% 0% 55
2 JOURNAL OF BIOLOGICAL CHEMISTRY 2287 15% 0% 80
3 PROTEIN SCIENCE 1717 3% 0% 14
4 CYTOKINE 1507 2% 0% 11
5 PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS 1037 2% 0% 11
6 JOURNAL OF LEUKOCYTE BIOLOGY 950 2% 0% 11
7 GLYCOBIOLOGY 948 1% 0% 7
8 STRUCTURE 925 1% 0% 8
9 PROTEIN EXPRESSION AND PURIFICATION 756 1% 0% 8
10 OPEN BIOLOGY 522 0% 0% 2

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 CHEMOKINE STRUCTURE 222475 1% 100% 4 Search CHEMOKINE+STRUCTURE Search CHEMOKINE+STRUCTURE
2 LYMPHOTACTIN 181873 2% 30% 11 Search LYMPHOTACTIN Search LYMPHOTACTIN
3 CYTOKINE RECEPTOR INTERACTIONS 111238 0% 100% 2 Search CYTOKINE+RECEPTOR+INTERACTIONS Search CYTOKINE+RECEPTOR+INTERACTIONS
4 IL 8 FAMILY 111238 0% 100% 2 Search IL+8+FAMILY Search IL+8+FAMILY
5 XCR1 RECEPTOR 111238 0% 100% 2 Search XCR1+RECEPTOR Search XCR1+RECEPTOR
6 CHEMOKINES 107744 25% 1% 138 Search CHEMOKINES Search CHEMOKINES
7 4 HELICAL CYTOKINE 55619 0% 100% 1 Search 4+HELICAL+CYTOKINE Search 4+HELICAL+CYTOKINE
8 7TMR ACTIVATION 55619 0% 100% 1 Search 7TMR+ACTIVATION Search 7TMR+ACTIVATION
9 ALLOSTERIC PEPTIDES 55619 0% 100% 1 Search ALLOSTERIC+PEPTIDES Search ALLOSTERIC+PEPTIDES
10 ALPHA AND BETA CHEMOKINES 55619 0% 100% 1 Search ALPHA+AND+BETA+CHEMOKINES Search ALPHA+AND+BETA+CHEMOKINES

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 SALANGA, CL , HANDEL, TM , (2011) CHEMOKINE OLIGOMERIZATION AND INTERACTIONS WITH RECEPTORS AND GLYCOSAMINOGLYCANS: THE ROLE OF STRUCTURAL DYNAMICS IN FUNCTION.EXPERIMENTAL CELL RESEARCH. VOL. 317. ISSUE 5. P. 590 -601 55 64% 62
2 WANG, X , SHARP, JS , HANDEL, TM , PRESTEGARD, JH , (2013) CHEMOKINE OLIGOMERIZATION IN CELL SIGNALING AND MIGRATION.OLIGOMERIZATION IN HEALTH AND DISEASE. VOL. 117. ISSUE . P. 531-578 73 44% 10
3 THIELE, S , ROSENKILDE, MM , (2014) INTERACTION OF CHEMOKINES WITH THEIR RECEPTORS - FROM INITIAL CHEMOKINE BINDING TO RECEPTOR ACTIVATING STEPS.CURRENT MEDICINAL CHEMISTRY. VOL. 21. ISSUE 31. P. 3594 -3614 81 33% 13
4 RAVINDRAN, A , SAWANT, KV , SARMIENTO, J , NAVARRO, J , RAJARATHNAM, K , (2013) CHEMOKINE CXCL1 DIMER IS A POTENT AGONIST FOR THE CXCR2 RECEPTOR.JOURNAL OF BIOLOGICAL CHEMISTRY. VOL. 288. ISSUE 17. P. 12244-12252 37 77% 11
5 JANSMA, A , HANDEL, TM , HAMEL, DJ , (2009) HOMO- AND HETERO-OLIGOMERIZATION OF CHEMOKINES.METHODS IN ENZYMOLOGY, VOL 461: CHEMOKINES, PART B. VOL. 461. ISSUE . P. 31-50 42 78% 2
6 RAJAGOPALAN, L , RAJARATHNAM, K , (2006) STRUCTURAL BASIS OF CHEMOKINE RECEPTOR FUNCTION - A MODEL FOR BINDING AFFINITY AND LIGAND SELECTIVITY.BIOSCIENCE REPORTS. VOL. 26. ISSUE 5. P. 325 -339 56 57% 45
7 SALANGA, CL , DYER, DP , KISELAR, JG , GUPTA, S , CHANCE, MR , HANDEL, TM , (2014) MULTIPLE GLYCOSAMINOGLYCAN-BINDING EPITOPES OF MONOCYTE CHEMOATTRACTANT PROTEIN-3/CCL7 ENABLE IT TO FUNCTION AS A NON-OLIGOMERIZING CHEMOKINE.JOURNAL OF BIOLOGICAL CHEMISTRY. VOL. 289. ISSUE 21. P. 14896 -14912 37 66% 8
8 RAJARATHNAM, K , (2002) DESIGNING DECOYS FOR CHEMOKINE-CHEMOKINE RECEPTOR INTERACTION.CURRENT PHARMACEUTICAL DESIGN. VOL. 8. ISSUE 24. P. 2159-2169 52 66% 20
9 KUFAREVA, I , SALANGA, CL , HANDEL, TM , (2015) CHEMOKINE AND CHEMOKINE RECEPTOR STRUCTURE AND INTERACTIONS: IMPLICATIONS FOR THERAPEUTIC STRATEGIES.IMMUNOLOGY AND CELL BIOLOGY. VOL. 93. ISSUE 4. P. 372 -383 44 42% 21
10 DYER, DP , SALANGA, CL , VOLKMAN, BF , KAWAMURA, T , HANDEL, TM , (2016) THE DEPENDENCE OF CHEMOKINE-GLYCOSAMINOGLYCAN INTERACTIONS ON CHEMOKINE OLIGOMERIZATION.GLYCOBIOLOGY. VOL. 26. ISSUE 3. P. 312 -326 38 47% 5

Classes with closest relation at Level 1


Rank Class id link
1 21331 CXCL4//CTAP III//CXCL4L1
2 7041 INTERLEUKIN 8//CXCR2 ANTAGONIST//CXCR2
3 7432 BB 10010//CCL2//LEUKOTACTIN 1
4 26252 TYROSYLPROTEIN SULFOTRANSFERASE//TYROSINE SULFATION//PROTEIN SULFATION
5 21780 DARC//DUFFY BLOOD GROUP//DUFFY ANTIGEN
6 19733 CCR2 ANTAGONIST//CCR2//CCR1
7 35950 CCL18//CC CHEMOKINE LIGAND 18//NIR1
8 16547 CCL20//CCR6//CCL21
9 27372 US28//STEALTH VIRUS//ACE PIGMENTS
10 1531 CXCR4//CXCL12//CXCR7

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