Class information for:
Level 1: TYROSINASE INHIBITOR//MUSHROOM TYROSINASE//TYROSINASE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
7357 1377 31.0 69%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
633 3       TYROSINASE//MELANOGENESIS//PIGMENT CELL RESEARCH 12915
1583 2             TYROSINASE//MELANOGENESIS//PIGMENT CELL RESEARCH 7222
7357 1                   TYROSINASE INHIBITOR//MUSHROOM TYROSINASE//TYROSINASE 1377

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 TYROSINASE INHIBITOR authKW 1975366 10% 64% 140
2 MUSHROOM TYROSINASE authKW 1630360 7% 74% 100
3 TYROSINASE authKW 1547464 30% 17% 413
4 KOJIC ACID authKW 1029198 8% 45% 104
5 GENZ GRP INVEST ENZIMOL address 623629 2% 94% 30
6 DIPHENOLASE ACTIVITY authKW 447039 2% 81% 25
7 MONOPHENOLASE authKW 344981 2% 68% 23
8 MONOPHENOLASE ACTIVITY authKW 296458 1% 70% 19
9 BIOQUIM BIOL MOL A address 227191 5% 17% 62
10 TYROSINASE INHIBITION authKW 217495 2% 30% 33

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Medicinal 6198 20% 0% 279
2 Chemistry, Applied 2464 13% 0% 181
3 Biochemistry & Molecular Biology 2346 36% 0% 498
4 Food Science & Technology 2210 15% 0% 212
5 Biotechnology & Applied Microbiology 1454 15% 0% 205
6 Agriculture, Multidisciplinary 891 6% 0% 78
7 Chemistry, Organic 877 13% 0% 176
8 Biophysics 282 6% 0% 86
9 Pharmacology & Pharmacy 245 10% 0% 142
10 Chemistry, Multidisciplinary 228 11% 0% 155

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 GENZ GRP INVEST ENZIMOL 623629 2% 94% 30
2 BIOQUIM BIOL MOL A 227191 5% 17% 62
3 GRP INVEST ENZIMOL 211285 1% 53% 18
4 ESCUELA TECN SUPER ALBACETE 179605 1% 90% 9
5 GRP SYNTHET ORGAN CHEM 110868 0% 100% 5
6 QCBA GRP QUIM CARBOHIDRATOS BIOTECNOL ALIMENTOS 110868 0% 100% 5
7 GRP QUIM CARBOHIDRATOS BIOTECNOL ALIMENTOS 92388 0% 83% 5
8 GRP QUIM ORGAN SINTET 92388 0% 83% 5
9 QCBA GRP QUIM CARBOHIDRATOS TECNOL ALIMENTOS 88694 0% 100% 4
10 GRP INVEST ENZIMOLGENZ 79189 0% 71% 5

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 12376 2% 2% 33
2 JOURNAL OF FOOD BIOCHEMISTRY 5549 1% 1% 20
3 BIOORGANIC & MEDICINAL CHEMISTRY 5094 4% 0% 55
4 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 3635 5% 0% 65
5 JOURNAL OF COSMETIC SCIENCE 3392 1% 1% 11
6 JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 3380 5% 0% 73
7 PIGMENT CELL RESEARCH 2952 1% 1% 12
8 INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 1722 2% 0% 23
9 BULLETIN OF THE KOREAN CHEMICAL SOCIETY 1614 2% 0% 31
10 JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC 1075 1% 0% 13

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 TYROSINASE INHIBITOR 1975366 10% 64% 140 Search TYROSINASE+INHIBITOR Search TYROSINASE+INHIBITOR
2 MUSHROOM TYROSINASE 1630360 7% 74% 100 Search MUSHROOM+TYROSINASE Search MUSHROOM+TYROSINASE
3 TYROSINASE 1547464 30% 17% 413 Search TYROSINASE Search TYROSINASE
4 KOJIC ACID 1029198 8% 45% 104 Search KOJIC+ACID Search KOJIC+ACID
5 DIPHENOLASE ACTIVITY 447039 2% 81% 25 Search DIPHENOLASE+ACTIVITY Search DIPHENOLASE+ACTIVITY
6 MONOPHENOLASE 344981 2% 68% 23 Search MONOPHENOLASE Search MONOPHENOLASE
7 MONOPHENOLASE ACTIVITY 296458 1% 70% 19 Search MONOPHENOLASE+ACTIVITY Search MONOPHENOLASE+ACTIVITY
8 TYROSINASE INHIBITION 217495 2% 30% 33 Search TYROSINASE+INHIBITION Search TYROSINASE+INHIBITION
9 DIPHENOLASE 213591 1% 57% 17 Search DIPHENOLASE Search DIPHENOLASE
10 TYROSINASE INHIBITORY ACTIVITY 189162 2% 37% 23 Search TYROSINASE+INHIBITORY+ACTIVITY Search TYROSINASE+INHIBITORY+ACTIVITY

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 CHANG, TS , (2009) AN UPDATED REVIEW OF TYROSINASE INHIBITORS.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. VOL. 10. ISSUE 6. P. 2440 -2475 98 62% 326
2 LEE, SY , BAEK, N , NAM, TG , (2016) NATURAL, SEMISYNTHETIC AND SYNTHETIC TYROSINASE INHIBITORS.JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY. VOL. 31. ISSUE 1. P. 1 -13 78 60% 2
3 LOIZZO, MR , TUNDIS, R , MENICHINI, F , (2012) NATURAL AND SYNTHETIC TYROSINASE INHIBITORS AS ANTIBROWNING AGENTS: AN UPDATE.COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY. VOL. 11. ISSUE 4. P. 378-398 74 60% 60
4 YOU, A , ZHOU, J , SONG, SC , ZHU, GX , SONG, HC , YI, W , (2015) STRUCTURE-BASED MODIFICATION OF 3-/4-AMINOACETOPHENONES GIVING A PROFOUND CHANGE OF ACTIVITY ON TYROSINASE: FROM POTENT ACTIVATORS TO HIGHLY EFFICIENT INHIBITORS.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. VOL. 93. ISSUE . P. 255 -262 52 88% 4
5 SONG, HC , YI, W , YOU, A , ZHOU, J , SONG, SC , ZHU, GX , (2015) RATIONAL DESIGN, SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF 4-ALKOXY- AND 4-ACYLOXY-PHENYLETHYLENETHIOSEMICARBAZONE ANALOGUES AS NOVEL TYROSINASE INHIBITORS.BIOORGANIC & MEDICINAL CHEMISTRY. VOL. 23. ISSUE 5. P. 924 -931 47 90% 6
6 KHAN, MTH , (2012) NOVEL TYROSINASE INHIBITORS FROM NATURAL RESOURCES - THEIR COMPUTATIONAL STUDIES.CURRENT MEDICINAL CHEMISTRY. VOL. 19. ISSUE 14. P. 2262 -2272 68 62% 29
7 PILLAIYAR, T , MANICKAM, M , NAMASIVAYAM, V , (2017) SKIN WHITENING AGENTS: MEDICINAL CHEMISTRY PERSPECTIVE OF TYROSINASE INHIBITORS.JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY. VOL. 32. ISSUE 1. P. 403 -425 78 55% 0
8 MENDES, E , PERRY, MDJ , FRANCISCO, AP , (2014) DESIGN AND DISCOVERY OF MUSHROOM TYROSINASE INHIBITORS AND THEIR THERAPEUTIC APPLICATIONS.EXPERT OPINION ON DRUG DISCOVERY. VOL. 9. ISSUE 5. P. 533 -554 55 62% 14
9 FAIRHEAD, M , THONY-MEYER, L , (2012) BACTERIAL TYROSINASES: OLD ENZYMES WITH NEW RELEVANCE TO BIOTECHNOLOGY.NEW BIOTECHNOLOGY. VOL. 29. ISSUE 2. P. 183 -191 61 54% 27
10 CHEN, ZY , CAI, DC , MOU, DH , YAN, Q , SUN, YF , PAN, WL , WAN, YQ , SONG, HC , YI, W , (2014) DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF HYDROXY- OR METHOXY-SUBSTITUTED 5-BENZYLIDENE (THIO) BARBITURATES AS NOVEL TYROSINASE INHIBITORS.BIOORGANIC & MEDICINAL CHEMISTRY. VOL. 22. ISSUE 13. P. 3279 -3284 35 88% 11

Classes with closest relation at Level 1


Rank Class id link
1 6570 POLYPHENOL OXIDASE//ENZYMATIC BROWNING//BROWNING
2 25710 CYSTEAMINYLPHENOL//5 S GAD//ANTIMELANOMA
3 705 MELANOGENESIS//TYROSINASE//MELANOCYTE
4 20559 BETA N ACETYL D GLUCOSAMINIDASE//RAPID EQUILIBRIUM//UNSTABLE PRODUCT
5 25068 MELANOSIS//DEEPWATER PINK SHRIMP//4 HEXYLRESORCINOL
6 12157 TYROSINASE//TYROSINASE BIOSENSOR//PHENOL BIOSENSOR
7 5047 CATECHOLASE ACTIVITY//CATECHOL OXIDASE//CATECHOLASE
8 11512 HEMOCYANIN//RAPANA THOMASIANA//RESPIRATORY PROTEIN
9 16711 HYDROXYPYRIDINONE//3 HYDROXY 4 PYRIDINONES//3 HYDROXYPYRIDIN 4 ONE
10 37709 SEROFENDIC ACID//2E N 2 MORPHOLIN 4 YLETHYL CINNAMIDE//3 HYDROXY FURANE 25H ONE

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