Class information for:
Level 1: ADAM17//ADAM12//ADAM

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
6862 1434 47.4 94%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
111 3       THROMBOSIS RESEARCH//THROMBOSIS AND HAEMOSTASIS//HEMATOLOGY 71244
707 2             MATRIX METALLOPROTEINASE//METALLOPROTEINASES//MT1 MMP 12920
6862 1                   ADAM17//ADAM12//ADAM 1434

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ADAM17 authKW 1150503 8% 49% 111
2 ADAM12 authKW 908423 4% 67% 64
3 ADAM authKW 772829 7% 36% 101
4 ADAM10 authKW 451970 5% 33% 65
5 ADAM8 authKW 449787 2% 81% 26
6 ADAM15 authKW 443473 2% 77% 27
7 TACE authKW 314194 5% 20% 73
8 ARTHRIT TISSUE DEGENERAT PROGRAM address 287296 3% 36% 38
9 ADAM9 authKW 257615 2% 55% 22
10 ECTODOMAIN SHEDDING authKW 234587 3% 24% 46

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Cell Biology 2436 22% 0% 320
2 Biochemistry & Molecular Biology 2305 35% 0% 506
3 Oncology 1112 16% 0% 231
4 Developmental Biology 580 4% 0% 63
5 Immunology 294 9% 0% 124
6 Biophysics 193 5% 0% 76
7 Medicine, Research & Experimental 163 5% 0% 74
8 Genetics & Heredity 122 5% 0% 76
9 Pathology 88 3% 0% 42
10 Hematology 77 3% 0% 44

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ARTHRIT TISSUE DEGENERAT PROGRAM 287296 3% 36% 38
2 PHYSIOL SYST BIOL BIOPHYS 63876 0% 100% 3
3 ARTHRITIS TISSUE DEGENERAT PROGRAM 61583 1% 32% 9
4 PEDIAT MOL INTEGRAT PHYSIOL 47906 0% 75% 3
5 GROWTH REGULAT 43905 1% 15% 14
6 ANTIAGING ORTHOPED ORTHOPED SURG 42584 0% 100% 2
7 BIOPHYS SYST BIOL PROGRAM 42584 0% 100% 2
8 MOL TARGETED THER EUT 42584 0% 100% 2
9 ORTHOPED SURG ANTIAGING ORTHOPED 42584 0% 100% 2
10 PHYSIOL BIOPHYS SYST BIOL 32526 1% 17% 9

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF BIOLOGICAL CHEMISTRY 1973 9% 0% 123
2 PRENATAL DIAGNOSIS 1072 1% 0% 17
3 BIOCHEMICAL JOURNAL 607 2% 0% 30
4 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 596 3% 0% 46
5 CURRENT ALZHEIMER RESEARCH 353 0% 0% 4
6 JOURNAL OF LEUKOCYTE BIOLOGY 350 1% 0% 11
7 EXPERIMENTAL CELL RESEARCH 350 1% 0% 15
8 MOLECULAR BIOLOGY OF THE CELL 347 1% 0% 12
9 MOLECULAR MEDICINE REPORTS 332 1% 0% 10
10 AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 325 1% 0% 9

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 ADAM17 1150503 8% 49% 111 Search ADAM17 Search ADAM17
2 ADAM12 908423 4% 67% 64 Search ADAM12 Search ADAM12
3 ADAM 772829 7% 36% 101 Search ADAM Search ADAM
4 ADAM10 451970 5% 33% 65 Search ADAM10 Search ADAM10
5 ADAM8 449787 2% 81% 26 Search ADAM8 Search ADAM8
6 ADAM15 443473 2% 77% 27 Search ADAM15 Search ADAM15
7 TACE 314194 5% 20% 73 Search TACE Search TACE
8 ADAM9 257615 2% 55% 22 Search ADAM9 Search ADAM9
9 ECTODOMAIN SHEDDING 234587 3% 24% 46 Search ECTODOMAIN+SHEDDING Search ECTODOMAIN+SHEDDING
10 DISINTEGRIN 202862 4% 17% 56 Search DISINTEGRIN Search DISINTEGRIN

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 EDWARDS, DR , HANDSLEY, MM , PENNINGTON, CJ , (2008) THE ADAM METALLOPROTEINASES.MOLECULAR ASPECTS OF MEDICINE. VOL. 29. ISSUE 5. P. 258-289 181 61% 464
2 KLEIN, T , BISCHOFF, R , (2011) ACTIVE METALLOPROTEASES OF THE A DISINTEGRIN AND METALLOPROTEASE (ADAM) FAMILY: BIOLOGICAL FUNCTION AND STRUCTURE.JOURNAL OF PROTEOME RESEARCH. VOL. 10. ISSUE 1. P. 17 -33 174 73% 57
3 WEBER, S , SAFTIG, P , (2012) ECTODOMAIN SHEDDING AND ADAMS IN DEVELOPMENT.DEVELOPMENT. VOL. 139. ISSUE 20. P. 3693-3709 150 65% 56
4 DREYMUELLER, D , PRUESSMEYER, J , GROTH, E , LUDWIG, A , (2012) THE ROLE OF ADAM-MEDIATED SHEDDING IN VASCULAR BIOLOGY.EUROPEAN JOURNAL OF CELL BIOLOGY. VOL. 91. ISSUE 6-7. P. 472-485 140 68% 57
5 ZHANG, P , SHEN, MC , FERNANDEZ-PATRON, C , KASSIRI, Z , (2016) ADAMS FAMILY AND RELATIVES IN CARDIOVASCULAR PHYSIOLOGY AND PATHOLOGY.JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. VOL. 93. ISSUE . P. 186 -199 103 58% 6
6 DREYMUELLER, D , THEODOROU, K , DONNERS, M , LUDWIG, A , (2017) FINE TUNING CELL MIGRATION BY A DISINTEGRIN AND METALLOPROTEINASES.MEDIATORS OF INFLAMMATION. VOL. . ISSUE . P. - 139 56% 0
7 KVEIBORG, M , ALBRECHTSEN, R , COUCHMAN, JR , WEWER, UA , (2008) CELLULAR ROLES OF ADAM12 IN HEALTH AND DISEASE.INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. VOL. 40. ISSUE 9. P. 1685-1702 102 77% 80
8 REISS, K , SAFTIG, P , (2009) THE "A DISINTEGRIN AND METALLOPROTEASE" (ADAM) FAMILY OF SHEDDASES: PHYSIOLOGICAL AND CELLULAR FUNCTIONS.SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY. VOL. 20. ISSUE 2. P. 126-137 104 58% 164
9 SEALS, DF , COURTNEIDGE, SA , (2003) THE ADAMS FAMILY OF METALLOPROTEASES: MULTIDOMAIN PROTEINS WITH MULTIPLE FUNCTIONS.GENES & DEVELOPMENT. VOL. 17. ISSUE 1. P. 7-30 100 53% 645
10 ROSSELLO, A , NUTI, E , FERRINI, S , FABBI, M , (2016) TARGETING ADAM17 SHEDDASE ACTIVITY IN CANCER.CURRENT DRUG TARGETS. VOL. 17. ISSUE 16. P. 1908 -1927 117 57% 0

Classes with closest relation at Level 1


Rank Class id link
1 16963 CYSTEINE RICH SECRETORY PROTEIN//FERTILIN//IZUMO1
2 13756 HB EGF//AMPHIREGULIN//HEPARIN BINDING EPIDERMAL GROWTH FACTOR LIKE GROWTH FACTOR
3 14204 AGGRECANASE//ADAMTS//ADAMTS 4
4 6635 TACE INHIBITORS//MMP INHIBITORS//MATRIX METALLOPROTEINASE INHIBITOR
5 24952 PHARMACEUT PROTE//TNFR2//TNF DEFICIENCY
6 28577 CXCL16//CXCR6//SR PSOX
7 16892 GENISTEIN INHIBITION//TYROSINE KINASE//ANGIOTENSIN II
8 23378 CTRP3//SORSBY FUNDUS DYSTROPHY//SORSBYS FUNDUS DYSTROPHY
9 9024 MT1 MMP//CANC CELL//MEMBRANE TYPE 1 MATRIX METALLOPROTEINASE
10 9210 FE65//AMYLOID PRECURSOR PROTEIN//APP

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