Class information for:
Level 1: TACE INHIBITORS//MMP INHIBITORS//MATRIX METALLOPROTEINASE INHIBITOR

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
6635 1461 42.5 84%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
111 3       THROMBOSIS RESEARCH//THROMBOSIS AND HAEMOSTASIS//HEMATOLOGY 71244
707 2             MATRIX METALLOPROTEINASE//METALLOPROTEINASES//MT1 MMP 12920
6635 1                   TACE INHIBITORS//MMP INHIBITORS//MATRIX METALLOPROTEINASE INHIBITOR 1461

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 TACE INHIBITORS authKW 752899 3% 97% 37
2 MMP INHIBITORS authKW 329951 3% 34% 46
3 MATRIX METALLOPROTEINASE INHIBITOR authKW 268257 3% 26% 49
4 GELATINASE INHIBITOR authKW 194515 1% 85% 11
5 ZINC BINDING GROUP authKW 147290 1% 41% 17
6 MMP 2 INHIBITORS authKW 146290 0% 100% 7
7 HYDROXAMATE authKW 128235 3% 17% 37
8 MATRIX METALLOPROTEINASE authKW 107131 13% 3% 193
9 ABT BIOCHEM 1 address 99567 1% 53% 9
10 47J address 87076 0% 83% 5

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Medicinal 23528 38% 0% 549
2 Chemistry, Organic 3288 22% 0% 327
3 Biochemistry & Molecular Biology 2998 39% 0% 572
4 Pharmacology & Pharmacy 398 12% 0% 176
5 Biophysics 305 6% 0% 92
6 Biochemical Research Methods 298 6% 0% 83
7 Chemistry, Multidisciplinary 102 9% 0% 125
8 Cell Biology 69 6% 0% 83
9 Rheumatology 43 1% 0% 19
10 Chemistry, Analytical 24 3% 0% 49

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ABT BIOCHEM 1 99567 1% 53% 9
2 47J 87076 0% 83% 5
3 CANC AREA 75230 0% 60% 6
4 HOKKAIDO ABORAT 47020 0% 75% 3
5 INFLAMMAT ONCOL 47020 0% 75% 3
6 CHEM PHYS SCI INFLAMMATORY DIS 41797 0% 100% 2
7 MEDBIOMOL IFR53 41797 0% 100% 2
8 PHARMBIOMOL IFR53 41797 0% 100% 2
9 PROTEASES CANC PROGRAM 34824 0% 33% 5
10 AG PROT DYNAM 27864 0% 67% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 31214 13% 1% 194
2 JOURNAL OF MEDICINAL CHEMISTRY 10644 7% 0% 105
3 BIOORGANIC & MEDICINAL CHEMISTRY 6720 4% 1% 65
4 EXPERT OPINION ON THERAPEUTIC PATENTS 5832 2% 1% 25
5 CHEMMEDCHEM 2925 1% 1% 18
6 CHEMICAL BIOLOGY & DRUG DESIGN 2116 1% 1% 13
7 MATRIX BIOLOGY 1863 1% 1% 11
8 JOURNAL OF ENZYME INHIBITION 1458 0% 1% 5
9 JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 1281 1% 1% 11
10 ANALES DE LA REAL ACADEMIA NACIONAL DE FARMACIA 1248 0% 2% 3

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 TACE INHIBITORS 752899 3% 97% 37 Search TACE+INHIBITORS Search TACE+INHIBITORS
2 MMP INHIBITORS 329951 3% 34% 46 Search MMP+INHIBITORS Search MMP+INHIBITORS
3 MATRIX METALLOPROTEINASE INHIBITOR 268257 3% 26% 49 Search MATRIX+METALLOPROTEINASE+INHIBITOR Search MATRIX+METALLOPROTEINASE+INHIBITOR
4 GELATINASE INHIBITOR 194515 1% 85% 11 Search GELATINASE+INHIBITOR Search GELATINASE+INHIBITOR
5 ZINC BINDING GROUP 147290 1% 41% 17 Search ZINC+BINDING+GROUP Search ZINC+BINDING+GROUP
6 MMP 2 INHIBITORS 146290 0% 100% 7 Search MMP+2+INHIBITORS Search MMP+2+INHIBITORS
7 HYDROXAMATE 128235 3% 17% 37 Search HYDROXAMATE Search HYDROXAMATE
8 MATRIX METALLOPROTEINASE 107131 13% 3% 193 Search MATRIX+METALLOPROTEINASE Search MATRIX+METALLOPROTEINASE
9 MMP SELECTIVITY 83595 0% 100% 4 Search MMP+SELECTIVITY Search MMP+SELECTIVITY
10 CGS 27023A 62696 0% 100% 3 Search CGS+27023A Search CGS+27023A

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 RAO, BG , (2005) RECENT DEVELOPMENTS IN THE DESIGN OF SPECIFIC MATRIX METALLOPROTEINASE INHIBITORS AIDED BY STRUCTURAL AND COMPUTATIONAL STUDIES.CURRENT PHARMACEUTICAL DESIGN. VOL. 11. ISSUE 3. P. 295-322 113 87% 147
2 AURELI, L , GIOIA, M , CERBARA, I , MONACO, S , FASCIGLIONE, GF , MARINI, S , ASCENZI, P , TOPAI, A , COLETTA, M , (2008) STRUCTURAL BASES FOR SUBSTRATE AND INHIBITOR RECOGNITION BY MATRIX METALLOPROTEINASES.CURRENT MEDICINAL CHEMISTRY. VOL. 15. ISSUE 22. P. 2192-2222 134 68% 44
3 JACOBSEN, JA , JOURDEN, JLM , MILLER, MT , COHEN, SM , (2010) TO BIND ZINC OR NOT TO BIND ZINC: AN EXAMINATION OF INNOVATIVE APPROACHES TO IMPROVED METALLOPROTEINASE INHIBITION.BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. VOL. 1803. ISSUE 1. P. 72-94 100 72% 72
4 WHITTAKER, M , FLOYD, CD , BROWN, P , GEARING, AJH , (1999) DESIGN AND THERAPEUTIC APPLICATION OF MATRIX METALLOPROTEINASE INHIBITORS.CHEMICAL REVIEWS. VOL. 99. ISSUE 9. P. 2735 -2776 132 46% 707
5 SERRA, P , BRUCZKO, M , ZAPICO, JM , PUCKOWSKA, A , GARCIA, MA , MARTIN-SANTAMARIA, S , RAMOS, A , DE PASCUAL-TERESA, B , (2012) MMP-2 SELECTIVITY IN HYDROXAMATE-TYPE INHIBITORS.CURRENT MEDICINAL CHEMISTRY. VOL. 19. ISSUE 7. P. 1036-1064 91 71% 16
6 SKILES, JW , GONNELLA, NC , JENG, AY , (2004) THE DESIGN, STRUCTURE, AND CLINICAL UPDATE OF SMALL MOLECULAR WEIGHT MATRIX METALLOPROTEINASE INHIBITORS.CURRENT MEDICINAL CHEMISTRY. VOL. 11. ISSUE 22. P. 2911-2977 105 66% 134
7 LI, NG , SHI, ZH , TANG, YP , WANG, ZJ , SONG, SL , QIAN, LH , QIAN, DW , DUAN, JA , (2011) NEW HOPE FOR THE TREATMENT OF OSTEOARTHRITIS THROUGH SELECTIVE INHIBITION OF MMP-13.CURRENT MEDICINAL CHEMISTRY. VOL. 18. ISSUE 7. P. 977 -1001 89 67% 35
8 FABRE, B , RAMOS, A , DE PASCUAL-TERESA, B , (2014) TARGETING MATRIX METALLOPROTEINASES: EXPLORING THE DYNAMICS OF THE S1' POCKET IN THE DESIGN OF SELECTIVE, SMALL MOLECULE INHIBITORS.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 57. ISSUE 24. P. 10205 -10219 79 72% 5
9 LI, BK , CONG, Y , TIAN, ZY , XUE, Y , (2014) PREDICTING AND VIRTUALLY SCREENING THE SELECTIVE INHIBITORS OF MMP-13 OVER MMP-1 BY MOLECULAR DESCRIPTORS AND MACHINE LEARNING METHODS.ACTA PHYSICO-CHIMICA SINICA. VOL. 30. ISSUE 1. P. 171-+ 71 71% 1
10 LI, NG , SHI, ZH , TANG, YP , WEI-LI , LIAN-YIN , DUAN, JA , (2012) DISCOVERY OF SELECTIVE SMALL MOLECULAR TACE INHIBITORS FOR THE TREATMENT OF RHEUMATOID ARTHRITIS.CURRENT MEDICINAL CHEMISTRY. VOL. 19. ISSUE 18. P. 2924-2956 81 62% 9

Classes with closest relation at Level 1


Rank Class id link
1 9024 MT1 MMP//CANC CELL//MEMBRANE TYPE 1 MATRIX METALLOPROTEINASE
2 239 TIMP 1//MATRIX METALLOPROTEINASE//TIMP 2
3 24459 CLOSTRIDIUM HISTOLYTICUM//BACILLUS LICHENIFORMIS F114//FISHERIES PROD TECHNOL
4 6862 ADAM17//ADAM12//ADAM
5 23215 DEGRADOMICS//LIFE SCI 4 401//N TERMINOMICS
6 9057 MATRIX METALLOPROTEINASE//MMP 9//MATRIX METALLOPROTEINASE 9
7 14204 AGGRECANASE//ADAMTS//ADAMTS 4
8 17517 MODIFIED TETRACYCLINE//PAEDIAT PNEUMONOL ALLERGOL//DBMR
9 21098 CARBOXYPEPTIDASE A//GENERAL ACID GENERAL BASE//5 BROMOACETYLSALICYLIC ACID
10 22352 HYDROXAMIC ACID//FORMOHYDROXAMIC ACID//N HYDROXY PEPTIDES

Go to start page