Class information for:
Level 1: ROLIPRAM//PHOSPHODIESTERASE//PDE4

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
658 3202 42.3 79%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
343 3       NITRIC OXIDE//PEROXYNITRITE//NITRIC OXIDE SYNTHASE 36678
1338 2             PHOSPHODIESTERASE//ROLIPRAM//PDE4 8346
658 1                   ROLIPRAM//PHOSPHODIESTERASE//PDE4 3202

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ROLIPRAM authKW 1231951 7% 54% 239
2 PHOSPHODIESTERASE authKW 1019701 13% 25% 423
3 PDE4 authKW 831173 4% 69% 127
4 ROFLUMILAST authKW 578831 3% 71% 85
5 PDE4 INHIBITOR authKW 556587 3% 70% 83
6 PDE10A authKW 548429 2% 91% 63
7 PHOSPHODIESTERASE 4 authKW 343181 2% 55% 66
8 PHOSPHODIESTERASE 4 INHIBITOR authKW 252696 2% 49% 54
9 PHOSPHODIESTERASE INHIBITORS authKW 218874 5% 15% 150
10 PHOSPHODIESTERASE 10A authKW 193985 1% 88% 23

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Pharmacology & Pharmacy 9398 33% 0% 1047
2 Chemistry, Medicinal 7024 14% 0% 461
3 Biochemistry & Molecular Biology 2302 25% 0% 814
4 Respiratory System 846 5% 0% 154
5 Neurosciences 727 11% 0% 359
6 Chemistry, Organic 428 7% 0% 220
7 Cell Biology 357 7% 0% 239
8 Biophysics 228 4% 0% 134
9 Allergy 169 1% 0% 41
10 Immunology 93 5% 0% 146

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PHARMACOMETR PHARMACOKINET 68098 0% 71% 10
2 MOL PHARMACOL GRP 61031 2% 13% 50
3 PULM CRIT CARE MED BRANCH 39312 1% 13% 32
4 BEHAV MED PSYCHIAT 36998 1% 15% 26
5 SACKLER PULM PHARMACOL 29783 1% 12% 27
6 MATERNITE PORT ROYAL COCHIN 28603 0% 100% 3
7 TOXICOL PHARM CHEM 28603 0% 100% 3
8 SMALL MOL CHEM 24510 0% 43% 6
9 CNS DRUG DISCOVERY UNIT 20859 0% 24% 9
10 BIOCHEM INFLAMMAT 19069 0% 100% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ADVANCES IN SECOND MESSENGER AND PHOSPHOPROTEIN RESEARCH 16055 1% 8% 20
2 ADVANCES IN CYCLIC NUCLEOTIDE AND PROTEIN PHOSPHORYLATION RESEARCH 15747 0% 11% 15
3 CELLULAR SIGNALLING 10935 2% 2% 71
4 PULMONARY PHARMACOLOGY & THERAPEUTICS 9763 1% 3% 39
5 JOURNAL OF CYCLIC NUCLEOTIDE AND PROTEIN PHOSPHORYLATION RESEARCH 9675 0% 9% 11
6 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 9490 5% 1% 160
7 SECOND MESSENGERS AND PHOSPHOPROTEINS 7774 0% 12% 7
8 BRITISH JOURNAL OF PHARMACOLOGY 5893 3% 1% 106
9 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 4934 3% 1% 106
10 EXPERT OPINION ON THERAPEUTIC PATENTS 4333 1% 1% 32

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 ROLIPRAM 1231951 7% 54% 239 Search ROLIPRAM Search ROLIPRAM
2 PHOSPHODIESTERASE 1019701 13% 25% 423 Search PHOSPHODIESTERASE Search PHOSPHODIESTERASE
3 PDE4 831173 4% 69% 127 Search PDE4 Search PDE4
4 ROFLUMILAST 578831 3% 71% 85 Search ROFLUMILAST Search ROFLUMILAST
5 PDE4 INHIBITOR 556587 3% 70% 83 Search PDE4+INHIBITOR Search PDE4+INHIBITOR
6 PDE10A 548429 2% 91% 63 Search PDE10A Search PDE10A
7 PHOSPHODIESTERASE 4 343181 2% 55% 66 Search PHOSPHODIESTERASE+4 Search PHOSPHODIESTERASE+4
8 PHOSPHODIESTERASE 4 INHIBITOR 252696 2% 49% 54 Search PHOSPHODIESTERASE+4+INHIBITOR Search PHOSPHODIESTERASE+4+INHIBITOR
9 PHOSPHODIESTERASE INHIBITORS 218874 5% 15% 150 Search PHOSPHODIESTERASE+INHIBITORS Search PHOSPHODIESTERASE+INHIBITORS
10 PHOSPHODIESTERASE 10A 193985 1% 88% 23 Search PHOSPHODIESTERASE+10A Search PHOSPHODIESTERASE+10A

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 LUGNIER, C , (2006) CYCLIC NUCLEOTIDE PHOSPHODIESTERASE (PDE) SUPERFAMILY: A NEW TARGET FOR THE DEVELOPMENT OF SPECIFIC THERAPEUTIC AGENTS.PHARMACOLOGY & THERAPEUTICS. VOL. 109. ISSUE 3. P. 366-398 235 70% 437
2 BENDER, AT , BEAVO, JA , (2006) CYCLIC NUCLEOTIDE PHOSPHODIESTERASES: MOLECULAR REGULATION TO CLINICAL USE.PHARMACOLOGICAL REVIEWS. VOL. 58. ISSUE 3. P. 488-520 170 69% 805
3 FRANCIS, SH , BLOUNT, MA , CORBIN, JD , (2011) MAMMALIAN CYCLIC NUCLEOTIDE PHOSPHODIESTERASES: MOLECULAR MECHANISMS AND PHYSIOLOGICAL FUNCTIONS.PHYSIOLOGICAL REVIEWS. VOL. 91. ISSUE 2. P. 651 -690 222 56% 167
4 OMORI, K , KOTERA, J , (2007) OVERVIEW OF PDES AND THEIR REGULATION.CIRCULATION RESEARCH. VOL. 100. ISSUE 3. P. 309-327 138 82% 324
5 FRANCIS, SH , TURKO, IV , CORBIN, JD , (2001) CYCLIC NUCLEOTIDE PHOSPHODIESTERASES: RELATING STRUCTURE AND FUNCTION.PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, VOL 65. VOL. 65. ISSUE . P. 1 -52 195 68% 339
6 BURNOUF, C , PRUNIAUX, MP , (2002) RECENT ADVANCES IN PDE4 INHIBITORS AS IMMUNOREGULATORS AND ANTI-INFLAMMATORY DRUGS.CURRENT PHARMACEUTICAL DESIGN. VOL. 8. ISSUE 14. P. 1255 -1296 176 84% 98
7 TORPHY, TJ , (1998) PHOSPHODIESTERASE ISOZYMES - MOLECULAR TARGETS FOR NOVEL ANTIASTHMA AGENTS.AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. VOL. 157. ISSUE 2. P. 351 -370 168 70% 490
8 AZEVEDO, MF , FAUCZ, FR , BIMPAKI, E , HORVATH, A , LEVY, I , DE ALEXANDRE, RB , AHMAD, F , MANGANIELLO, V , STRATAKIS, CA , (2014) CLINICAL AND MOLECULAR GENETICS OF THE PHOSPHODIESTERASES (PDES).ENDOCRINE REVIEWS. VOL. 35. ISSUE 2. P. 195 -233 211 48% 20
9 SCHRODER, S , WENZEL, B , DEUTHER-CONRAD, W , SCHEUNEMANN, M , BRUST, P , (2016) NOVEL RADIOLIGANDS FOR CYCLIC NUCLEOTIDE PHOSPHODIESTERASE IMAGING WITH POSITRON EMISSION TOMOGRAPHY: AN UPDATE ON DEVELOPMENTS SINCE 2012.MOLECULES. VOL. 21. ISSUE 5. P. - 127 82% 0
10 MAURICE, DH , KE, HM , AHMAD, F , WANG, YS , CHUNG, J , MANGANIELLO, VC , (2014) ADVANCES IN TARGETING CYCLIC NUCLEOTIDE PHOSPHODIESTERASES.NATURE REVIEWS DRUG DISCOVERY. VOL. 13. ISSUE 4. P. 290 -314 116 48% 120

Classes with closest relation at Level 1


Rank Class id link
1 37587 IBUDILAST//CAS 50847 11 5//3 ISOBUTYRYL 2 ISOPROPYLPYRAZOLO1 5 APYRIDINE PHARMACOLOGY
2 24362 UROL TRANSPLANTAT UNIT//THEOPHYLLINE//2 6 DIOXO PURIN 7 YL DERIVATIVES
3 11840 AKAP//A KINASE ANCHORING PROTEIN//GRAVIN
4 19890 SILDENAFIL//PDE5//PDE 5 INHIBITION
5 16151 CGMP DEPENDENT PROTEIN KINASE//TYPE II CGMP DEPENDENT PROTEIN KINASE//CANC MOL BIOL SECT
6 24640 TBRPDEB1//TARGET REPURPOSING//ANTIINFECT SCREENING CORE
7 26520 DRUG INDUCED VASCULAR INJURY//ARTERIAL TOXICITY//MEDIAL NECROSIS
8 3744 ENOXIMONE//MILRINONE//AMRINONE
9 17435 CILOSTAZOL//CLIN PHARMACOKINET PHARMACODYNAM METAB//TRIPLE ANTIPLATELET THERAPY
10 33916 INTESTINAL NERVE OF REMAK//REMAKS NERVE//ADJUVANT INDUCED ARTHRITIC RAT

Go to start page