Class information for:
Level 1: IBUDILAST//CAS 50847 11 5//3 ISOBUTYRYL 2 ISOPROPYLPYRAZOLO1 5 APYRIDINE PHARMACOLOGY

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
37587 54 28.1 73%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
8 4 CARDIAC & CARDIOVASCULAR SYSTEM//PERIPHERAL VASCULAR DISEASES//CARDIOL 1276458
213 3       BURNS//CRITICAL CARE MEDICINE//SEPSIS 51408
3412 2             PENTOXIFYLLINE//PROPENTOFYLLINE//BUFLOMEDIL 1593
37587 1                   IBUDILAST//CAS 50847 11 5//3 ISOBUTYRYL 2 ISOPROPYLPYRAZOLO1 5 APYRIDINE PHARMACOLOGY 54

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 IBUDILAST authKW 7495307 48% 51% 26
2 CAS 50847 11 5 authKW 753967 4% 67% 2
3 3 ISOBUTYRYL 2 ISOPROPYLPYRAZOLO1 5 APYRIDINE PHARMACOLOGY authKW 565476 2% 100% 1
4 IBUDILAST PROSTANOID authKW 565476 2% 100% 1
5 KC 404 PHARMACOLOGY authKW 565476 2% 100% 1
6 KETASR authKW 565476 2% 100% 1
7 KYORIN SCOTLAND S address 565476 2% 100% 1
8 MIXED PHOSPHODIESTERASE PDE 3 4 INHIBITOR authKW 565476 2% 100% 1
9 NEURONEXT address 565476 2% 100% 1
10 221 MIYAMA address 282737 2% 50% 1

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Pharmacology & Pharmacy 569 59% 0% 32
2 Neurosciences 55 20% 0% 11
3 Clinical Neurology 53 15% 0% 8
4 Peripheral Vascular Diseases 15 6% 0% 3
5 Chemistry, Medicinal 14 6% 0% 3
6 Allergy 7 2% 0% 1
7 Pathology 6 4% 0% 2
8 Toxicology 5 4% 0% 2
9 Physiology 3 4% 0% 2
10 Medicine, Research & Experimental 2 4% 0% 2

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 KYORIN SCOTLAND S 565476 2% 100% 1
2 NEURONEXT 565476 2% 100% 1
3 221 MIYAMA 282737 2% 50% 1
4 CEREBRAL CIRCULAT 188491 2% 33% 1
5 NITR 80781 2% 14% 1
6 JOINT THER IES INTRACTABLE DIS 70683 2% 13% 1
7 BEHAV ADDICT MED 51405 2% 9% 1
8 KLIN SRBIJE 37697 2% 7% 1
9 MED NORTH 35340 2% 6% 1
10 BIOEQUIVALENCE BRIDGING STUDY 18847 2% 3% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MULTIPLE SCLEROSIS 9115 6% 1% 3
2 NEURON GLIA BIOLOGY 2928 2% 1% 1
3 GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM 1974 6% 0% 3
4 BALKAN MEDICAL JOURNAL 1364 2% 0% 1
5 CARDIOVASCULAR DRUG REVIEWS 1344 2% 0% 1
6 JOURNAL OF PAIN RESEARCH 1313 2% 0% 1
7 ARCHIVES INTERNATIONALES DE PHARMACODYNAMIE ET DE THERAPIE 1000 4% 0% 2
8 FOLIA NEUROPATHOLOGICA 668 2% 0% 1
9 GENERAL PHARMACOLOGY 661 2% 0% 1
10 FOLIA PHARMACOLOGICA JAPONICA 513 2% 0% 1

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 IBUDILAST 7495307 48% 51% 26 Search IBUDILAST Search IBUDILAST
2 CAS 50847 11 5 753967 4% 67% 2 Search CAS+50847+11+5 Search CAS+50847+11+5
3 3 ISOBUTYRYL 2 ISOPROPYLPYRAZOLO1 5 APYRIDINE PHARMACOLOGY 565476 2% 100% 1 Search 3+ISOBUTYRYL+2+ISOPROPYLPYRAZOLO1+5+APYRIDINE+PHARMACOLOGY Search 3+ISOBUTYRYL+2+ISOPROPYLPYRAZOLO1+5+APYRIDINE+PHARMACOLOGY
4 IBUDILAST PROSTANOID 565476 2% 100% 1 Search IBUDILAST+PROSTANOID Search IBUDILAST+PROSTANOID
5 KC 404 PHARMACOLOGY 565476 2% 100% 1 Search KC+404+PHARMACOLOGY Search KC+404+PHARMACOLOGY
6 KETASR 565476 2% 100% 1 Search KETASR Search KETASR
7 MIXED PHOSPHODIESTERASE PDE 3 4 INHIBITOR 565476 2% 100% 1 Search MIXED+PHOSPHODIESTERASE+PDE+3+4+INHIBITOR Search MIXED+PHOSPHODIESTERASE+PDE+3+4+INHIBITOR
8 NON NMDA GLUTAMATE RECEPTORS 251320 4% 22% 2 Search NON+NMDA+GLUTAMATE+RECEPTORS Search NON+NMDA+GLUTAMATE+RECEPTORS
9 CEREBRAL VASODILATOR 188491 2% 33% 1 Search CEREBRAL+VASODILATOR Search CEREBRAL+VASODILATOR
10 KC 404 188491 2% 33% 1 Search KC+404 Search KC+404

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 BARKHOF, F , HULST, HE , DRULOVIC, J , UITDEHAAG, BMJ , MATSUDA, K , LANDIN, R , (2010) IBUDILAST IN RELAPSING-REMITTING MULTIPLE SCLEROSIS A NEUROPROTECTANT?.NEUROLOGY. VOL. 74. ISSUE 13. P. 1033 -1040 10 56% 57
2 LEE, JY , CHO, E , KO, YE , KIM, I , LEE, KJ , KWON, SU , KANG, DW , KIM, JS , (2012) IBUDILAST, A PHOSPHODIESTERASE INHIBITOR WITH ANTI-INFLAMMATORY ACTIVITY, PROTECTS AGAINST ISCHEMIC BRAIN INJURY IN RATS.BRAIN RESEARCH. VOL. 1431. ISSUE . P. 97-106 14 42% 7
3 GIBSON, LCD , HASTINGS, SF , MCPHEE, I , CLAYTON, RA , DARROCH, CE , MACKENZIE, A , MACKENZIE, FL , NAGASAWA, M , STEVENS, PA , MACKENZIE, SJ , (2006) THE INHIBITORY PROFILE OF IBUDILAST AGAINST THE HUMAN PHOSPHODIESTERASE ENZYME FAMILY.EUROPEAN JOURNAL OF PHARMACOLOGY. VOL. 538. ISSUE 1-3. P. 39-42 12 44% 55
4 YOON, H , CHO, HY , LEE, YB , (2010) DETERMINATION OF IBUDILAST IN HUMAN SERUM BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY FOR PHARMACOKINETIC STUDY.BIOMEDICAL CHROMATOGRAPHY. VOL. 24. ISSUE 3. P. 324-328 5 83% 1
5 GOODMAN, AD , GYANG, T , SMITH, AD , (2016) IBUDILAST FOR THE TREATMENT OF MULTIPLE SCLEROSIS.EXPERT OPINION ON INVESTIGATIONAL DRUGS. VOL. 25. ISSUE 10. P. 1231 -1237 13 26% 0
6 WANG, H , MEI, ZL , ZHONG, KL , HU, M , LONG, Y , MIAO, MX , LI, N , YAN, TH , HONG, H , (2014) PRETREATMENT WITH ANTIASTHMATIC DRUG IBUDILAST AMELIORATES A BETA(1-42)-INDUCED MEMORY IMPAIRMENT AND NEUROTOXICITY IN MICE.PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR. VOL. 124. ISSUE . P. 373 -379 13 27% 1
7 LEDEBOER, A , LIU, TY , SHUMILLA, JA , MAHONEY, JH , VIJAY, S , GROSS, MI , VARGAS, JA , SULTZBAUGH, L , CLAYPOOL, MD , SANFTNER, LM , ET AL (2006) THE GLIAL MODULATORY DRUG AV(411) ATTENUATES MECHANICAL ALLODYNIA IN RAT MODELS OF NEUROPATHIC PAIN.NEURON GLIA BIOLOGY. VOL. 2. ISSUE . P. 279 -291 15 25% 11
8 HOSHINO, T , IKEDA, T , (2002) INHIBITORY EFFECT OF IBUDILAST ON URINARY ALBUMIN EXCRETION IN TYPE 2 DIABETES MELLITUS WITH MICROALBUMINURIA.NEPHRON. VOL. 90. ISSUE 2. P. 154 -157 7 54% 4
9 KANEDA, T , KONNO, Y , URAKAWA, N , NAKAJYO, S , SHIMIZU, K , (2007) IBUDILAST-INDUCED DECREASES IN CYTOSOLIC CA2+ LEVEL AND CONTRACTION IN RAT AORTA.JOURNAL OF PHARMACOLOGICAL SCIENCES. VOL. 104. ISSUE 4. P. 311-318 9 36% 1
10 KISHI, Y , OHTA, S , KASUYA, N , SAKITA, S , ASHIKAGA, T , ISOBE, M , (2001) IBUDILAST: A NON-SELECTIVE PDE INHIBITOR WITH MULTIPLE ACTIONS ON BLOOD CELLS AND THE VASCULAR WALL.CARDIOVASCULAR DRUG REVIEWS. VOL. 19. ISSUE 3. P. 215 -225 10 34% 39

Classes with closest relation at Level 1


Rank Class id link
1 31754 PROPENTOFYLLINE//HYDROXYPROPENTOFYLLINE//MEDULLARY VISCERAL ZONE
2 32892 BIFEMELANE HYDROCHLORIDE//BIFEMELANE//INDELOXAZINE HYDROCHLORIDE
3 33820 HUMAN URINARY KALLIDINOGENASE SK 827//1 5 BRADYKININ//353 TRIIODOTHYRONINE CLINICAL STUDIES RESPONSE TO GLUCOSE INGESTION
4 34223 BOVINE BRONCHI//8 BRCGMP 8 BROMOGUANOSINE 3 5 CYCLIC MONOPHOSPHATE//ACROLEIN UPTAKE
5 658 ROLIPRAM//PHOSPHODIESTERASE//PDE4
6 34415 SUPLATAST TOSILATE//CX 659S//TH2 TYPE REACTION
7 37709 SEROFENDIC ACID//2E N 2 MORPHOLIN 4 YLETHYL CINNAMIDE//3 HYDROXY FURANE 25H ONE
8 33591 CARDIOSPERMUM HALICACABUM//CARDIOSPERMUM HALICACABUM L//BIOKINET INTER PROBLEM
9 14911 CEREBRAL CIRCULATION//PIAL ARTERIOLES//PERINATAL BIOL
10 1457 NEUROPATHIC PAIN//HYPERALGESIA//CHRONIC CONSTRICTION INJURY

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