Class information for:
Level 3: NITRIC OXIDE//PEROXYNITRITE//NITRIC OXIDE SYNTHASE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
343 36678 41.0 77%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
343 3       NITRIC OXIDE//PEROXYNITRITE//NITRIC OXIDE SYNTHASE 36678
295 2             NITRIC OXIDE//PEROXYNITRITE//NITRIC OXIDE-BIOLOGY AND CHEMISTRY 18821
1338 2             PHOSPHODIESTERASE//ROLIPRAM//PDE4 8346
2535 2             NADPH DIAPHORASE//NITRIC OXIDE//NITRIC OXIDE SYNTHASE 3763
2821 2             NITRATE TOLERANCE//NITROGLYCERIN//ORGANIC NITRATES 3020
3531 2             INCOMPATIBILITIES//AMERICAN JOURNAL OF HOSPITAL PHARMACY//DEXTROSE 1383
3554 2             CU GNRH//DNA COUPLED COLUMN//STREPTOVERTICILLIUM RIMOFACIENS 1345

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 NITRIC OXIDE authKW 1155011 22% 18% 7039
2 PEROXYNITRITE authKW 349446 3% 37% 997
3 NITRIC OXIDE SYNTHASE authKW 335342 5% 23% 1534
4 INCOMPATIBILITIES authKW 241728 2% 40% 87
5 NITRIC OXIDE-BIOLOGY AND CHEMISTRY journal 212406 2% 41% 554
6 AMERICAN JOURNAL OF HOSPITAL PHARMACY journal 187612 6% 11% 256
7 S NITROSOTHIOLS authKW 187226 1% 71% 280
8 PHOSPHODIESTERASE authKW 183353 2% 34% 571
9 CGMP authKW 182102 2% 27% 707
10 ROLIPRAM authKW 125911 1% 55% 243

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Biochemistry & Molecular Biology 34764 30% 1% 9645
2 Pharmacology & Pharmacy 33338 21% 1% 6655
3 Cardiac & Cardiovascular System 13094 9% 1% 2936
4 Cell Biology 9769 11% 0% 3478
5 Neurosciences 8079 12% 0% 3751
6 Peripheral Vascular Diseases 7141 5% 1% 1644
7 Chemistry, Medicinal 6109 5% 1% 1556
8 Biophysics 6068 6% 1% 1948
9 Physiology 6019 6% 1% 1833
10 Endocrinology & Metabolism 2154 4% 0% 1431

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 FREE RAD BIOL 49218 0% 37% 141
2 HEART BRAIN CIRCULAT 38959 0% 81% 51
3 MOL KARDIOL 31504 0% 45% 10
4 GRIPE GRP INVESTIGADOR PROBLEMAS ENFERMEDADES INF 27729 0% 67% 6
5 PHARMACOL 26273 7% 1% 2252
6 FREE RAD BIOMED 25346 0% 46% 58
7 GALEN HOSP PHARM 22185 0% 80% 4
8 SPANISH CANC ASSOC 22185 0% 80% 4
9 RADIAT BIOL BRANCH 21218 0% 23% 99
10 COMPARAT CARCINOGENESIS 20203 0% 21% 105

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 NITRIC OXIDE-BIOLOGY AND CHEMISTRY 212406 2% 41% 554
2 AMERICAN JOURNAL OF HOSPITAL PHARMACY 187612 6% 11% 256
3 FREE RADICAL BIOLOGY AND MEDICINE 23653 1% 6% 471
4 BRITISH JOURNAL OF PHARMACOLOGY 14428 2% 3% 536
5 JOURNAL OF BIOLOGICAL CHEMISTRY 10479 4% 1% 1424
6 EUROPEAN JOURNAL OF PHARMACOLOGY 8867 2% 2% 539
7 AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 8361 1% 3% 343
8 HERZ KREISLAUF 8155 1% 3% 34
9 HERZ 7288 1% 2% 52
10 SHOCK 7204 1% 5% 177

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class		 LCSH search Wikipedia search
1 NITRIC OXIDE 1155011 22% 18% 7039 Search NITRIC+OXIDE Search NITRIC+OXIDE
2 PEROXYNITRITE 349446 3% 37% 997 Search PEROXYNITRITE Search PEROXYNITRITE
3 NITRIC OXIDE SYNTHASE 335342 5% 23% 1534 Search NITRIC+OXIDE+SYNTHASE Search NITRIC+OXIDE+SYNTHASE
4 INCOMPATIBILITIES 241728 2% 40% 87 Search INCOMPATIBILITIES Search INCOMPATIBILITIES
5 S NITROSOTHIOLS 187226 1% 71% 280 Search S+NITROSOTHIOLS Search S+NITROSOTHIOLS
6 PHOSPHODIESTERASE 183353 2% 34% 571 Search PHOSPHODIESTERASE Search PHOSPHODIESTERASE
7 CGMP 182102 2% 27% 707 Search CGMP Search CGMP
8 ROLIPRAM 125911 1% 55% 243 Search ROLIPRAM Search ROLIPRAM
9 NADPH DIAPHORASE 117618 1% 39% 317 Search NADPH+DIAPHORASE Search NADPH+DIAPHORASE
10 CYCLIC GMP 110994 1% 27% 430 Search CYCLIC+GMP Search CYCLIC+GMP

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 PACHER, P , BECKMAN, JS , LIAUDET, L , (2007) NITRIC OXIDE AND PEROXYNITRITE IN HEALTH AND DISEASE.PHYSIOLOGICAL REVIEWS. VOL. 87. ISSUE 1. P. 315 -424 473 35% 2067
2 FRANCIS, SH , BLOUNT, MA , CORBIN, JD , (2011) MAMMALIAN CYCLIC NUCLEOTIDE PHOSPHODIESTERASES: MOLECULAR MECHANISMS AND PHYSIOLOGICAL FUNCTIONS.PHYSIOLOGICAL REVIEWS. VOL. 91. ISSUE 2. P. 651 -690 279 70% 167
3 LUGNIER, C , (2006) CYCLIC NUCLEOTIDE PHOSPHODIESTERASE (PDE) SUPERFAMILY: A NEW TARGET FOR THE DEVELOPMENT OF SPECIFIC THERAPEUTIC AGENTS.PHARMACOLOGY & THERAPEUTICS. VOL. 109. ISSUE 3. P. 366-398 260 78% 437
4 BENDER, AT , BEAVO, JA , (2006) CYCLIC NUCLEOTIDE PHOSPHODIESTERASES: MOLECULAR REGULATION TO CLINICAL USE.PHARMACOLOGICAL REVIEWS. VOL. 58. ISSUE 3. P. 488-520 189 77% 805
5 FRANCIS, SH , BUSCH, JL , CORBIN, JD , (2010) CGMP-DEPENDENT PROTEIN KINASES AND CGMP PHOSPHODIESTERASES IN NITRIC OXIDE AND CGMP ACTION.PHARMACOLOGICAL REVIEWS. VOL. 62. ISSUE 3. P. 525 -563 268 58% 289
6 WANG, PG , XIAN, M , TANG, XP , WU, XJ , WEN, Z , CAI, TW , JANCZUK, AJ , (2002) NITRIC OXIDE DONORS: CHEMICAL ACTIVITIES AND BIOLOGICAL APPLICATIONS.CHEMICAL REVIEWS. VOL. 102. ISSUE 4. P. 1091 -1134 302 60% 614
7 ALDERTON, WK , COOPER, CE , KNOWLES, RG , (2001) NITRIC OXIDE SYNTHASES: STRUCTURE, FUNCTION AND INHIBITION.BIOCHEMICAL JOURNAL. VOL. 357. ISSUE . P. 593-615 150 71% 2177
8 MAURICE, DH , KE, HM , AHMAD, F , WANG, YS , CHUNG, J , MANGANIELLO, VC , (2014) ADVANCES IN TARGETING CYCLIC NUCLEOTIDE PHOSPHODIESTERASES.NATURE REVIEWS DRUG DISCOVERY. VOL. 13. ISSUE 4. P. 290 -314 160 66% 120
9 AZEVEDO, MF , FAUCZ, FR , BIMPAKI, E , HORVATH, A , LEVY, I , DE ALEXANDRE, RB , AHMAD, F , MANGANIELLO, V , STRATAKIS, CA , (2014) CLINICAL AND MOLECULAR GENETICS OF THE PHOSPHODIESTERASES (PDES).ENDOCRINE REVIEWS. VOL. 35. ISSUE 2. P. 195 -233 264 61% 20
10 OMORI, K , KOTERA, J , (2007) OVERVIEW OF PDES AND THEIR REGULATION.CIRCULATION RESEARCH. VOL. 100. ISSUE 3. P. 309-327 148 88% 324

Classes with closest relation at Level 3


Rank Class id link
1 285 ERDOSTEINE//PEROXIREDOXIN//GLUTATHIONE
2 57 ANGIOTENSIN II//HYPERTENSION//PERIPHERAL VASCULAR DISEASES
3 519 BLOOD SUBSTITUTES//NEUROGLOBIN//HEMOGLOBIN
4 522 MAGNESIUM-BULLETIN//MAGNESIUM RESEARCH//MAGNESIUM
5 630 HEPATIC ENCEPHALOPATHY//ASYMMETRIC DIMETHYLARGININE//HYPERAMMONEMIA
6 62 CARDIAC & CARDIOVASCULAR SYSTEM//HEART FAILURE//PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
7 535 TAURINE//CHRONIC GRANULOMATOUS DISEASE//L FORMS
8 668 ENDOTHELIN//ENDOTHELIN 1//ENDOTHELIN RECEPTORS
9 11 ATRIAL FIBRILLATION//CARDIAC & CARDIOVASCULAR SYSTEM//CATHETER ABLATION
10 213 BURNS//CRITICAL CARE MEDICINE//SEPSIS

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