Class information for: |
Basic class information |
Class id | #P | Avg. number of references |
Database coverage of references |
---|---|---|---|
12290 | 917 | 45.0 | 89% |
Hierarchy of classes |
The table includes all classes above and classes immediately below the current class. |
Cluster id | Level | Cluster label | #P |
---|---|---|---|
0 | 4 | BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY | 4064930 |
269 | 3 | CELL BIOLOGY//CAVEOLIN 1//CAVEOLAE | 44007 |
536 | 2 | X LINKED AGAMMAGLOBULINEMIA//BTK//SH2 DOMAIN | 14793 |
12290 | 1 | SH3 DOMAIN//SH2 DOMAIN//GRB2 | 917 |
Terms with highest relevance score |
rank | Term | termType | Chi square | Shr. of publ. in class containing term |
Class's shr. of term's tot. occurrences |
#P with term in class |
---|---|---|---|---|---|---|
1 | SH3 DOMAIN | authKW | 610003 | 10% | 20% | 93 |
2 | SH2 DOMAIN | authKW | 467392 | 8% | 20% | 70 |
3 | GRB2 | authKW | 462733 | 7% | 23% | 60 |
4 | SH3 | authKW | 208344 | 4% | 19% | 33 |
5 | SH2 | authKW | 201417 | 3% | 21% | 29 |
6 | GRB2 SH2 DOMAIN | authKW | 138739 | 1% | 83% | 5 |
7 | BIACORE X | authKW | 99893 | 0% | 100% | 3 |
8 | INTERTWINED DIMER | authKW | 99893 | 0% | 100% | 3 |
9 | SRC SH2 DOMAIN | authKW | 99893 | 0% | 100% | 3 |
10 | GRB2 SH2 | authKW | 88791 | 0% | 67% | 4 |
Web of Science journal categories |
Rank | Term | Chi square | Shr. of publ. in class containing term |
Class's shr. of term's tot. occurrences |
#P with term in class |
---|---|---|---|---|---|
1 | Biochemistry & Molecular Biology | 5862 | 65% | 0% | 595 |
2 | Chemistry, Medicinal | 2043 | 15% | 0% | 133 |
3 | Biophysics | 1758 | 17% | 0% | 152 |
4 | Cell Biology | 1319 | 21% | 0% | 190 |
5 | Chemistry, Organic | 605 | 13% | 0% | 119 |
6 | Biochemical Research Methods | 430 | 8% | 0% | 74 |
7 | Mathematical & Computational Biology | 40 | 2% | 0% | 14 |
8 | Crystallography | 14 | 2% | 0% | 16 |
9 | Spectroscopy | 8 | 2% | 0% | 14 |
10 | Oncology | 6 | 4% | 0% | 34 |
Address terms |
Rank | Term | Chi square | Shr. of publ. in class containing term |
Class's shr. of term's tot. occurrences |
#P with term in class |
---|---|---|---|---|---|
1 | RAYMOND BEVERLY SACKLER GENET MOL MED | 76098 | 1% | 29% | 8 |
2 | GWEN JULES KN P BIOMED DISCOVERY | 66595 | 0% | 100% | 2 |
3 | VET ADM FDN | 66595 | 0% | 100% | 2 |
4 | VAKGRP COMP WETEN PEN | 59933 | 0% | 60% | 3 |
5 | USYLVESTER BRAMAN FAMILY BREAST CANC | 44392 | 0% | 33% | 4 |
6 | UM SYLVESTER BRAMAN FAMILY BREAST CANC | 42808 | 0% | 43% | 3 |
7 | TEXAS DRUG DIAGNOST DEV | 36315 | 1% | 18% | 6 |
8 | BECKMAN 3019 | 33298 | 0% | 100% | 1 |
9 | BEVERLY SACKLER GENET MOL MED | 33298 | 0% | 100% | 1 |
10 | BIOCHEM OXFORD MOLEC SCI | 33298 | 0% | 100% | 1 |
Journals |
Rank | Term | Chi square | Shr. of publ. in class containing term |
Class's shr. of term's tot. occurrences |
#P with term in class |
---|---|---|---|---|---|
1 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 3514 | 6% | 0% | 52 |
2 | NATURE STRUCTURAL BIOLOGY | 3023 | 1% | 1% | 12 |
3 | JOURNAL OF MEDICINAL CHEMISTRY | 2815 | 5% | 0% | 43 |
4 | PROTEIN SCIENCE | 2536 | 2% | 0% | 22 |
5 | CHEMISTRY & BIOLOGY | 2427 | 2% | 1% | 14 |
6 | JOURNAL OF MOLECULAR BIOLOGY | 2121 | 4% | 0% | 39 |
7 | BIOCHEMISTRY | 1958 | 6% | 0% | 57 |
8 | JOURNAL OF BIOMOLECULAR NMR | 1781 | 1% | 0% | 12 |
9 | MOLECULAR & CELLULAR PROTEOMICS | 1535 | 1% | 0% | 12 |
10 | INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS | 1532 | 1% | 1% | 5 |
Author Key Words |
Rank | Term | Chi square | Shr. of publ. in class containing term |
Class's shr. of term's tot. occurrences |
#P with term in class |
LCSH search | Wikipedia search |
---|---|---|---|---|---|---|---|
1 | SH3 DOMAIN | 610003 | 10% | 20% | 93 | Search SH3+DOMAIN | Search SH3+DOMAIN |
2 | SH2 DOMAIN | 467392 | 8% | 20% | 70 | Search SH2+DOMAIN | Search SH2+DOMAIN |
3 | GRB2 | 462733 | 7% | 23% | 60 | Search GRB2 | Search GRB2 |
4 | SH3 | 208344 | 4% | 19% | 33 | Search SH3 | Search SH3 |
5 | SH2 | 201417 | 3% | 21% | 29 | Search SH2 | Search SH2 |
6 | GRB2 SH2 DOMAIN | 138739 | 1% | 83% | 5 | Search GRB2+SH2+DOMAIN | Search GRB2+SH2+DOMAIN |
7 | BIACORE X | 99893 | 0% | 100% | 3 | Search BIACORE+X | Search BIACORE+X |
8 | INTERTWINED DIMER | 99893 | 0% | 100% | 3 | Search INTERTWINED+DIMER | Search INTERTWINED+DIMER |
9 | SRC SH2 DOMAIN | 99893 | 0% | 100% | 3 | Search SRC+SH2+DOMAIN | Search SRC+SH2+DOMAIN |
10 | GRB2 SH2 | 88791 | 0% | 67% | 4 | Search GRB2+SH2 | Search GRB2+SH2 |
Core articles |
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c: (1) Number of references referring to publications in the class. (2) Share of total number of active references referring to publications in the class. (3) Age of the article. New articles get higher score than old articles. (4) Citation rate, normalized to year. |
Rank | Reference | # ref. in cl. |
Shr. of ref. in cl. |
Citations |
---|---|---|---|---|
1 | PENG, D , ZHI, Y , XUE, T , GAO, HY , LONG, YQ , (2011) LIGAND-BASED STRUCTURAL OPTIMIZATION OF GRB2-SH2 INHIBITORS: HIGH AFFINITY, LOW CHARGE AND REDUCED PEPTIDIC NATURE.CHINESE JOURNAL OF ORGANIC CHEMISTRY. VOL. 31. ISSUE 12. P. 2019 -2033 | 49 | 98% | 0 |
2 | BURKE, TR , (2006) DEVELOPMENT OF GRB2 SH2 DOMAIN SIGNALING ANTAGONISTS: A POTENTIAL NEW CLASS OF ANTIPROLIFERATIVE AGENTS.INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS. VOL. 12. ISSUE 1. P. 33-48 | 56 | 92% | 23 |
3 | MULLER, G , (2001) PEPTIDOMIMETIC SH2 DOMAIN ANTAGONISTS FOR TARGETING SIGNAL TRANSDUCTION.BIOORGANIC CHEMISTRY OF BIOLOGICAL SIGNAL TRANSDUCTION. VOL. 211. ISSUE . P. 17 -59 | 88 | 56% | 24 |
4 | GARCIA-ECHEVERRIA, C , (2001) ANTAGONISTS OF THE SRC HOMOLOGY 2 (SH2) DOMAINS OF GRB2, SRC, LCK AND ZAP-70.CURRENT MEDICINAL CHEMISTRY. VOL. 8. ISSUE 13. P. 1589-1604 | 67 | 63% | 40 |
5 | LADBURY, JE , AROLD, ST , (2011) ENERGETICS OF SRC HOMOLOGY DOMAIN INTERACTIONS IN RECEPTOR TYROSINE KINASE-MEDIATED SIGNALING.METHODS IN ENZYMOLOGY, VOL 488: BIOTHERMODYNAMICS, PT C. VOL. . ISSUE . P. 147-183 | 58 | 56% | 7 |
6 | VIDAL, M , GIGOUX, V , GARBAY, C , (2001) SH2 AND SH3 DOMAINS AS TARGETS FOR ANTI-PROLIFERATIVE AGENTS.CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY. VOL. 40. ISSUE 2. P. 175-186 | 62 | 64% | 49 |
7 | LUNG, FDT , TSAI, JY , (2003) GRB2 SH2 DOMAIN-BINDING PEPTIDE ANALOGS AS POTENTIAL ANTICANCER AGENTS.BIOPOLYMERS. VOL. 71. ISSUE 2. P. 132-140 | 51 | 75% | 16 |
8 | KRASKOUSKAYA, D , DUODU, E , ARPIN, CC , GUNNING, PT , (2013) PROGRESS TOWARDS THE DEVELOPMENT OF SH2 DOMAIN INHIBITORS.CHEMICAL SOCIETY REVIEWS. VOL. 42. ISSUE 8. P. 3337 -3370 | 86 | 30% | 24 |
9 | FRETZ, H , FURET, P , GARCIA-ECHEVERRIA, C , RAHUEL, J , SCHOEPFER, J , (2000) STRUCTURE-BASED DESIGN OF COMPOUNDS INHIBITING GRB2-SH2 MEDIATED PROTEIN-PROTEIN INTERACTIONS IN SIGNAL TRANSDUCTION PATHWAYS.CURRENT PHARMACEUTICAL DESIGN. VOL. 6. ISSUE 18. P. 1777-1796 | 51 | 73% | 55 |
10 | MACHIDA, K , MAYER, BJ , (2005) THE SH2 DOMAIN: VERSATILE SIGNALING MODULE AND PHARMACEUTICAL TARGET.BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS. VOL. 1747. ISSUE 1. P. 1-25 | 85 | 33% | 134 |
Classes with closest relation at Level 1 |
Rank | Class id | link |
---|---|---|
1 | 25087 | PHOSPHOPEPTIDE SYNTHESIS//DI T BUTYL N N DIETHYLPHOSPHORAMIDITE//TYRP CONTAINING PEPTIDES |
2 | 17831 | P66SHC//SHC//SHC FAMILY |
3 | 13788 | SLP 76//ADAP//SECT LYMPHOCYTE SIGNALING |
4 | 21034 | GRB7//GRB14//GRB10 |
5 | 13570 | NEDD9//CRK//CRKL |
6 | 3485 | CSK//CSK HOMOLOGOUS KINASE//HEMATOL MED ENZYMOL |
7 | 22610 | WWP1//WW DOMAIN//CKIP 1 |
8 | 9250 | SHP2//SHP 2//SHP 1 |
9 | 22654 | VAV//VAV1//VAV PROTO ONCOGENE |
10 | 11898 | PDZ DOMAIN//SYNTENIN//MAGUK |