Class information for:
Level 1: INSULIN RECEPTOR SUBSTRATE//INSULIN RECEPTOR SUBSTRATE 1//IRS 1

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
9406 1158 45.7 92%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
269 3       CELL BIOLOGY//CAVEOLIN 1//CAVEOLAE 44007
536 2             X LINKED AGAMMAGLOBULINEMIA//BTK//SH2 DOMAIN 14793
9406 1                   INSULIN RECEPTOR SUBSTRATE//INSULIN RECEPTOR SUBSTRATE 1//IRS 1 1158

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 INSULIN RECEPTOR SUBSTRATE authKW 620715 5% 41% 57
2 INSULIN RECEPTOR SUBSTRATE 1 authKW 446191 6% 26% 64
3 IRS 1 authKW 433644 6% 26% 64
4 IRS 2 authKW 255212 2% 44% 22
5 INSULIN RECEPTOR SUBSTRATE 2 authKW 183027 2% 37% 19
6 INSULIN RECEPTOR SUBSTRATE 1 IRS 1 authKW 146022 1% 46% 12
7 IRS1 authKW 143525 2% 26% 21
8 IRS 3 authKW 131837 0% 100% 5
9 INSULIN RECEPTOR SUBSTRATE 4 authKW 84374 0% 80% 4
10 GLY972ARG authKW 79102 0% 100% 3

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Endocrinology & Metabolism 8325 33% 0% 382
2 Biochemistry & Molecular Biology 2495 40% 0% 463
3 Cell Biology 1257 18% 0% 212
4 Medicine, Research & Experimental 230 6% 0% 74
5 Biophysics 211 6% 0% 69
6 Oncology 104 7% 0% 82
7 Physiology 80 4% 0% 45
8 Genetics & Heredity 15 3% 0% 35
9 Nutrition & Dietetics 11 1% 0% 17
10 Biology 4 1% 0% 15

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MED SCI CYBERJAYA 79102 0% 100% 3
2 CELL REGULATBUNKYO KU 65914 0% 50% 5
3 JOSLIN DIABET 48307 4% 4% 49
4 U568 44396 1% 21% 8
5 PROGRAM BIOMED BIOL SCI 42183 0% 40% 4
6 INTERNAL MED ENDOCRINOL METAB PATHOBIOCHEM 35155 0% 67% 2
7 U145 29648 1% 13% 9
8 AGR AGR CHEM BIOCHEM BUNKYO KU 26367 0% 100% 1
9 AGR LIFE SCI PL ANIM SCI 26367 0% 100% 1
10 ANIM SCI PL BIOL SCI 26367 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF BIOLOGICAL CHEMISTRY 5639 16% 0% 182
2 DIABETES 5435 4% 0% 50
3 DIABETOLOGIA 4540 3% 0% 38
4 MOLECULAR ENDOCRINOLOGY 3379 2% 0% 27
5 ENDOCRINOLOGY 3152 5% 0% 55
6 VITAMINS AND HORMONES SERIES 2661 0% 3% 3
7 MOLECULAR AND CELLULAR BIOLOGY 1399 3% 0% 35
8 AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 1012 1% 0% 16
9 JOURNAL OF ENDOCRINOLOGY 889 1% 0% 17
10 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 866 4% 0% 49

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 INSULIN RECEPTOR SUBSTRATE 620715 5% 41% 57 Search INSULIN+RECEPTOR+SUBSTRATE Search INSULIN+RECEPTOR+SUBSTRATE
2 INSULIN RECEPTOR SUBSTRATE 1 446191 6% 26% 64 Search INSULIN+RECEPTOR+SUBSTRATE+1 Search INSULIN+RECEPTOR+SUBSTRATE+1
3 IRS 1 433644 6% 26% 64 Search IRS+1 Search IRS+1
4 IRS 2 255212 2% 44% 22 Search IRS+2 Search IRS+2
5 INSULIN RECEPTOR SUBSTRATE 2 183027 2% 37% 19 Search INSULIN+RECEPTOR+SUBSTRATE+2 Search INSULIN+RECEPTOR+SUBSTRATE+2
6 INSULIN RECEPTOR SUBSTRATE 1 IRS 1 146022 1% 46% 12 Search INSULIN+RECEPTOR+SUBSTRATE+1+IRS+1 Search INSULIN+RECEPTOR+SUBSTRATE+1+IRS+1
7 IRS1 143525 2% 26% 21 Search IRS1 Search IRS1
8 IRS 3 131837 0% 100% 5 Search IRS+3 Search IRS+3
9 INSULIN RECEPTOR SUBSTRATE 4 84374 0% 80% 4 Search INSULIN+RECEPTOR+SUBSTRATE+4 Search INSULIN+RECEPTOR+SUBSTRATE+4
10 GLY972ARG 79102 0% 100% 3 Search GLY972ARG Search GLY972ARG

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 MARDILOVICH, K , PANKRATZ, SL , SHAW, LM , (2009) EXPRESSION AND FUNCTION OF THE INSULIN RECEPTOR SUBSTRATE PROTEINS IN CANCER.CELL COMMUNICATION AND SIGNALING. VOL. 7. ISSUE . P. - 94 54% 54
2 SESTI, G , FEDERICI, M , HRIBAL, ML , LAURO, D , SBRACCIA, P , LAURO, R , (2001) DEFECTS OF THE INSULIN RECEPTOR SUBSTRATE (IRS) SYSTEM IN HUMAN METABOLIC DISORDERS.FASEB JOURNAL. VOL. 15. ISSUE 12. P. 2099 -2111 69 79% 195
3 SUN, XJ , LIU, F , (2009) PHOSPHORYLATION OF IRS PROTEINS: YIN-YANG REGULATION OF INSULIN SIGNALING.VITAMINS AND HORMONES INSULIN AND IGFS. VOL. 80. ISSUE . P. 351-+ 99 45% 24
4 DEARTH, RK , CUI, XJ , KIM, HJ , HADSELL, DL , LEE, AV , (2007) ONCOGENIC TRANSFORMATION BY THE SIGNALING ADAPTOR PROTEINS INSULIN RECEPTOR SUBSTRATE (IRS)-1 AND IRS-2.CELL CYCLE. VOL. 6. ISSUE 6. P. 705-713 76 53% 88
5 COPPS, KD , WHITE, MF , (2012) REGULATION OF INSULIN SENSITIVITY BY SERINE/THREONINE PHOSPHORYLATION OF INSULIN RECEPTOR SUBSTRATE PROTEINS IRS1 AND IRS2.DIABETOLOGIA. VOL. 55. ISSUE 10. P. 2565-2582 66 39% 148
6 THIRONE, ACP , HUANG, C , KLIP, A , (2006) TISSUE-SPECIFIC ROLES OF IRS PROTEINS IN INSULIN SIGNALING AND GLUCOSE TRANSPORT.TRENDS IN ENDOCRINOLOGY AND METABOLISM. VOL. 17. ISSUE 2. P. 70-76 50 88% 10
7 FRITSCHE, L , WEIGERT, C , HARING, HU , LEHMANN, R , (2008) HOW INSULIN RECEPTOR SUBSTRATE PROTEINS REGULATE THE METABOLIC CAPACITY OF THE LIVER - IMPLICATIONS FOR HEALTH AND DISEASE.CURRENT MEDICINAL CHEMISTRY. VOL. 15. ISSUE 13. P. 1316 -1329 93 37% 63
8 HAKUNO, F , FUKUSHIMA, T , YONEYAMA, Y , KAMEI, H , OZOE, A , YOSHIHARA, H , YAMANAKA, D , SHIBANO, T , SONE-YONEZAWA, M , YU, BC , ET AL (2015) THE NOVEL FUNCTIONS OF HIGH-MOLECULAR-MASS COMPLEXES CONTAINING INSULIN RECEPTOR SUBSTRATES IN MEDIATION AND MODULATION OF INSULIN-LIKE ACTIVITIES: EMERGING CONCEPT OF DIVERSE FUNCTIONS BY IRS-ASSOCIATED PROTEINS.FRONTIERS IN ENDOCRINOLOGY. VOL. 6. ISSUE . P. - 82 37% 2
9 GORGISEN, G , BALCI, MK , CELIK, FC , GOKKAYA, M , OZDEM, S , OZEL, D , OZES, ON , (2016) DIFFERENTIAL ACTIVATION AND EXPRESSION OF INSULIN RECEPTOR SUBSTRATE 1 (IRS1) IN MONONUCLEAR CELLS OF TYPE 2 DIABETES PATIENTS AFTER INSULIN STIMULATION.CELLULAR AND MOLECULAR BIOLOGY. VOL. 62. ISSUE 2. P. 25 -30 38 78% 0
10 BOURA-HALFON, S , ZICK, Y , (2009) SERINE KINASES OF INSULIN RECEPTOR SUBSTRATE PROTEINS.VITAMINS AND HORMONES INSULIN AND IGFS. VOL. 80. ISSUE . P. 313 -349 77 41% 22

Classes with closest relation at Level 1


Rank Class id link
1 1594 INSULIN RECEPTOR//LEPRECHAUNISM//DONOHUE SYNDROME
2 31211 H 411E CELLS//ALPHA LINOLENIC ACID ALA 18 3N3//ANDROID TYPE OBESITY
3 17831 P66SHC//SHC//SHC FAMILY
4 21034 GRB7//GRB14//GRB10
5 29639 ASPARTYL ASPARAGINYL BETA HYDROXYLASE//ASPARTYL BETA HYDROXYLASE//HUMBUG
6 1277 GLUT4//GLUCOSE TRANSPORT//GLUCOSE TRANSPORTER
7 8615 BETA CELL MASS//BETA CELL PROLIFERATION//BETA CELL
8 1648 IGF 1R//IGF IR//INSULIN LIKE GROWTH FACTOR 1 RECEPTOR
9 5678 PI3K GAMMA//PHOSPHOINOSITIDE 3 KINASE//P110 DELTA
10 5790 TBC1D1//GLUCOSE TRANSPORT//GLUT4

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