Class information for:
Level 1: JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS//NONMEM//NONLINEAR MIXED EFFECTS MODEL

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
5621 1596 28.3 64%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
230 3       P GLYCOPROTEIN//FMO3//TRIMETHYLAMINURIA 49374
1171 2             JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS//JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS//NONMEM 9352
5621 1                   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS//NONMEM//NONLINEAR MIXED EFFECTS MODEL 1596

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS journal 1661492 14% 38% 226
2 NONMEM authKW 815193 10% 26% 164
3 NONLINEAR MIXED EFFECTS MODEL authKW 489039 5% 34% 75
4 INDIRECT RESPONSE MODELS authKW 379967 2% 83% 24
5 PHARMACOKINET DRUG THER Y address 313325 3% 30% 54
6 PHARMACOMETRICS authKW 306735 3% 38% 42
7 JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS journal 275956 6% 14% 103
8 POPULATION PHARMACOKINETICS authKW 240375 7% 11% 116
9 PHARMACEUT BIOSCI address 208629 9% 8% 136
10 NONLINEAR MIXED EFFECT MODELS authKW 197341 1% 74% 14

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Pharmacology & Pharmacy 27156 74% 0% 1189
2 Statistics & Probability 5696 15% 0% 238
3 Medical Informatics 3803 6% 0% 98
4 Mathematical & Computational Biology 2814 8% 0% 127
5 Computer Science, Interdisciplinary Applications 260 4% 0% 65
6 Biology 203 4% 0% 62
7 Engineering, Biomedical 184 3% 0% 52
8 Computer Science, Theory & Methods 101 3% 0% 46
9 Medicine, Research & Experimental 81 4% 0% 62
10 Chemistry, Multidisciplinary 70 8% 0% 120

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PHARMACOKINET DRUG THER Y 313325 3% 30% 54
2 PHARMACEUT BIOSCI 208629 9% 8% 136
3 PHARMACOMETR 185943 2% 28% 35
4 PL PHARMACOKINET 117991 2% 16% 38
5 PHARMACOMETR GRP 116318 1% 41% 15
6 PHARMACOKINET PHARMACOMETR 86085 0% 75% 6
7 CLIN PHARMACOL MODELLING SIMULAT 81376 1% 21% 20
8 UMR 738 80263 1% 26% 16
9 PHARSIGHT CONSULTING SERV 62604 0% 55% 6
10 ADV PK PD MODELING SIMULAT 58293 1% 38% 8

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS 1661492 14% 38% 226
2 JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS 275956 6% 14% 103
3 AAPS JOURNAL 87630 5% 6% 72
4 CLINICAL PHARMACOKINETICS 26338 4% 2% 57
5 JOURNAL OF CLINICAL PHARMACOLOGY 24791 5% 2% 84
6 JOURNAL OF BIOPHARMACEUTICAL STATISTICS 22730 2% 4% 33
7 CLINICAL PHARMACOLOGY & THERAPEUTICS 18406 5% 1% 75
8 PHARMACEUTICAL RESEARCH 15233 5% 1% 80
9 PHARMACEUTICAL STATISTICS 10498 1% 3% 17
10 STATISTICS IN MEDICINE 6601 3% 1% 50

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 NONMEM 815193 10% 26% 164 Search NONMEM Search NONMEM
2 NONLINEAR MIXED EFFECTS MODEL 489039 5% 34% 75 Search NONLINEAR+MIXED+EFFECTS+MODEL Search NONLINEAR+MIXED+EFFECTS+MODEL
3 INDIRECT RESPONSE MODELS 379967 2% 83% 24 Search INDIRECT+RESPONSE+MODELS Search INDIRECT+RESPONSE+MODELS
4 PHARMACOMETRICS 306735 3% 38% 42 Search PHARMACOMETRICS Search PHARMACOMETRICS
5 POPULATION PHARMACOKINETICS 240375 7% 11% 116 Search POPULATION+PHARMACOKINETICS Search POPULATION+PHARMACOKINETICS
6 NONLINEAR MIXED EFFECT MODELS 197341 1% 74% 14 Search NONLINEAR+MIXED+EFFECT+MODELS Search NONLINEAR+MIXED+EFFECT+MODELS
7 MODEL BASED DRUG DEVELOPMENT 138837 1% 48% 15 Search MODEL+BASED+DRUG+DEVELOPMENT Search MODEL+BASED+DRUG+DEVELOPMENT
8 SAEM 136642 1% 71% 10 Search SAEM Search SAEM
9 TURNOVER MODELS 133915 0% 100% 7 Search TURNOVER+MODELS Search TURNOVER+MODELS
10 SAMPLING WINDOWS 117174 0% 88% 7 Search SAMPLING+WINDOWS Search SAMPLING+WINDOWS

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 LEANDER, J , ALMQUIST, J , AHLSTROM, C , GABRIELSSON, J , JIRSTRAND, M , (2015) MIXED EFFECTS MODELING USING STOCHASTIC DIFFERENTIAL EQUATIONS: ILLUSTRATED BY PHARMACOKINETIC DATA OF NICOTINIC ACID IN OBESE ZUCKER RATS.AAPS JOURNAL. VOL. 17. ISSUE 3. P. 586 -596 27 100% 3
2 VOZEH, S , STEIMER, JL , ROWLAND, M , MORSELLI, P , MENTRE, F , BALANT, LP , AARONS, L , (1996) THE USE OF POPULATION PHARMACOKINETICS IN DRUG DEVELOPMENT.CLINICAL PHARMACOKINETICS. VOL. 30. ISSUE 2. P. 81 -93 70 57% 76
3 OGUNGBENRO, K , AARONS, L , (2007) DESIGN OF POPULATION PHARMACOKINETIC EXPERIMENTS USING PRIOR INFORMATION.XENOBIOTICA. VOL. 37. ISSUE 10-11. P. 1311 -1330 40 77% 7
4 DOKOUMETZIDIS, A , AARONS, L , OGUNGBENRO, K , (2009) APPLICATION OF OPTIMAL DESIGN METHODOLOGIES IN CLINICAL PHARMACOLOGY EXPERIMENTS.PHARMACEUTICAL STATISTICS. VOL. 8. ISSUE 3. P. 239 -252 40 71% 11
5 PLAN, EL , MALONEY, A , MENTRE, F , KARLSSON, MO , BERTRAND, J , (2012) PERFORMANCE COMPARISON OF VARIOUS MAXIMUM LIKELIHOOD NONLINEAR MIXED-EFFECTS ESTIMATION METHODS FOR DOSE-RESPONSE MODELS.AAPS JOURNAL. VOL. 14. ISSUE 3. P. 420 -432 27 96% 10
6 PILLAI, G , MENTRE, F , STEIMER, JL , (2005) NON-LINEAR MIXED EFFECTS MODELING - FROM METHODOLOGY AND SOFTWARE DEVELOPMENT TO DRIVING IMPLEMENTATION IN DRUG DEVELOPMENT SCIENCE.JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS. VOL. 32. ISSUE 2. P. 161-183 40 74% 38
7 NYBERG, J , BAZZOLI, C , OGUNGBENRO, K , ALIEV, A , LEONOV, S , DUFFULL, S , HOOKER, AC , MENTRE, F , (2015) METHODS AND SOFTWARE TOOLS FOR DESIGN EVALUATION IN POPULATION PHARMACOKINETICS-PHARMACODYNAMICS STUDIES.BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. VOL. 79. ISSUE 1. P. 6 -17 21 91% 9
8 NGUYEN, TT , BAZZOLI, C , MENTRE, F , (2012) DESIGN EVALUATION AND OPTIMISATION IN CROSSOVER PHARMACOKINETIC STUDIES ANALYSED BY NONLINEAR MIXED EFFECTS MODELS.STATISTICS IN MEDICINE. VOL. 31. ISSUE 11-12. P. 1043 -1058 25 93% 5
9 AARONS, L , OGUNGBENRO, K , (2010) OPTIMAL DESIGN OF PHARMACOKINETIC STUDIES.BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY. VOL. 106. ISSUE 3. P. 250 -255 27 84% 14
10 TOD, M , JULLIEN, V , PONS, G , (2008) FACILITATION OF DRUG EVALUATION IN CHILDREN BY POPULATION METHODS AND MODELLING.CLINICAL PHARMACOKINETICS. VOL. 47. ISSUE 4. P. 231-243 41 47% 94

Classes with closest relation at Level 1


Rank Class id link
1 14290 JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS//IVIVC//NONLINEAR COMPARTMENTAL MODEL
2 35119 METAL ION CHARACTERISTIC//OMO UMO QUANTUM STATES//QUANTITATIVE ION CHARACTER ACTIVITY RELATIONSHIP
3 9031 D OPTIMALITY//APPROXIMATE DESIGN//C OPTIMALITY
4 10569 FCRN//NEONATAL FC RECEPTOR//TARGET MEDIATED DRUG DISPOSITION
5 15849 LYMPHOCYTE IMMUNOSUPPRESSANT SENSITIVITY TEST LIST//ATTENUATION OF APOPTOSIS//DANMO CAPSULES
6 35824 INO 2628 CZ//EFFICIENCY OF ENTEROHEPATIC CIRCULATION//MNP001
7 10766 ETOPOSIDE//ETOPOSIDE PHOSPHATE//ORAL ETOPOSIDE
8 5153 AMINOGLYCOSIDES//GENTAMICIN//AMIKACIN
9 13520 BIOEQUIVALENCE//INDIVIDUAL BIOEQUIVALENCE//HIGHLY VARIABLE DRUGS
10 8193 OFF LABEL//UNLICENSED//OFF LABEL DRUG USE

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