Class information for:
Level 1: BIOEQUIVALENCE//INDIVIDUAL BIOEQUIVALENCE//HIGHLY VARIABLE DRUGS

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
13520 831 20.0 49%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
9 4 COMPUTER SCIENCE, THEORY & METHODS//COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE//COMPUTER SCIENCE, INFORMATION SYSTEMS 1247339
34 3       STATISTICS & PROBABILITY//STAT//COMMUNICATIONS IN STATISTICS-THEORY AND METHODS 105938
1075 2             ADAPTIVE DESIGN//STATISTICS IN MEDICINE//STATISTICS & PROBABILITY 9928
13520 1                   BIOEQUIVALENCE//INDIVIDUAL BIOEQUIVALENCE//HIGHLY VARIABLE DRUGS 831

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOEQUIVALENCE authKW 1565295 32% 16% 265
2 INDIVIDUAL BIOEQUIVALENCE authKW 1081455 4% 89% 33
3 HIGHLY VARIABLE DRUGS authKW 900218 3% 88% 28
4 AVERAGE BIOEQUIVALENCE authKW 683995 3% 85% 22
5 POPULATION BIOEQUIVALENCE authKW 589942 2% 94% 17
6 TWO ONE SIDED TESTS PROCEDURE authKW 261288 1% 89% 8
7 INTERVAL HYPOTHESIS authKW 228937 1% 69% 9
8 SCALED BIOEQUIVALENCE LIMITS authKW 220463 1% 100% 6
9 SUBJECT BY FORMULATION INTERACTION authKW 183719 1% 100% 5
10 ABSORPTION RATE authKW 175076 3% 21% 23

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Statistics & Probability 17357 35% 0% 293
2 Pharmacology & Pharmacy 8737 59% 0% 492
3 Mathematical & Computational Biology 5451 15% 0% 125
4 Medical Informatics 5212 10% 0% 82
5 Medicine, Research & Experimental 404 9% 0% 77
6 Chemistry, Medicinal 318 6% 0% 54
7 Public, Environmental & Occupational Health 300 9% 0% 75
8 Chemistry, Multidisciplinary 162 12% 0% 99
9 Biology 61 3% 0% 26
10 Psychology, Mathematical 47 1% 0% 5

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PHARMACOKINET SERV 117579 0% 80% 4
2 PHARMALYT INC 82672 0% 75% 3
3 PHARMACOL CLIN EVALUAT 78271 1% 30% 7
4 AREA FARM TECNOL 73488 0% 100% 2
5 PHRMA CMC STAT EXPERT TEAM 73488 0% 100% 2
6 SPRI STAT 73488 0% 100% 2
7 REGULATORY AFFAIRS QUAL 73484 0% 50% 4
8 OFF PHARMACEUT SCI 68387 2% 10% 18
9 BIOMETR PHARMACOKINET RD 66137 0% 60% 3
10 BIOEQUIVALENCE 64687 1% 20% 9

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF BIOPHARMACEUTICAL STATISTICS 74250 5% 5% 43
2 INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS 50284 9% 2% 73
3 PHARMACEUTICAL STATISTICS 33832 3% 4% 22
4 STATISTICS IN MEDICINE 21620 8% 1% 65
5 EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS 13741 3% 2% 24
6 PHARMACEUTICAL RESEARCH 12387 6% 1% 52
7 AAPS JOURNAL 11701 2% 2% 19
8 BIOMETRICAL JOURNAL 8898 3% 1% 24
9 JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS 8423 2% 2% 13
10 EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 4578 3% 1% 21

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 BIOEQUIVALENCE 1565295 32% 16% 265 Search BIOEQUIVALENCE Search BIOEQUIVALENCE
2 INDIVIDUAL BIOEQUIVALENCE 1081455 4% 89% 33 Search INDIVIDUAL+BIOEQUIVALENCE Search INDIVIDUAL+BIOEQUIVALENCE
3 HIGHLY VARIABLE DRUGS 900218 3% 88% 28 Search HIGHLY+VARIABLE+DRUGS Search HIGHLY+VARIABLE+DRUGS
4 AVERAGE BIOEQUIVALENCE 683995 3% 85% 22 Search AVERAGE+BIOEQUIVALENCE Search AVERAGE+BIOEQUIVALENCE
5 POPULATION BIOEQUIVALENCE 589942 2% 94% 17 Search POPULATION+BIOEQUIVALENCE Search POPULATION+BIOEQUIVALENCE
6 TWO ONE SIDED TESTS PROCEDURE 261288 1% 89% 8 Search TWO+ONE+SIDED+TESTS+PROCEDURE Search TWO+ONE+SIDED+TESTS+PROCEDURE
7 INTERVAL HYPOTHESIS 228937 1% 69% 9 Search INTERVAL+HYPOTHESIS Search INTERVAL+HYPOTHESIS
8 SCALED BIOEQUIVALENCE LIMITS 220463 1% 100% 6 Search SCALED+BIOEQUIVALENCE+LIMITS Search SCALED+BIOEQUIVALENCE+LIMITS
9 SUBJECT BY FORMULATION INTERACTION 183719 1% 100% 5 Search SUBJECT+BY+FORMULATION+INTERACTION Search SUBJECT+BY+FORMULATION+INTERACTION
10 ABSORPTION RATE 175076 3% 21% 23 Search ABSORPTION+RATE Search ABSORPTION+RATE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 TOTHFALUSI, L , ENDRENYI, L , ARIETA, AG , (2009) EVALUATION OF BIOEQUIVALENCE FOR HIGHLY VARIABLE DRUGS WITH SCALED AVERAGE BIOEQUIVALENCE.CLINICAL PHARMACOKINETICS. VOL. 48. ISSUE 11. P. 725 -743 52 81% 21
2 KARALIS, V , MACHERAS, P , (2012) CURRENT REGULATORY APPROACHES OF BIOEQUIVALENCE TESTING.EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY. VOL. 8. ISSUE 8. P. 929 -942 43 72% 7
3 VAHL, CI , KANG, Q , (2016) EQUIVALENCE CRITERIA FOR THE SAFETY EVALUATION OF A GENETICALLY MODIFIED CROP: A STATISTICAL PERSPECTIVE.JOURNAL OF AGRICULTURAL SCIENCE. VOL. 154. ISSUE 3. P. 383 -406 44 56% 0
4 KARALIS, V , SYMILLIDES, M , MACHERAS, P , (2011) NOVEL METHODS TO ASSESS BIOEQUIVALENCE.EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY. VOL. 7. ISSUE 1. P. 79 -88 32 80% 4
5 ENDRENYI, L , TOTHFALUSI, L , (2012) METRICS FOR THE EVALUATION OF BIOEQUIVALENCE OF MODIFIED-RELEASE FORMULATIONS.AAPS JOURNAL. VOL. 14. ISSUE 4. P. 813 -819 26 76% 6
6 KARALIS, V , SYMILLIDES, M , MACHERAS, P , (2012) BIOEQUIVALENCE OF HIGHLY VARIABLE DRUGS: A COMPARISON OF THE NEWLY PROPOSED REGULATORY APPROACHES BY FDA AND EMA.PHARMACEUTICAL RESEARCH. VOL. 29. ISSUE 4. P. 1066 -1077 20 95% 11
7 HARDE, H , AGRAWAL, AK , JAIN, SY , (2015) TETANUS TOXOIDS LOADED GLUCOMANNOSYLATED CHITOSAN BASED NANOHOMING VACCINE ADJUVANT WITH IMPROVED ORAL STABILITY AND IMMUNOSTIMULATORY RESPONSE.PHARMACEUTICAL RESEARCH. VOL. 32. ISSUE 1. P. 122 -143 16 100% 4
8 DU, LP , CHOI, L , (2015) LIKELIHOOD APPROACH FOR EVALUATING BIOEQUIVALENCE OF HIGHLY VARIABLE DRUGS.PHARMACEUTICAL STATISTICS. VOL. 14. ISSUE 2. P. 82 -94 21 81% 0
9 FREITAG, G , CZADO, C , MUNK, A , (2007) A NONPARAMETRIC TEST FOR SIMILARITY OF MARGINALS - WITH APPLICATIONS TO THE ASSESSMENT OF POPULATION BIOEQUIVALENCE.JOURNAL OF STATISTICAL PLANNING AND INFERENCE. VOL. 137. ISSUE 3. P. 697 -711 26 79% 3
10 KARALIS, V , SYMILLIDES, M , MACHERAS, P , (2011) ON THE LEVELING-OFF PROPERTIES OF THE NEW BIOEQUIVALENCE LIMITS FOR HIGHLY VARIABLE DRUGS OF THE EMA GUIDELINE.EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. VOL. 44. ISSUE 4. P. 497-505 18 100% 6

Classes with closest relation at Level 1


Rank Class id link
1 22251 NONINFERIORITY MARGIN//NON INFERIORITY//THREE ARM DESIGN
2 36874 PARALLEL LINE BIOASSAY//SLOPE RATIO BIOASSAY//COMMON LOG RELATIVE POTENCY
3 18923 CROSSOVER DESIGN//UNIVERSAL OPTIMALITY//REPEATED MEASUREMENTS DESIGN
4 35726 DESIGN TRIALS STAT GRP//332 N LAUDERDALE POB 318//ADAPTATION AND SELF CARE IN ADOLESCENTS WITH CANCER
5 14290 JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS//IVIVC//NONLINEAR COMPARTMENTAL MODEL
6 5560 GENERIC SUBSTITUTION//GENERIC DRUGS//GENERIC MEDICINES
7 22935 JOURNAL OF SENSORY STUDIES//DIFFERENCE TEST//DUO TRIO
8 30783 DIRECTION OF DEPENDENCE//ROAD SAFETY MEASURE//GURU TEG BAHADUR TECHNOL
9 21983 ESTIMATION AFTER SELECTION//PROBABILITY OF CORRECT SELECTION//SUBSET SELECTION
10 14993 BIOSIMILAR//ANTI ERYTHROPOIETIN ANTIBODIES//CT P13

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