Class information for:
Level 1: BLOOD BRAIN BARRIER//BRAIN TARGETING//SMART DRUG DELIVERY

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
6821 1440 57.0 86%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
12 4 POLYMER SCIENCE//MATERIALS SCIENCE, PAPER & WOOD//CHEMISTRY, PHYSICAL 1084170
41 3       INTERNATIONAL JOURNAL OF PHARMACEUTICS//DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY//PHARMACOLOGY & PHARMACY 99449
147 2             SOLID LIPID NANOPARTICLES//POLYMERIC MICELLES//LIPOSOMES 23275
6821 1                   BLOOD BRAIN BARRIER//BRAIN TARGETING//SMART DRUG DELIVERY 1440

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BLOOD BRAIN BARRIER authKW 629702 34% 6% 489
2 BRAIN TARGETING authKW 598680 5% 36% 79
3 SMART DRUG DELIVERY address 519862 7% 26% 95
4 BRAIN DELIVERY authKW 279068 3% 31% 42
5 ANGIOPEP 2 authKW 259739 1% 88% 14
6 OX26 authKW 150778 1% 89% 8
7 ANGIOPEP authKW 129869 0% 88% 7
8 GLIOMA TARGETING authKW 129869 0% 88% 7
9 TRANSFERRIN RECEPTOR authKW 129049 5% 8% 76
10 RECEPTOR MEDIATED TRANSCYTOSIS authKW 111588 1% 53% 10

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Pharmacology & Pharmacy 8793 46% 0% 660
2 Materials Science, Biomaterials 3865 9% 0% 126
3 Nanoscience & Nanotechnology 1700 12% 0% 178
4 Engineering, Biomedical 910 7% 0% 98
5 Chemistry, Multidisciplinary 831 18% 0% 258
6 Medicine, Research & Experimental 670 9% 0% 131
7 Neurosciences 406 12% 0% 175
8 Chemistry, Medicinal 360 5% 0% 78
9 Biochemistry & Molecular Biology 135 13% 0% 183
10 Biotechnology & Applied Microbiology 118 5% 0% 77

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 SMART DRUG DELIVERY 519862 7% 26% 95
2 TE FAR TI GRP 67849 0% 80% 4
3 NANOMED NANOMIB 63610 0% 100% 3
4 STAB VIDA 63610 0% 100% 3
5 EA 2648 42407 0% 100% 2
6 GALIEN PARIS SUD UMR CNRS 8612 42407 0% 100% 2
7 INVEST SERV CIENCIAS BIOL LDA 42407 0% 100% 2
8 ITFM IFR141 42407 0% 100% 2
9 PLA PHARMACEUT 42407 0% 100% 2
10 UNIT IMAGERY 42407 0% 100% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF DRUG TARGETING 57560 5% 4% 65
2 JOURNAL OF CONTROLLED RELEASE 17281 5% 1% 78
3 MOLECULAR PHARMACEUTICS 11825 3% 1% 42
4 BIOMATERIALS 8103 5% 1% 76
5 PHARMACEUTICAL RESEARCH 7954 4% 1% 55
6 NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 6582 1% 2% 20
7 INTERNATIONAL JOURNAL OF NANOMEDICINE 5520 2% 1% 29
8 ADVANCED DRUG DELIVERY REVIEWS 3465 1% 1% 21
9 NANOMEDICINE 3387 1% 1% 14
10 EXPERT OPINION ON DRUG DELIVERY 3323 1% 1% 13

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 BLOOD BRAIN BARRIER 629702 34% 6% 489 Search BLOOD+BRAIN+BARRIER Search BLOOD+BRAIN+BARRIER
2 BRAIN TARGETING 598680 5% 36% 79 Search BRAIN+TARGETING Search BRAIN+TARGETING
3 BRAIN DELIVERY 279068 3% 31% 42 Search BRAIN+DELIVERY Search BRAIN+DELIVERY
4 ANGIOPEP 2 259739 1% 88% 14 Search ANGIOPEP+2 Search ANGIOPEP+2
5 OX26 150778 1% 89% 8 Search OX26 Search OX26
6 ANGIOPEP 129869 0% 88% 7 Search ANGIOPEP Search ANGIOPEP
7 GLIOMA TARGETING 129869 0% 88% 7 Search GLIOMA+TARGETING Search GLIOMA+TARGETING
8 TRANSFERRIN RECEPTOR 129049 5% 8% 76 Search TRANSFERRIN+RECEPTOR Search TRANSFERRIN+RECEPTOR
9 RECEPTOR MEDIATED TRANSCYTOSIS 111588 1% 53% 10 Search RECEPTOR+MEDIATED+TRANSCYTOSIS Search RECEPTOR+MEDIATED+TRANSCYTOSIS
10 BLOOD BRAIN BARRIER BBB 109367 2% 15% 34 Search BLOOD+BRAIN+BARRIER+BBB Search BLOOD+BRAIN+BARRIER+BBB

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 KREUTER, J , (2014) DRUG DELIVERY TO THE CENTRAL NERVOUS SYSTEM BY POLYMERIC NANOPARTICLES: WHAT DO WE KNOW?.ADVANCED DRUG DELIVERY REVIEWS. VOL. 71. ISSUE . P. 2 -14 88 69% 102
2 OLLER-SALVIA, B , SANCHEZ-NAVARRO, M , GIRALT, E , TEIXIDO, M , (2016) BLOOD-BRAIN BARRIER SHUTTLE PEPTIDES: AN EMERGING PARADIGM FOR BRAIN DELIVERY.CHEMICAL SOCIETY REVIEWS. VOL. 45. ISSUE 17. P. 4690 -4707 96 55% 4
3 WOHLFART, S , GELPERINA, S , KREUTER, J , (2012) TRANSPORT OF DRUGS ACROSS THE BLOOD-BRAIN BARRIER BY NANOPARTICLES.JOURNAL OF CONTROLLED RELEASE. VOL. 161. ISSUE 2. P. 264-273 64 65% 150
4 LAJOIE, JM , SHUSTA, EV , (2015) TARGETING RECEPTOR-MEDIATED TRANSPORT FOR DELIVERY OF BIOLOGICS ACROSS THE BLOOD-BRAIN BARRIER.ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 55. VOL. 55. ISSUE . P. 613 -631 70 60% 16
5 JONES, AR , SHUSTA, EV , (2007) BLOOD-BRAIN BARRIER TRANSPORT OF THERAPEUTICS VIA RECEPTOR-MEDIATION.PHARMACEUTICAL RESEARCH. VOL. 24. ISSUE 9. P. 1759-1771 63 68% 142
6 TOSI, G , MUSUMECI, T , RUOZI, B , CARBONE, C , BELLETTI, D , PIGNATELLO, R , VANDELLI, MA , PUGLISI, G , (2016) THE "FATE" OF POLYMERIC AND LIPID NANOPARTICLES FOR BRAIN DELIVERY AND TARGETING: STRATEGIES AND MECHANISM OF BLOOD-BRAIN BARRIER CROSSING AND TRAFFICKING INTO THE CENTRAL NERVOUS SYSTEM.JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY. VOL. 32. ISSUE . P. 66 -76 58 62% 2
7 COSTANTINO, L , BORASCHI, D , (2012) IS THERE A CLINICAL FUTURE FOR POLYMERIC NANOPARTICLES AS BRAIN-TARGETING DRUG DELIVERY AGENTS?.DRUG DISCOVERY TODAY. VOL. 17. ISSUE 7-8. P. 367-378 73 53% 30
8 MALAKOUTIKHAH, M , TEIXIDO, M , GIRALT, E , (2011) SHUTTLE-MEDIATED DRUG DELIVERY TO THE BRAIN.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. VOL. 50. ISSUE 35. P. 7998 -8014 70 56% 26
9 TRAPASSO, E , PAOLINO, D , CELIA, C , CARAFA, M , FRESTA, M , COSCO, D , DI MARZIO, L , MARIANECCI, C , (2014) COLLOIDAL SUPRAMOLECULAR AGGREGATES FOR THERAPEUTIC APPLICATION IN NEUROMEDICINE.CURRENT MEDICINAL CHEMISTRY. VOL. 21. ISSUE 36. P. 4132 -4153 92 42% 3
10 KREUTER, J , (2013) MECHANISM OF POLYMERIC NANOPARTICLE-BASED DRUG TRANSPORT ACROSS THE BLOOD-BRAIN BARRIER (BBB).JOURNAL OF MICROENCAPSULATION. VOL. 30. ISSUE 1. P. 49-54 36 88% 37

Classes with closest relation at Level 1


Rank Class id link
1 23064 FOCUSED ULTRASOUND//BLOOD BRAIN BARRIER OPENING//BLOOD BRAIN BARRIER DISRUPTION
2 14667 CONVECTION ENHANCED DELIVERY//FUNCT NEUROSURG GRP//INTRATUMORAL DRUG DELIVERY
3 4989 BLOOD BRAIN BARRIER//BBB//TIGHT JUNCTION
4 26650 NANOART//PHARMACEUT NANOMAT SCI//PHARMACOL EXPT NEUROSCI
5 33987 LIPID NANOCAPSULES//U646//U1066
6 13359 POLYALKYLCYANOACRYLATE//POLYBUTYLCYANOACRYLATE//POLYETHYLCYANOACRYLATE
7 36748 1 2 3 THIADIAZOLE 4 CARBOXYLIC ACID//BOVINE PANCREATIC PROTEINASE INHIBITOR//CAPTURE COMPETITION ELISA
8 12145 RMP 7//INTRACAROTID CHEMOTHERAPY//BLOOD TUMOR BARRIER
9 9553 CANCER NANOTECHNOLOGY//SHENZHEN GENE ANTIBODY THER Y//NANOSCI NANOENGN INITIAT NUSNNI
10 3809 SOLID LIPID NANOPARTICLES//NANOSTRUCTURED LIPID CARRIERS//LIPID NANOPARTICLES

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