Class information for:
Level 1: 5 LIPOXYGENASE//LEUKOTRIENES//5 LIPOXYGENASE ACTIVATING PROTEIN

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
3852 1895 39.0 86%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
275 3       NSAIDS//CYCLOOXYGENASE//CYCLOOXYGENASE 2 43399
566 2             EPOXYEICOSATRIENOIC ACIDS//LIPOXYGENASE//LEUKOTRIENES 14430
3852 1                   5 LIPOXYGENASE//LEUKOTRIENES//5 LIPOXYGENASE ACTIVATING PROTEIN 1895

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 5 LIPOXYGENASE authKW 1022961 12% 28% 223
2 LEUKOTRIENES authKW 750425 15% 16% 293
3 5 LIPOXYGENASE ACTIVATING PROTEIN authKW 494289 2% 65% 47
4 LEUKOTRIENE A4 HYDROLASE authKW 452240 2% 70% 40
5 CHEM 2 address 327893 3% 38% 53
6 BLT2 authKW 299359 1% 77% 24
7 LEUKOTRIENE B 4 authKW 251140 5% 15% 101
8 ALOX5AP authKW 200552 1% 66% 19
9 LEUKOTRIENE A4 authKW 196404 1% 76% 16
10 5 LIPOXYGENASE ACTIVATING PROTEIN FLAP authKW 161119 1% 100% 10

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 4163 40% 0% 764
2 Chemistry, Medicinal 2111 11% 0% 199
3 Cell Biology 1258 15% 0% 281
4 Biophysics 1109 10% 0% 184
5 Immunology 1031 13% 0% 242
6 Pharmacology & Pharmacy 1021 16% 0% 298
7 Medicine, Research & Experimental 337 6% 0% 116
8 Hematology 309 5% 0% 89
9 Endocrinology & Metabolism 253 6% 0% 108
10 Respiratory System 224 3% 0% 65

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CHEM 2 327893 3% 38% 53
2 PHYSIOL CHEM 2 141250 3% 18% 50
3 CHAIR PHARMACEUT MED CHEM 112755 1% 33% 21
4 MED BIOCHEM BIOPHYS 89265 7% 4% 135
5 PHARMACEUT ANALYT 72477 1% 25% 18
6 PHARMACEUT CHEM ZAFES 50183 0% 35% 9
7 RECH INFLAMMAT IMMUNOL RHUMATOL 42962 0% 67% 4
8 CARDIOPULM PHARMACOL 39534 0% 27% 9
9 AFFILIATED CLIN 4 32224 0% 100% 2
10 ARRHENIUS A4 32224 0% 100% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ADVANCES IN PROSTAGLANDIN THROMBOXANE AND LEUKOTRIENE RESEARCH 30868 2% 5% 39
2 JOURNAL OF LIPID MEDIATORS 17024 1% 6% 17
3 PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS 7017 2% 1% 37
4 PROSTAGLANDINS & OTHER LIPID MEDIATORS 5990 1% 1% 26
5 BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 3712 1% 1% 25
6 PROSTAGLANDINS 2440 1% 1% 15
7 JOURNAL OF MEDICINAL CHEMISTRY 2106 3% 0% 54
8 JOURNAL OF LIPID MEDIATORS AND CELL SIGNALLING 1444 0% 2% 5
9 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 1397 3% 0% 48
10 JOURNAL OF BIOLOGICAL CHEMISTRY 1338 6% 0% 119

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 5 LIPOXYGENASE 1022961 12% 28% 223 Search 5+LIPOXYGENASE Search 5+LIPOXYGENASE
2 LEUKOTRIENES 750425 15% 16% 293 Search LEUKOTRIENES Search LEUKOTRIENES
3 5 LIPOXYGENASE ACTIVATING PROTEIN 494289 2% 65% 47 Search 5+LIPOXYGENASE+ACTIVATING+PROTEIN Search 5+LIPOXYGENASE+ACTIVATING+PROTEIN
4 LEUKOTRIENE A4 HYDROLASE 452240 2% 70% 40 Search LEUKOTRIENE+A4+HYDROLASE Search LEUKOTRIENE+A4+HYDROLASE
5 BLT2 299359 1% 77% 24 Search BLT2 Search BLT2
6 LEUKOTRIENE B 4 251140 5% 15% 101 Search LEUKOTRIENE+B+4 Search LEUKOTRIENE+B+4
7 ALOX5AP 200552 1% 66% 19 Search ALOX5AP Search ALOX5AP
8 LEUKOTRIENE A4 196404 1% 76% 16 Search LEUKOTRIENE+A4 Search LEUKOTRIENE+A4
9 5 LIPOXYGENASE ACTIVATING PROTEIN FLAP 161119 1% 100% 10 Search 5+LIPOXYGENASE+ACTIVATING+PROTEIN+FLAP Search 5+LIPOXYGENASE+ACTIVATING+PROTEIN+FLAP
10 LTA4 HYDROLASE 128887 1% 67% 12 Search LTA4+HYDROLASE Search LTA4+HYDROLASE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 HAEGGSTROM, JZ , FUNK, CD , (2011) LIPOXYGENASE AND LEUKOTRIENE PATHWAYS: BIOCHEMISTRY, BIOLOGY, AND ROLES IN DISEASE.CHEMICAL REVIEWS. VOL. 111. ISSUE 10. P. 5866 -5898 221 50% 196
2 BACK, M , (2009) INHIBITORS OF THE 5-LIPOXYGENASE PATHWAY IN ATHEROSCLEROSIS.CURRENT PHARMACEUTICAL DESIGN. VOL. 15. ISSUE 27. P. 3116 -3132 121 65% 19
3 RADMARK, O , WERZ, O , STEINHILBER, D , SAMUELSSON, B , (2015) 5-LIPOXYGENASE, A KEY ENZYME FOR LEUKOTRIENE BIOSYNTHESIS IN HEALTH AND DISEASE.BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS. VOL. 1851. ISSUE 4. P. 331 -339 72 69% 23
4 RADMARK, O , SAMUELSSON, B , (2007) 5-LIPOXYGENASE: REGULATION AND POSSIBLE INVOLVEMENT IN ATHEROSCLEROSIS.PROSTAGLANDINS & OTHER LIPID MEDIATORS. VOL. 83. ISSUE 3. P. 162-174 87 81% 51
5 DI GENNARO, A , HAEGGSTROM, JZ , (2014) TARGETING LEUKOTRIENE B-4 IN INFLAMMATION.EXPERT OPINION ON THERAPEUTIC TARGETS. VOL. 18. ISSUE 1. P. 79-93 85 72% 8
6 PETERS-GOLDEN, M , BROCK, TG , (2003) 5-LIPOXYGENASE AND FLAP.PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS. VOL. 69. ISSUE 2-3. P. 99-109 90 78% 118
7 CALISKAN, B , BANOGLU, E , (2013) OVERVIEW OF RECENT DRUG DISCOVERY APPROACHES FOR NEW GENERATION LEUKOTRIENE A(4) HYDROLASE INHIBITORS.EXPERT OPINION ON DRUG DISCOVERY. VOL. 8. ISSUE 1. P. 49 -63 69 82% 7
8 DI GENNARO, A , HAEGGSTROM, JZ , (2012) THE LEUKOTRIENES: IMMUNE-MODULATING LIPID MEDIATORS OF DISEASE.ADVANCES IN IMMUNOLOGY, VOL 116. VOL. 116. ISSUE . P. 51-92 96 55% 30
9 RADMARK, O , (2002) ARACHIDONATE 5-LIPOXYGENASE.PROSTAGLANDINS & OTHER LIPID MEDIATORS. VOL. 68-9. ISSUE . P. 211-234 109 65% 66
10 HAEGGSTROM, JZ , WETTERHOLM, A , (2002) ENZYMES AND RECEPTORS IN THE LEUKOTRIENE CASCADE.CELLULAR AND MOLECULAR LIFE SCIENCES. VOL. 59. ISSUE 5. P. 742 -753 92 72% 52

Classes with closest relation at Level 1


Rank Class id link
1 6315 MONTELUKAST//LEUKOTRIENE RECEPTOR ANTAGONIST//CYSTEINYL LEUKOTRIENES
2 17640 12S HETE//LY293111//ZYFLAMEND
3 822 PROSTAGLANDINS//ADVANCES IN PROSTAGLANDIN THROMBOXANE AND LEUKOTRIENE RESEARCH//BAY U9773
4 30350 LICOFELONE//TEPOXALIN//2 2 DIMETHYL 6 4 CHLOROPHENYL 7 PHENYL 2 3 DIHYDRO 1H PYRROLIZINE 5 YL ACETIC ACID
5 1822 LIPOXYGENASE//HYDROPEROXIDE LYASE//15 LIPOXYGENASE
6 8131 EXPT THER EUT REPERFUS INJURY//RESOLVINS//LIPOXINS
7 24950 MEMORY AND LEARNING IMPAIRMENT//GAMMA SECRETASE ACTIVATING PROTEIN//ALZHEIMER KOR KUTATOCSOPORT
8 24065 5 OXO ETE//HEPOXILIN A3//CLAUDE PEPPER
9 19756 MPGES 1//PROSTAGLANDIN E SYNTHASE//MPGES 1 INHIBITORS
10 13461 DGLA//15 HETRE//DIHOMO GAMMA LINOLENIC ACID

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