Class information for:
Level 1: 12S HETE//LY293111//ZYFLAMEND

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
17640 589 43.5 86%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
275 3       NSAIDS//CYCLOOXYGENASE//CYCLOOXYGENASE 2 43399
566 2             EPOXYEICOSATRIENOIC ACIDS//LIPOXYGENASE//LEUKOTRIENES 14430
17640 1                   12S HETE//LY293111//ZYFLAMEND 589

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 12S HETE authKW 338683 2% 47% 14
2 LY293111 authKW 331782 1% 80% 8
3 ZYFLAMEND authKW 207366 1% 100% 4
4 12 LIPOXYGENASE authKW 191679 4% 15% 25
5 BIOMIDE S address 155525 1% 100% 3
6 CYSLT2R authKW 138241 1% 67% 4
7 5 LIPOXYGENASE authKW 133988 8% 6% 45
8 MK 886 authKW 122361 2% 20% 12
9 5 OXOETE authKW 103683 0% 100% 2
10 CYSTEINYLLT1R authKW 103683 0% 100% 2

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Oncology 3062 38% 0% 223
2 Cell Biology 1062 23% 0% 135
3 Biochemistry & Molecular Biology 754 32% 0% 189
4 Medicine, Research & Experimental 572 13% 0% 74
5 Biophysics 197 8% 0% 45
6 Endocrinology & Metabolism 102 6% 0% 37
7 Pharmacology & Pharmacy 33 7% 0% 42
8 Gastroenterology & Hepatology 32 3% 0% 18
9 Biology 20 2% 0% 14
10 Physiology 17 3% 0% 17

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOMIDE S 155525 1% 100% 3
2 GASTROINTESTINAL ONCOL S 103683 0% 100% 2
3 CELL EXPT PATHOL 80995 1% 31% 5
4 LUMINAL GASTROENTEROL 69121 0% 67% 2
5 GERSHENSON RADIAT ONCOL 60842 2% 13% 9
6 PATHOL EXPTL CANC 1 58318 1% 38% 3
7 ALLGEMEINCHIRURG VISCERALCHIRURG 51842 0% 100% 1
8 ANIM PHYSIOL GEN ZOOL 51842 0% 100% 1
9 BIOCHEM BIONFORMAT 51842 0% 100% 1
10 BIOTECHNOL BIOCHEM MICROBIOL 51842 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS 7307 4% 1% 21
2 ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY 3173 5% 0% 32
3 CANCER PREVENTION RESEARCH 2699 1% 1% 8
4 PROSTAGLANDINS & OTHER LIPID MEDIATORS 1824 1% 0% 8
5 EXPERIMENTAL CELL RESEARCH 894 3% 0% 15
6 INTERNATIONAL JOURNAL OF CANCER 807 3% 0% 18
7 CANCER AND METASTASIS REVIEWS 674 1% 0% 4
8 CLINICAL PHYSIOLOGY AND BIOCHEMISTRY 650 0% 1% 2
9 CANCER RESEARCH 611 4% 0% 22
10 VETERINARY AND COMPARATIVE ONCOLOGY 569 0% 1% 2

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 12S HETE 338683 2% 47% 14 Search 12S+HETE Search 12S+HETE
2 LY293111 331782 1% 80% 8 Search LY293111 Search LY293111
3 ZYFLAMEND 207366 1% 100% 4 Search ZYFLAMEND Search ZYFLAMEND
4 12 LIPOXYGENASE 191679 4% 15% 25 Search 12+LIPOXYGENASE Search 12+LIPOXYGENASE
5 CYSLT2R 138241 1% 67% 4 Search CYSLT2R Search CYSLT2R
6 5 LIPOXYGENASE 133988 8% 6% 45 Search 5+LIPOXYGENASE Search 5+LIPOXYGENASE
7 MK 886 122361 2% 20% 12 Search MK+886 Search MK+886
8 5 OXOETE 103683 0% 100% 2 Search 5+OXOETE Search 5+OXOETE
9 CYSTEINYLLT1R 103683 0% 100% 2 Search CYSTEINYLLT1R Search CYSTEINYLLT1R
10 CYSTEINYLLT1R ANTAGONIST 103683 0% 100% 2 Search CYSTEINYLLT1R+ANTAGONIST Search CYSTEINYLLT1R+ANTAGONIST

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 STEINHILBER, D , FISCHER, AS , METZNER, J , STEINBRINK, SD , ROOS, J , RUTHARDT, M , MAIER, TJ , (2010) 5-LIPOXYGENASE: UNDERAPPRECIATED ROLE OF A PRO-INFLAMMATORY ENZYME IN TUMORIGENESIS.FRONTIERS IN PHARMACOLOGY. VOL. 1. ISSUE . P. - 38 58% 10
2 MELSTROM, LG , BENTREM, DJ , SALABAT, MR , KENNEDY, TJ , DING, XZ , STROUCH, M , RAO, SM , WITT, RC , TERNENT, CA , TALAMONTI, MS , ET AL (2008) OVEREXPRESSION OF 5-LIPOXYGENASE IN COLON POLYPS AND CANCER AND THE EFFECT OF 5-LOX INHIBITORS IN VITRO AND IN A MURINE MODEL.CLINICAL CANCER RESEARCH. VOL. 14. ISSUE 20. P. 6525-6530 27 77% 61
3 CHEN, XX , SOOD, S , YANG, CS , LI, N , SUN, Z , (2006) FIVE-LIPOXYGENASE PATHWAY OF ARACHIDONIC ACID METABOLISM IN CARCINOGENESIS AND CANCER CHEMOPREVENTION.CURRENT CANCER DRUG TARGETS. VOL. 6. ISSUE 7. P. 613-622 52 33% 34
4 GUO, YD , ZHANG, WL , GIROUX, C , CAI, YL , EKAMBARAM, P , DILLY, AK , HSU, A , ZHOU, SL , MADDIPATI, KR , LIU, JJ , ET AL (2011) IDENTIFICATION OF THE ORPHAN G PROTEIN-COUPLED RECEPTOR GPR31 AS A RECEPTOR FOR 12-(S)-HYDROXYEICOSATETRAENOIC ACID.JOURNAL OF BIOLOGICAL CHEMISTRY. VOL. 286. ISSUE 39. P. 33832-33840 21 66% 43
5 DILLY, AK , EKAMBARAM, P , GUO, YD , CAI, YL , TUCKER, SC , FRIDMAN, R , KANDOUZ, M , HONN, KV , (2013) PLATELET-TYPE 12-LIPOXYGENASE INDUCES MMP9 EXPRESSION AND CELLULAR INVASION VIA ACTIVATION OF PI3K/AKT/NF-B.INTERNATIONAL JOURNAL OF CANCER. VOL. 133. ISSUE 8. P. 1784-1791 18 67% 19
6 MORENO, JJ , (2009) NEW ASPECTS OF THE ROLE OF HYDROXYEICOSATETRAENOIC ACIDS IN CELL GROWTH AND CANCER DEVELOPMENT.BIOCHEMICAL PHARMACOLOGY. VOL. 77. ISSUE 1. P. 1-10 33 33% 77
7 YOSHIMURA, R , INOUE, K , KAWAHITO, Y , MITSUHASHI, M , TSUCHIDA, K , MATSUYAMA, M , SANO, H , NAKATANI, T , (2004) EXPRESSION OF 12-LIPOXYGENASE IN HUMAN RENAL CELL CARCINOMA AND GROWTH PREVENTION BY ITS INHIBITOR.INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. VOL. 13. ISSUE 1. P. 41-46 18 78% 22
8 XU, XM , DENG, JJ , YUAN, GJ , YANG, F , GUO, HT , XIANG, M , GE, W , WU, YG , (2011) 5-LIPOXYGENASE CONTRIBUTES TO THE PROGRESSION OF HEPATOCELLULAR CARCINOMA.MOLECULAR MEDICINE REPORTS. VOL. 4. ISSUE 6. P. 1195-1200 16 70% 5
9 ZHOU, GX , DING, XL , WU, SB , ZHANG, HF , CAO, W , QU, LS , ZHANG, H , (2015) INHIBITION OF 5-LIPOXYGENASE TRIGGERS APOPTOSIS IN PANCREATIC CANCER CELLS.ONCOLOGY REPORTS. VOL. 33. ISSUE 2. P. 661 -668 18 53% 3
10 HONN, KV , GUO, YD , CAI, YL , LEE, MJ , DYSON, G , ZHANG, WL , TUCKER, SC , (2016) 12-HETER1/GPR31, A HIGH-AFFINITY 12(S)-HYDROXYEICOSATETRAENOIC ACID RECEPTOR, IS SIGNIFICANTLY UP-REGULATED IN PROSTATE CANCER AND PLAYS A CRITICAL ROLE IN PROSTATE CANCER PROGRESSION.FASEB JOURNAL. VOL. 30. ISSUE 6. P. 2360 -2369 25 38% 0

Classes with closest relation at Level 1


Rank Class id link
1 27621 NORDIHYDROGUAIARETIC ACID//NDGA//LARREA DIVARICATA CAV
2 3852 5 LIPOXYGENASE//LEUKOTRIENES//5 LIPOXYGENASE ACTIVATING PROTEIN
3 21584 13 OXOOCTADECADIENOIC ACID//13 HODE//HYDROXY OCTADECADIENOIC ACID
4 1822 LIPOXYGENASE//HYDROPEROXIDE LYASE//15 LIPOXYGENASE
5 30350 LICOFELONE//TEPOXALIN//2 2 DIMETHYL 6 4 CHLOROPHENYL 7 PHENYL 2 3 DIHYDRO 1H PYRROLIZINE 5 YL ACETIC ACID
6 12187 CANCER PROCOAGULANT//TUMOR PROCOAGULANT//CANCER CELL DERIVED BLOOD COAGULATING ACTIVITY 1
7 24065 5 OXO ETE//HEPOXILIN A3//CLAUDE PEPPER
8 23913 PTGS2//CYCLOOXYGENASE 2 GENE//COX 2 POLYMORPHISM
9 3973 MED PHYSIOL UNIT//GAMMA LINOLENIC ACID//DOCOSAHEXAENOIC ACID
10 180 CYCLOOXYGENASE 2//COX 2//CELECOXIB

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