Class information for:
Level 1: ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT//ANTISENSE OLIGONUCLEOTIDES//ANTISENSE RESEARCH AND DEVELOPMENT

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
2407 2255 40.3 80%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
5 4 CHEMISTRY, ORGANIC//CHEMISTRY, INORGANIC & NUCLEAR//CHEMISTRY, MULTIDISCIPLINARY 1745167
183 3       APTAMER//G QUADRUPLEX//RIBOZYME 56307
389 2             NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS//OLIGONUCLEOTIDES//PEPTIDE NUCLEIC ACID 16949
2407 1                   ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT//ANTISENSE OLIGONUCLEOTIDES//ANTISENSE RESEARCH AND DEVELOPMENT 2255

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT journal 586867 6% 34% 127
2 ANTISENSE OLIGONUCLEOTIDES authKW 388163 9% 13% 213
3 ANTISENSE RESEARCH AND DEVELOPMENT journal 309437 2% 57% 40
4 ANTISENSE authKW 295248 10% 10% 215
5 PHOSPHOROTHIOATE authKW 250368 3% 25% 74
6 OLIGONUCLEOTIDES authKW 223059 9% 8% 213
7 OLIGODEOXYNUCLEOTIDE authKW 109416 2% 15% 55
8 PHOSPHOROTHIOATE OLIGONUCLEOTIDES authKW 101174 1% 36% 21
9 ANTISENSE OLIGODEOXYNUCLEOTIDE authKW 97189 2% 13% 55
10 C 5 PROPYNE authKW 54158 0% 100% 4

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 5999 44% 0% 988
2 Medicine, Research & Experimental 2453 13% 0% 298
3 Pharmacology & Pharmacy 2318 21% 0% 464
4 Biotechnology & Applied Microbiology 2136 14% 0% 320
5 Chemistry, Medicinal 479 5% 0% 114
6 Biochemical Research Methods 468 6% 0% 129
7 Oncology 455 9% 0% 212
8 Biophysics 233 5% 0% 108
9 Virology 225 3% 0% 66
10 Hematology 105 3% 0% 66

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ASTON GENE BASED THER EUT 27079 0% 100% 2
2 JIANGXI OAI GEMEINSAMES 27079 0% 100% 2
3 PSYCHIAT 6214 27079 0% 100% 2
4 STELLAR CHANCE S 513B 27079 0% 100% 2
5 CHEM G 838 27075 0% 50% 4
6 BIOTECHNOL BASED MED 18051 0% 67% 2
7 CHIM THER EUT RADIOPHARM 18051 0% 67% 2
8 GRP DRUG TARGETING DELIVERY POORLY STABLE CPDS 18051 0% 67% 2
9 IFR PATHOL INFECT INSERM U386 18051 0% 67% 2
10 UCL 7541 18051 0% 67% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT 586867 6% 34% 127
2 ANTISENSE RESEARCH AND DEVELOPMENT 309437 2% 57% 40
3 NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS 25012 4% 2% 93
4 NUCLEIC ACID THERAPEUTICS 13616 1% 6% 16
5 ANTI-CANCER DRUG DESIGN 13448 1% 4% 25
6 OLIGONUCLEOTIDES 12855 1% 6% 16
7 CURRENT OPINION IN MOLECULAR THERAPEUTICS 11254 1% 3% 27
8 NUCLEIC ACIDS RESEARCH 8704 7% 0% 161
9 ANTIVIRAL RESEARCH 1853 1% 1% 22
10 JOURNAL OF DRUG TARGETING 1681 1% 1% 14

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 ANTISENSE OLIGONUCLEOTIDES 388163 9% 13% 213 Search ANTISENSE+OLIGONUCLEOTIDES Search ANTISENSE+OLIGONUCLEOTIDES
2 ANTISENSE 295248 10% 10% 215 Search ANTISENSE Search ANTISENSE
3 PHOSPHOROTHIOATE 250368 3% 25% 74 Search PHOSPHOROTHIOATE Search PHOSPHOROTHIOATE
4 OLIGONUCLEOTIDES 223059 9% 8% 213 Search OLIGONUCLEOTIDES Search OLIGONUCLEOTIDES
5 OLIGODEOXYNUCLEOTIDE 109416 2% 15% 55 Search OLIGODEOXYNUCLEOTIDE Search OLIGODEOXYNUCLEOTIDE
6 PHOSPHOROTHIOATE OLIGONUCLEOTIDES 101174 1% 36% 21 Search PHOSPHOROTHIOATE+OLIGONUCLEOTIDES Search PHOSPHOROTHIOATE+OLIGONUCLEOTIDES
7 ANTISENSE OLIGODEOXYNUCLEOTIDE 97189 2% 13% 55 Search ANTISENSE+OLIGODEOXYNUCLEOTIDE Search ANTISENSE+OLIGODEOXYNUCLEOTIDE
8 C 5 PROPYNE 54158 0% 100% 4 Search C+5+PROPYNE Search C+5+PROPYNE
9 PHOSPHOROTHIOATE OLIGODEOXYNUCLEOTIDES 44305 0% 55% 6 Search PHOSPHOROTHIOATE+OLIGODEOXYNUCLEOTIDES Search PHOSPHOROTHIOATE+OLIGODEOXYNUCLEOTIDES
10 RNASE H 43996 1% 12% 28 Search RNASE+H Search RNASE+H

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 CROOKE, ST , (2004) PROGRESS IN ANTISENSE TECHNOLOGY.ANNUAL REVIEW OF MEDICINE. VOL. 55. ISSUE . P. 61-95 85 68% 297
2 GARCIA-CHAUMONT, C , SEKSEK, O , GRZYBOWSKA, J , BOROWSKI, E , BOLARD, J , (2000) DELIVERY SYSTEMS FOR ANTISENSE OLIGONUCLEOTIDES.PHARMACOLOGY & THERAPEUTICS. VOL. 87. ISSUE 2-3. P. 255 -277 120 65% 76
3 CROOKE, ST , (2000) PROGRESS IN ANTISENSE TECHNOLOGY: THE END OF THE BEGINNING.ANTISENSE TECHNOLOGY, PT A. VOL. 313. ISSUE . P. 3 -45 97 67% 121
4 DIAS, N , STEIN, CA , (2002) ANTISENSE OLIGONUCLEOTIDES: BASIC CONCEPTS AND MECHANISMS.MOLECULAR CANCER THERAPEUTICS. VOL. 1. ISSUE 5. P. 347-355 66 59% 353
5 CROOKE, ST , (2004) ANTISENSE STRATEGIES.CURRENT MOLECULAR MEDICINE. VOL. 4. ISSUE 5. P. 465 -487 73 61% 93
6 STEIN, CA , CHENG, YC , (1993) ANTISENSE OLIGONUCLEOTIDES AS THERAPEUTIC AGENTS - IS THE BULLET REALLY MAGICAL.SCIENCE. VOL. 261. ISSUE 5124. P. 1004-1012 62 51% 1235
7 LEBEDEVA, IV , STEIN, CA , (2000) ANTISENSE OLIGONUCLEOTIDES IN CANCER - RECENT ADVANCES.BIODRUGS. VOL. 13. ISSUE 3. P. 195 -216 106 51% 11
8 CROOKE, ST , BENNETT, CF , (1996) PROGRESS IN ANTISENSE OLIGONUCLEOTIDE THERAPEUTIC.ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY. VOL. 36. ISSUE . P. 107-129 83 55% 239
9 CROOKE, ST , (1998) ANTISENSE THERAPEUTICS.BIOTECHNOLOGY & GENETIC ENGINEERING REVIEWS, VOL. 15. VOL. 15. ISSUE . P. 121 -157 92 57% 53
10 GEWIRTZ, AM , SOKOL, DL , RATAJCZAK, MZ , (1998) NUCLEIC ACID THERAPEUTICS: STATE OF THE ART AND FUTURE PROSPECTS.BLOOD. VOL. 92. ISSUE 3. P. 712 -736 99 44% 187

Classes with closest relation at Level 1


Rank Class id link
1 29317 AOGEN//BRADYTROPHIC PHENOCOPY//CONTROL OF TRANSGENE EXPRESSION
2 4600 NUCLE ACID//SYNTHET BIOORGAN CHEM//NUCL ACID
3 17872 EXON SKIPPING//MC LOCKWOOD MUSCULAR DYSTROPHY//NEUROMUSCULAR ALS
4 17788 NOVOSIBIRSK BIOORGAN CHEM//OLIGONUCLEOTIDE DERIVATIVES//PHOTOAFFINITY MODIFICATION
5 19375 OBLIMERSEN//G3139//ANTISENSE BCL 2
6 1458 NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS//H PHOSPHONATES//BORANOPHOSPHATE
7 24918 TRANSCRIPTION FACTOR DECOY//DECOY//NF KAPPA B DECOY
8 3100 TRIPLEX DNA//TRIPLEX//DNA TRIPLEX
9 9258 OLIGONUCLEOTIDE PEPTIDE CONJUGATES//NUCLEOPEPTIDES//PEPTIDE OLIGONUCLEOTIDE CONJUGATE
10 4649 CPG ODN//CPG MOTIF//CPG DNA

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