Class information for:
Level 1: CPG ODN//CPG MOTIF//CPG DNA

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
4649 1749 44.4 92%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
449 3       FAMILIAL MEDITERRANEAN FEVER//TOLL LIKE RECEPTORS//INFLAMMASOME 25887
543 2             TOLL LIKE RECEPTORS//INNATE IMMUNITY//CPG ODN 14712
4649 1                   CPG ODN//CPG MOTIF//CPG DNA 1749

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CPG ODN authKW 1459238 10% 48% 173
2 CPG MOTIF authKW 1088779 6% 58% 108
3 CPG DNA authKW 914026 5% 55% 96
4 CPG OLIGODEOXYNUCLEOTIDES authKW 878242 5% 59% 86
5 TLR9 authKW 438717 5% 26% 95
6 CPG OLIGONUCLEOTIDE authKW 397567 3% 52% 44
7 SECT RETROVIRAL IMMUNOL address 362427 2% 59% 35
8 CPG authKW 325337 6% 17% 107
9 TOLL LIKE RECEPTOR 9 authKW 269992 3% 26% 59
10 IMMUNOSTIMULATORY DNA authKW 196384 1% 75% 15

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Immunology 22775 54% 0% 950
2 Medicine, Research & Experimental 2282 14% 0% 251
3 Allergy 1097 4% 0% 68
4 Oncology 386 10% 0% 170
5 Pharmacology & Pharmacy 228 9% 0% 162
6 Cell Biology 210 8% 0% 134
7 Veterinary Sciences 159 4% 0% 78
8 Biochemistry & Molecular Biology 143 12% 0% 214
9 Biotechnology & Applied Microbiology 137 5% 0% 92
10 Hematology 116 3% 0% 58

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 SECT RETROVIRAL IMMUNOL 362427 2% 59% 35
2 SECT RETROVIRAL 162481 1% 85% 11
3 BIOPHARMACEUT DRUG METAB 134612 2% 21% 36
4 SAM ROSE STEIN AGING 85888 2% 15% 32
5 VACCINE INFECT DIS ORG 39923 2% 8% 30
6 SECT RADIAT MED 39277 0% 75% 3
7 MED MICROBIOL IMMUNOL HYG 37320 2% 5% 43
8 FDN MOL BIOL BIOINFORMAT 36363 0% 42% 5
9 COLEY PHARMACEUT GRP 34914 0% 100% 2
10 ERATO MICROBIAL DIS 34914 0% 100% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT 15170 1% 5% 18
2 JOURNAL OF IMMUNOLOGY 8743 9% 0% 165
3 VACCINE 7896 5% 1% 91
4 NUCLEIC ACID THERAPEUTICS 6854 1% 4% 10
5 SPRINGER SEMINARS IN IMMUNOPATHOLOGY 6712 1% 2% 17
6 OLIGONUCLEOTIDES 6470 1% 4% 10
7 INTERNATIONAL IMMUNOPHARMACOLOGY 4349 2% 1% 33
8 VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY 4076 2% 1% 36
9 EUROPEAN JOURNAL OF IMMUNOLOGY 3659 3% 0% 53
10 CURRENT OPINION IN MOLECULAR THERAPEUTICS 2398 1% 1% 11

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 CPG ODN 1459238 10% 48% 173 Search CPG+ODN Search CPG+ODN
2 CPG MOTIF 1088779 6% 58% 108 Search CPG+MOTIF Search CPG+MOTIF
3 CPG DNA 914026 5% 55% 96 Search CPG+DNA Search CPG+DNA
4 CPG OLIGODEOXYNUCLEOTIDES 878242 5% 59% 86 Search CPG+OLIGODEOXYNUCLEOTIDES Search CPG+OLIGODEOXYNUCLEOTIDES
5 TLR9 438717 5% 26% 95 Search TLR9 Search TLR9
6 CPG OLIGONUCLEOTIDE 397567 3% 52% 44 Search CPG+OLIGONUCLEOTIDE Search CPG+OLIGONUCLEOTIDE
7 CPG 325337 6% 17% 107 Search CPG Search CPG
8 TOLL LIKE RECEPTOR 9 269992 3% 26% 59 Search TOLL+LIKE+RECEPTOR+9 Search TOLL+LIKE+RECEPTOR+9
9 IMMUNOSTIMULATORY DNA 196384 1% 75% 15 Search IMMUNOSTIMULATORY+DNA Search IMMUNOSTIMULATORY+DNA
10 OLIGODEOXYNUCLEOTIDE 156922 3% 16% 58 Search OLIGODEOXYNUCLEOTIDE Search OLIGODEOXYNUCLEOTIDE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 KRIEG, AM , (2002) CPG MOTIFS IN BACTERIAL DNA AND THEIR IMMUNE EFFECTS.ANNUAL REVIEW OF IMMUNOLOGY. VOL. 20. ISSUE . P. 709 -760 163 60% 1613
2 KRIEG, AM , (2006) THERAPEUTIC POTENTIAL OF TOLL-LIKE RECEPTOR 9 ACTIVATION.NATURE REVIEWS DRUG DISCOVERY. VOL. 5. ISSUE 6. P. 471-484 123 65% 624
3 VOLLMER, J , KRIEG, AM , (2009) IMMUNOTHERAPEUTIC APPLICATIONS OF CPG OLIGODEOXYNUCLEOTIDE TLR9 AGONISTS.ADVANCED DRUG DELIVERY REVIEWS. VOL. 61. ISSUE 3. P. 195 -204 109 63% 215
4 WILSON, HL , DAR, A , NAPPER, SK , LOPEZ, AM , BABIUK, LA , MUTWIRI, GK , (2006) IMMUNE MECHANISMS AND THERAPEUTIC POTENTIAL OF CPG OLIGODEOXYNUCLEOTIDES.INTERNATIONAL REVIEWS OF IMMUNOLOGY. VOL. 25. ISSUE 3-4. P. 183 -213 122 77% 36
5 JURK, M , VOLLMER, J , (2007) THERAPEUTIC APPLICATIONS OF SYNTHETIC CPG OLIGODEOXYNUCLEOTIDES AS TLR9 AGONISTS FOR IMMUNE MODULATION.BIODRUGS. VOL. 21. ISSUE 6. P. 387-401 126 65% 50
6 BODE, C , ZHAO, G , STEINHAGEN, F , KINJO, T , KLINMAN, DM , (2011) CPG DNA AS A VACCINE ADJUVANT.EXPERT REVIEW OF VACCINES. VOL. 10. ISSUE 4. P. 499-511 83 62% 172
7 WANG, H , RAYBURN, E , ZHANG, RW , (2005) SYNTHETIC OLIGODEOXYNUCLEOTIDES CONTAINING DEOXYCYTIDYL-DEOXYGUANOSINE DINUCLEOTIDES (CPG ODNS) AND MODIFIED ANALOGS AS NOVEL ANTICANCER THERAPEUTICS.CURRENT PHARMACEUTICAL DESIGN. VOL. 11. ISSUE 22. P. 2889-2907 109 77% 26
8 UHLMANN, E , VOLLMER, J , (2003) RECENT ADVANCES IN THE DEVELOPMENT OF IMMUNOSTIMULATORY OLIGONUCLEOTIDES.CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT. VOL. 6. ISSUE 2. P. 204-217 108 78% 54
9 MANUJA, A , MANUJA, BK , KAUSHIK, J , SINGHA, H , SINGH, RK , (2013) IMMUNOTHERAPEUTIC POTENTIAL OF CPG OLIGODEOXYNUCLEOTIDES IN VETERINARY SPECIES.IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY. VOL. 35. ISSUE 5. P. 535-544 90 72% 2
10 MUTWIRI, GK , NICHANI, AK , BABIUK, S , BABIUK, LA , (2004) STRATEGIES FOR ENHANCING THE IMMUNOSTIMULATORY EFFECTS OF CPG OLIGODEOXYNUCLEOTIDES.JOURNAL OF CONTROLLED RELEASE. VOL. 97. ISSUE 1. P. 1-17 99 70% 86

Classes with closest relation at Level 1


Rank Class id link
1 4753 TOLL LIKE RECEPTORS//TLR7//TOLL LIKE RECEPTOR 7
2 12735 PLASMACYTOID DENDRITIC CELLS//BDCA 4//PDC
3 13681 TOLL LIKE RECEPTORS//TOLL LIKE RECEPTOR 9//TLR4
4 3573 DNA VACCINE//DNA IMMUNIZATION//DNA VACCINATION
5 2407 ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT//ANTISENSE OLIGONUCLEOTIDES//ANTISENSE RESEARCH AND DEVELOPMENT
6 15523 HETEROPHILS//CHICKEN INTERFERON GAMMA//CHICKEN
7 5170 VACCINE DELIVERY//ADJUVANT//ANTIGEN DELIVERY
8 22844 MYCOBACTERIUM VACCAE//ALLERGEN FREE IMMUNOTHERAPY//HEAT KILLED BCG
9 36064 DERMO EPIDERMAL SEPARATION//INNATE IMMUNITY OF THE SKIN//PERMAFROST MICROORGANISMS
10 18301 NAKED PLASMID DNA//HYDRODYNAMICS BASED TRANSFECTION//HYDRODYNAMIC GENE DELIVERY

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