Class information for:
Level 1: NUCLE ACID//SYNTHET BIOORGAN CHEM//NUCL ACID

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
4600 1758 35.5 79%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
5 4 CHEMISTRY, ORGANIC//CHEMISTRY, INORGANIC & NUCLEAR//CHEMISTRY, MULTIDISCIPLINARY 1745167
183 3       APTAMER//G QUADRUPLEX//RIBOZYME 56307
389 2             NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS//OLIGONUCLEOTIDES//PEPTIDE NUCLEIC ACID 16949
4600 1                   NUCLE ACID//SYNTHET BIOORGAN CHEM//NUCL ACID 1758

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NUCLE ACID address 462914 5% 31% 85
2 SYNTHET BIOORGAN CHEM address 453871 2% 93% 28
3 NUCL ACID address 231515 2% 33% 40
4 BRIDGED NUCLEIC ACIDS authKW 178635 1% 86% 12
5 LOCKED NUCLEIC ACID authKW 165345 2% 24% 40
6 NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS journal 140259 11% 4% 194
7 OLIGONUCLEOTIDES authKW 104889 7% 5% 129
8 ALPHA L LNA authKW 101044 0% 73% 8
9 ANTISENSE AGENTS authKW 99493 1% 30% 19
10 BNA authKW 93778 1% 60% 9

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Organic 14701 41% 0% 728
2 Biochemistry & Molecular Biology 2998 36% 0% 636
3 Chemistry, Medicinal 2483 12% 0% 206
4 Chemistry, Multidisciplinary 1410 20% 0% 360
5 Biophysics 28 3% 0% 46
6 Biochemical Research Methods 13 2% 0% 34
7 Crystallography 11 1% 0% 24
8 Medicine, Research & Experimental 4 2% 0% 32
9 Biotechnology & Applied Microbiology 1 2% 0% 34
10 Medicine, Legal -0 0% 0% 1

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NUCLE ACID 462914 5% 31% 85
2 SYNTHET BIOORGAN CHEM 453871 2% 93% 28
3 NUCL ACID 231515 2% 33% 40
4 NUCLEIC ACID 78933 1% 45% 10
5 SYNTHET BIORGAN CHEM 52103 0% 100% 3
6 SYNTH BIOORGAN CHEM 39076 0% 75% 3
7 2280 FARADAY AVE 34735 0% 100% 2
8 TECHNOL GROWTH 34735 0% 100% 2
9 UNIV CORE DNA SERV 34735 0% 100% 2
10 SYNTH PHYS CHIM MOL INTERET BIOL 32680 0% 24% 8

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS 140259 11% 4% 194
2 NUCLEIC ACID THERAPEUTICS 13375 1% 6% 14
3 NUCLEOSIDES & NUCLEOTIDES 11477 1% 3% 21
4 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 6918 6% 0% 101
5 NUCLEIC ACIDS RESEARCH 6839 7% 0% 126
6 JOURNAL OF ORGANIC CHEMISTRY 5957 8% 0% 134
7 OLIGONUCLEOTIDES 5212 1% 3% 9
8 ORGANIC & BIOMOLECULAR CHEMISTRY 3946 3% 0% 52
9 HELVETICA CHIMICA ACTA 3802 3% 1% 44
10 TETRAHEDRON LETTERS 3740 7% 0% 128

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 BRIDGED NUCLEIC ACIDS 178635 1% 86% 12 Search BRIDGED+NUCLEIC+ACIDS Search BRIDGED+NUCLEIC+ACIDS
2 LOCKED NUCLEIC ACID 165345 2% 24% 40 Search LOCKED+NUCLEIC+ACID Search LOCKED+NUCLEIC+ACID
3 OLIGONUCLEOTIDES 104889 7% 5% 129 Search OLIGONUCLEOTIDES Search OLIGONUCLEOTIDES
4 ALPHA L LNA 101044 0% 73% 8 Search ALPHA+L+LNA Search ALPHA+L+LNA
5 ANTISENSE AGENTS 99493 1% 30% 19 Search ANTISENSE+AGENTS Search ANTISENSE+AGENTS
6 BNA 93778 1% 60% 9 Search BNA Search BNA
7 BICYCLO DNA 69471 0% 100% 4 Search BICYCLO+DNA Search BICYCLO+DNA
8 TRICYCLO DNA 69471 0% 100% 4 Search TRICYCLO+DNA Search TRICYCLO+DNA
9 NUCLEASE RESISTANCE 64207 1% 26% 14 Search NUCLEASE+RESISTANCE Search NUCLEASE+RESISTANCE
10 LNA 61964 2% 10% 35 Search LNA Search LNA

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 WAN, WB , SETH, PP , (2016) THE MEDICINAL CHEMISTRY OF THERAPEUTIC OLIGONUCLEOTIDES.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 59. ISSUE 21. P. 9645 -9667 133 51% 1
2 OBIKA, S , RAHMAN, SMA , FUJISAKA, A , KAWADA, Y , BABA, T , IMANISHI, T , (2010) BRIDGED NUCLEIC ACIDS: DEVELOPMENT, SYNTHESIS AND PROPERTIES.HETEROCYCLES. VOL. 81. ISSUE 6. P. 1347-1392 77 75% 18
3 HERDEWIJN, P , (2010) NUCLEIC ACIDS WITH A SIX-MEMBERED 'CARBOHYDRATE' MIMIC IN THE BACKBONE.CHEMISTRY & BIODIVERSITY. VOL. 7. ISSUE 1. P. 1-59 70 72% 27
4 PRAKASH, TP , (2011) AN OVERVIEW OF SUGAR-MODIFIED OLIGONUCLEOTIDES FOR ANTISENSE THERAPEUTICS.CHEMISTRY & BIODIVERSITY. VOL. 8. ISSUE 9. P. 1616 -1641 63 68% 61
5 ISOBE, H , FUJINO, T , (2014) TRIAZOLE-LINKED ANALOGUES OF DNA AND RNA ((TL)DNA AND (TL)RNA): SYNTHESIS AND FUNCTIONS.CHEMICAL RECORD. VOL. 14. ISSUE 1. P. 41-51 58 74% 5
6 ZHOU, CZ , CHATTOPADHYAYA, J , (2012) INTRAMOLECULAR FREE-RADICAL CYCLIZATION REACTIONS ON PENTOSE SUGARS FOR THE SYNTHESIS OF CARBA-LNA AND CARBA-ENA AND THE APPLICATION OF THEIR MODIFIED OLIGONUCLEOTIDES AS POTENTIAL RNA TARGETED THERAPEUTICS.CHEMICAL REVIEWS. VOL. 112. ISSUE 7. P. 3808 -3832 64 63% 20
7 KAUR, H , BABU, BR , MAITI, S , (2007) PERSPECTIVES ON CHEMISTRY AND THERAPEUTIC APPLICATIONS OF LOCKED NUCLEIC ACID (LNA).CHEMICAL REVIEWS. VOL. 107. ISSUE 11. P. 4672-4697 75 50% 154
8 MELDGAARD, M , WENGEL, J , (2000) BICYCLIC NUCLEOSIDES AND CONFORMATIONAL RESTRICTION OF OLIGONUCLEOTIDES.JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1. VOL. . ISSUE 21. P. 3539 -3554 57 83% 82
9 YAMAMOTO, T , NAKATANI, M , NARUKAWA, K , OBIKA, S , (2011) ANTISENSE DRUG DISCOVERY AND DEVELOPMENT.FUTURE MEDICINAL CHEMISTRY. VOL. 3. ISSUE 3. P. 339 -365 84 41% 32
10 FREIER, SM , ALTMANN, KH , (1997) THE UPS AND DOWNS OF NUCLEIC ACID DUPLEX STABILITY: STRUCTURE-STABILITY STUDIES ON CHEMICALLY-MODIFIED DNA:RNA DUPLEXES.NUCLEIC ACIDS RESEARCH. VOL. 25. ISSUE 22. P. 4429-4443 60 57% 495

Classes with closest relation at Level 1


Rank Class id link
1 2407 ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT//ANTISENSE OLIGONUCLEOTIDES//ANTISENSE RESEARCH AND DEVELOPMENT
2 5118 NUCLEOSIDES & NUCLEOTIDES//NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS//KETONUCLEOSIDES
3 1458 NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS//H PHOSPHONATES//BORANOPHOSPHATE
4 36765 PROGRAM BIOCHEM CHEM//2 SELENOURIDINE TRIPHOSPHATE//3 5 O DIACETYL 5 AMINOMETHYL 2 DEOXYURIDINE
5 6706 PEPTIDE NUCLEIC ACID//PNA//BIOMOL RECOGNIT
6 9916 NEWCAT//WOLFSON RAT STRUCT BASED DESIGN MOL DIAGNOST//CHEM BIOL PL CHEM
7 17872 EXON SKIPPING//MC LOCKWOOD MUSCULAR DYSTROPHY//NEUROMUSCULAR ALS
8 17844 GILEAD IOCB//REVERSIBLE TERMINATOR//LIFE SCI SOLUT GRP
9 26418 TAS 106//DUPLEX DRUG//3 C ETHYNYLCYTIDINE
10 22219 PHARMACEUT SCI KITA 12 NISHI 6 KITA KU//1 2 UNSATURATED NUCLEOSIDE//ANOMERIC RADICAL

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