Class information for:
Level 1: PTGS2//CYCLOOXYGENASE 2 GENE//COX 2 POLYMORPHISM

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
23913 330 38.3 91%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
275 3       NSAIDS//CYCLOOXYGENASE//CYCLOOXYGENASE 2 43399
2305 2             CYCLOOXYGENASE 2//COX 2//CELECOXIB 4519
23913 1                   PTGS2//CYCLOOXYGENASE 2 GENE//COX 2 POLYMORPHISM 330

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PTGS2 authKW 863129 8% 37% 25
2 CYCLOOXYGENASE 2 GENE authKW 475871 2% 86% 6
3 COX 2 POLYMORPHISM authKW 296097 1% 80% 4
4 765G C authKW 277592 1% 100% 3
5 RS5275 authKW 277592 1% 100% 3
6 COX 2 765G C RS20417 POLYMORPHISM authKW 185062 1% 100% 2
7 COX2 765G C authKW 185062 1% 100% 2
8 HEPATITIS B RELATED LIVER CANCER authKW 185062 1% 100% 2
9 RS20417 authKW 185062 1% 100% 2
10 COX 2 GENE authKW 134585 1% 36% 4

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Oncology 2023 41% 0% 135
2 Gastroenterology & Hepatology 294 10% 0% 32
3 Genetics & Heredity 228 12% 0% 40
4 Medicine, Research & Experimental 44 5% 0% 18
5 Public, Environmental & Occupational Health 28 5% 0% 17
6 Peripheral Vascular Diseases 25 3% 0% 11
7 Biochemistry & Molecular Biology 22 12% 0% 38
8 Pathology 17 3% 0% 9
9 Allergy 15 1% 0% 4
10 Pharmacology & Pharmacy 15 7% 0% 22

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ABRUZZO SECT 92531 0% 100% 1
2 BEIJING CANC CANC EPIDEMIOL 92531 0% 100% 1
3 BEIJING CANC ETIOL 92531 0% 100% 1
4 BEIJING CANC MED ONCOL 92531 0% 100% 1
5 BRIGHAM WOMENS HOSP EPIDEMIOL AGING 92531 0% 100% 1
6 CANC PREVENTOFF PREVENT ONCOLCANC PREVENT F 92531 0% 100% 1
7 CANC UK PUBL HLTH 92531 0% 100% 1
8 CASE COMPREHENS CANC FAMILY MED 92531 0% 100% 1
9 CLIN RADIOTHER Y CHEMOTHER Y 3 92531 0% 100% 1
10 EPOCA CLIN 92531 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MOLECULAR BIOLOGY REPORTS 1565 3% 0% 10
2 CARCINOGENESIS 1332 4% 0% 13
3 ASIAN PACIFIC JOURNAL OF CANCER PREVENTION 1324 3% 0% 9
4 CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION 1179 3% 0% 9
5 MOLECULAR CARCINOGENESIS 827 2% 0% 5
6 INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 822 2% 0% 8
7 GENES AND NUTRITION 767 1% 0% 2
8 PHARMACOGENETICS AND GENOMICS 729 1% 0% 3
9 GENETICS AND MOLECULAR RESEARCH 675 2% 0% 7
10 CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY 576 0% 1% 1

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 PTGS2 863129 8% 37% 25 Search PTGS2 Search PTGS2
2 CYCLOOXYGENASE 2 GENE 475871 2% 86% 6 Search CYCLOOXYGENASE+2+GENE Search CYCLOOXYGENASE+2+GENE
3 COX 2 POLYMORPHISM 296097 1% 80% 4 Search COX+2+POLYMORPHISM Search COX+2+POLYMORPHISM
4 765G C 277592 1% 100% 3 Search 765G+C Search 765G+C
5 RS5275 277592 1% 100% 3 Search RS5275 Search RS5275
6 COX 2 765G C RS20417 POLYMORPHISM 185062 1% 100% 2 Search COX+2+765G+C+RS20417+POLYMORPHISM Search COX+2+765G+C+RS20417+POLYMORPHISM
7 COX2 765G C 185062 1% 100% 2 Search COX2+765G+C Search COX2+765G+C
8 HEPATITIS B RELATED LIVER CANCER 185062 1% 100% 2 Search HEPATITIS+B+RELATED+LIVER+CANCER Search HEPATITIS+B+RELATED+LIVER+CANCER
9 RS20417 185062 1% 100% 2 Search RS20417 Search RS20417
10 COX 2 GENE 134585 1% 36% 4 Search COX+2+GENE Search COX+2+GENE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 WANG, XF , HUANG, MZ , ZHANG, XW , HUA, RX , GUO, WJ , (2013) COX-2-765G > C POLYMORPHISM INCREASES THE RISK OF CANCER: A META-ANALYSIS.PLOS ONE. VOL. 8. ISSUE 9. P. - 59 67% 8
2 AGUNDEZ, JAG , BLANCA, M , CORNEJO-GARCIA, JA , GARCIA-MARTIN, E , (2015) PHARMACOGENOMICS OF CYCLOOXYGENASES.PHARMACOGENOMICS. VOL. 16. ISSUE 5. P. 501 -522 72 51% 1
3 WANG, YF , JIANG, HP , LIU, TY , TANG, WF , MA, ZQ , (2015) CYCLOOXYGENASE-2-1195G > A (RS689466) POLYMORPHISM AND CANCER SUSCEPTIBILITY: AN UPDATED META-ANALYSIS INVOLVING 50,672 SUBJECTS.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE. VOL. 8. ISSUE 8. P. 12448 -12462 43 64% 1
4 ZHAO, F , CAO, Y , ZHU, H , HUANG, M , YI, C , HUANG, Y , (2014) THE-765G>C POLYMORPHISM IN THE CYCLOOXYGENASE-2 GENE AND DIGESTIVE SYSTEM CANCER: A META-ANALYSIS.ASIAN PACIFIC JOURNAL OF CANCER PREVENTION. VOL. 15. ISSUE 19. P. 8301 -8310 39 62% 4
5 SKARKE, C , SCHUSS, P , KIRCHHOF, A , DOEHRING, A , GEISSLINGER, G , LOTSCH, J , (2007) PYROSEQUENCING (TM) OF POLYMORPHISMS IN THE COX-2 GENE (PTGS2) WITH REPORTED CLINICAL RELEVANCE.PHARMACOGENOMICS. VOL. 8. ISSUE 12. P. 1643-1660 38 73% 13
6 DONG, J , DAI, JC , ZHANG, MF , HU, ZB , SHEN, HB , (2010) POTENTIALLY FUNCTIONAL COX-2-1195G > A POLYMORPHISM INCREASES THE RISK OF DIGESTIVE SYSTEM CANCERS: A META-ANALYSIS.JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY. VOL. 25. ISSUE 6. P. 1042 -1050 41 54% 33
7 THORN, CF , GROSSER, T , KLEIN, TE , ALTMAN, RB , (2011) PHARMGKB SUMMARY: VERY IMPORTANT PHARMACOGENE INFORMATION FOR PTGS2.PHARMACOGENETICS AND GENOMICS. VOL. 21. ISSUE 9. P. 607 -613 40 53% 6
8 PIRANDA, DN , FESTA-VASCONCELLOS, JS , AMARAL, LM , BERGMANN, A , VIANNA-JORGE, R , (2010) POLYMORPHISMS IN REGULATORY REGIONS OF CYCLOOXYGENASE-2 GENE AND BREAST CANCER RISK IN BRAZILIANS: A CASE-CONTROL STUDY.BMC CANCER. VOL. 10. ISSUE . P. - 31 65% 15
9 FESTA-VASCONCELLOS, JS , PIRANDA, DN , AMARAL, LM , INDIO-DO-BRASIL, V , KOIFMAN, S , VIANNA-JORGE, R , (2012) POLYMORPHISMS IN CYCLOXYGENASE-2 GENE AND BREAST CANCER PROGNOSIS: ASSOCIATION BETWEEN PTGS2 HAPLOTYPES AND HISTOPATHOLOGICAL FEATURES.BREAST CANCER RESEARCH AND TREATMENT. VOL. 132. ISSUE 1. P. 251 -258 29 60% 10
10 AGUNDEZ, JAG , GONZALEZ-ALVAREZ, DL , VEGA-RODRIGUEZ, MA , BOTELLO, E , GARCIA-MARTIN, E , (2014) GENE VARIANTS AND HAPLOTYPES MODIFYING TRANSCRIPTION FACTOR BINDING SITES IN THE HUMAN CYCLOOXYGENASE 1 AND 2 (PTGS1 AND PTGS2) GENES.CURRENT DRUG METABOLISM. VOL. 15. ISSUE 2. P. 182-195 38 43% 5

Classes with closest relation at Level 1


Rank Class id link
1 180 CYCLOOXYGENASE 2//COX 2//CELECOXIB
2 29444 NFKB1//NFKBIA//94INS DELATTG
3 34596 CYCLOOXYGENASE 1 INHIBITOR//ANTIOXIDANT DEFENSE MECHANISM//BIOMED NETWORK HEPAT DIGEST DIS
4 11362 COXIBS//SOLUMATRIX//ROFECOXIB
5 17640 12S HETE//LY293111//ZYFLAMEND
6 10285 IL1RN//INTERLEUKIN 1 BETA GENE//INTERLEUKIN 1B
7 2243 CYCLOOXYGENASE//PROSTAGLANDIN H SYNTHASE//AB HANCOCK JR MEM CANC
8 17299 174G C//INTERLEUKIN 6//INTERLEUKIN 6 POLYMORPHISM
9 25991 15 HYDROXYPROSTAGLANDIN DEHYDROGENASE//15 PGDH//15 HYDROXYPROSTAGLANDIN DEHYDROGENASE 15 PGDH
10 27806 EXPT THER EUT PHARMACOINFORMAT//PROSTACYCLIN SYNTHASE//PROSTACYCLIN SYNTHASE GENE

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