Class information for:
Level 1: ERK5//MEK5//EXTRACELLULAR SIGNAL REGULATED KINASE 5

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
22274 388 44.5 94%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
204 3       PROTEASOME//UBIQUITIN//UNFOLDED PROTEIN RESPONSE 52492
1195 2             JNK//ERK5//MAP KINASE 9252
22274 1                   ERK5//MEK5//EXTRACELLULAR SIGNAL REGULATED KINASE 5 388

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ERK5 authKW 4061806 21% 65% 80
2 MEK5 authKW 1052218 5% 70% 19
3 EXTRACELLULAR SIGNAL REGULATED KINASE 5 authKW 811831 4% 74% 14
4 MEKK2 authKW 634829 3% 73% 11
5 EXTRACELLULAR SIGNAL REGULATED KINASE 5 ERK5 authKW 579504 2% 82% 9
6 BMK1 authKW 524651 3% 67% 10
7 BIG MITOGEN ACTIVATED PROTEIN KINASE 1 BMK1 authKW 236096 1% 100% 3
8 BIX02189 authKW 236096 1% 100% 3
9 DISTAL CEREBROSPINAL FLUID CONTACTING NEURONS authKW 236096 1% 100% 3
10 THE DISTAL CEREBROSPINAL FLUID CONTACTING NEURONS authKW 236096 1% 100% 3

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Cell Biology 1658 34% 0% 132
2 Biochemistry & Molecular Biology 1005 43% 0% 168
3 Oncology 330 17% 0% 65
4 Biophysics 95 7% 0% 26
5 Peripheral Vascular Diseases 51 4% 0% 16
6 Neurosciences 40 9% 0% 33
7 Hematology 39 4% 0% 15
8 Genetics & Heredity 26 5% 0% 19
9 Immunology 17 5% 0% 20
10 Physiology 17 3% 0% 13

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 IST TOSCANO TUMORI CORE 157397 1% 100% 2
2 JIANGSU PROVINCE ANAESTHESIOL 157397 1% 100% 2
3 ABSL3 78699 0% 100% 1
4 AFFLIDATED HOSP 78699 0% 100% 1
5 BIOMED SCI IMMUNOL PROGRAMS 78699 0% 100% 1
6 BLSMD 78699 0% 100% 1
7 CANCPROGRAM MOL CELLULAR BIOL 78699 0% 100% 1
8 DEV MOL BIOLHLTH SCI 78699 0% 100% 1
9 IFR GFAS 140CNRS UMR 6061CELL CYCLE GRP 78699 0% 100% 1
10 INTEGRATED BIOLBUNKYO KU 78699 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CELLULAR SIGNALLING 4610 4% 0% 16
2 MOLECULAR AND CELLULAR BIOLOGY 1123 5% 0% 18
3 JOURNAL OF BIOLOGICAL CHEMISTRY 1006 12% 0% 45
4 EMBO REPORTS 575 1% 0% 4
5 CIRCULATION RESEARCH 487 2% 0% 8
6 ONCOGENE 420 3% 0% 10
7 ONCOTARGET 398 2% 0% 8
8 CURRENT SIGNAL TRANSDUCTION THERAPY 361 0% 0% 1
9 ONCOLOGY LETTERS 225 1% 0% 4
10 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 207 4% 0% 14

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 ERK5 4061806 21% 65% 80 Search ERK5 Search ERK5
2 MEK5 1052218 5% 70% 19 Search MEK5 Search MEK5
3 EXTRACELLULAR SIGNAL REGULATED KINASE 5 811831 4% 74% 14 Search EXTRACELLULAR+SIGNAL+REGULATED+KINASE+5 Search EXTRACELLULAR+SIGNAL+REGULATED+KINASE+5
4 MEKK2 634829 3% 73% 11 Search MEKK2 Search MEKK2
5 EXTRACELLULAR SIGNAL REGULATED KINASE 5 ERK5 579504 2% 82% 9 Search EXTRACELLULAR+SIGNAL+REGULATED+KINASE+5+ERK5 Search EXTRACELLULAR+SIGNAL+REGULATED+KINASE+5+ERK5
6 BMK1 524651 3% 67% 10 Search BMK1 Search BMK1
7 BIG MITOGEN ACTIVATED PROTEIN KINASE 1 BMK1 236096 1% 100% 3 Search BIG+MITOGEN+ACTIVATED+PROTEIN+KINASE+1+BMK1 Search BIG+MITOGEN+ACTIVATED+PROTEIN+KINASE+1+BMK1
8 BIX02189 236096 1% 100% 3 Search BIX02189 Search BIX02189
9 DISTAL CEREBROSPINAL FLUID CONTACTING NEURONS 236096 1% 100% 3 Search DISTAL+CEREBROSPINAL+FLUID+CONTACTING+NEURONS Search DISTAL+CEREBROSPINAL+FLUID+CONTACTING+NEURONS
10 THE DISTAL CEREBROSPINAL FLUID CONTACTING NEURONS 236096 1% 100% 3 Search THE+DISTAL+CEREBROSPINAL+FLUID+CONTACTING+NEURONS Search THE+DISTAL+CEREBROSPINAL+FLUID+CONTACTING+NEURONS

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 NITHIANANDARAJAH-JONES, GN , WILM, B , GOLDRING, CEP , MULLER, J , CROSS, MJ , (2012) ERK5: STRUCTURE, REGULATION AND FUNCTION.CELLULAR SIGNALLING. VOL. 24. ISSUE 11. P. 2187 -2196 72 58% 48
2 LOCHHEAD, PA , GILLEY, R , COOK, SJ , (2012) ERK5 AND ITS ROLE IN TUMOUR DEVELOPMENT.BIOCHEMICAL SOCIETY TRANSACTIONS. VOL. 40. ISSUE . P. 251 -256 45 74% 35
3 WANG, X , TOURNIER, C , (2006) REGULATION OF CELLULAR FUNCTIONS BY THE ERK5 SIGNALLING PATHWAY.CELLULAR SIGNALLING. VOL. 18. ISSUE 6. P. 753 -760 50 69% 162
4 WILHELMSEN, K , XU, FY , FARRAR, K , TRAN, A , KHAKPOUR, S , SUNDAR, S , PRAKASH, A , WANG, JH , GRAY, NS , HELLMAN, J , (2015) EXTRACELLULAR SIGNAL-REGULATED KINASE 5 PROMOTES ACUTE CELLULAR AND SYSTEMIC INFLAMMATION.SCIENCE SIGNALING. VOL. 8. ISSUE 391. P. - 62 51% 1
5 DREW, BA , BUROW, ME , BECKMAN, BS , (2012) MEK5/ERK5 PATHWAY: THE FIRST FIFTEEN YEARS.BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER. VOL. 1825. ISSUE 1. P. 37-48 56 51% 44
6 SIMOES, AES , RODRIGUES, CMP , BORRALHO, PM , (2016) THE MEK5/ERK5 SIGNALLING PATHWAY IN CANCER: A PROMISING NOVEL THERAPEUTIC TARGET.DRUG DISCOVERY TODAY. VOL. 21. ISSUE 10. P. 1654 -1663 54 56% 0
7 ROBERTS, OL , HOLMES, K , MULLER, J , CROSS, DAE , CROSS, MJ , (2009) ERK5 AND THE REGULATION OF ENDOTHELIAL CELL FUNCTION.BIOCHEMICAL SOCIETY TRANSACTIONS. VOL. 37. ISSUE . P. 1254-1259 46 70% 37
8 YANG, QK , LEE, JD , (2011) TARGETING THE BMK1 MAP KINASE PATHWAY IN CANCER THERAPY.CLINICAL CANCER RESEARCH. VOL. 17. ISSUE 11. P. 3527-3532 43 69% 10
9 INESTA-VAQUERA, FA , CAMPBELL, DG , TOURNIER, C , GOMEZ, N , LIZCANO, JM , CUENDA, A , (2010) ALTERNATIVE ERK5 REGULATION BY PHOSPHORYLATION DURING THE CELL CYCLE.CELLULAR SIGNALLING. VOL. 22. ISSUE 12. P. 1829-1837 34 79% 15
10 NITHIANANDARAJAH-JONES, GN , WILM, B , GOLDRING, CEP , MULLER, J , CROSS, MJ , (2014) THE ROLE OF ERK5 IN ENDOTHELIAL CELL FUNCTION.BIOCHEMICAL SOCIETY TRANSACTIONS. VOL. 42. ISSUE . P. 1584 -1589 40 63% 1

Classes with closest relation at Level 1


Rank Class id link
1 36872 FAM83D//FAM83B//ANAT DEV REGENERAT BIOL
2 16802 MEF2C//MEF2//MEF2D
3 9419 DUAL SPECIFICITY PHOSPHATASE//MKP 1//MAP KINASE PHOSPHATASE
4 33806 MODULAR PHARMACOLOGY//RAS RAF ERK1 2//RAS RAF ERK1 2 SIGNALING PATHWAY
5 5457 JNK//MKK4//C JUN N TERMINAL KINASE
6 9970 MAP KINASE KINASE//MAP KINASE//MAP KINASE ACTIVATOR
7 19822 PAR 4//ATYPICAL PROTEIN KINASE C//PROTEIN KINASE C IOTA
8 5307 MK2//P38 INHIBITORS//P38 ALPHA
9 29236 TPL2//TPL 2//COT TPL2
10 24101 MIXED LINEAGE KINASE//RPM 1//DLK

Go to start page