Class information for:
Level 1: MK2//P38 INHIBITORS//P38 ALPHA

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
5307 1643 44.0 91%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
204 3       PROTEASOME//UBIQUITIN//UNFOLDED PROTEIN RESPONSE 52492
1195 2             JNK//ERK5//MAP KINASE 9252
5307 1                   MK2//P38 INHIBITORS//P38 ALPHA 1643

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MK2 authKW 547308 3% 63% 47
2 P38 INHIBITORS authKW 292678 1% 75% 21
3 P38 ALPHA authKW 211148 2% 45% 25
4 P38 authKW 202773 8% 8% 136
5 MAPKAPK2 authKW 199864 1% 51% 21
6 MK5 authKW 185834 1% 100% 10
7 P38 MAP KINASE authKW 183494 4% 15% 68
8 P38 GAMMA authKW 154858 1% 83% 10
9 P38 MAPK authKW 154541 7% 7% 121
10 ERK3 authKW 132733 1% 71% 10

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Medicinal 7681 21% 0% 339
2 Biochemistry & Molecular Biology 2360 34% 0% 553
3 Cell Biology 1882 19% 0% 308
4 Chemistry, Organic 725 11% 0% 180
5 Pharmacology & Pharmacy 523 13% 0% 210
6 Immunology 375 9% 0% 148
7 Biophysics 235 5% 0% 89
8 Rheumatology 115 2% 0% 30
9 Oncology 95 6% 0% 101
10 Crystallography 56 2% 0% 37

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ANTIBIOT BIOARCHITECT GRP 92917 0% 100% 5
2 SHOCK MICROCIRCULAT PLA 38710 0% 42% 5
3 SIGNAL DEPENDENT TRANSCRIPT 38710 0% 42% 5
4 PHARMACEUT MED CHEM 37639 4% 4% 58
5 ALMIRALL S 37167 0% 100% 2
6 CARDIOVASC UROGENITARY ONCOL EXCELLENCE DRU 37167 0% 100% 2
7 DENT UNIT ORAL MICROBIOL 37167 0% 100% 2
8 PHARMCOKINET DRUG METAB 37167 0% 100% 2
9 PROTE GONGDONG PROV 37167 0% 100% 2
10 CANC OSTEOPOROSIS 37163 0% 50% 4

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 13339 8% 1% 135
2 JOURNAL OF MEDICINAL CHEMISTRY 3682 4% 0% 66
3 EXPERT OPINION ON THERAPEUTIC PATENTS 3648 1% 1% 21
4 CURRENT TOPICS IN MEDICINAL CHEMISTRY 1363 1% 1% 13
5 JOURNAL OF BIOLOGICAL CHEMISTRY 1280 7% 0% 108
6 GAS ENGINEERING & MANAGEMENT 1237 0% 7% 1
7 MOLECULAR AND CELLULAR BIOLOGY 802 2% 0% 32
8 CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT 741 0% 1% 5
9 CELLULAR SIGNALLING 698 1% 0% 13
10 MEDCHEMCOMM 662 0% 1% 7

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 MK2 547308 3% 63% 47 Search MK2 Search MK2
2 P38 INHIBITORS 292678 1% 75% 21 Search P38+INHIBITORS Search P38+INHIBITORS
3 P38 ALPHA 211148 2% 45% 25 Search P38+ALPHA Search P38+ALPHA
4 P38 202773 8% 8% 136 Search P38 Search P38
5 MAPKAPK2 199864 1% 51% 21 Search MAPKAPK2 Search MAPKAPK2
6 MK5 185834 1% 100% 10 Search MK5 Search MK5
7 P38 MAP KINASE 183494 4% 15% 68 Search P38+MAP+KINASE Search P38+MAP+KINASE
8 P38 GAMMA 154858 1% 83% 10 Search P38+GAMMA Search P38+GAMMA
9 P38 MAPK 154541 7% 7% 121 Search P38+MAPK Search P38+MAPK
10 ERK3 132733 1% 71% 10 Search ERK3 Search ERK3

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 GANGWAL, RP , BHADAURIYA, A , DAMRE, MV , DHOKE, GV , SANGAMWAR, AT , (2013) P38 MITOGEN-ACTIVATED PROTEIN KINASE INHIBITORS: A REVIEW ON PHARMACOPHORE MAPPING AND QSAR STUDIES.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 13. ISSUE 9. P. 1015 -1035 122 85% 5
2 FIORE, M , FORLI, S , MANETTI, F , (2016) TARGETING MITOGEN-ACTIVATED PROTEIN KINASE-ACTIVATED PROTEIN KINASE 2 (MAPKAPK2, MK2): MEDICINAL CHEMISTRY EFFORTS TO LEAD SMALL MOLECULE INHIBITORS TO CLINICAL TRIALS.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 59. ISSUE 8. P. 3609 -3634 66 75% 3
3 AMIR, M , SOMAKALA, K , ALI, S , (2013) P38 MAP KINASE INHIBITORS AS ANTI INFLAMMATORY AGENTS.MINI-REVIEWS IN MEDICINAL CHEMISTRY. VOL. 13. ISSUE 14. P. 2082-2096 66 89% 12
4 CUADRADO, A , NEBREDA, AR , (2010) MECHANISMS AND FUNCTIONS OF P38 MAPK SIGNALLING.BIOCHEMICAL JOURNAL. VOL. 429. ISSUE . P. 403 -417 72 44% 408
5 ASTOLFI, A , IRACI, N , MANFRONI, G , BARRECA, ML , CECCHETTI, V , (2015) A COMPREHENSIVE STRUCTURAL OVERVIEW OF P38 MAPK IN COMPLEX WITH TYPEI INHIBITORS.CHEMMEDCHEM. VOL. 10. ISSUE 6. P. 957 -969 65 79% 1
6 GUPTA, J , NEBREDA, AR , (2015) ROLES OF P38 ALPHA MITOGEN-ACTIVATED PROTEIN KINASE IN MOUSE MODELS OF INFLAMMATORY DISEASES AND CANCER.FEBS JOURNAL. VOL. 282. ISSUE 10. P. 1841 -1857 72 63% 9
7 PEIFER, C , WAGNER, G , LAUFER, S , (2006) NEW APPROACHES TO THE TREATMENT OF INFLAMMATORY DISORDERS SMALL MOLECULE INHIBITORS OF P38 MAP KINASE.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 6. ISSUE 2. P. 113-149 62 84% 100
8 FISCHER, S , KOEBERLE, SC , LAUFER, SA , (2011) P38 ALPHA MITOGEN-ACTIVATED PROTEIN KINASE INHIBITORS, A PATENT REVIEW (2005-2011).EXPERT OPINION ON THERAPEUTIC PATENTS. VOL. 21. ISSUE 12. P. 1843 -1866 54 90% 15
9 SCIOR, T , DOMEYER, DM , CUANALO-CONTRERAS, K , LAUFER, SA , (2011) PHARMACOPHORE DESIGN OF P38 ALPHA MAP KINASE INHIBITORS WITH EITHER 2,4,5-TRISUBSTITUTED OR 1,2,4,5-TETRASUBSTITUTED IMIDAZOLE SCAFFOLD.CURRENT MEDICINAL CHEMISTRY. VOL. 18. ISSUE 10. P. 1526 -1539 72 68% 8
10 KUMAR, S , BOEHM, J , LEE, JC , (2003) P38 MAP KINASES: KEY SIGNALLING MOLECULES AS THERAPEUTIC TARGETS FOR INFLAMMATORY DISEASES.NATURE REVIEWS DRUG DISCOVERY. VOL. 2. ISSUE 9. P. 717-726 46 70% 735

Classes with closest relation at Level 1


Rank Class id link
1 36922 FR167653//BRAIN KOREA PROJECT TEAM NANOBIOMAT CELL BASED IM//CYTOKINE SUPPRESSANT
2 9419 DUAL SPECIFICITY PHOSPHATASE//MKP 1//MAP KINASE PHOSPHATASE
3 5457 JNK//MKK4//C JUN N TERMINAL KINASE
4 24258 TAK1//TAB1//TGF BETA ACTIVATED KINASE 1
5 9970 MAP KINASE KINASE//MAP KINASE//MAP KINASE ACTIVATOR
6 22274 ERK5//MEK5//EXTRACELLULAR SIGNAL REGULATED KINASE 5
7 16660 COFFIN LOWRY SYNDROME//RSK2//PHOSPHOHISTONE H3
8 17333 2 4 5 TRISUBSTITUTED IMIDAZOLES//1 2 4 5 TETRASUBSTITUTED IMIDAZOLES//TETRASUBSTITUTED IMIDAZOLES
9 29236 TPL2//TPL 2//COT TPL2
10 8526 CARDIAC HYPERTROPHY//HYPERTROPHY//CARDIAC MED SECT

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