Class information for:
Level 1: MODULAR PHARMACOLOGY//RAS RAF ERK1 2//RAS RAF ERK1 2 SIGNALING PATHWAY

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
33806 120 48.0 92%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
204 3       PROTEASOME//UBIQUITIN//UNFOLDED PROTEIN RESPONSE 52492
1195 2             JNK//ERK5//MAP KINASE 9252
33806 1                   MODULAR PHARMACOLOGY//RAS RAF ERK1 2//RAS RAF ERK1 2 SIGNALING PATHWAY 120

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MODULAR PHARMACOLOGY authKW 508926 2% 100% 2
2 RAS RAF ERK1 2 authKW 508926 2% 100% 2
3 RAS RAF ERK1 2 SIGNALING PATHWAY authKW 339283 2% 67% 2
4 BHID authKW 254463 1% 100% 1
5 BIOMARKER TARGET authKW 254463 1% 100% 1
6 CLIN FUNDAMENTAL CHINESE MED address 254463 1% 100% 1
7 CONCHA MARGARITIFERA authKW 254463 1% 100% 1
8 DISAPPEARED RESPONSIVE MODULE authKW 254463 1% 100% 1
9 EMBRYONIC RAT MIDBRAIN PRIMARY CELL CULTURES authKW 254463 1% 100% 1
10 EMERGED RESPONSIVE MODULE authKW 254463 1% 100% 1

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Neurosciences 710 45% 0% 54
2 Biochemistry & Molecular Biology 140 31% 0% 37
3 Pharmacology & Pharmacy 30 12% 0% 14
4 Cell Biology 18 8% 0% 10
5 Biophysics 14 5% 0% 6
6 Medicine, Research & Experimental 13 5% 0% 6
7 Tropical Medicine 11 2% 0% 2
8 Pathology 5 3% 0% 3
9 Biology 5 3% 0% 3
10 Integrative & Complementary Medicine 4 1% 0% 1

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CLIN FUNDAMENTAL CHINESE MED 254463 1% 100% 1
2 JIANGSU PROVINCIAL S HUMAN FUNCT GEN 254463 1% 100% 1
3 MED GENET MECROBIOL 254463 1% 100% 1
4 MED MED 1 STROKE HYPERTENS 254463 1% 100% 1
5 NEUROBIOL CELL MOLEC 254463 1% 100% 1
6 ROBERT F FURCHGOTT SOC 254463 1% 100% 1
7 CROSBY NEUROSURG 254461 2% 50% 2
8 TRADIT CHINESE MED PROTECT UTILIZAT 169639 2% 33% 2
9 INTEGRAT MED PEDIAT 127231 1% 50% 1
10 POST DOCTORAL TRAINING PROGRAM 127231 1% 50% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS 1149 2% 0% 2
2 ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE 607 2% 0% 2
3 NEUROSCIENCE LETTERS 516 7% 0% 8
4 MOLECULAR NEUROBIOLOGY 458 2% 0% 2
5 JOURNAL OF NEUROCHEMISTRY 433 5% 0% 6
6 NUTRITION RESEARCH AND PRACTICE 415 1% 0% 1
7 CNS NEUROSCIENCE & THERAPEUTICS 344 1% 0% 1
8 JOURNAL OF TRADITIONAL CHINESE MEDICINE 338 1% 0% 1
9 FOLIA NEUROPATHOLOGICA 300 1% 0% 1
10 JOURNAL OF NEUROSCIENCE RESEARCH 257 3% 0% 3

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 MODULAR PHARMACOLOGY 508926 2% 100% 2 Search MODULAR+PHARMACOLOGY Search MODULAR+PHARMACOLOGY
2 RAS RAF ERK1 2 508926 2% 100% 2 Search RAS+RAF+ERK1+2 Search RAS+RAF+ERK1+2
3 RAS RAF ERK1 2 SIGNALING PATHWAY 339283 2% 67% 2 Search RAS+RAF+ERK1+2+SIGNALING+PATHWAY Search RAS+RAF+ERK1+2+SIGNALING+PATHWAY
4 BHID 254463 1% 100% 1 Search BHID Search BHID
5 BIOMARKER TARGET 254463 1% 100% 1 Search BIOMARKER+TARGET Search BIOMARKER+TARGET
6 CONCHA MARGARITIFERA 254463 1% 100% 1 Search CONCHA+MARGARITIFERA Search CONCHA+MARGARITIFERA
7 DISAPPEARED RESPONSIVE MODULE 254463 1% 100% 1 Search DISAPPEARED+RESPONSIVE+MODULE Search DISAPPEARED+RESPONSIVE+MODULE
8 EMBRYONIC RAT MIDBRAIN PRIMARY CELL CULTURES 254463 1% 100% 1 Search EMBRYONIC+RAT+MIDBRAIN+PRIMARY+CELL+CULTURES Search EMBRYONIC+RAT+MIDBRAIN+PRIMARY+CELL+CULTURES
9 EMERGED RESPONSIVE MODULE 254463 1% 100% 1 Search EMERGED+RESPONSIVE+MODULE Search EMERGED+RESPONSIVE+MODULE
10 ERK CREB PATHWAY 254463 1% 100% 1 Search ERK+CREB+PATHWAY Search ERK+CREB+PATHWAY

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 SUBRAMANIAM, S , UNSICKER, K , (2010) ERK AND CELL DEATH: ERK1/2 IN NEURONAL DEATH.FEBS JOURNAL. VOL. 277. ISSUE 1. P. 22 -29 18 26% 86
2 LIU, T , CAO, FJ , XU, DD , XU, YQ , FENG, SQ , (2015) UPREGULATED RAS/RAF/ERK1/2 SIGNALING PATHWAY: A NEW HOPE IN THE REPAIR OF SPINAL CORD INJURY.NEURAL REGENERATION RESEARCH. VOL. 10. ISSUE 5. P. 792 -796 10 48% 1
3 PARK, KH , PARK, HJ , SHIN, KS , CHOI, HS , KAI, M , LEE, MK , (2012) MODULATION OF PC12 CELL VIABILITY BY FORSKOLIN-INDUCED CYCLIC AMP LEVELS THROUGH ERK AND JNK PATHWAYS: AN IMPLICATION FOR L-DOPA-INDUCED CYTOTOXICITY IN NIGROSTRIATAL DOPAMINE NEURONS.TOXICOLOGICAL SCIENCES. VOL. 128. ISSUE 1. P. 247-257 14 29% 7
4 CHU, CT , LEVINTHAL, DJ , KULICH, SM , CHALOVICH, EM , DEFRANCO, DB , (2004) OXIDATIVE NEURONAL INJURY - THE DARK SIDE OF ERK1/2.EUROPEAN JOURNAL OF BIOCHEMISTRY. VOL. 271. ISSUE 11. P. 2060-2066 16 23% 183
5 PARK, KH , PARK, HJ , SHIN, KS , LEE, MK , (2014) MULTIPLE TREATMENTS WITH L-3,4-DIHYDROXYPHENYLALANINE MODULATE DOPAMINE BIOSYNTHESIS AND NEUROTOXICITY THROUGH THE PROTEIN KINASE A-TRANSIENT EXTRACELLULAR SIGNAL-REGULATED KINASE AND EXCHANGE PROTEIN ACTIVATION BY CYCLIC AMP-SUSTAINED EXTRACELLULAR SIGNAL-REGULATED KINASE SIGNALING PATHWAYS.JOURNAL OF NEUROSCIENCE RESEARCH. VOL. 92. ISSUE 12. P. 1746 -1756 10 29% 2
6 ZHAN, LX , YAN, HX , ZHOU, HR , SUN, WW , HOU, QH , XU, E , (2013) HYPOXIC PRECONDITIONING ATTENUATES NEURONAL CELL DEATH BY PREVENTING MEK/ERK SIGNALING PATHWAY ACTIVATION AFTER TRANSIENT GLOBAL CEREBRAL ISCHEMIA IN ADULT RATS.MOLECULAR NEUROBIOLOGY. VOL. 48. ISSUE 1. P. 109-119 10 28% 7
7 PARK, HJ , PARK, KH , SHIN, KS , LEE, MK , (2013) THE ROLES OF CYCLIC AMP-ERK-BAD SIGNALING PATHWAYS ON 6-HYDROXYDOPAMINE-INDUCED CELL SURVIVAL AND DEATH IN PC12 CELLS.TOXICOLOGY IN VITRO. VOL. 27. ISSUE 8. P. 2233-2241 11 23% 8
8 LI, J , FAN, Y , ZHANG, YN , SUN, DJ , FU, SB , MA, L , JIANG, LH , CUI, C , DING, HF , YANG, J , (2012) THE RAF-1 INHIBITOR GW5074 AND THE ERK1/2 PATHWAY INHIBITOR U0126 AMELIORATE PC12 CELLS APOPTOSIS INDUCED BY 6-HYDROXYDOPAMINE.PHARMAZIE. VOL. 67. ISSUE 8. P. 718-724 8 27% 1
9 LUO, Y , DEFRANCO, DB , (2006) OPPOSING ROLES FOR ERK1/2 IN NEURONAL OXIDATIVE TOXICITY - DISTINCT MECHANISMS OF ERK1/2 ACTION AT EARLY VERSUS LATE PHASES OF OXIDATIVE STRESS.JOURNAL OF BIOLOGICAL CHEMISTRY. VOL. 281. ISSUE 24. P. 16436-16442 9 23% 76
10 SUBRAMANIAM, S , UNSICKER, K , (2006) EXTRACELLULAR SIGNAL-REGULATED KINASE AS AN INDUCER OF NON-APOPTOTIC NEURONAL DEATH.NEUROSCIENCE. VOL. 138. ISSUE 4. P. 1055-1065 18 12% 58

Classes with closest relation at Level 1


Rank Class id link
1 27763 EXPT VASC//WNC//CLIN EXPT
2 9970 MAP KINASE KINASE//MAP KINASE//MAP KINASE ACTIVATOR
3 5457 JNK//MKK4//C JUN N TERMINAL KINASE
4 18669 XCT//SYSTEM XC//CYSTINE GLUTAMATE ANTIPORTER
5 22274 ERK5//MEK5//EXTRACELLULAR SIGNAL REGULATED KINASE 5
6 9419 DUAL SPECIFICITY PHOSPHATASE//MKP 1//MAP KINASE PHOSPHATASE
7 37725 FGF BP//FGF BINDING PROTEIN//HBP17 FGFBP 1
8 17233 CEREBELLAR GRANULE CELLS//CEREBELLAR GRANULE NEURONS//ACTIVITY DEPENDENT SURVIVAL
9 32412 1 2 OLEOYLACETYLGLYCEROL OAG//BETA IPKC//BIBLICAL TRAGEDY
10 26162 AUTOPHAGY//AUTOPHAGIC NEURON DEATH//BIOMFG BIOTECHNOL ENTERPRISE BRITE

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