Class information for:
Level 1: INTERLEUKIN 8//CXCR2 ANTAGONIST//CXCR2

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
7041 1412 37.4 86%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
578 3       CHEMOKINES//CXCR4//MACROPHAGE MIGRATION INHIBITORY FACTOR 16225
546 2             CHEMOKINES//CXCR4//CHEMOKINE RECEPTOR 14674
7041 1                   INTERLEUKIN 8//CXCR2 ANTAGONIST//CXCR2 1412

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 INTERLEUKIN 8 authKW 229127 12% 6% 168
2 CXCR2 ANTAGONIST authKW 222414 1% 86% 12
3 CXCR2 authKW 219993 4% 19% 53
4 IL 8 RECEPTOR authKW 135373 1% 52% 12
5 CYTOKINE INDUCED NEUTROPHIL CHEMOATTRACTANT authKW 127945 1% 31% 19
6 NEUTROPHIL CHEMOTACTIC FACTOR authKW 92255 1% 53% 8
7 CXCR2 RECEPTOR ANTAGONIST authKW 86496 0% 100% 4
8 GRO ALPHA authKW 85336 1% 26% 15
9 CXCR1 authKW 78600 1% 18% 20
10 MGSA authKW 77225 0% 71% 5

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Immunology 7200 35% 0% 491
2 Cell Biology 1636 19% 0% 266
3 Respiratory System 1036 8% 0% 107
4 Biochemistry & Molecular Biology 937 25% 0% 348
5 Critical Care Medicine 489 4% 0% 56
6 Hematology 478 6% 0% 90
7 Dermatology 281 4% 0% 55
8 Medicine, Research & Experimental 213 6% 0% 81
9 Biophysics 192 5% 0% 75
10 Chemistry, Medicinal 157 4% 0% 55

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 IMMUNOPHARMACOL BIOCHEM IMMUNOL 43248 0% 100% 2
2 REGA MED IMMUNOBIOL 28831 0% 67% 2
3 3 RECH INFLAMMAT IMMUNOL RHUMATOL 21624 0% 100% 1
4 ALIMENTARY PHARMABIOT UNIV CORK 21624 0% 100% 1
5 ANESTHESIOL KAMIGYO KU 21624 0% 100% 1
6 ANTIBIOT HUMORAL IMMUN 21624 0% 100% 1
7 CINMPIS PHARM CHEM 21624 0% 100% 1
8 CLIN ORO RIABILITAZ 21624 0% 100% 1
9 COLT SEDINBURGH LUNG ENVIRONM GRP INITI 21624 0% 100% 1
10 CORP IMMUNOL INFECT DIS GLYCOSCI 21624 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CYTOKINE 8582 3% 1% 42
2 JOURNAL OF LEUKOCYTE BIOLOGY 7098 3% 1% 48
3 JOURNAL OF IMMUNOLOGY 4600 8% 0% 108
4 INFLAMMATION 4001 2% 1% 22
5 AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 3309 2% 1% 28
6 AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 1197 1% 0% 18
7 INFLAMMATION RESEARCH 1092 1% 0% 12
8 EUROPEAN CYTOKINE NETWORK 1064 0% 1% 7
9 IMMUNOLOGY 1054 1% 0% 21
10 JOURNAL OF INVESTIGATIVE DERMATOLOGY 1048 2% 0% 23

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 INTERLEUKIN 8 229127 12% 6% 168 Search INTERLEUKIN+8 Search INTERLEUKIN+8
2 CXCR2 ANTAGONIST 222414 1% 86% 12 Search CXCR2+ANTAGONIST Search CXCR2+ANTAGONIST
3 CXCR2 219993 4% 19% 53 Search CXCR2 Search CXCR2
4 IL 8 RECEPTOR 135373 1% 52% 12 Search IL+8+RECEPTOR Search IL+8+RECEPTOR
5 CYTOKINE INDUCED NEUTROPHIL CHEMOATTRACTANT 127945 1% 31% 19 Search CYTOKINE+INDUCED+NEUTROPHIL+CHEMOATTRACTANT Search CYTOKINE+INDUCED+NEUTROPHIL+CHEMOATTRACTANT
6 NEUTROPHIL CHEMOTACTIC FACTOR 92255 1% 53% 8 Search NEUTROPHIL+CHEMOTACTIC+FACTOR Search NEUTROPHIL+CHEMOTACTIC+FACTOR
7 CXCR2 RECEPTOR ANTAGONIST 86496 0% 100% 4 Search CXCR2+RECEPTOR+ANTAGONIST Search CXCR2+RECEPTOR+ANTAGONIST
8 GRO ALPHA 85336 1% 26% 15 Search GRO+ALPHA Search GRO+ALPHA
9 CXCR1 78600 1% 18% 20 Search CXCR1 Search CXCR1
10 MGSA 77225 0% 71% 5 Search MGSA Search MGSA

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 BAGGIOLINI, M , DEWALD, B , MOSER, B , (1994) INTERLEUKIN-8 AND RELATED CHEMOTACTIC CYTOKINES - CXC AND CC CHEMOKINES.ADVANCES IN IMMUNOLOGY, VOL 55. VOL. 55. ISSUE . P. 97 -179 158 36% 2016
2 DWYER, MP , YU, YN , (2014) CXCR2 RECEPTOR ANTAGONISTS: A MEDICINAL CHEMISTRY PERSPECTIVE.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 14. ISSUE 13. P. 1590 -1605 71 70% 5
3 STILLIE, R , FAROOQ, SM , GORDON, JR , STADNYK, AW , (2009) THE FUNCTIONAL SIGNIFICANCE BEHIND EXPRESSING TWO IL-8 RECEPTOR TYPES ON PMN.JOURNAL OF LEUKOCYTE BIOLOGY. VOL. 86. ISSUE 3. P. 529-543 71 46% 115
4 OPPENHEIM, JJ , ZACHARIAE, COC , MUKAIDA, N , MATSUSHIMA, K , (1991) PROPERTIES OF THE NOVEL PROINFLAMMATORY SUPERGENE INTERCRINE CYTOKINE FAMILY.ANNUAL REVIEW OF IMMUNOLOGY. VOL. 9. ISSUE . P. 617-648 49 42% 1888
5 BOPPANA, NB , DEVARAJAN, A , GOPAL, K , BARATHAN, M , BAKAR, SA , SHANKAR, EM , EBRAHIM, AS , FAROOQ, SM , (2014) BLOCKADE OF CXCR2 SIGNALLING: A POTENTIAL THERAPEUTIC TARGET FOR PREVENTING NEUTROPHIL-MEDIATED INFLAMMATORY DISEASES.EXPERIMENTAL BIOLOGY AND MEDICINE. VOL. 239. ISSUE 5. P. 509 -518 43 48% 15
6 DWYER, MP , YU, YN , (2014) CXCR2 MODULATORS: A PATENT REVIEW (2009-2013).EXPERT OPINION ON THERAPEUTIC PATENTS. VOL. 24. ISSUE 5. P. 519 -534 31 70% 8
7 HOCH, RC , SCHRAUFSTATTER, IU , COCHRANE, CG , (1996) IN VIVO, IN VITRO, AND MOLECULAR ASPECTS OF INTERLEUKIN-8 AND THE INTERLEUKIN-8 RECEPTORS.JOURNAL OF LABORATORY AND CLINICAL MEDICINE. VOL. 128. ISSUE 2. P. 134 -145 54 60% 84
8 LEE, J , CACALANO, G , CAMERATO, T , TOY, K , MOORE, MW , WOOD, WI , (1995) CHEMOKINE BINDING AND ACTIVITIES MEDIATED BY THE MOUSE IL-8 RECEPTOR.JOURNAL OF IMMUNOLOGY. VOL. 155. ISSUE 4. P. 2158-2164 30 88% 239
9 DWYER, MP , BIJU, P , (2010) DISCOVERY OF 3,4-DIAMINOCYCLOBUT-3-ENE-1,2-DIONE-BASED CXCR2 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISORDERS.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 10. ISSUE 13. P. 1339 -1350 35 64% 2
10 HEBERT, CA , BAKER, JB , (1993) INTERLEUKIN-8 - A REVIEW.CANCER INVESTIGATION. VOL. 11. ISSUE 6. P. 743-750 48 70% 84

Classes with closest relation at Level 1


Rank Class id link
1 18490 CHEMOKINE STRUCTURE//LYMPHOTACTIN//CYTOKINE RECEPTOR INTERACTIONS
2 14765 CXCR2//INTERLEUKIN 8//CXCL5
3 21331 CXCL4//CTAP III//CXCL4L1
4 7432 BB 10010//CCL2//LEUKOTACTIN 1
5 36082 FAILURE OF NEUTROPHIL MIGRATION//NEUTROPHIL MIGRATION FAILURE//NEUTROPHIL MIGRATION INHIBITION
6 19733 CCR2 ANTAGONIST//CCR2//CCR1
7 34429 ACID ASPIRATION//GASTRIC ASPIRATION PNEUMONIA//PARTICULATE ASPIRATION
8 25523 EXPT LUNG//LUNG INFLAMMAT INFECT//PULM CRIT CARE MED INFECT DIS
9 21780 DARC//DUFFY BLOOD GROUP//DUFFY ANTIGEN
10 32913 TRANSEPITHELIAL MIGRATION//ALLERGY INFLAMMAT INFECT INFLAMMAT IMMUN//APICAL BASOLATERAL PLASMA MEMBRANES

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