Class information for:
Level 1: APAF 1//CASPASE 2//CASPASE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
1845 2462 47.8 92%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
441 3       TRAIL//SURVIVIN//APOPTOSIS 26474
306 2             TRAIL//SURVIVIN//APOPTOSIS 18497
1845 1                   APAF 1//CASPASE 2//CASPASE 2462

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 APAF 1 authKW 484731 4% 42% 94
2 CASPASE 2 authKW 480477 3% 50% 77
3 CASPASE authKW 428286 20% 7% 489
4 APOPTOSOME authKW 364518 3% 47% 63
5 PIDDOSOME authKW 223834 1% 95% 19
6 RAIDD authKW 167080 1% 84% 16
7 PIDD authKW 154356 1% 66% 19
8 CED 4 authKW 143343 1% 68% 17
9 CED 3 authKW 127981 1% 61% 17
10 CASPASE 9 authKW 112190 3% 14% 66

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Cell Biology 11331 35% 0% 867
2 Biochemistry & Molecular Biology 9179 51% 0% 1252
3 Oncology 956 12% 0% 298
4 Biophysics 854 8% 0% 191
5 Chemistry, Medicinal 569 5% 0% 129
6 Genetics & Heredity 190 5% 0% 126
7 Medicine, Research & Experimental 144 4% 0% 100
8 Developmental Biology 135 2% 0% 46
9 Immunology 135 5% 0% 135
10 Biochemical Research Methods 62 3% 0% 66

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PROGRAM OPTOSIS CELL DEATH 89376 1% 23% 32
2 OPTOSIS SECT 63774 0% 86% 6
3 TAUB STUDY ALZHEIMERS DIS AGING BRAIN 36065 0% 36% 8
4 PROGRAM CELL DEATH 28341 0% 57% 4
5 MOL BIOL HTS 27900 0% 75% 3
6 LEWIS THOMAS 18831 1% 9% 17
7 AERONAUT MIL 16533 0% 67% 2
8 NTRAC COORDINATING 16533 0% 67% 2
9 SKELETAL MUSCLE DEV METAB 16533 0% 67% 2
10 SMURFIT 14735 1% 9% 13

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CELL DEATH AND DIFFERENTIATION 73487 6% 4% 137
2 PEZCOLLER FOUNDATION SYMPOSIA 19885 2% 3% 57
3 PROGRAMMED CELL DEATH 4506 0% 18% 2
4 JOURNAL OF BIOLOGICAL CHEMISTRY 3083 8% 0% 202
5 ONCOGENE 2219 2% 0% 58
6 CELL 1393 2% 0% 42
7 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 1196 2% 0% 51
8 FISH & SHELLFISH IMMUNOLOGY 1088 1% 0% 20
9 MOLECULAR CELL 1061 1% 0% 22
10 EXPERIMENTAL CELL RESEARCH 943 1% 0% 32

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 APAF 1 484731 4% 42% 94 Search APAF+1 Search APAF+1
2 CASPASE 2 480477 3% 50% 77 Search CASPASE+2 Search CASPASE+2
3 CASPASE 428286 20% 7% 489 Search CASPASE Search CASPASE
4 APOPTOSOME 364518 3% 47% 63 Search APOPTOSOME Search APOPTOSOME
5 PIDDOSOME 223834 1% 95% 19 Search PIDDOSOME Search PIDDOSOME
6 RAIDD 167080 1% 84% 16 Search RAIDD Search RAIDD
7 PIDD 154356 1% 66% 19 Search PIDD Search PIDD
8 CED 4 143343 1% 68% 17 Search CED+4 Search CED+4
9 CED 3 127981 1% 61% 17 Search CED+3 Search CED+3
10 CASPASE 9 112190 3% 14% 66 Search CASPASE+9 Search CASPASE+9

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 COHEN, GM , (1997) CASPASES: THE EXECUTIONERS OF APOPTOSIS.BIOCHEMICAL JOURNAL. VOL. 326. ISSUE . P. 1-16 99 65% 3218
2 EARNSHAW, WC , MARTINS, LM , KAUFMANN, SH , (1999) MAMMALIAN CASPASES: STRUCTURE, ACTIVATION, SUBSTRATES, AND FUNCTIONS DURING APOPTOSIS.ANNUAL REVIEW OF BIOCHEMISTRY. VOL. 68. ISSUE . P. 383 -424 149 40% 1865
3 POREBA, M , SZALEK, A , KASPERKIEWICZ, P , RUT, W , SALVESEN, GS , DRAG, M , (2015) Y SMALL MOLECULE ACTIVE SITE DIRECTED TOOLS FOR STUDYING HUMAN CASPASES.CHEMICAL REVIEWS. VOL. 115. ISSUE 22. P. 12546 -12629 191 50% 2
4 LI, P , NIJHAWAN, D , BUDIHARDJO, I , SRINIVASULA, SM , AHMAD, M , ALNEMRI, ES , WANG, XD , (1997) CYTOCHROME C AND DATP-DEPENDENT FORMATION OF APAF-1/CASPASE-9 COMPLEX INITIATES AN APOPTOTIC PROTEASE CASCADE.CELL. VOL. 91. ISSUE 4. P. 479-489 41 75% 5025
5 DEGTEREV, A , BOYCE, M , YUAN, JY , (2003) A DECADE OF CASPASES.ONCOGENE. VOL. 22. ISSUE 53. P. 8543-8567 127 43% 650
6 SLEE, EA , HARTE, MT , KLUCK, RM , WOLF, BB , CASIANO, CA , NEWMEYER, DD , WANG, HG , REED, JC , NICHOLSON, DW , ALNEMRI, ES , ET AL (1999) ORDERING THE CYTOCHROME C-INITIATED CASPASE CASCADE: HIERARCHICAL ACTIVATION OF CASPASES-2, -3, -6, -7, -8, AND -10 IN A CASPASE-9-DEPENDENT MANNER.JOURNAL OF CELL BIOLOGY. VOL. 144. ISSUE 2. P. 281 -292 52 83% 1313
7 CRYNS, V , YUAN, JY , (1998) PROTEASES TO DIE FOR.GENES & DEVELOPMENT. VOL. 12. ISSUE 11. P. 1551 -1570 101 45% 991
8 CLARK, AC , (2016) CASPASE ALLOSTERY AND CONFORMATIONAL SELECTION.CHEMICAL REVIEWS. VOL. 116. ISSUE 11. P. 6666 -6706 106 51% 1
9 NICHOLSON, DW , THORNBERRY, NA , (1997) CASPASES: KILLER PROTEASES.TRENDS IN BIOCHEMICAL SCIENCES. VOL. 22. ISSUE 8. P. 299-306 43 83% 1830
10 KITEVSKA, T , SPENCER, DMS , HAWKINS, CJ , (2009) CASPASE-2: CONTROVERSIAL KILLER OR CHECKPOINT CONTROLLER?.APOPTOSIS. VOL. 14. ISSUE 7. P. 829-848 105 59% 32

Classes with closest relation at Level 1


Rank Class id link
1 28260 CASP8 652 6N DEL//CASPASE8//CASP8
2 14354 DRONC//DIAP1//REAPER
3 14699 C FLIP//FADD//DEATH EFFECTOR DOMAIN
4 21946 APOPTOSIS AND CEREBROVASCULAR INJURY//APOPTOSIS AND NEURODEGENERATION//BRAIN AGING DEMENTIA
5 9988 BCL 2//ROBERT S DOW NEUROBIOL S//EOSINOPHILIC NEURON
6 25040 APOPTOSIS INDUCING FACTOR//AIF//AMID
7 6794 XIAP//LIVIN//SMAC
8 35523 APOPTOTIC INDUCTION//IN VIVO ANTIFUNGAL ACTIVITIES//ARALIA CONTINENTALIS
9 640 MCL 1//BCL 2 FAMILY//BH3 MIMETIC
10 23215 DEGRADOMICS//LIFE SCI 4 401//N TERMINOMICS

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