Class information for:
Level 1: MCL 1//BCL 2 FAMILY//BH3 MIMETIC

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
640 3219 51.2 94%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
441 3       TRAIL//SURVIVIN//APOPTOSIS 26474
306 2             TRAIL//SURVIVIN//APOPTOSIS 18497
640 1                   MCL 1//BCL 2 FAMILY//BH3 MIMETIC 3219

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MCL 1 authKW 764786 7% 36% 224
2 BCL 2 FAMILY authKW 444179 5% 28% 165
3 BH3 MIMETIC authKW 421632 2% 65% 68
4 ABT 737 authKW 408742 2% 57% 76
5 BH3 ONLY authKW 266197 1% 70% 40
6 BAK authKW 265905 3% 30% 94
7 BCL 2 authKW 228895 13% 6% 424
8 BH3 ONLY PROTEINS authKW 224202 2% 46% 51
9 BAX authKW 224025 9% 9% 277
10 BH3 authKW 223123 1% 59% 40

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Cell Biology 17213 38% 0% 1216
2 Biochemistry & Molecular Biology 9210 45% 0% 1456
3 Oncology 7043 25% 0% 818
4 Hematology 922 6% 0% 191
5 Biophysics 709 6% 0% 207
6 Genetics & Heredity 544 7% 0% 219
7 Chemistry, Medicinal 409 4% 0% 132
8 Medicine, Research & Experimental 120 4% 0% 113
9 Developmental Biology 72 1% 0% 43
10 Immunology 62 4% 0% 132

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MOL GENET CANC 68901 1% 28% 26
2 TEAM CELL SURVIVAL TUMOR ESC E BREAST CANC 8 50577 0% 67% 8
3 UMR601 46468 0% 70% 7
4 PROGRAM CANC CHEM BIOL 34825 0% 28% 13
5 SERONO PHARMACEUT 33737 0% 32% 11
6 PLATEFORME IMPACT 25288 0% 67% 4
7 WALTER ELIZA HALL MED 24484 2% 4% 60
8 BIOGENOUEST RECH THER EUT 21338 0% 75% 3
9 LINDE PROGRAM CANC CHEM BIOL 20076 0% 35% 6
10 EQUIPE ELISEE LIGUE 5 18968 0% 100% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CELL DEATH AND DIFFERENTIATION 67330 5% 5% 150
2 CELL DEATH & DISEASE 17964 2% 3% 67
3 PEZCOLLER FOUNDATION SYMPOSIA 13118 2% 3% 53
4 ONCOGENE 7782 4% 1% 123
5 JOURNAL OF BIOLOGICAL CHEMISTRY 3709 8% 0% 254
6 MOLECULAR CANCER THERAPEUTICS 3481 1% 1% 39
7 MOLECULAR CELL 2713 1% 1% 40
8 APOPTOSIS 2518 0% 4% 6
9 BLOOD 2143 3% 0% 91
10 CANCER CELL 1763 1% 1% 17

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 MCL 1 764786 7% 36% 224 Search MCL+1 Search MCL+1
2 BCL 2 FAMILY 444179 5% 28% 165 Search BCL+2+FAMILY Search BCL+2+FAMILY
3 BH3 MIMETIC 421632 2% 65% 68 Search BH3+MIMETIC Search BH3+MIMETIC
4 ABT 737 408742 2% 57% 76 Search ABT+737 Search ABT+737
5 BH3 ONLY 266197 1% 70% 40 Search BH3+ONLY Search BH3+ONLY
6 BAK 265905 3% 30% 94 Search BAK Search BAK
7 BCL 2 228895 13% 6% 424 Search BCL+2 Search BCL+2
8 BH3 ONLY PROTEINS 224202 2% 46% 51 Search BH3+ONLY+PROTEINS Search BH3+ONLY+PROTEINS
9 BAX 224025 9% 9% 277 Search BAX Search BAX
10 BH3 223123 1% 59% 40 Search BH3 Search BH3

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 CZABOTAR, PE , LESSENE, G , STRASSER, A , ADAMS, JM , (2014) CONTROL OF APOPTOSIS BY THE BCL-2 PROTEIN FAMILY: IMPLICATIONS FOR PHYSIOLOGY AND THERAPY.NATURE REVIEWS MOLECULAR CELL BIOLOGY. VOL. 15. ISSUE 1. P. 49 -63 157 74% 433
2 YOULE, RJ , STRASSER, A , (2008) THE BCL-2 PROTEIN FAMILY: OPPOSING ACTIVITIES THAT MEDIATE CELL DEATH.NATURE REVIEWS MOLECULAR CELL BIOLOGY. VOL. 9. ISSUE 1. P. 47 -59 108 67% 2030
3 DELBRIDGE, ARD , GRABOW, S , STRASSER, A , VAUX, DL , (2016) THIRTY YEARS OF BCL-2: TRANSLATING CELL DEATH DISCOVERIES INTO NOVEL CANCER THERAPIES.NATURE REVIEWS CANCER. VOL. 16. ISSUE 2. P. 99 -109 116 63% 16
4 WESTPHAL, D , KLUCK, RM , DEWSON, G , (2014) BUILDING BLOCKS OF THE APOPTOTIC PORE: HOW BAX AND BAK ARE ACTIVATED AND OLIGOMERIZE DURING APOPTOSIS.CELL DEATH AND DIFFERENTIATION. VOL. 21. ISSUE 2. P. 196-205 102 86% 63
5 SHAMAS-DIN, A , KALE, J , LEBER, B , ANDREWS, DW , (2013) MECHANISMS OF ACTION OF BCL-2 FAMILY PROTEINS.COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY. VOL. 5. ISSUE 4. P. - 103 82% 86
6 SIDDIQUI, WA , AHAD, A , AHSAN, H , (2015) THE MYSTERY OF BCL2 FAMILY: BCL-2 PROTEINS AND APOPTOSIS: AN UPDATE.ARCHIVES OF TOXICOLOGY. VOL. 89. ISSUE 3. P. 289 -317 137 53% 40
7 BHOLA, PD , LETAI, A , (2016) MITOCHONDRIA-JUDGES AND EXECUTIONERS OF CELL DEATH SENTENCES.MOLECULAR CELL. VOL. 61. ISSUE 5. P. 695 -704 85 66% 16
8 LEVERSON, JD , ZHANG, H , CHEN, J , TAHIR, SK , PHILLIPS, DC , XUE, J , NIMMER, P , JIN, S , SMITH, M , XIAO, Y , ET AL (2015) POTENT AND SELECTIVE SMALL-MOLECULE MCL-1 INHIBITORS DEMONSTRATE ON-TARGET CANCER CELL KILLING ACTIVITY AS SINGLE AGENTS AND IN COMBINATION WITH ABT-263 (NAVITOCLAX).CELL DEATH & DISEASE. VOL. 6. ISSUE . P. - 59 89% 75
9 ROY, MJ , VOM, A , CZABOTAR, PE , LESSENE, G , (2014) CELL DEATH AND THE MITOCHONDRIA: THERAPEUTIC TARGETING OF THE BCL-2 FAMILY-DRIVEN PATHWAY.BRITISH JOURNAL OF PHARMACOLOGY. VOL. 171. ISSUE 8. P. 1973-1987 107 79% 26
10 SHAMAS-DIN, A , BRAHMBHATT, H , LEBER, B , ANDREWS, DW , (2011) BH3-ONLY PROTEINS: ORCHESTRATORS OF APOPTOSIS.BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. VOL. 1813. ISSUE 4. P. 508-520 110 76% 95

Classes with closest relation at Level 1


Rank Class id link
1 30791 PUMA//PUMA GENE//P53 UPREGULATED MODULATOR OF APOPTOSIS PUMA
2 27975 MOL CELLULAR SIGNALING//TAT BH4//2 EPI 2 O ACETYLTHEVETIN BGHSC 74
3 19375 OBLIMERSEN//G3139//ANTISENSE BCL 2
4 37421 BCL2L12//BCL2L12A//BRAIN TUMOR GENET MED
5 35782 ALTERNOL//DELISHENG//AND TUMOR INVASION
6 1845 APAF 1//CASPASE 2//CASPASE
7 36295 MIR 335//MICRORNA 335//B CELL CLL LYMPHOMA 2 LIKE 2
8 25856 BNIP3//BCH DOMAIN//HGTD P
9 9988 BCL 2//ROBERT S DOW NEUROBIOL S//EOSINOPHILIC NEURON
10 27700 JOINT SERV BIOMARKER EVALUAT ONCOL//KI67 SCORE//LOCDIR

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