Class information for:
Level 1: VALPROIC ACID//VALPROATE//VALNOCTAMIDE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
3625 1942 30.3 62%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
11 4 NEUROSCIENCES//CLINICAL NEUROLOGY//NEUROL 1112395
143 3       EPILEPSY//EPILEPSIA//EPILEPSY & BEHAVIOR 64226
230 2             ANTIEPILEPTIC DRUGS//LEVETIRACETAM//EPILEPSY 20331
3625 1                   VALPROIC ACID//VALPROATE//VALNOCTAMIDE 1942

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 VALPROIC ACID authKW 1279660 20% 21% 392
2 VALPROATE authKW 617843 12% 17% 228
3 VALNOCTAMIDE authKW 181259 1% 82% 14
4 VALPROMIDE authKW 162259 1% 61% 17
5 TRANS 2 EN VALPROATE authKW 141497 0% 100% 9
6 DAVID R BLOOM PHARM address 111419 2% 16% 44
7 HYPERAMMONEMIA authKW 94446 3% 9% 64
8 VALPROATE ENCEPHALOPATHY authKW 78610 0% 100% 5
9 SODIUM VALPROATE authKW 78119 2% 12% 41
10 2 PROPYL 4 PENTENOIC ACID authKW 62888 0% 100% 4

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Clinical Neurology 7957 29% 0% 554
2 Pharmacology & Pharmacy 6123 34% 0% 656
3 Toxicology 1122 8% 0% 153
4 Pediatrics 1107 9% 0% 177
5 Medical Laboratory Technology 875 4% 0% 73
6 Psychiatry 559 7% 0% 139
7 Neurosciences 384 11% 0% 207
8 Chemistry, Medicinal 140 3% 0% 64
9 Chemistry, Analytical 133 5% 0% 99
10 Medicine, General & Internal 71 5% 0% 89

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DAVID R BLOOM PHARM 111419 2% 16% 44
2 R 4PK 62888 0% 100% 4
3 R4PK 42790 0% 39% 7
4 CLIN CHEM PAEDIAT 37725 0% 40% 6
5 EBN SINA HOSP 31444 0% 100% 2
6 FOOD TOXICOL CHEM ANAL FOOD TOXICOL 31444 0% 100% 2
7 ENVIRONM GENET MED 29500 1% 14% 13
8 STUDIES DRUG DISPOSIT 24599 0% 26% 6
9 TOXICOGENOM CONSORTIUM 20961 0% 67% 2
10 NAT PROD MED CHEM 20525 0% 15% 9

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 EPILEPSIA 38056 8% 2% 147
2 EPILEPSY RESEARCH 8528 2% 1% 46
3 THERAPEUTIC DRUG MONITORING 8084 2% 1% 44
4 BIOPHARMACEUTICS & DRUG DISPOSITION 5061 1% 1% 25
5 JOURNAL DE MEDECINE DE STRASBOURG 4739 0% 8% 4
6 DRUG METABOLISM AND DISPOSITION 2964 2% 1% 38
7 PHARMACEUTISCH WEEKBLAD-SCIENTIFIC EDITION 2743 1% 2% 10
8 JOURNAL OF EPILEPSY 2519 0% 2% 8
9 JOURNAL OF CHILD NEUROLOGY 2149 1% 1% 26
10 NEUROLOGY 2082 3% 0% 54

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 VALPROIC ACID 1279660 20% 21% 392 Search VALPROIC+ACID Search VALPROIC+ACID
2 VALPROATE 617843 12% 17% 228 Search VALPROATE Search VALPROATE
3 VALNOCTAMIDE 181259 1% 82% 14 Search VALNOCTAMIDE Search VALNOCTAMIDE
4 VALPROMIDE 162259 1% 61% 17 Search VALPROMIDE Search VALPROMIDE
5 TRANS 2 EN VALPROATE 141497 0% 100% 9 Search TRANS+2+EN+VALPROATE Search TRANS+2+EN+VALPROATE
6 HYPERAMMONEMIA 94446 3% 9% 64 Search HYPERAMMONEMIA Search HYPERAMMONEMIA
7 VALPROATE ENCEPHALOPATHY 78610 0% 100% 5 Search VALPROATE+ENCEPHALOPATHY Search VALPROATE+ENCEPHALOPATHY
8 SODIUM VALPROATE 78119 2% 12% 41 Search SODIUM+VALPROATE Search SODIUM+VALPROATE
9 2 PROPYL 4 PENTENOIC ACID 62888 0% 100% 4 Search 2+PROPYL+4+PENTENOIC+ACID Search 2+PROPYL+4+PENTENOIC+ACID
10 VALPROIC ACID INTOXICATION 62888 0% 100% 4 Search VALPROIC+ACID+INTOXICATION Search VALPROIC+ACID+INTOXICATION

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 LHEUREUX, PER , HANTSON, P , (2009) CARNITINE IN THE TREATMENT OF VALPROIC ACID-INDUCED TOXICITY.CLINICAL TOXICOLOGY. VOL. 47. ISSUE 2. P. 101 -111 74 94% 74
2 SILVA, MFB , AIRES, CCP , LUIS, PBM , RUITER, JPN , IJIST, L , DURAN, M , WANDERS, RJA , DE ALMEIDA, IT , (2008) VALPROIC ACID METABOLISM AND ITS EFFECTS ON MITOCHONDRIAL FATTY ACID OXIDATION: A REVIEW.JOURNAL OF INHERITED METABOLIC DISEASE. VOL. 31. ISSUE 2. P. 205 -216 66 75% 108
3 LHEUREUX, PER , PENALOZA, A , ZAHIR, S , GRIS, M , (2005) SCIENCE REVIEW: CARNITINE IN THE TREATMENT OF VALPROIC ACID-INDUCED TOXICITY - WHAT IS THE EVIDENCE?.CRITICAL CARE. VOL. 9. ISSUE 5. P. 431-440 57 90% 70
4 FRYE, MA , CHOPRA, A , KOLLA, BP , MANSUKHANI, MP , NETZEL, P , (2012) VALPROATE-INDUCED HYPERAMMONEMIC ENCEPHALOPATHY: AN UPDATE ON RISK FACTORS, CLINICAL CORRELATES AND MANAGEMENT.GENERAL HOSPITAL PSYCHIATRY. VOL. 34. ISSUE 3. P. 290 -298 47 90% 16
5 LOSCHER, W , (1999) VALPROATE: A REAPPRAISAL OF ITS PHARMACODYNAMIC PROPERTIES AND MECHANISMS OF ACTION.PROGRESS IN NEUROBIOLOGY. VOL. 58. ISSUE 1. P. 31 -59 86 51% 321
6 SZTAJNKRYCER, MD , (2002) VALPROIC ACID TOXICITY: OVERVIEW AND MANAGEMENT.JOURNAL OF TOXICOLOGY-CLINICAL TOXICOLOGY. VOL. 40. ISSUE 6. P. 789-801 60 78% 102
7 MANOGUERRA, AS , ERDMAN, AR , WOOLF, AD , CHYKA, PA , CARAVATI, EM , SCHARMAN, EJ , BOOZE, LL , CHRISTIANSON, G , NELSON, LS , COBAUGH, DJ , ET AL (2008) VALPROIC ACID POISONING: AN EVIDENCE-BASED CONSENSUS GUIDELINE FOR OUT-OF-HOSPITAL MANAGEMENT.CLINICAL TOXICOLOGY. VOL. 46. ISSUE 7. P. 661 -676 45 92% 8
8 GHANNOUM, M , LALIBERTE, M , NOLIN, TD , MACTIER, R , LAVERGNE, V , HOFFMAN, RS , GOSSELIN, S , (2015) EXTRACORPOREAL TREATMENT FOR VALPROIC ACID POISONING: SYSTEMATIC REVIEW AND RECOMMENDATIONS FROM THE EXTRIP WORKGROUP.CLINICAL TOXICOLOGY. VOL. 53. ISSUE 5. P. 454 -465 50 62% 2
9 COTARIU, D , ZAIDMAN, JL , (1988) VALPROIC ACID AND THE LIVER.CLINICAL CHEMISTRY. VOL. 34. ISSUE 5. P. 890-897 83 78% 50
10 REED, RC , DUTTA, S , LIU, W , (2009) ONCE-DAILY DOSING IS APPROPRIATE FOR EXTENDED-RELEASE DIVALPROEX OVER A WIDE DOSE RANGE, BUT NOT FOR ENTERIC-COATED, DELAYED-RELEASE DIVALPROEX: EVIDENCE VIA COMPUTER SIMULATIONS AND IMPLICATIONS FOR EPILEPSY THERAPY.EPILEPSY RESEARCH. VOL. 87. ISSUE 2-3. P. 260 -267 40 78% 5

Classes with closest relation at Level 1


Rank Class id link
1 6145 CARBAMAZEPINE 10 11 EPOXIDE//CARBAMAZEPINE//THERAPEUTIC DRUG MONITORING
2 4849 ANTIEPILEPTIC DRUGS//TERATOGENICITY//KERALA REGISTRY EPILEPSY PREGNANCY
3 3055 LAMOTRIGINE//FELBAMATE//OXCARBAZEPINE
4 20462 VERDUN HOSP//CHARCOAL HEMOPERFUSION//HEMOPERFUSION
5 10557 CATAMENIAL EPILEPSY//HARVARD NEUROENDOCRINE UNIT//CATAMENIAL
6 25954 STAVANGER NEUROL UNIT//ADDUCTION LAG//AGE ACCELERATED ATHEROSCLEROSIS
7 18501 PILOCARPINE//EXPT BIOL SCI//DL HOMOCYSTEIC ACID INDUCED SEIZURES
8 35824 INO 2628 CZ//EFFICIENCY OF ENTEROHEPATIC CIRCULATION//MNP001
9 12378 DRESS SYNDROME//DRUG INDUCED HYPERSENSITIVITY SYNDROME//HYPERSENSITIVITY SYNDROME
10 16431 LY 300164//FLUNARIZINE//EXPTL EPILEPSIEFOR

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