Class information for:
Level 1: SUBGROUP ANALYSIS//MULTIREGIONAL CLINICAL TRIAL//MULTIREGIONAL TRIAL

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
16116 672 26.6 67%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
9 4 COMPUTER SCIENCE, THEORY & METHODS//COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE//COMPUTER SCIENCE, INFORMATION SYSTEMS 1247339
34 3       STATISTICS & PROBABILITY//STAT//COMMUNICATIONS IN STATISTICS-THEORY AND METHODS 105938
1075 2             ADAPTIVE DESIGN//STATISTICS IN MEDICINE//STATISTICS & PROBABILITY 9928
16116 1                   SUBGROUP ANALYSIS//MULTIREGIONAL CLINICAL TRIAL//MULTIREGIONAL TRIAL 672

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 SUBGROUP ANALYSIS authKW 847799 9% 30% 62
2 MULTIREGIONAL CLINICAL TRIAL authKW 757297 3% 83% 20
3 MULTIREGIONAL TRIAL authKW 408944 1% 100% 9
4 QUALITATIVE INTERACTION authKW 344365 2% 63% 12
5 BRIDGING STUDY authKW 290785 2% 40% 16
6 CONSISTENT TREND authKW 272629 1% 100% 6
7 SUBGROUP IDENTIFICATION authKW 230023 1% 56% 9
8 REGIONAL SAMPLE SIZE authKW 227191 1% 100% 5
9 SUBJECT TREATMENT INTERACTION authKW 181753 1% 100% 4
10 SUBGROUP ANALYSES authKW 177341 2% 35% 11

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Statistics & Probability 19135 41% 0% 276
2 Mathematical & Computational Biology 10805 23% 0% 157
3 Medical Informatics 8364 14% 0% 93
4 Medicine, Research & Experimental 2149 22% 0% 146
5 Pharmacology & Pharmacy 1203 26% 0% 176
6 Health Care Sciences & Services 1192 9% 0% 63
7 Public, Environmental & Occupational Health 823 15% 0% 103
8 Oncology 283 13% 0% 84
9 Medicine, General & Internal 111 8% 0% 51
10 Biology 93 4% 0% 27

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DRUG DEV REGULATORY SCI PHARM 90876 0% 100% 2
2 OB OTS CDER DB1 90876 0% 100% 2
3 OFF SCI POLICY GOVT AFFAIRS 90876 0% 100% 2
4 SUNNYBROOK WOMENS UNIT 90876 0% 100% 2
5 CLIN TRIAL STAT 87375 1% 38% 5
6 BIOSTAT DECIS SCI 75097 1% 18% 9
7 INNOVAT BIOMED INFORMAT 58411 1% 21% 6
8 OFF BIOSTAT 53919 5% 3% 34
9 BIOMETR BRANCH 52637 4% 4% 26
10 BIOMETR 1 47659 1% 13% 8

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF BIOPHARMACEUTICAL STATISTICS 129209 8% 6% 51
2 STATISTICS IN BIOPHARMACEUTICAL RESEARCH 53745 3% 6% 19
3 CLINICAL TRIALS 47956 4% 4% 28
4 PHARMACEUTICAL STATISTICS 45740 3% 4% 23
5 STATISTICS IN MEDICINE 36618 11% 1% 76
6 DRUG INFORMATION JOURNAL 34778 4% 3% 29
7 CONTROLLED CLINICAL TRIALS 9154 2% 1% 14
8 CONTEMPORARY CLINICAL TRIALS 6329 2% 1% 14
9 BIOMETRICS 6267 4% 1% 25
10 THERAPEUTIC INNOVATION & REGULATORY SCIENCE 6120 1% 2% 7

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 SUBGROUP ANALYSIS 847799 9% 30% 62 Search SUBGROUP+ANALYSIS Search SUBGROUP+ANALYSIS
2 MULTIREGIONAL CLINICAL TRIAL 757297 3% 83% 20 Search MULTIREGIONAL+CLINICAL+TRIAL Search MULTIREGIONAL+CLINICAL+TRIAL
3 MULTIREGIONAL TRIAL 408944 1% 100% 9 Search MULTIREGIONAL+TRIAL Search MULTIREGIONAL+TRIAL
4 QUALITATIVE INTERACTION 344365 2% 63% 12 Search QUALITATIVE+INTERACTION Search QUALITATIVE+INTERACTION
5 BRIDGING STUDY 290785 2% 40% 16 Search BRIDGING+STUDY Search BRIDGING+STUDY
6 CONSISTENT TREND 272629 1% 100% 6 Search CONSISTENT+TREND Search CONSISTENT+TREND
7 SUBGROUP IDENTIFICATION 230023 1% 56% 9 Search SUBGROUP+IDENTIFICATION Search SUBGROUP+IDENTIFICATION
8 REGIONAL SAMPLE SIZE 227191 1% 100% 5 Search REGIONAL+SAMPLE+SIZE Search REGIONAL+SAMPLE+SIZE
9 SUBJECT TREATMENT INTERACTION 181753 1% 100% 4 Search SUBJECT+TREATMENT+INTERACTION Search SUBJECT+TREATMENT+INTERACTION
10 SUBGROUP ANALYSES 177341 2% 35% 11 Search SUBGROUP+ANALYSES Search SUBGROUP+ANALYSES

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 TANNIOU, J , VAN DER TWEEL, I , TEERENSTRA, S , ROES, KCB , (2016) SUBGROUP ANALYSES IN CONFIRMATORY CLINICAL TRIALS: TIME TO BE SPECIFIC ABOUT THEIR PURPOSES.BMC MEDICAL RESEARCH METHODOLOGY. VOL. 16. ISSUE . P. - 62 93% 0
2 LIPKOVICH, I , DMITRIENKO, A , D'AGOSTINO, RB , (2017) TUTORIAL IN BIOSTATISTICS: DATA-DRIVEN SUBGROUP IDENTIFICATION AND ANALYSIS IN CLINICAL TRIALS.STATISTICS IN MEDICINE. VOL. 36. ISSUE 1. P. 136 -196 39 50% 1
3 TAJIK, P , ZWINDERMAN, AH , MOL, BW , BOSSUYT, PM , (2013) TRIAL DESIGNS FOR PERSONALIZING CANCER CARE: A SYSTEMATIC REVIEW AND CLASSIFICATION.CLINICAL CANCER RESEARCH. VOL. 19. ISSUE 17. P. 4578 -4588 48 64% 16
4 ANTONIOU, M , JORGENSEN, AL , KOLAMUNNAGE-DONA, R , (2016) BIOMARKER-GUIDED ADAPTIVE TRIAL DESIGNS IN PHASE II AND PHASE III: A METHODOLOGICAL REVIEW.PLOS ONE. VOL. 11. ISSUE 2. P. - 52 45% 2
5 AN, MW , SARGENT, DJ , MANDREKAR, SJ , RENFRO, LA , MALLICK, H , (2016) CLINICAL TRIAL DESIGNS INCORPORATING PREDICTIVE BIOMARKERS.CANCER TREATMENT REVIEWS. VOL. 43. ISSUE . P. 74 -82 41 64% 0
6 ONDRA, T , DMITRIENKO, A , FRIEDE, T , GRAF, A , MILLER, F , STALLARD, N , POSCH, M , (2016) METHODS FOR IDENTIFICATION AND CONFIRMATION OF TARGETED SUBGROUPS IN CLINICAL TRIALS: A SYSTEMATIC REVIEW.JOURNAL OF BIOPHARMACEUTICAL STATISTICS. VOL. 26. ISSUE 1. P. 99 -119 37 51% 2
7 DMITRIENKO, A , MUYSERS, C , FRITSCH, A , LIPKOVICH, I , (2016) GENERAL GUIDANCE ON EXPLORATORY AND CONFIRMATORY SUBGROUP ANALYSIS IN LATE-STAGE CLINICAL TRIALS.JOURNAL OF BIOPHARMACEUTICAL STATISTICS. VOL. 26. ISSUE 1. P. 71 -98 26 67% 0
8 JANES, H , BROWN, MD , PEPE, MS , (2015) DESIGNING A STUDY TO EVALUATE THE BENEFIT OF A BIOMARKER FOR SELECTING PATIENT TREATMENT.STATISTICS IN MEDICINE. VOL. 34. ISSUE 27. P. 3503 -3515 22 73% 0
9 JANES, H , PEPE, MS , MCSHANE, LM , SARGENT, DJ , HEAGERTY, PJ , (2015) THE FUNDAMENTAL DIFFICULTY WITH EVALUATING THE ACCURACY OF BIOMARKERS FOR GUIDING TREATMENT.JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. VOL. 107. ISSUE 8. P. - 18 82% 3
10 WILHELM-BENARTZI, CS , MT-ISA, S , FIORENTINO, F , BROWN, R , ASHBY, D , (2017) CHALLENGES AND METHODOLOGY IN THE INCORPORATION OF BIOMARKERS IN CANCER CLINICAL TRIALS.CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY. VOL. 110. ISSUE . P. 49 -61 25 57% 0

Classes with closest relation at Level 1


Rank Class id link
1 27428 COVARIATE ADJUSTMENT//LINEAR MODELS EQUATING COVARIATE MEANS//RANDOMIZATION BASED NONPARAMETRIC COVARIANCE ADJUSTMENT
2 1949 ADAPTIVE DESIGN//INTERIM ANALYSIS//GROUP SEQUENTIAL TEST
3 21566 SURVIVAL TREE//RECURSIVE PARTITIONING//REGRESSION TREE
4 26445 DRUG LAG//JAPANESE CLINICAL TRIALS//GLOBAL DRUG DEVELOPMENT
5 30357 COMPOSITE ENDPOINTS//WIN RATIO//WORST RANK SCORES
6 13323 EXPLAINED VARIATION//TUFTS CTSI//EXPLAINED RANDOMNESS
7 22251 NONINFERIORITY MARGIN//NON INFERIORITY//THREE ARM DESIGN
8 18139 SURROGATE ENDPOINT//SURROGATE OUTCOME//PRENTICE CRITERION
9 15440 RESPONSE ADAPTIVE DESIGN//URN MODEL//BIASED COIN DESIGN
10 8662 PHARMACOGENOMICS//HLA B5701//PERSONALIZED MEDICINE

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