Class information for:
Level 1: RENIN INHIBITOR//KETOPIPERAZINE//REMIKIREN

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
15903 684 30.5 61%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
8 4 CARDIAC & CARDIOVASCULAR SYSTEM//PERIPHERAL VASCULAR DISEASES//CARDIOL 1276458
57 3       ANGIOTENSIN II//HYPERTENSION//PERIPHERAL VASCULAR DISEASES 89232
85 2             ANGIOTENSIN II//RENIN ANGIOTENSIN SYSTEM//ANGIOTENSIN 27105
15903 1                   RENIN INHIBITOR//KETOPIPERAZINE//REMIKIREN 684

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 RENIN INHIBITOR authKW 1714810 14% 39% 98
2 KETOPIPERAZINE authKW 267846 1% 100% 6
3 REMIKIREN authKW 218737 1% 70% 7
4 RO 42 5892 authKW 178564 1% 100% 4
5 DIHYDROXYETHYLENE ISOSTERE authKW 133923 0% 100% 3
6 ENALKIREN authKW 100441 0% 75% 3
7 2S 3R 4S 4 AMINO 5 CYCLOHEXYL 1 MORPHOLINO 2 3 PENTANEDIOL authKW 89282 0% 100% 2
8 CGP 38560A authKW 89282 0% 100% 2
9 CI 992 authKW 89282 0% 100% 2
10 DAIICHI SANKYO LIFE SCI INDIA address 89282 0% 100% 2

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Medicinal 5543 27% 0% 184
2 Peripheral Vascular Diseases 1717 15% 0% 104
3 Chemistry, Organic 1206 20% 0% 137
4 Pharmacology & Pharmacy 1030 24% 0% 166
5 Cardiac & Cardiovascular System 297 9% 0% 64
6 Biochemistry & Molecular Biology 93 14% 0% 97
7 Chemistry, Multidisciplinary 64 9% 0% 64
8 Physiology 54 4% 0% 28
9 Biophysics 37 4% 0% 26
10 Biochemical Research Methods 23 3% 0% 20

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DAIICHI SANKYO LIFE SCI INDIA 89282 0% 100% 2
2 DRUG DISCOVERY CHEM BIOCHEM 59520 0% 67% 2
3 BIOCHEM CENT S MEGURO KU 44641 0% 100% 1
4 CENT S BIOCHEM MEGURO KU 44641 0% 100% 1
5 MED CHEM S I 44641 0% 100% 1
6 NEW LEAD 44641 0% 100% 1
7 NEW LEAD SHINAGAWA KU 44641 0% 100% 1
8 PHARMACOL CENT S MEGURO KU 44641 0% 100% 1
9 PREPARAT SEPARAT BIOREACT GRP 44641 0% 100% 1
10 SSACRINSPMBBRC 44641 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF MEDICINAL CHEMISTRY 11678 11% 0% 75
2 CLINICAL AND EXPERIMENTAL HYPERTENSION PART A-THEORY AND PRACTICE 7313 2% 1% 15
3 HYPERTENSION 6186 6% 0% 40
4 JOURNAL OF HYPERTENSION 5954 5% 0% 36
5 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 3868 7% 0% 47
6 JOURNAL OF CARDIOVASCULAR PHARMACOLOGY 2504 4% 0% 25
7 ANNUAL REPORTS IN MEDICINAL CHEMISTRY 2447 1% 1% 7
8 TRANSACTIONS OF THE ASSOCIATION OF AMERICAN PHYSICIANS 1290 0% 1% 2
9 ORGANIC PROCESS RESEARCH & DEVELOPMENT 921 1% 0% 8
10 BIOTELEMETRY AND PATIENT MONITORING 857 0% 2% 1

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 RENIN INHIBITOR 1714810 14% 39% 98 Search RENIN+INHIBITOR Search RENIN+INHIBITOR
2 KETOPIPERAZINE 267846 1% 100% 6 Search KETOPIPERAZINE Search KETOPIPERAZINE
3 REMIKIREN 218737 1% 70% 7 Search REMIKIREN Search REMIKIREN
4 RO 42 5892 178564 1% 100% 4 Search RO+42+5892 Search RO+42+5892
5 DIHYDROXYETHYLENE ISOSTERE 133923 0% 100% 3 Search DIHYDROXYETHYLENE+ISOSTERE Search DIHYDROXYETHYLENE+ISOSTERE
6 ENALKIREN 100441 0% 75% 3 Search ENALKIREN Search ENALKIREN
7 2S 3R 4S 4 AMINO 5 CYCLOHEXYL 1 MORPHOLINO 2 3 PENTANEDIOL 89282 0% 100% 2 Search 2S+3R+4S+4+AMINO+5+CYCLOHEXYL+1+MORPHOLINO+2+3+PENTANEDIOL Search 2S+3R+4S+4+AMINO+5+CYCLOHEXYL+1+MORPHOLINO+2+3+PENTANEDIOL
8 CGP 38560A 89282 0% 100% 2 Search CGP+38560A Search CGP+38560A
9 CI 992 89282 0% 100% 2 Search CI+992 Search CI+992
10 DIHYDROXYETHYLENE DIPEPTIDE ISOSTERE 89282 0% 100% 2 Search DIHYDROXYETHYLENE+DIPEPTIDE+ISOSTERE Search DIHYDROXYETHYLENE+DIPEPTIDE+ISOSTERE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 LIN, C , FRISHMAN, WH , (1996) RENIN INHIBITION: A NOVEL THERAPY FOR CARDIOVASCULAR DISEASE.AMERICAN HEART JOURNAL. VOL. 131. ISSUE 5. P. 1024-1034 67 83% 15
2 GREENLEE, WJ , (1990) RENIN INHIBITORS.MEDICINAL RESEARCH REVIEWS. VOL. 10. ISSUE 2. P. 173-236 83 54% 274
3 MAIBAUM, J , FELDMAN, DL , (2003) RENIN INHIBITORS AS NOVEL TREATMENTS FOR CARDIOVASCULAR DISEASE.EXPERT OPINION ON THERAPEUTIC PATENTS. VOL. 13. ISSUE 5. P. 589-603 54 63% 38
4 WOOD, JM , CUMIN, F , MAIBAUM, J , (1994) PHARMACOLOGY OF RENIN INHIBITORS AND THEIR APPLICATION TO THE TREATMENT OF HYPERTENSION.PHARMACOLOGY & THERAPEUTICS. VOL. 61. ISSUE 3. P. 325-344 63 64% 36
5 CORVOL, P , CHAUVEAU, D , JEUNEMAITRE, X , MENARD, J , (1990) HUMAN RENIN INHIBITOR PEPTIDES.HYPERTENSION. VOL. 16. ISSUE 1. P. 1-11 55 76% 55
6 YOKOKAWA, F , (2013) RECENT PROGRESS ON THE DISCOVERY OF NON-PEPTIDIC DIRECT RENIN INHIBITORS FOR THE CLINICAL MANAGEMENT OF HYPERTENSION.EXPERT OPINION ON DRUG DISCOVERY. VOL. 8. ISSUE 6. P. 673-690 35 56% 8
7 FRISHMAN, WH , FOZAILOFF, A , LIN, C , DIKE, C , (1994) RENIN INHIBITION - A NEW APPROACH TO CARDIOVASCULAR THERAPY.JOURNAL OF CLINICAL PHARMACOLOGY. VOL. 34. ISSUE 9. P. 873-880 42 81% 17
8 HABER, E , (1989) WHY RENIN INHIBITORS.JOURNAL OF HYPERTENSION. VOL. 7. ISSUE . P. S81-S86 51 84% 12
9 SUBRAMANIAN, G , (2013) COMPUTATIONAL MODELING AND DESIGN OF RENIN INHIBITORS.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. VOL. 23. ISSUE 2. P. 460-465 28 68% 1
10 KLEINERT, HD , (1996) HEMODYNAMIC EFFECTS OF RENIN INHIBITORS.AMERICAN JOURNAL OF NEPHROLOGY. VOL. 16. ISSUE 3. P. 252-260 35 76% 1

Classes with closest relation at Level 1


Rank Class id link
1 12014 HAPALOSIN//HYDROXYETHYLENE DIPEPTIDE ISOSTERE//ALPHA AMINO ALDEHYDES
2 9376 ALISKIREN//PRORENIN RECEPTOR//DIRECT RENIN INHIBITOR
3 3425 PRORENIN//RENIN//JUXTAGLOMERULAR CELLS
4 10106 ANGIOTENSINOGEN//ADRENAL RENIN//HIGH MOLECULAR WEIGHT ANGIOTENSINOGEN
5 31640 ANGIOTENSIN II VACCINE//EA4222//KINOID
6 5422 ASPARTIC PROTEINASE//CATHEPSIN E//MILK CLOTTING ENZYME
7 4516 CANDESARTAN CILEXETIL//ANGIOTENSIN II RECEPTOR ANTAGONIST//LOSARTAN
8 1245 CAS 89396 94 1//TA 6366//IMIDAPRIL
9 2183 HIV 1 PROTEASE//HIV PROTEASE//HIV 1 PROTEASE INHIBITORS
10 12385 BETA TURN MIMETIC//PEPTIDOMIMETICS//BICYCLIC DIPEPTIDE

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